Distinction between signaling mechanisms in lipid rafts vs. caveolae
Open accessAbstract
The relative importance of lipid rafts vs. specialized rafts termed caveolae to influence signal transduction is not known. Here we show that in cells lacking caveolae, the dually acylated protein, endothelial nitric oxide synthase (eNOS), localizes to cholesterol-rich lipid raft domains of the plasma membrane. In these cells, expression of caveolin-1 (cav-1) stimulates caveolae biogenesis, promotes the interaction of cav-1 with eNOS, and the inhibition of NO release from cells. Interestingly, in cells where cav-1 does not drive caveolae assembly, despite equal levels of cav-1 and eNOS and localization of both proteins to raft domains of the plasmalemma, the physical interaction of eNOS with cav-1 is dramatically less resulting in less inhibition of NO release. Thus, cav-1 concentrated in caveolae, not in rafts, is in closer proximity to eNOS and is necessary for negative regulation of eNOS function, thereby providing the first clear example of spatial regulation of signaling in this organelle that is distinct from raft domains.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
NOX2 expression has been reported in other cell types including endothelial cells and adventitial fibroblasts.
“NOX2 expression has been also reported in other cell types including endothelial cells and adventitial fibroblasts (376, 382, 657, 714, 715, 736, 876) (FIGURE 9, Table 5).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [876]
Macrophage NOX2 is more detrimental in the development of cardiovascular disease.
“The current paradigm indicates that macrophage NOX2 is more detrimental in the development of cardiovascular disease (395, 876), with endothelial NOX2 probably involved in the initiation, but not so much in the development of the disease, and a subsequent progress of the atherosclerotic lesion dependent on immune cells (243, 573, 976).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [876]
NOX4 is the most abundant isoform in ECs, and it is also present in VSMCs and adventitial fibroblasts.
“NOX4 is the most abundant isoform in ECs, and it is also present in VSMCs and adventitial fibroblasts (10, 265, 736, 832, 876, 1036).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [876]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
Fulton, D. J., Gratton, J., McCabe, T. J. D., Fontana, J. T., Fujio, Y., Walsh, K., Franke, T. F., Papapetropoulos, A., & Sessa, W. C. (1999) · Nature · doi:10.1038/21218 · Cited by 2,612 · see citing works
Self-citationLipid sorting in epithelial cells
Simons, K., & Gerrit van, M. E. E. R. (1988) · Biochemistry · doi:10.1021/bi00417a001 · Cited by 1,373 · see citing works
Dynamic activation of endothelial nitric oxide synthase by Hsp90
García‐Cardeña, G., Fan, R., Shah, V. H., Sorrentino, R., Cirino, G., Papapetropoulos, A., & Sessa, W. C. (1998) · Nature · doi:10.1038/33934 · Cited by 1,029 · see citing works
Self-citationSong, K. S., Li, S. C., Okamoto, T., Quilliam, L. A., Sargiacomo, M., & Lisanti, M. P. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.16.9690 · Cited by 1,000 · see citing works
Lisanti, M. P., Scherer, P. E., Vidugirienė, J., Tang, Z., Hermanowski‐Vosatka, A., Tu, Y. H., Cook, R. F., & Sargiacomo, M. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.126.1.111 · Cited by 906 · see citing works
Dissecting the Interaction between Nitric Oxide Synthase (NOS) and Caveolin
Garcı́a-Cardeña, G., Martasek, P., Masters, B. S. S., Skidd, P. M., Couet, J., Li, S., Lisanti, M. P., & Sessa, W. C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.41.25437 · Cited by 821 · see citing works
Self-citationPotocytosis: Sequestration and Transport of Small Molecules by Caveolae
Anderson, R. G. W., Kamen, B. A., Rothberg, K. G., & Lacey, S. W. (1992) · Science · doi:10.1126/science.1310359 · Cited by 734 · see citing works
García‐Cardeña, G., Oh, P., Liu, J., Schnitzer, J. E., & Sessa, W. C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6448 · Cited by 679 · see citing works
Self-citationEndothelial Nitric Oxide Synthase Targeting to Caveolae
