Endothelial nitric oxide (NO) and its pathophysiologic regulation

Chatterjee, Anuran; Catravas, John D.

doi:10.1016/j.vph.2008.06.008

Cited by 236Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease PreventionAngiogenesis and VEGF in Cancer

Endothelial nitric oxide (NO) and its pathophysiologic regulation

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Chatterjee, Anuran, Catravas, John D.·2008·Vascular Pharmacology

DOI 10.1016/j.vph.2008.06.008PMC PMC2592563

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Abstract

Nitric oxide (NO) is a gaseous lipophilic free radical generated by three distinct isoforms of nitric oxide synthases (NOS), type 1 or neuronal (nNOS), type 2 or inducible (iNOS) and type 3 or endothelial NOS (eNOS). Expression of eNOS is altered in many types of cardiovascular disease, such as atherosclerosis, diabetes and hypertension. The ubiquitous chaperone heat shock protein 90 (hsp90) associates with NOS and is important for its proper folding and function. Current studies point toward a therapeutic potential by modulating hsp90-NOS association in various vascular diseases. Here we review the transcriptional regulation of endothelial NOS and factors affecting eNOS activity and function, as well as the important vascular pathologies associated with altered NOS function, focusing on the regulatory role of hsp90 and other factors in NO-associated pathogenesis of these diseases.

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NO acts directly on smooth muscle cells via activation of soluble guanylyl cyclase leading to formation of cGMP, which promotes smooth muscle relaxation and inhibits platelet function and vascular smooth muscle cell proliferation and migration.
“Chiefly, NO acts directly on smooth muscle cells via activation of soluble guanylyl cyclase leading to formation of the second-messenger, cyclic guanosine monophosphate (cGMP), that in turn promotes smooth muscle relaxation and inhibits both platelet function and vascular smooth muscle cell proliferation and migration[19–21].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [21]

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Uncoupling of Endothelial Nitric Oxidase Synthase by Hypochlorous Acid
Xu, J., Xie, Z., Reece, R., Pimental, D. R., & Zou, M. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000249394.94588.82 · Cited by 144 · see citing works
Retracted
Tumor angiogenesis: therapeutic implications
Sherwood, L. M., Parris, E. E., & Folkman, J. (1971) · New England Journal of Medicine · doi:10.1056/nejm197111182852108 · Cited by 10,187 · see citing works
Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
Beckman, J. S., & Koppenol, W. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.5.c1424 · Cited by 5,513 · see citing works
Nitric oxide: an endogenous modulator of leukocyte adhesion.
Kubes, P., Suzuki, M., & Granger, D. N. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.11.4651 · Cited by 3,052 · see citing works
Diabetes and Atherosclerosis
Beckman, J. A., Creager, M. A., & Libby, P. (2002) · JAMA · doi:10.1001/jama.287.19.2570 · Cited by 2,723 · see citing works
Hypertension in mice lacking the gene for endothelial nitric oxide synthase
Huang, P. L., Huang, Z., Mashimo, H., Bloch, K. D., Moskowitz, M. A., Bevan, J. A., & Fishman, M. C. (1995) · Nature · doi:10.1038/377239a0 · Cited by 2,070 · see citing works
Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase
Ischiropoulos, H., Zhu, L., Chen, J., Tsai, M., Martin, J. C., Smith, C. D. L., & Beckman, J. S. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90431-u · Cited by 1,495 · see citing works
Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide
Koppenol, W. H., Moreno, J. J., Pryor, W. A., Ischiropoulos, H., & Beckman, J. S. (1992) · Chemical Research in Toxicology · doi:10.1021/tx00030a017 · Cited by 1,338 · see citing works
Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus.
Johnstone, M. T., Creager, S. J., Scales, K. M., Cusco, J. A., Lee, B. K., & Creager, M. A. (1993) · Circulation · doi:10.1161/01.cir.88.6.2510 · Cited by 1,117 · see citing works
Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus
Williams, S. B., Cusco, J. A., Roddy, M.-A., Johnstone, M. T., & Creager, M. A. (1996) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00522-6 · Cited by 1,014 · see citing works
Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells.
Pollock, J. S., Förstermann, U., Mitchell, J. A., Warner, T. D., Schmidt, H. H. H. W., Nakane, M., & Murad, F. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10480 · Cited by 979 · see citing works
Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression.
Sessa, W. C., Pritchard, K., Seyedi, N., Wang, J., & Hintze, T. H. (1994) · Circulation Research · doi:10.1161/01.res.74.2.349 · Cited by 934 · cited 2× · see citing works
“, 2005), exercise (Sessa et al., 1994; Yang et al., 2002) and hypoxia (Le Cras et al.”
Background
Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene
Marsden, P. A., Heng, H. H., Scherer, S. W., Stewart, R. J., Hall, A. V., Shi, X.-M., Tsui, L.-C., & Schappert, K. T. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85359-0 · Cited by 871 · see citing works
Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life
Yoshizumi, M., Perrella, M. A., Burnett, J. C., & Lee, M. E. (1993) · Circulation Research · doi:10.1161/01.res.73.1.205 · Cited by 771 · cited 2× · see citing works
“, 2000) and tumor necrosis factor-α (Yoshizumi et al., 1993) decrease eNOS gene expression by reducing the stability of eNOS mRNAs.”
