NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS generation
Serrander, Lena, Cartier, Laetitia, Bedard, Karen, Banfi, Botond, Lardy, Bernard, Plastre, Olivier, Sienkiewicz, Andrzej, Fórró, Lászlo +2 more·2007·Biochemical Journal
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- NADPH oxidase 4 protects against development of endothelial dysfunction and atherosclerosis in LDL receptor deficient miceLangbein, Heike, Brunssen, Coy, Hofmann, Anja, Cimalla, Peter, Brux, Melanie, Bornstein, Stefan R., Deussen, Andreas, Koch, Edmund, Morawietz, Henning · 2016 · European Heart Journal
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- Nox4-derived reactive oxygen species mediate cardiomyocyte injury in early type 1 diabetesRita Maalouf, Assaad Antoine Eid, Yves C. Gorin, Karen L. Block, Gladys Patricia Escobar, Steven R. Bailey, Hanna E. Abboud · 2011 · American Journal of Physiology-Cell Physiology
- Differential Roles of the NADPH-Oxidase 1 and 2 in Platelet Activation and ThrombosisMichael Keegan Delaney, Kyungho Kim, Brian Estevez, Zheng Xu, Aleksandra Stojanovic‐Terpo, Bo Shen, Masuko Ushio‐Fukai, Jaehyung Cho, Xiaoping Du · 2016 · Arteriosclerosis Thrombosis and Vascular Biology
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- Structural Insights into Nox4 and Nox2: Motifs Involved in Function and Cellular LocalizationKatharina von Löhneysen, Deborah Noack, Malcolm R. Wood, Jeffrey S. Friedman, Ulla G. Knaus · 2009 · Molecular and Cellular Biology
- Mitochondrial Reactive Oxygen Species Mediate Cardiomyocyte Formation from Embryonic Stem Cells in High GlucoseFrancisco Luna Crespo, Verónica R. Sobrado, Laura Gómez, Ana M. Cervera, Kenneth J. McCreath · 2010 · Stem Cells
- NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of actionVincent Jaquet, Julien Marcoux, Éric Forest, Kevin G. Leidal, Sally J. McCormick, Yvonne Westermaier, Remo Perozzo, Olivier Plastre, Laetitia Fioraso-Cartier, Becky A. Diebold et al. · 2011 · British Journal of Pharmacology
- Oxygen-coupled redox regulation of the skeletal muscle ryanodine receptor-Ca 2+ release channel by NADPH oxidase 4Qi-An Sun, Douglas T. Hess, Leonardo Nogueira, Sandro Yong, Dawn E. Bowles, Jerry P. Eu, Kenneth R. Laurita, Gerhard Meissner, Jonathan S. Stamler · 2011 · Proceedings of the National Academy of Sciences
- NOX5: from basic biology to signaling and diseaseKaren Bedard, Vincent Jaquet, Karl‐Heinz Krause · 2011 · Free Radical Biology and Medicine
- Peroxiredoxin II Is an Essential Antioxidant Enzyme that Prevents the Oxidative Inactivation of VEGF Receptor-2 in Vascular Endothelial CellsDong Hoon Kang, Doo Jae Lee, Kyung Wha Lee, Yoon Sun Park, Joo Young Lee, Sang‐Hee Lee, Young Jun Koh, Gou-Young Koh, Chulhee Choi, Dae‐Yeul Yu et al. · 2011 · Molecular Cell
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- Prevention of Treacher Collins syndrome craniofacial anomalies in mouse models via maternal antioxidant supplementationDaisuke Sakai, Jill Dixon, Annita Achilleos, Michael James Dixon, Paul A. Trainor · 2016 · Nature Communications
- NADPH oxidase in the vasculature: Expression, regulation and signalling pathways; role in normal cardiovascular physiology and its dysregulation in hypertensionGreg A. Knock · 2019 · Free Radical Biology and Medicine
- ROS and RNS Signaling in Heart Disorders: Could Antioxidant Treatment Be Successful?Igor B. Afanasʹev · 2011 · Oxidative Medicine and Cellular Longevity
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- Mutational Analysis Reveals Distinct Features of the Nox4-p22 ComplexKatharina von Löhneysen, Deborah Noack, Algirdas J. Jesaitis, Mary C. Dinauer, Ulla G. Knaus · 2008 · Journal of Biological Chemistry
- Activation of microglia with zymosan promotes excitatory amino acid release via volume‐regulated anion channels: the role of NADPH oxidasesHarrigan, Timothy J., Abdullaev, Iskandar F., Jourd’heuil, David, Mongin, Alexander A. · 2008 · Journal of Neurochemistry