Féron, O., Belhassen, L., Kobzik, L., Smith, T. W., Kelly, R. A., & Michel, T. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.37.22810 · Cited by 676 · see citing works
Direct Interaction of Endothelial Nitric-oxide Synthase and Caveolin-1 Inhibits Synthase Activity
Ju, H., Zou, R., Venema, V. J., & Venema, R. C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18522 · Cited by 641 · see citing works
Reciprocal Regulation of Endothelial Nitric-oxide Synthase by Ca2+-Calmodulin and Caveolin
Michel, J. B., Féron, O., Sacks, D. B., & Michel, T. M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.25.15583 · Cited by 613 · see citing works
Förstermann, U., Pollock, J. S., Schmidt, H. H. H. W., Heller, M., & Murad, F. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.5.1788 · Cited by 592 · see citing works
Bucci, M., Gratton, J., Rudic, R. D., Acevedo, L. M., Roviezzo, F., Cirino, G., & Sessa, W. C. (2000) · Nature Medicine · doi:10.1038/82176 · Cited by 573 · see citing works
Self-citationKurzchalia, T. V., Dupree, P., Parton, R. G., Kellner, R., Virta, H., Lehnert, M., & Simons, K. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.118.5.1003 · Cited by 559 · see citing works
Cell cholesterol efflux: integration of old and new observations provides new insights
Rothblat, G. H., de la Llera-Moya, M., Atger, V., Kellner-Weibel, G., Williams, D. L., & Phillips, M. C. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32113-1 · Cited by 502 · see citing works
A Role for Caveolin in Transport of Cholesterol from Endoplasmic Reticulum to Plasma Membrane
Smart, E. J., Ying, Y., Donzell, W. C., & Anderson, R. G. W. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.46.29427 · Cited by 501 · see citing works
Role of plasmalemmal caveolae in signal transduction
Shaul, P. W., & Anderson, R. G. W. (1998) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1998.275.5.l843 · Cited by 465 · see citing works
Roy, S., Luetterforst, R., Harding, A. S., Apolloni, A., Etheridge, M., Stang, E., Rolls, B. J., Hancock, J. F., & Parton, R. G. (1999) · Nature Cell Biology · doi:10.1038/10067 · Cited by 454 · see citing works
Role of GTP Hydrolysis in Fission of Caveolae Directly from Plasma Membranes
Schnitzer, J. E., Oh, P., & McIntosh, D. P. (1996) · Science · doi:10.1126/science.274.5285.239 · Cited by 376 · see citing works
Gratton, J., Fontana, J. T., O’Connor, D. S., García‐Cardeña, G., McCabe, T. J. D., & Sessa, W. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001644200 · Cited by 327 · see citing works
Self-citationRizzo, V., McIntosh, D. P., Oh, P., & Schnitzer, J. E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.52.34724 · Cited by 306 · see citing works
Caveolin-1 and -2 in the Exocytic Pathway of MDCK Cells
Scheiffele, P., Verkade, P., Fra, A., Virta, H., Simons, K., & Ikonen, E. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.140.4.795 · Cited by 301 · see citing works
Plasma membrane caveolae mediate the efflux of cellular free cholesterol
Fielding, P. E., & Fielding, C. J. (1995) · Biochemistry · doi:10.1021/bi00044a004 · Cited by 276 · see citing works
Sessa, W. C., Garca-Cardea, G., Liu, J., Keh, A., Pollock, J. S., Bradley, J. R., Thiru, S., Braverman, I. M., & Desai, K. M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.30.17641 · Cited by 258 · see citing works
Self-citationMora, R. C., Bonilha, V. L., Marmorstein, A. D., Scherer, P. E., Brown, D., Lisanti, M. P., & Rodriguez-Boulan, E. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.36.25708 · Cited by 216 · see citing works
Cell-specific targeting of caveolin-1 to caveolae, secretory vesicles, cytoplasm or mitochondria
Li, W., Liu, P., Pilcher, B. K., & Anderson, R. G. W. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.7.1397 · Cited by 197 · see citing works
Lipardi, C., Mora, R. C., Colomer, V., Paladino, S., Nitsch, L., Rodriguez-Boulan, E. J., & Zurzolo, C. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.140.3.617 · Cited by 139 · see citing works
Trafficking of Endothelial Nitric-oxide Synthase in Living Cells
Sowa, G., Liu, J., Papapetropoulos, A., Rex‐Haffner, M., Hughes, T. E., & Sessa, W. C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.32.22524 · Cited by 119 · see citing works