Background
The Chaperone Function of hsp70 Is Required for Protection against Stress-Induced Apoptosis
Mosser, D., Caron, A., Bourget, L., Meriin, A. B., Sherman, M., Morimoto, R., & Massie, B. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.19.7146-7159.2000 · Cited by 768 · see citing works
High Glucose Increases Nitric Oxide Synthase Expression and Superoxide Anion Generation in Human Aortic Endothelial Cells
Cosentino, F., Hishikawa, K., Katušić, Z. S., & Lüscher, T. F. (1997) · Circulation · doi:10.1161/01.cir.96.1.25 · Cited by 762 · see citing works
Vitamin C Improves Endothelium-Dependent Vasodilation by Restoring Nitric Oxide Activity in Essential Hypertension
Taddei, S., Virdis, A., Ghiadoni, L., Magagna, A., & Salvetti, A. (1998) · Circulation · doi:10.1161/01.cir.97.22.2222 · Cited by 757 · see citing works
Angiogenesis: regulators and clinical applications
Liekens, S., De Clercq, E., & Neyts, J. (2001) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00529-3 · Cited by 748 · see citing works
NITRIC OXIDE SYNTHASE: Role in the Genesis of Vascular Disease
Cooke, J. P., & Dzau, V. J. (1997) · Annual Review of Medicine · doi:10.1146/annurev.med.48.1.489 · Cited by 706 · see citing works
Antiatherogenic effects of L-arginine in the hypercholesterolemic rabbit.
Cooke, J. P., Singer, A. H., Tsao, P. S., Zera, P. H., Rowan, R. A., & Billingham, M. E. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115937 · Cited by 683 · see citing works
Impaired Nitric Oxide Synthase Pathway in Diabetes Mellitus
Lin, K. Y., Ito, A., Asagami, T., Tsao, P. S., Adimoolam, S., Kimoto, M., Tsuji, H., Reaven, G. M., & Cooke, J. P. (2002) · Circulation · doi:10.1161/01.cir.0000027109.14149.67 · Cited by 651 · see citing works
Contribution of kinins to the cardiovascular actions of angiotensin-converting enzyme inhibitors.
Linz, W., Wiemer, G., Gohlke, P., Unger, T., & Schölkens, B. A. (1995) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06820-6 · Cited by 648 · see citing works
Hsp90: Chaperoning signal transduction
Richter, K., & Büchner, J. (2001) · Journal of Cellular Physiology · doi:10.1002/jcp.1131 · Cited by 570 · see citing works
eNOS at a glance
Sessa, W. C. (2004) · Journal of Cell Science · doi:10.1242/jcs.01165 · Cited by 561 · see citing works
Cardiovascular Biology of the Asymmetric Dimethylarginine:Dimethylarginine Dimethylaminohydrolase Pathway
Vallance, P., & Leiper, J. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000128897.54893.26 · Cited by 553 · see citing works
The Heat Shock Protein 90 Antagonist Novobiocin Interacts with a Previously Unrecognized ATP-binding Domain in the Carboxyl Terminus of the Chaperone
Marcu, M. G., Chadli, A., Bouhouche, I., CATELLI, M. G., & Neckers, L. Μ. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003701200 · Cited by 504 · see citing works
Tyrosine nitration: Localisation, quantification, consequences for protein function and signal transduction
Greenacre, S., & Ischiropoulos, H. (2001) · Free Radical Research · doi:10.1080/10715760100300471 · Cited by 500 · see citing works
Arginase Reciprocally Regulates Nitric Oxide Synthase Activity and Contributes to Endothelial Dysfunction in Aging Blood Vessels
Berkowitz, D. E., White, R., Li, D., Minhas, K. M., Cernetich, A., Kim, S., Burke, S., Shoukas, A. A., Nyhan, D., Champion, H. C., et al. (2003) · Circulation · doi:10.1161/01.cir.0000092948.04444.c7 · Cited by 486 · see citing works
Mechanisms of Disease: endothelial dysfunction in insulin resistance and diabetes
Rask‐Madsen, C., & King, G. L. (2006) · Nature Clinical Practice Endocrinology &#38 Metabolism · doi:10.1038/ncpendmet0366 · Cited by 483 · see citing works
Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases
LEIPER, J. M., MARIA, J. S., Chubb, A., MacAllister, R. J., Charles, I. G., Whitley, G. S. J., & Vallance, P. J. (1999) · Biochemical Journal · doi:10.1042/bj3430209 · Cited by 478 · see citing works
Activation of the AMP-Activated Kinase by Antidiabetes Drug Metformin Stimulates Nitric Oxide Synthesis In Vivo by Promoting the Association of Heat Shock Protein 90 and Endothelial Nitric Oxide Synthase
Davis, B. J., Xie, Z., Viollet, B., & Zou, M. (2006) · Diabetes · doi:10.2337/diabetes.55.02.06.db05-1064 · Cited by 464 · see citing works
Nitric Oxide Modulates the Expression of Monocyte Chemoattractant Protein 1 in Cultured Human Endothelial Cells
Zeiher, A. M., Fißlthaler, B., Schray-Utz, B., & Busse, R. (1995) · Circulation Research · doi:10.1161/01.res.76.6.980 · Cited by 461 · see citing works
Nitric oxide in septic shock
Titheradge, M. A. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00031-6 · Cited by 457 · see citing works
Tetrahydrobiopterin Improves Endothelium-Dependent Vasodilation in Chronic Smokers
Heitzer, T. A., Brockhoff, C. J., Mayer, B., Warnholtz, A., Mollnau, H., Henne, S., Meinertz, T., & Münzel, T. F. (2000) · Circulation Research · doi:10.1161/01.res.86.2.e36 · Cited by 449 · see citing works
Hypercholesterolemia decreases nitric oxide production by promoting the interaction of caveolin and endothelial nitric oxide synthase
Féron, O., Dessy, C., Moniotte, S., Desager, J., & Balligand, J. (1999) · Journal of Clinical Investigation · doi:10.1172/jci4829 · Cited by 413 · see citing works
Hypertension and left ventricular hypertrophy are associated with impaired endothelium-mediated relaxation in human coronary resistance vessels.