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- Oxidative Stress at the Crossroads of Aging, Stroke and DepressionAnwen Shao, Danfeng Lin, Lingling Wang, Sheng Tu, Cameron Lenahan, Jianmin Zhang · 2020 · Aging and Disease
- High glucose concentration affects the oxidant‐antioxidant balance in cultured mouse podocytesAgnieszka Piwkowska, Dorota Rogacka, Irena Audzeyenka, Maciej Jankowski, Stefan Angielski · 2011 · Journal of Cellular Biochemistry
- Evidence of the Importance of Nox4 in Production of Hypertension in Dahl Salt-Sensitive RatsAllen W. Cowley, Chun Yang, Nadezhda N. Zheleznova, Alexander Staruschenko, Theresa M. Kurth, Lisa Rein, Vikash Kumar, Katherine Sadovnikov, Alex Dayton, Matthew J. Hoffman et al. · 2015 · Hypertension
- Characteristics and roles of the volume-sensitive outwardly rectifying (VSOR) anion channel in the central nervous systemTenpei Akita, Yasunobu Okada · 2014 · Neuroscience
- Protein disulfide isomerase overexpression in vascular smooth muscle cells induces spontaneous preemptive NADPH oxidase activation and Nox1 mRNA expression: Effects of nitrosothiol exposureDenise C. Fernandes, Ana Heloisa O. Manoel, João Wosniak, Francisco Rafael Martins Laurindo · 2009 · Archives of Biochemistry and Biophysics
- Control of Hepatic Nuclear Superoxide Production by Glucose 6-Phosphate Dehydrogenase and NADPH Oxidase-4Netanya Y. Spencer, Ziying Yan, Ryan L. Boudreau, Yulong Zhang, Meihui Luo, Qiang Li, Xin Tian, Ajay M. Shah, Robin L. Davisson, Beverly L. Davidson et al. · 2011 · Journal of Biological Chemistry
- Genetic Silencing of Nox2 and Nox4 Reveals Differential Roles of These NADPH Oxidase Homologues in the Vasopressor and Dipsogenic Effects of Brain Angiotensin IIJeffrey R. Peterson, Melissa A. Burmeister, Xin Tian, Yi Zhou, Mallikarjuna R. Guruju, John A. Stupinski, Ram V. Sharma, Robin L. Davisson · 2009 · Hypertension
- Nitric Oxide, NAD(P)H Oxidase, and AtherosclerosisGregor M. Müller, Henning Morawietz · 2009 · Antioxidants and Redox Signaling
- Reactive oxygen species as important determinants of medullary flow, sodium excretion, and hypertensionAllen W. Cowley, Michiaki Abe, Takefumi Mori, Paul Michael O'Connor, Yusuke Ohsaki, Nadezhda N. Zheleznova · 2014 · American Journal of Physiology-Renal Physiology
- Mitochondrial-localized NADPH oxidase 4 is a source of superoxide in angiotensin II-stimulated neuronsCase, Adam J., Li, Shumin, Basu, Urmi, Tian, Jun, Zimmerman, Matthew C. · 2013 · American Journal of Physiology-Heart and Circulatory Physiology
- Oxidative and nitrosative stress in the maintenance of myocardial functionYixuan Zhang, Carlo Gabriele Tocchetti, Thomas Krieg, An L. Moens · 2012 · Free Radical Biology and Medicine
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- NOX4 as a critical effector mediating neuroinflammatory cytokines, myeloperoxidase and osteopontin, specifically in astrocytes in the hippocampus in Parkinson's diseaseNapissara Boonpraman, Sunmi Yoon, Chae Young Kim, Jong‐Seok Moon, Sun Shin Yi · 2023 · Redox Biology
- Hepatoprotective effects of berberine on liver fibrosis via activation of AMP-activated protein kinaseJing Li, Yue Pan, Mujie Kan, Xuanang Xiao, Yunjing Wang, Fengying Guan, Xuewen Zhang, Li Chen · 2014 · Life Sciences
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- Oxidative Stress in Kidney Injury and HypertensionWillaim J. Arendshorst, Aleksandr E. Vendrov, Nitin Kumar, Santhi K. Ganesh, Nageswara R. Madamanchi · 2024 · Antioxidants
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- Differential roles of PKCα and PKCɛ in controlling the gene expression of Nox4 in human endothelial cellsXu, Hui, Goettsch, Claudia, Xia, Ning, Horke, Sven, Morawietz, Henning, Förstermann, Ulrich, Li, Huige · 2008 · Free Radical Biology and Medicine