Self-citationChen, A. F. Y., O’Brien, T., Tsutsui, M., Kinoshita, H., Pompili, V. J., Crotty, T. B., Spector, D. J., & Katušić, Z. S. (1997) · Circulation Research · doi:10.1161/01.res.80.3.327 · Cited by 111 · see citing works
Endothelial nitric oxide synthase interactions with G-protein-coupled receptors
Marrero, M. B., Venema, V. J., Ju, H., He, H., Liang, H., Caldwell, R. B., & Venema, R. C. (1999) · Biochemical Journal · doi:10.1042/bj3430335 · Cited by 105 · see citing works
Okamoto, C. T. (1998) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(97)00080-x · Cited by 74 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Nitric oxide synthases: regulation and function
Forstermann, U., & Sessa, W. C. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehr304 · Cited by 4,409 · see citing works
Self-citationZidovetzki, R., & Levitan, I. (2007) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.03.026 · Cited by 1,113 · see citing works
Cholesterol, lipid rafts, and disease
Simons, K., & Ehehalt, R. (2002) · Journal of Clinical Investigation · doi:10.1172/jci16390 · Cited by 995 · see citing works
Caveolae: From Cell Biology to Animal Physiology
Razani, B., Woodman, S. E., & Lisanti, M. P. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.3.431 · Cited by 983 · see citing works
Caveolae as plasma membrane sensors, protectors and organizers
Parton, R. G., & del Pozo, M. Á. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3512 · Cited by 928 · see citing works
Cholesterol, lipid rafts, and disease
Simons, K., & Ehehalt, R. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0216390 · Cited by 916 · see citing works
Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation
Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541 · see citing works
Li, L., Haynes, M. P., & Bender, J. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0831079100 · Cited by 466 · see citing works
Ostrom, R. S., & Insel, P. A. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705930 · Cited by 398 · see citing works
Yu, J. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27100 · Cited by 384 · see citing works
Transporters for L‐glutamate: An update on their molecular pharmacology and pathological involvement
Beart, P., & O'Shea, R. D. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706949 · Cited by 419 · see citing works
Endocytosis and signaling: Cell logistics shape the eukaryotic cell plan
Sigismund, S., Confalonieri, S., Ciliberto, A., Polo, S., Scita, G., & Di Fiore, P. P. (2012) · Physiological Reviews · doi:10.1152/physrev.00005.2011 · Cited by 338 · see citing works
Caveolae and Caveolins in the Cardiovascular System
Gratton, J., Bernatchez, P. N., & Sessa, W. C. (2004) · Circulation Research · doi:10.1161/01.res.0000129178.56294.17 · Cited by 317 · see citing works
Self-citationCaveolae, caveolins, and cavins: complex control of cellular signalling and inflammation
Chidlow, J. H., & Sessa, W. C. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq075 · Cited by 310 · see citing works
Self-citationCaveolin regulation of endothelial function
Minshall, R. D., Sessa, W. C., Stan, R. V., Anderson, R. G. W., & Malik, A. B. (2003) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00242.2003 · Cited by 303 · see citing works
Self-citationCaveolae: anchored, multifunctional platforms in the lipid ocean
van Deurs, B., Roepstorff, K., Hommelgaard, A. M., & Sandvig, K. (2003) · Trends in Cell Biology · doi:10.1016/s0962-8924(02)00039-9 · Cited by 296 · see citing works
Caveolae: Structure, Function, and Relationship to Disease
Parton, R. G. (2018) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100617-062737 · Cited by 294 · see citing works
Lipid rafts/caveolae as microdomains of calcium signaling
Pani, B., & Singh, B. B. (2009) · Cell Calcium · doi:10.1016/j.ceca.2009.02.009 · Cited by 263 · see citing works
Endothelial dysfunction in obesity
Engin, A. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_15 · Cited by 255 · see citing works
Caveolae: One Function or Many?
Cheng, J. P. X., & Nichols, B. J. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.10.010 · Cited by 242 · see citing works
Clathrin‐Dependent or Not: Is It Still the Question?