Treasure, C. B., Klein, J. L., Vita, J. A., Manoukian, S. V., Renwick, G. H., Selwyn, A. P., Ganz, P., & Alexander, R. W. (1993) · Circulation · doi:10.1161/01.cir.87.1.86 · Cited by 392 · see citing works
The loss of endothelium-dependent vascular relaxation in hypertension.
Lockette, W. E., Otsuka, Y., & Carretero, O. A. (1986) · Hypertension · doi:10.1161/01.hyp.8.6_pt_2.ii61 · Cited by 372 · see citing works
Vascular NADH/NADPH Oxidase Is Involved in Enhanced Superoxide Production in Spontaneously Hypertensive Rats
Zalba, G., Beaumont, J., José, G. S., Fortuño, A., Fortuño, M. A., Etayo, J. C., & Dı́ez, J. (2000) · Hypertension · doi:10.1161/01.hyp.35.5.1055 · Cited by 368 · see citing works
Increased superoxide anion release from human endothelial cells in response to cytokines.
Matsubara, T., & Ziff, M. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.137.10.3295 · Cited by 361 · see citing works
Oxidized Low Density Lipoprotein Displaces Endothelial Nitric-oxide Synthase (eNOS) from Plasmalemmal Caveolae and Impairs eNOS Activation
Blair, A., Shaul, P. W., Yuhanna, I. S., Conrad, P. A., & Smart, E. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.45.32512 · Cited by 360 · see citing works
Endothelial Nitric Oxide Synthase Deficiency Produces Accelerated Nephropathy in Diabetic Mice
Zhao, H. J., Wang, S., Cheng, H., Zhang, M., Takahashi, T., Fogo, A. B., Breyer, M. D., & Harris, R. C. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006070798 · Cited by 359 · see citing works
Reactive oxygen species signaling in vascular smooth muscle cells
Clempus, R. E., & Griendling, K. K. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.02.033 · Cited by 358 · see citing works
The l-arginine paradox: Importance of the l-arginine/asymmetrical dimethylarginine ratio
BODEBOGER, S., SCALERA, F., & IGNARRO, L. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.03.002 · Cited by 347 · see citing works
High Glucose Induces Antioxidant Enzymes in Human Endothelial Cells in Culture: Evidence Linking Hyperglycemia and Oxidative Stress
Ceriello, A., Russo, P. D., Amstad, P., & Cerutti, P. (1996) · Diabetes · doi:10.2337/diab.45.4.471 · Cited by 324 · see citing works
Tetrahydrobiopterin-dependent preservation of nitric oxide–mediated endothelial function in diabetes by targeted transgenic GTP–cyclohydrolase I overexpression
Alp, N. J., Mussa, S., Khoo, J. P., Cai, S., Guzik, T. J., Jefferson, A., Goh, N., Rockett, K. A., & Channon, K. M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17786 · Cited by 321 · see citing works
Endothelium-derived nitric oxide and vascular physiology and pathology
Arnal, J.-F., Dinh-Xuan, A.-T., Pueyo, M., Darblade, B., & Rami, J. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050358 · Cited by 313 · see citing works
Shear Stress Regulates Endothelial Nitric Oxide Synthase Expression Through c-Src by Divergent Signaling Pathways
Davis, M. E., Cai, H. “., Drummond, G. R., & Harrison, D. G. (2001) · Circulation Research · doi:10.1161/hh2301.100806 · Cited by 310 · see citing works
Biochemistry of protein tyrosine nitration in cardiovascular pathology
Peluffo, G., & Radí, R. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.04.024 · Cited by 290 · see citing works
Superoxide dismutase recovers altered endothelium-dependent relaxation in diabetic rat aorta
Hattori, Y., 川崎, 久., Abe, K., & Kanno, M. (1991) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1991.261.4.h1086 · Cited by 279 · see citing works
Nitric Oxide Regulation of Tissue Free Radical Injury
Rubbo, H., Darley-Usmar, V. M., & Freeman, B. Α. (1996) · Chemical Research in Toxicology · doi:10.1021/tx960037q · Cited by 274 · see citing works
Hsp90 and Caveolin Are Key Targets for the Proangiogenic Nitric Oxide–Mediated Effects of Statins
Brouet, A., Sonveaux, P., Dessy, C., Moniotte, S., Balligand, J., & Féron, O. (2001) · Circulation Research · doi:10.1161/hh2201.100319 · Cited by 268 · see citing works
Structure and Functional Relationships of Hsp90
Prodromou, C., & Pearl, L. H. (2003) · Current Cancer Drug Targets · doi:10.2174/1568009033481877 · Cited by 262 · see citing works
Arginase activity in endothelial cells: inhibition by NG-hydroxy-L-arginine during high-output NO production
Buga, G. M., Singh, R., Pervin, S., Rogers, N. E., Schmitz, D. A., Jenkinson, C. P., Cederbaum, S. D., & Ignarro, L. J. (1996) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1996.271.5.h1988 · Cited by 257 · see citing works
Ethinylestradiol does not enhance the expression of nitric oxide synthase in bovine endothelial cells but increases the release of bioactive nitric oxide by inhibiting superoxide anion production.
Arnal, J., Clamens, S., Pechet, C., Nègre‐Salvayre, A., Allera, C., Girolami, J. P., Salvayre, R., & Bayard, F. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.4108 · Cited by 254 · see citing works
Chronic hypoxia upregulates endothelial and inducible NO synthase gene and protein expression in rat lung
Cras, T. D. L., Xue, C., Rengasamy, A., & Johns, R. A. (1996) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1996.270.1.l164 · Cited by 254 · see citing works
Impairment of endothelium‐dependent relaxation in aortae from spontaneously diabetic rats
Durante, W., Sen, A. K., & Sunahara, F. A. (1988) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1988.tb11548.x · Cited by 250 · see citing works
The Cell-specific Expression of Endothelial Nitric-oxide Synthase
Chan, Y., Fish, J. E., D'Abreo, C., Lin, S., Robb, G. B., Teichert, A.-M., Karantzoulis-Fegaras, F., Keightley, A. M., Steer, B. M., & Marsden, P. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405063200 · Cited by 243 · see citing works
Dietary l -Arginine Reduces the Progression of Atherosclerosis in Cholesterol-Fed Rabbits
Böger, R. H., Bode‐Böger, S. M., Brandes, R. P., Phivthong‐ngam, L., Böhme, M., Nafe, R., Mügge, A., & Frölich, J. C. (1997) · Circulation · doi:10.1161/01.cir.96.4.1282 · Cited by 242 · see citing works
Differential Expression of iNOS and cNOS mRNA in Human Vascular Smooth Muscle Cells and Endothelial Cells under Normal and Inflammatory Conditions
MacNaul, K. L., & Hutchinson, N. I. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.2398 · Cited by 239 · see citing works
Estrogens Increase Transcription of the Human Endothelial NO Synthase Gene
Kleinert, H., Wallerath, T., Euchenhofer, C., Ihrig‐Biedert, I., Li, H., & Förstermann, U. (1998) · Hypertension · doi:10.1161/01.hyp.31.2.582 · Cited by 239 · see citing works
Doxorubicin-induced Apoptosis Is Associated with Increased Transcription of Endothelial Nitric-oxide Synthase
Kalivendi, S. V., Kotamraju, S., Zhao, H., Joseph, J., & Kalyanaraman, B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106829200 · Cited by 225 · see citing works
Hyperglycaemia-induced superoxide production decreases eNOS expression via AP-1 activation in aortic endothelial cells
Srinivasan, S. R., Hatley, M., Bolick, D. T., Palmer, L. A., Edelstein, D., Brownlee, M., & Hedrick, C. C. (2004) · Diabetologia · doi:10.1007/s00125-004-1525-1 · Cited by 216 · see citing works
Is NO an endogenous antiatherogenic molecule?
Cooke, J. P., & Tsao, P. S. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.5.653 · Cited by 216 · see citing works
Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression
Searles, C. D. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00457.2005 · Cited by 208 · see citing works
Supplemention With Tetrahydrobiopterin Suppresses the Development of Hypertension in Spontaneously Hypertensive Rats
Hong, H.-J., Hsiao, G., Cheng, T.-H., & Yen, M.-H. (2001) · Hypertension · doi:10.1161/hy1101.095331 · Cited by 203 · see citing works
Effect of MMP-2 Deficiency on Atherosclerotic Lesion Formation in ApoE-Deficient Mice
Kuzuya, M., Nakamura, K., Sasaki, T., et al. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000218496.60097.e0 · Cited by 202 · see citing works
Origin of superoxide production by endothelial nitric oxide synthase
Stroes, E. S. G., Hijmering, M. L., van Zandvoort, M. A. M. J., Wever, R. M. F., Rabelink, T. J., & van Faassen, E. E. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01292-7 · Cited by 188 · see citing works
Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydrobiopterin deficiency
Meininger, C. J., MARINOS, R. S., Hatakeyama, K., Martı́nez–Zaguilán, R., Rojas, J. D., Kelly, K. A., & Wu, G. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3490353 · Cited by 186 · see citing works
Decreased Endothelium-dependent Relaxation in New Zealand Genetic Hypertensive Rats
Winquist, R. J., Bunting, P. B., Baskin, E. P., & Wallace, A. A. (1984) · Journal of Hypertension · doi:10.1097/00004872-198410000-00015 · Cited by 184 · see citing works
Ischemia‐reperfusion selectively impairs nitric oxide‐ mediated dilation in coronary arterioles: counteracting role of arginase
Hein, T. W., Zhang, C., Wang, W., Chang, C., Thengchaisri, N., & Kuo, L. (2003) · The FASEB Journal · doi:10.1096/fj.03-0115fje · Cited by 182 · see citing works
Oral l-arginine improves endothelium-dependent dilatation and reduces monocyte adhesion to endothelial cells in young men with coronary artery disease
Adams, M. R., McCredie, R. J., Jessup, W., Robinson, J. T. C., SULLIVAN, D. R., & Celermajer, D. S. (1997) · Atherosclerosis · doi:10.1016/s0021-9150(96)06044-3 · Cited by 181 · see citing works
Macrophage Endothelial Nitric-oxide Synthase Autoregulates Cellular Activation and Pro-inflammatory Protein Expression
Connelly, L., Jacobs, A. T., Palacios‐Callender, M., Moncada, S., & Hobbs, A. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302238200 · Cited by 178 · see citing works
Tetrahydrobiopterin and endothelial nitric oxide synthase activity
Cosentino, F. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00134-0 · Cited by 173 · see citing works
Oral l -Arginine in Patients With Coronary Artery Disease on Medical Management
Blum, A., Hathaway, L., Mincemoyer, R., Schenke, W. H., Kirby, M., Csákó, G., Waclawiw, M. A., Panza, J. A., & Cannon, R. O. (2000) · Circulation · doi:10.1161/01.cir.101.18.2160 · Cited by 162 · see citing works
Endothelial relaxation is disturbed by oxidative stress in the diabetic rat heart: influence of tocopherol as antioxidant
R�sen, P., Ballhausen, T., Bloch, W., & Addicks, K. (1995) · Diabetologia · doi:10.1007/bf00422364 · Cited by 160 · see citing works
Extracellular Roles for the Molecular Chaperone, HSP90
Eustace, B. K., & Jay, D. G. (2004) · Cell Cycle · doi:10.4161/cc.3.9.1088 · Cited by 160 · see citing works
Effect of metformin treatment on multiple cardiovascular disease risk factors in patients with type 2 diabetes mellitus
Abbasi, F., Chu, J. W., McLaughlin, T., Lamendola, C. A., Leary, E. T., & Reaven, G. M. (2004) · Metabolism · doi:10.1016/j.metabol.2003.07.020 · Cited by 160 · see citing works
Dimerization and N-terminal domain proximity underlie the function of the molecular chaperone heat shock protein 90.