Johannes, L., & Lamaze, C. (2002) · Traffic · doi:10.1034/j.1600-0854.2002.30701.x · Cited by 239 · see citing works
Caveolae in CNS arterioles mediate neurovascular coupling
Chow, B. W., Nuñez, V., Kaplan, L., Granger, A. J., Bistrong, K., Zucker, H. L., Kumar, P., Sabatini, B. L., & Gu, C. (2020) · Nature · doi:10.1038/s41586-020-2026-1 · Cited by 234 · see citing works
Bastiani, M., & Parton, R. G. (2010) · Journal of Cell Science · doi:10.1242/jcs.070102 · Cited by 209 · see citing works
Membrane Targeting of Lipid Modified Signal Transduction Proteins
Resh, M. D. (2004) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-1-4757-5806-1_6 · Cited by 203 · see citing works
Lipid Raft Clustering and Redox Signaling Platform Formation in Coronary Arterial Endothelial Cells
Zhang, A. Y., Yi, F., Zhang, G., Gulbins, E., & Li, P. (2005) · Hypertension · doi:10.1161/01.hyp.0000196727.53300.62 · Cited by 202 · see citing works
Initiation and Transduction of Stretch-induced RhoA and Rac1 Activation through Caveolae
Kawamura, S., Miyamoto, S., & Brown, J. H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300725200 · Cited by 193 · see citing works
eNOS phosphorylation in health and disease
Kolluru, G. K., Siamwala, J. H., & Chatterjee, S. (2010) · Biochimie · doi:10.1016/j.biochi.2010.03.020 · Cited by 183 · see citing works
Sehgal, P. B., Guo, G. G., Shah, M., Kumar, V., & Patel, K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200018200 · Cited by 184 · see citing works
Post-translational regulation of endothelial nitric oxide synthase in vascular endothelium
Qian, J., & Fulton, D. J. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00347 · Cited by 176 · see citing works
Caveolae, caveolins, cavins, and endothelial cell function: new insights
Sowa, G. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2011.00120 · Cited by 174 · see citing works
Self-citationMicrobial entry through caveolae: variations on a theme
Duncan, M. J., Shin, J., & Abraham, S. N. (2002) · Cellular Microbiology · doi:10.1046/j.1462-5822.2002.00230.x · Cited by 167 · see citing works
Caveolins and the regulation of endothelial nitric oxide synthase in the heart
Féron, O., & Balligand, J. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.12.014 · Cited by 163 · see citing works
Caveolins: structure and function in signal transduction.
Krajewska, W. M., & Masłowska, I. (2004) · PubMed · Cited by 162 · see citing works
Xie, C., Lund, E. G., Turley, S. D., Russell, D. W., & Dietschy, J. M. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m300164-jlr200 · Cited by 159 · see citing works
Relationships between caveolae and eNOS: everything in proximity and the proximity of everything
Goligorsky, M. S., Li, H., Brodsky, S. V., & Chen, J. (2002) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00377.2001 · Cited by 154 · see citing works
Antifibrotic properties of caveolin-1 scaffolding domain in vitro and in vivo
Tourkina, E., Richard, M., Göőz, P., Bonner, M., Pannu, J., Harley, R. A., Bernatchez, P. N., Sessa, W. C., Silver, R. M., & Hoffman, S. (2008) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00295.2007 · Cited by 153 · see citing works
Self-citationCaveolae — from ultrastructure to molecular mechanisms
Parton, R. G. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1017 · Cited by 151 · see citing works
Jayanthi, L. D., Samuvel, D. J., & Ramamoorthy, S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311172200 · Cited by 147 · see citing works
Lipid Rafts and Caveolae and Their Role in Compartmentation of Redox Signaling
Patel, H. H., & Insel, P. A. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2365 · Cited by 139 · see citing works
Gonzalez, E., Nagiel, A., Lin, A. J., Golan, D. E., & Michel, T. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407051200 · Cited by 138 · see citing works
A Role for Caveolae/Lipid Rafts in the Uptake and Recycling of the Endogenous Cannabinoid Anandamide
McFarland, M. J., Porter, A. C., Rakhshan, F., Rawat, D. S., Gibbs, R. A., & Barker, E. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407250200 · Cited by 135 · see citing works
Lipid Raft Redox Signaling: Molecular Mechanisms in Health and Disease