Chadli, A., Bouhouche, I., Sullivan, W. J., Stensgard, B., McMahon, N., Catelli, M., & Toft, D. (2000) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.220430297 · Cited by 159 · see citing works
Increased expression of iNOS is associated with endothelial dysfunction and impaired pressor responsiveness in streptozotocin-induced diabetes
Nagareddy, P. R., Xia, Z., McNeill, J. H., & MacLeod, K. M. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00591.2005 · Cited by 158 · see citing works
l -Arginine Prevents Xanthoma Development and Inhibits Atherosclerosis in LDL Receptor Knockout Mice
Aji, W., Stefano Ravalli, A., Szabolcs, M. J., Jiang, X.-C., Sciacca, R. R., Michler, R. E., & Cannon, P. (1997) · Circulation · doi:10.1161/01.cir.95.2.430 · Cited by 156 · see citing works
Hsp90: an emerging target for breast cancer therapy
Beliakoff, J., & Whitesell, L. J. (2004) · Anti-Cancer Drugs · doi:10.1097/01.cad.0000136876.11928.be · Cited by 156 · see citing works
Endothelial Dysfunction of Coronary Resistance Arteries Is Improved by Tetrahydrobiopterin in Atherosclerosis
Tiefenbacher, C., Bleeke, T., Vahl, C. F., Amann, K., Vogt, A. M., & Kübler, W. (2000) · Circulation · doi:10.1161/01.cir.102.18.2172 · Cited by 154 · see citing works
Hsp90 regulation of endothelial nitric oxide synthase contributes to vascular control in portal hypertension
Shah, V. H., Wiest, R., García‐Cardeña, G., Cadelina, G. W., Groszmann, R. J., & Sessa, W. C. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.277.2.g463 · Cited by 149 · see citing works
Post-transcriptional Regulation of Endothelial Nitric-oxide Synthase by an Overlapping Antisense mRNA Transcript
Robb, G. B., Carson, A. R., Tai, S. C., Fish, J. E., Singh, S., Yamada, T., Scherer, S. W., Nakabayashi, K., & Marsden, P. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400271200 · Cited by 148 · see citing works
Substrate-dependent regulation of intracellular amino acid concentrations in cultured bovine aortic endothelial cells
Baydoun, A. R., Emery, P. W., Pearson, J. D., & Mann, G. E. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(05)80876-9 · Cited by 146 · see citing works
Endothelial nitric oxide synthase activation is critical for vascular leakage during acute inflammation in vivo
Bucci, M., Roviezzo, F., Posadas, I., Yu, J., Parente, L., Sessa, W. C., Ignarro, L. J., & Cirino, G. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408906102 · Cited by 140 · see citing works
Resistance to Endotoxin Shock in Transgenic Mice Overexpressing Endothelial Nitric Oxide Synthase
Yamashita, T., Kawashima, S., Ohashi, Y., Ozaki, M., Ueyama, T., Ishida, T., Inoue, N., Hirata, K., Akita, H., & Yokoyama, M. (2000) · Circulation · doi:10.1161/01.cir.101.8.931 · Cited by 140 · see citing works
Distinct arginase isoforms expressed in primary and transformed macrophages: regulation by oxygen tension
Louis, C. A., Reichner, J. S., Henry, W. L., Mastrofrancesco, B., Gotoh, T., Mori, M., & Albina, J. E. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.3.r775 · Cited by 136 · see citing works
Heat Shock Protein 90 Inhibitors Prolong Survival, Attenuate Inflammation, and Reduce Lung Injury in Murine Sepsis
Chatterjee, A., Dimitropoulou, C., Drakopanayiotakis, F., Antonova, G. N., Snead, C. M., Cannon, J. G., Venema, R. C., & Catravas, J. D. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200702-291oc · Cited by 134 · see citing works
Self-citation
Is NO an endogenous antiatherogenic molecule
PCooke, J., & STsao, P. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · Cited by 134 · see citing works
Differential regulation of nitric oxide synthases and their allosteric regulators in heart and vessels of hypertensive rats
Piech, A. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00676-4 · Cited by 132 · see citing works
Protein–protein interactions controlling nitric oxide synthases
Kone (2000) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2000.00629.x · Cited by 127 · see citing works
Subcellular targeting and trafficking of nitric oxide synthases
Oess, S., Icking, A., Fulton, D., Govers, R., & Müller-Esterl, W. (2006) · Biochemical Journal · doi:10.1042/bj20060321 · Cited by 125 · see citing works
Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase
Venema, R. C., Venema, V. J., Ju, H., Harris, M. B., Snead, C. M., Jilling, T., Dimitropoulou, C., Maragoudakis, M. E., & Catravas, J. D. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01025.2002 · Cited by 120 · see citing works
Self-citation
Angiotensin II AT1 Receptor Blockade Abolishes Brain Microvascular Inflammation and Heat Shock Protein Responses in Hypertensive Rats
Zhou, J., Ando, H., Macova, M., Dou, J., & Saavedra, J. M. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600082 · Cited by 114 · see citing works
Oxidation-sensitive mechanisms, vascular apoptosis and atherosclerosis
de Nigris, F., Lerman, A., Ignarro, L. J., Williams‐Ignarro, S., Sica, V., Baker, A. H., Lerman, L. O., Geng, Y., & Claudio Napoli, A. (2003) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(03)00139-4 · Cited by 107 · see citing works
Chronic pulmonary hypertension‐the monocrotaline model and involvement of the hemostatic system
Schultze, A. E., & Roth, R. A. (1998) · Journal of Toxicology and Environmental Health Part B · doi:10.1080/10937409809524557 · Cited by 105 · see citing works
Regulation of endothelial derived nitric oxide in health and disease
Sessa, W. C. (2005) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/s0074-02762005000900004 · Cited by 104 · see citing works
Effects of l -Arginine Infusion on Renal Hemodynamics in Patients With Mild Essential Hypertension
Higashi, Y., Oshima, T., Ozono, R., Watanabe, M., Matsuura, H., & Kajiyama, G. (1995) · Hypertension · doi:10.1161/01.hyp.25.4.898 · Cited by 104 · see citing works
Regulation of the genes for arginase isoforms and related enzymes in mouse macrophages by lipopolysaccharide
Salimuddin, Nagasaki, A., Gotoh, T., Isobe, H., & Mori, M. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.1.e110 · Cited by 103 · see citing works
NAD(P)H Oxidase Activation: A Potential Target Mechanism for Diabetic Vascular Complications, Progressive β-Cell Dysfunction and Metabolic Syndrome
Inoguchi, T., & Nawata, H. (2005) · Current Drug Targets · doi:10.2174/1389450054021927 · Cited by 101 · see citing works
Functional Relevance of Golgi- and Plasma Membrane-Localized Endothelial NO Synthase in Reconstituted Endothelial Cells
Zhang, Q., Church, J. E., Jagnandan, D., Catravas, J. D., Sessa, W. C., & Fulton, D. J. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000216044.49494.c4 · Cited by 100 · see citing works
Self-citation
Inflammation and the metabolic syndrome: Role of angiotensin II and oxidative stress
Ferder, L., Inserra, F., & Martínez–Maldonado, M. (2006) · Current Hypertension Reports · doi:10.1007/s11906-006-0050-7 · Cited by 97 · see citing works
Shear stress induces eNOS mRNA expression and improves endothelium-dependent dilation in senescent soleus muscle feed arteries
Woodman, C. R., Price, E. M., & Laughlin, M. H. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00408.2004 · Cited by 92 · see citing works
Interaction between nitric oxide and angiotensin II in the endothelium: role in atherosclerosis and hypertension
Schulman, I. H., Zhou, M.-S., & Raij, L. R. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000220406.46246.f2 · Cited by 91 · see citing works
Superoxide dismutase restores the influence of nitric oxide on renal arterioles in diabetes mellitus.
Ohishi, K., & Carmines, P. K. (1995) · Journal of the American Society of Nephrology · doi:10.1681/asn.v581559 · Cited by 89 · see citing works
Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2/neu-dependent breast tumors
de Candia, P., Solit, D. B., Giri, D. D., Brogi, E., Siegel, P. M., Olshen, A. B., Muller, W. J., Rosen, N. X., & Benezra, R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2031337100 · Cited by 87 · see citing works
A novel role for calpains in the endothelial dysfunction of hyperglycemia
Stalker, T. J., Skvarka, C. B., & Scalia, R. G. (2003) · The FASEB Journal · doi:10.1096/fj.02-1213fje · Cited by 85 · see citing works
Increased superoxide anion formation in endothelial cells during hyperglycemia: an adaptive response or initial step of vascular dysfunction?
Graier, W. F., Posch, K., Fleischhacker, E., Wascher, T. C., & Kostner, G. M. (1999) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(99)00045-5 · Cited by 84 · see citing works
Response of human coronary arteries to aggregating platelets: importance of endothelium-derived relaxing factor and prostanoids.