Jin, S., Zhou, F., Katirai, F., & Li, P. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3619 · Cited by 129 · see citing works
Lipid rafts mediate H 2 O 2 prosurvival effects in cultured endothelial cells
Yang, B., Oo, T. N., & Rizzo, V. (2006) · The FASEB Journal · doi:10.1096/fj.05-5359fje · Cited by 126 · see citing works
Subcellular targeting and trafficking of nitric oxide synthases
Oess, S., Icking, A., Fulton, D., Govers, R., & Müller-Esterl, W. (2006) · Biochemical Journal · doi:10.1042/bj20060321 · Cited by 125 · see citing works
Nitric oxide signalling in the regulation of cardiovascular and platelet function
Gkaliagkousi, Ε. (2010) · Frontiers in bioscience · doi:10.2741/3828 · Cited by 124 · see citing works
Relationship between cholesterol trafficking and signaling in rafts and caveolae
Fielding, C. J., & Fielding, P. E. (2003) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(03)00020-8 · Cited by 124 · see citing works
Caveolin-1: A tumor-promoting role in human cancer
Shatz, M., & Liscovitch, M. (2008) · International Journal of Radiation Biology · doi:10.1080/09553000701745293 · Cited by 123 · see citing works
Caveolin-1: a critical regulator of lung injury
Jin, Y., Lee, S., Minshall, R. D., & Choi, A. M. K. (2010) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00170.2010 · Cited by 120 · see citing works
Kang, N., Cao, S., Chatterjee, S., Yao, J. Z., Egan, L. J., Semela, D., Mukhopadhyay, D., & Shah, V. H. (2007) · Journal of Cell Science · doi:10.1242/jcs.03361 · Cited by 121 · see citing works
Biochemical characterization of detergent-resistant membranes: a systematic approach
Babiychuk, E. B., & Draeger, A. (2006) · Biochemical Journal · doi:10.1042/bj20060056 · Cited by 112 · see citing works
Monastyrskaya, K., Hostettler, A., Bürgi, S., & Draeger, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405806200 · Cited by 110 · see citing works
Estrogen receptors in membrane lipid rafts and signal transduction in breast cancer
Márquez, D. C., Chen, H., Curran, E. M., Welshons, W. V., & Pietras, R. J. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.11.020 · Cited by 109 · see citing works
Terasaka, N., Westerterp, M., Koetsveld, J., Fernández-Hernando, C., Yvan-Charvet, L., Wang, N., Sessa, W. C., & Tall, A. R. (2010) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.110.213215 · Cited by 107 · see citing works
Self-citationSepúlveda, M. R., Berrocal, M., Gasset, M., & Mata, A. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506950200 · Cited by 106 · see citing works
Sowa, G., Pypaert, M., Fulton, D. J., & Sessa, W. C. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1031672100 · Cited by 105 · see citing works
Self-citationTubes and the single C. elegans excretory cell
Buechner, M. (2002) · Trends in Cell Biology · doi:10.1016/s0962-8924(02)02364-4 · Cited by 104 · see citing works
An Overview of NO Signaling Pathways in Aging
Pourbagher-Shahri, A. M., Farkhondeh, T., Talebi, M., Kopustinskiene, D. M., Samarghandian, S., & Bernatoniene, J. (2021) · Molecules · doi:10.3390/molecules26154533 · Cited by 101 · see citing works
Zhang, Q., Church, J. E., Jagnandan, D., Catravas, J. D., Sessa, W. C., & Fulton, D. J. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000216044.49494.c4 · Cited by 100 · see citing works
Self-citationOstrom, R. S., Bundey, R. A., & Insel, P. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313440200 · Cited by 100 · see citing works
Modulating endothelial nitric oxide synthase: a new cardiovascular therapeutic strategy
Zhang, Y., Janssens, S. P., Wingler, K., Schmidt, H. H. H. W., & Moens, A. L. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01315.2010 · Cited by 96 · see citing works
Maurer‐Stroh, S., Gouda, M., Novatchkova, M., Schleiffer, A., Schneider, G., Sirota, F. L., Wildpaner, M., Hayashi, N., & Eisenhaber, F. (2004) · Genome biology · doi:10.1186/gb-2004-5-3-r21 · Cited by 94 · see citing works
Cholesterol, lipid rafts, and disease
Simons, K., & Ehehalt, R. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200216390 · Cited by 93 · see citing works
Baritaki, S., Apostolakis, S. Z., Kanellou, P., Dimanche‐Boitrel, M., Spandidos, D. A., & Bonavida, B. (2007) · Advances in cancer research · doi:10.1016/s0065-230x(06)98005-1 · Cited by 92 · see citing works
Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1