Förstermann, U., Mügge, A., Bode, S. M., et al. (1988) · Circulation Research · doi:10.1161/01.res.63.2.306 · Cited by 81 · see citing works
Induction of Angiogenesis by Heat Shock Protein 90 Mediated by Protein Kinase Akt and Endothelial Nitric Oxide Synthase
Sun, J., & Liao, J. K. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000147894.22300.4c · Cited by 80 · see citing works
Posttranscriptional Regulation of Endothelial Nitric Oxide Synthase During Cell Growth
Searles, C. D., Miwa, Y., Harrison, D. G., & Ramasamy, S. (1999) · Circulation Research · doi:10.1161/01.res.85.7.588 · Cited by 78 · see citing works
Arginine Intake and Risk of Coronary Heart Disease Mortality in Elderly Men
Oomen, C. M., van Erk, M. J., Feskens, E. J. M., Kok, F. J., & Kromhout, D. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.9.2134 · Cited by 78 · see citing works
Differences in eNOS Activity Because of Subcellular Localization Are Dictated by Phosphorylation State Rather than the Local Calcium Environment
Church, J. E., & Fulton, D. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505968200 · Cited by 78 · see citing works
High glucose induces antioxidant enzymes in human endothelial cells in culture. Evidence linking hyperglycemia and oxidative stress
Ceriello, A., Russo, P. D., Amstad, P., et al. (1996) · Diabetes · doi:10.2337/diabetes.45.4.471 · Cited by 78 · see citing works
Bcl-2 protein family: Implications in vascular apoptosis and atherosclerosis
Kütük, Ö., & Başağa, H. (2006) · APOPTOSIS · doi:10.1007/s10495-006-9402-7 · Cited by 76 · see citing works
Reversal by L-arginine of a dysfunctional arginine/nitric oxide pathway in the endothelium of the genetic diabetic BB rat
Pieper, G. M., Siebeneich, W., Hilton, G., & Roza, A. M. (1997) · Diabetologia · doi:10.1007/s001250050767 · Cited by 74 · see citing works
Arginine restores nitric oxide activity and inhibits monocyte accumulation after vascular injury in hypercholesterolemic rabbits
Wang, B., Candipan, R. C., Arjomandi, M., Hsiun, P. T. C., Tsao, P. S., & Cooke, J. P. (1996) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(96)00337-3 · Cited by 71 · see citing works
Effect of High Glucose on Nitric Oxide Production and Endothelial Nitric Oxide Synthase Protein Expression in Human Glomerular Endothelial Cells
Hoshiyama, M., Li, B., Yao, J. Q., Harada, T., Morioka, T., & Oite, T. (2003) · Nephron Experimental Nephrology · doi:10.1159/000073673 · Cited by 70 · see citing works
Oral Administration of Tetrahydrobiopterin Slows the Progression of Atherosclerosis in Apolipoprotein E-Knockout Mice
Hattori, Y., Hattori, S., Wang, X., Satoh, H., Nakanishi, N., & Kasai, K. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000258946.55438.0e · Cited by 65 · see citing works
Coordinated regulation of endothelial nitric oxide synthase activity by phosphorylation and subcellular localization
Boo, Y. C., Kim, H. J., Song, H. W., Fulton, D. J., Sessa, W. C., & Jo, H. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.03.024 · Cited by 62 · see citing works
Nitric Oxide in Cardiovascular Diseases
Nava, E., Noll, G., & Lüscher, T. F. (1995) · Annals of Medicine · doi:10.3109/07853899509002587 · Cited by 62 · see citing works
A Radicicol Derivative, KF58333, Inhibits Expression of Hypoxia‐inducible Factor‐1α and Vascular Endothelial Growth Factor, Angiogenesis and Growth of Human Breast Cancer Xenografts
Kurebayashi, J., Otsuki, T., Kurosumi, M., Soga, S., Akinaga, S., & Sonoo, H. (2001) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.2001.tb02159.x · Cited by 60 · see citing works
Downregulation of eNOS mRNA expression by TNFα: identification and functional characterization of RNA–protein interactions in the 3′UTR
Lai, P. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(03)00296-7 · Cited by 57 · see citing works
Aberrant cytoplasmic sequestration of eNOS in endothelial cells after monocrotaline, hypoxia, and senescence: live-cell caveolar and cytoplasmic NO imaging
Mukhopadhyay, S., Xu, F., & Sehgal, P. B. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00990.2006 · Cited by 55 · see citing works
Pathophysiological Mechanisms of Angiogenesis
Walsh, D. A. (2007) · Advances in clinical chemistry · doi:10.1016/s0065-2423(07)44006-9 · Cited by 52 · see citing works
Chronic Exercise Increases Both Inducible and Endothelial Nitric Oxide Synthase Gene Expression in Endothelial Cells of Rat Aorta
Yang, A.-L., Tsai, S., Jiang, M. J., Jen, C. J., & Chen, H. (2002) · Journal of Biomedical Science · doi:10.1159/000048211 · Cited by 51 · see citing works
DDAH gene and cardiovascular risk
Valkonen, V.-P., Tuomainen, T., & Laaksonen, R. (2005) · Vascular Medicine · doi:10.1191/1358863x05vm600oa · Cited by 47 · see citing works
Impaired effectiveness of nitric oxide-donors in resistance arteries of patients with arterial hypertension
Preik, M., Kelm, M., Feelisch, M., et al. (1996) · Journal of Hypertension · doi:10.1097/00004872-199607000-00014 · Cited by 45 · see citing works
HSP90, HSP70, and GAPDH Directly Interact with the Cytoplasmic Domain of Macrophage Scavenger Receptors
Nakamura, T., Hinagata, J.-I., Tanaka, T., Imanishi, T., Wada, Y., Kodama, T., & Doi, T. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.6271 · Cited by 44 · see citing works
Oxidation of tetrahydrobiopterin by peroxynitrite or oxoferryl species occurs by a radical pathway
Kohnen, S. L., Mouithys-Mickalad, A. A., Deby-Dupont, G. P., Deby, C. M. T., Lamy, M., & Noels, A. F. (2001) · Free Radical Research · doi:10.1080/10715760100301221 · Cited by 43 · see citing works
Nitric oxide synthase activity in renal cortex and medulla of normotensive and spontaneously hypertensive rats
Nava, E., Llinás, M. T., GONZALEZ, J., et al. (1996) · American Journal of Hypertension · doi:10.1016/s0895-7061(96)00325-1 · Cited by 37 · see citing works
SERUM NITRIC OXIDE METABOLITE (NOX) LEVELS IN HYPERTENSIVE PATIENTS AT REST: A COMPARISON OF AGE, GENDER, BLOOD PRESSURE AND COMPLICATIONS USING NORMOTENSIVE CONTROLS
Higashino, H., Miya, H., Mukai, H., et al. (2007) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04617.x · Cited by 37 · see citing works
Tetrahydrobiopterin prevents endothelial dysfunction and restores adiponectin levels in rats
Wang, X., Hattori, Y., Satoh, H., Iwata, C., Banba, N., Monden, T., Uchida, K., Kamikawa, Y., & Kasai, K. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.10.017 · Cited by 33 · see citing works
Attenuation of acetylcholine-induced vasoconstriction by L-arginine is related to the progression of atherosclerosis
Otsuji, S., Nakajima, O., Waku, S., et al. (1995) · American Heart Journal · doi:10.1016/0002-8703(95)90388-7 · Cited by 33 · see citing works
Expression of Endothelial Nitric Oxide Synthase in Human Peritoneal Tissue
Arriero, M., Rodríguez-Feo, J. A., Celdrán, Á., de Miguel, L. S., González-Fernández, F., Fortes, J., Reyero, A., Frieyro, O., de la Pinta, J. C., Franco, A., et al. (2000) · Journal of the American Society of Nephrology · doi:10.1681/asn.v11101848 · Cited by 28 · see citing works
Nitric oxide preconditioning regulates endothelial monolayer integrity via the heat shock protein 90-soluble guanylate cyclase pathway
Antonova, G. N., Snead, C. M., Antonov, A. S., Dimitropoulou, C., Venema, R. C., & Catravas, J. D. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00498.2006 · Cited by 19 · see citing works
Self-citation
Impairment of endothelium-dependent vasorelaxation in experimental atherosclerosis is dependent on gender
Kojda, G. (1998) · Cardiovascular Research · doi:10.1016/s0008-6363(97)00268-x · Cited by 18 · see citing works
Estradiol Relaxes Rat Aorta via Endothelium-Dependent and -Independent Mechanisms
Abou-Mohamed, G., Elmarakby, A. A., Carrier, G. O., et al. (2003) · Pharmacology · doi:10.1159/000071268 · Cited by 17 · see citing works
Reduced pulmonary endothelium-bound angiotensin converting enzyme activity in diabetic rabbits
McCloud, L., Parkerson, J. B., Zou, L., et al. (2004) · Vascular Pharmacology · doi:10.1016/j.vph.2004.08.004 · Cited by 10 · see citing works
Expression of 90-kDa Heat Shock Protein Within Regenerative Tubular Cells in a Patient with Acute Oliguric Renal Failure Due to Malignant Hypertension
Komatsuda, A., Wakuil, H., Imai, H., et al. (1999) · Renal Failure · doi:10.3109/08860229909066975 · Cited by 10 · see citing works
Heat shock protein 90 is responsible for hyperdynamic circulation in portal hypertensive rats
Ai, J.-H., Yang, Z., Qiu, F.-Z., & Zhu, T. (2003) · World Journal of Gastroenterology · doi:10.3748/wjg.v9.i11.2544 · Cited by 5 · see citing works
[Debating the abortion issue is good--but do it as a neglected health problem].
Bergström, S., Bygdeman, M., Rehn, M., et al. (2006) · PubMed · Cited by 1 · see citing works

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Authors: Chatterjee, A., & Catravas, J. D.
Affiliations: Augusta University (US)
Corresponding author: Catravas, John D.
ORCID: Catravas, John D.
Venue: Vascular Pharmacology
Publisher: Elsevier BV
Published: 2008-10
Volume: 49
Issue: 4-6
Pages: 134-140
ISSN: 1537-1891 (ISSN-L)
DOI: 10.1016/j.vph.2008.06.008
PMC: PMC2592563
OpenAlex: W2082519175
Cited by: 236
References: 143
Citations by year: 2026: 2 · 2025: 9 · 2024: 6 · 2023: 7 · 2022: 9 · 2021: 10 · 2020: 7 · 2019: 11 · 2018: 13 · 2017: 14 · 2016: 13 · 2015: 17 · 2014: 16 · 2013: 19 · 2012: 24
FWCI: 2.13
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Vascular Pharmacology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: American Heart Association
National Heart, Lung, and Blood Institute (R01HL070214, HL 70142)
Topics: Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords: nitric oxide, endothelial nitric oxide synthase, nitric oxide synthase isoforms, HSP90, cardiovascular disease, atherosclerosis, diabetes mellitus, hypertension, vascular disease, no-signaling
MeSH terms: Animals, Endothelium, Vascular, Humans, Nitric Oxide, Vascular Diseases, Gene Expression Regulation, Enzymologic, HSP90 Heat-Shock Proteins, Nitric Oxide Synthase Type III

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