Bauer, P. M., Bauer, E. M., Rogers, N. M., Yao, M., Feijoo‐Cuaresma, M., Pilewski, J. M., Champion, H. C., Zuckerbraun, B. S., Calzada, M. J., & Isenberg, J. S. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvr356 · Cited by 91 · see citing works
Sarnataro, D., Grimaldi, C., Pisanti, S., Gazzerro, P., Laezza, C., Zurzolo, C., & Bifulco, M. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.10.016 · Cited by 91 · see citing works
Cholesterol-dependent Lipid Assemblies Regulate the Activity of the Ecto-nucleotidase CD39
Papanikolaou, A., Papafotika, A., Murphy, C., Papamarcaki, T., Tsolas, O., Dráb, M., Kurzchalia, T. V., Kasper, M. E., & Christoforidis, S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413927200 · Cited by 91 · see citing works
Protein Kinase Cγ Regulation of Gap Junction Activity through Caveolin-1–Containing Lipid Rafts
Lin, D., Zhou, J., Zelenka, P. S., & Takemoto, D. J. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.03-0296 · Cited by 87 · see citing works
Functional Role of Lipid Raft Microdomains in Cyclic Nucleotide-Gated Channel Activation
Brady, J. D., Rich, T. C., Le, X., Stafford, K., Fowler, C., Lynch, L. L., Karpen, J. W., Brown, R. L., & Martens, J. R. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.3.503 · Cited by 87 · see citing works
Schilling, K., Opitz, N., Wiesenthal, A., Oess, S., Tikkanen, R., Müller‐Esterl, W., & Icking, A. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-08-0709 · Cited by 86 · see citing works
Wang, X.-Q., Sun, P., & Paller, A. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208257200 · Cited by 83 · see citing works
Barsacchi, R., Perrotta, C., Bulotta, S., Moncada, S., Borgese, N., & Clementi, E. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.4.886 · Cited by 82 · see citing works
Ferraro, J. T., Daneshmand, M. A., Bizios, R., & Rizzo, V. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00224.2003 · Cited by 81 · see citing works
Regulation of AMPA receptor localization in lipid rafts
Hou, Q., Huang, Y., Amato, S., Snyder, S. H., Huganir, R. L., & Man, H. (2008) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2008.02.010 · Cited by 79 · see citing works
Babiychuk, E. B., Monastyrskaya, K., Burkhard, F. C., Wray, S., & Draeger, A. (2002) · The FASEB Journal · doi:10.1096/fj.02-0070com · Cited by 79 · see citing works
Lipid Raft Redox Signaling Platforms in Endothelial Dysfunction
Li, P., Zhang, Y., & Yi, F. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1667 · Cited by 77 · see citing works
Subcellular Localization of Oxidants and Redox Modulation of Endothelial Nitric Oxide Synthase
Maron, B. A., & Michel, T. M. (2012) · Circulation Journal · doi:10.1253/circj.cj-12-1207 · Cited by 75 · see citing works
Ruel, M., Wu, G. F., Khan, T. A., Voisine, P., Bianchi, C. F., Li, J., Li, J., Laham, R. J., & Sellke, F. W. (2003) · Circulation · doi:10.1161/01.cir.0000087903.75204.ad · Cited by 72 · see citing works
Sphingolipids and membrane environments for caveolin
Sonnino, S., & Prinetti, A. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.01.007 · Cited by 70 · see citing works
Endothelial Dysfunction in Obesity and Therapeutic Targets
Engin, A. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-63657-8_17 · Cited by 71 · see citing works
Kíely, J.-M., Hu, Y., García‐Cardeña, G., & Gimbrone, M. A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.6.3216 · Cited by 64 · see citing works
The Endothelium but not the Syncytiotrophoblast of Human Placenta Expresses Caveolae
LYDEN, T. W., Anderson, C. L., & Robinson, J. M. (2002) · Placenta · doi:10.1053/plac.2002.0847 · Cited by 63 · see citing works
Caveolae-associated signalling in smooth muscle
Bergdahl, A., & Swärd, K. (2004) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y04-033 · Cited by 61 · see citing works
Plasma Membrane Cholesterol Content Affects Nitric Oxide Diffusion Dynamics and Signaling
Miersch, S., Espey, M. G., Chaube, R., Akarca, A., Tweten, R. K., Ananvoranich, S., & Mutus, B. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800440200 · Cited by 61 · see citing works
Nox4 regulates the eNOS uncoupling process in aging endothelial cells
Lee, H.-Y., Zeeshan, H. M. A., Kim, H., & Chae, H. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.09.010 · Cited by 61 · see citing works
Hong, S., Huo, H., Xu, J., & Liao, K. (2004) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401405 · Cited by 61 · see citing works
Gould, M. L., Williams, G., & Nicholson, H. D. (2010) · The Prostate · doi:10.1002/pros.21195 · Cited by 60 · see citing works
Levitan, I., & Gooch, K. J. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1686 · Cited by 58 · see citing works
A role for caveolin‐1 in post‐injury reactive neuronal plasticity
Gaudreault, S. B., Blain, J., Gratton, J., & Poirier, J. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02917.x · Cited by 58 · see citing works
Co-Regulation of Cell Polarization and Migration by Caveolar Proteins PTRF/Cavin-1 and Caveolin-1
Hill, M. M. C., Daud, N. H., Aung, C. S., Loo, D., Martin, S., Murphy, S., Black, D. M., Barry, R. E., Simpson, F., Liu, L., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043041 · Cited by 55 · see citing works
The Rotavirus Enterotoxin NSP4 Directly Interacts with the Caveolar Structural Protein Caveolin-1
Parr, R. D., Storey, S. M., Mitchell, D. M., McIntosh, A. L., Zhou, M., Mir, K. D., & Ball, J. M. (2006) · Journal of Virology · doi:10.1128/jvi.80.6.2842-2854.2006 · Cited by 55 · see citing works
Gratzinger, D. A., Barreuther, M., & Madri, J. A. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02982-0 · Cited by 55 · see citing works
Trafficking and activation of eNOS in epithelial cells
Ortiz, P. A., & Garvin, J. L. (2003) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2003.01207.x · Cited by 55 · see citing works
Callera, G. E., Yogi, Á., Briones, A. M., Montezano, A. C. I., He, Y., Tostes, R. C., Schiffrin, E. L., & Touyz, R. M. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr131 · Cited by 54 · see citing works
How Do Control-Based Approaches Enter into Biology?
LeDuc, P. R., MESSNER, W. C., & Wikswo, J. P. (2011) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071910-124651 · Cited by 53 · see citing works
Ohkura, T., Momose, F., Ichikawa, R., Takeuchi, K., & Morikawa, Y. (2014) · Journal of Virology · doi:10.1128/jvi.00586-14 · Cited by 53 · see citing works
Cai, C., Hua Zhu, C., & Chen, J. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.06.030 · Cited by 52 · see citing works
BATOVA, S., DeWever, J., Godfraind, T., Balligand, J., Dessy, C., & Féron, O. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.04.013 · Cited by 49 · see citing works
Dremina, E. S., Sharov, V. S., & Schöneich, C. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03115.x · Cited by 49 · see citing works
Caveolar and non-Caveolar Caveolin-1 in ocular homeostasis and disease
Enyong, E. N., Gurley, J. M., Ieso, M. L. D., Stamer, W. D., & Elliott, M. H. (2022) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2022.101094 · Cited by 46 · see citing works
Takaguri, A., Shirai, H., Kimura, K., Hinoki, A., Eguchi, K., Carlile-Klusacek, M., Yang, B., Rizzo, V., & Eguchi, S. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.12.009 · Cited by 46 · see citing works
- Authors
- Sowa, G., Pypaert, M., & Sessa, W. C.
- Affiliations
- Yale University (US)
- Corresponding author
- Sessa, William C.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2001-11-13
- Volume
- 98
- Issue
- 24
- Pages
- 14072-14077
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC61169
- OpenAlex
- W2076606695
- Cited by
- 233
- References
- 31
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 7 · 2020: 8 · 2019: 5 · 2018: 4 · 2017: 7 · 2016: 4 · 2015: 7 · 2014: 4 · 2013: 3 · 2012: 13
- FWCI
- 6.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL-61371, HL-64793, R01HL064793, R01HL057665, R01HL061371, R37HL061371)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- lipid rafts, caveolae, caveolin-1, endothelial nitric oxide synthase, signal transduction, cholesterol, protein-protein interaction, nitric oxide release, plasma membrane, spatial regulation of signaling
- MeSH terms
- Animals, Cells, Cultured, Cholesterol, Humans, Nitric Oxide, Rats, Inbred F344, Thyroid Gland, Signal Transduction, Nitric Oxide Synthase, Caveolae, Membrane Microdomains, Caveolins, Caveolin 1, Rats, Nitric Oxide Synthase Type III
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