- H2O2 Metabolism in Normal Thyroid Cells and in Thyroid Tumorigenesis: Focus on NADPH OxidasesIldikó Szántó, Marc Philippe Pusztaszeri, Maria Mavromati · 2019 · Antioxidants
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- Silencing Nox4 in the Paraventricular Nucleus Improves Myocardial Infarction–Induced Cardiac Dysfunction by Attenuating Sympathoexcitation and Periinfarct ApoptosisDavid W. Infanger, Xian Cao, Scott D. Butler, Melissa A. Burmeister, Yi Zhou, John A. Stupinski, Ram V. Sharma, Robin L. Davisson · 2010 · Circulation Research
- Redox stress in Marfan syndrome: Dissecting the role of the NADPH oxidase NOX4 in aortic aneurysmFrancesc Jiménez‐Altayó, Thayna Meirelles, Eva Crosas‐Molist, Maria Alba Sorolla, Darya Gorbenko del Blanco, Judit López‐Luque, Aleksandra Mas‐Stachurska, Ana-Maria Siegert, Fabio Bonorino, Laura Barberà et al. · 2018 · Free Radical Biology and Medicine
- Opposing Actions of Heat Shock Protein 90 and 70 Regulate Nicotinamide Adenine Dinucleotide Phosphate Oxidase Stability and Reactive Oxygen Species ProductionFeng Chen, Yanfang Yu, Jin Qian, Yusi Wang, Bo Cheng, Christiana Dimitropoulou, Vijay S Patel, Ahmed Chadli, Radu Daniel Rudic, David W. Stepp et al. · 2012 · Arteriosclerosis Thrombosis and Vascular Biology
- Atrial Cardiomyopathy: Pathophysiology and Clinical ConsequencesAndreas Goette, Uwe Lendeckel · 2021 · Cells
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- Endothelial NADPH oxidase 4 protects ApoE-/- mice from atherosclerotic lesionsCraige, Siobhan M., Kant, Shashi, Reif, Michaella, Chen, Kai, Pei, Yongmei, Angoff, Rebecca, Sugamura, Koichi, Fitzgibbons, Timothy, Keaney, John F. · 2015 · Free Radical Biology and Medicine
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- MicroRNA-146a Decreases High Glucose/Thrombin-Induced Endothelial Inflammation by Inhibiting NAPDH Oxidase 4 ExpressionHuang-Joe Wang, Yuan‐Li Huang, Ya-Yun Shih, Hsing-Yu Wu, Ching‐Tien Peng, Wan‐Yu Lo · 2014 · Mediators of Inflammation
- NADPH oxidases 1 and 4 mediate cellular senescence induced by resveratrol in human endothelial cellsYvonne D.C. Schilder, Elke H. Heiß, Daniel Schachner, Jürgen Ziegler, Gottfried Reznicek, Dan Sorescu, Verena Maria Dirsch · 2009 · Free Radical Biology and Medicine
- Differential vascular functions of Nox family NADPH oxidasesRalf Peter Brandes, Katrin Schröder · 2008 · Current Opinion in Lipidology
- Deficiency in the NADPH oxidase 4 predisposes towards diet-induced obesityY Li, Sarah Mouche, Tatjana Sajic, Christelle Veyrat‐Durebex, R Supale, Dominique D. Pierroz, Serge Ferrari, Francesco Negro, Ursula Hasler, Eric Féraille et al. · 2012 · International Journal of Obesity
- NADPH Oxidase and Cardiac FailureJunya Kuroda, Junichi Sadoshima · 2010 · Journal of Cardiovascular Translational Research
- Activation of the ACE2/Ang-(1–7)/Mas pathway reduces oxygen–glucose deprivation-induced tissue swelling, ROS production, and cell death in mouse brain with angiotensin II overproductionJian Zheng, G. Li, Shuzhen Chen, Ji Chen Bihl, J. Buck, Yulan Zhu, H. Xia, Eric D. Lazartigues, Y. Chen, James E. Olson · 2014 · Neuroscience
- A 28-kDa Splice Variant of NADPH Oxidase-4 Is Nuclear-Localized and Involved in Redox Signaling in Vascular CellsNarayana Panicker Anilkumar, Gorka San José, Iain A. Sawyer, Célio X.C. Santos, Claire A. Sand, Alison C. Brewer, Derek T Warren, Ajay M. Shah · 2013 · Arteriosclerosis Thrombosis and Vascular Biology
- Elimination of NADPH Oxidase Activity Promotes Reductive Stress and Sensitizes the Heart to Ischemic InjuryQiujun Yu, Chi Fung Lee, Wang Wang, Georgios Karamanlidis, Junya Kuroda, Shouji Matsushima, Junichi Sadoshima, Rong Tian · 2014 · Journal of the American Heart Association
- Nox4 Oxidase Overexpression Specifically Decreases Endogenous Nox4 mRNA and Inhibits Angiotensin II–Induced Adventitial Myofibroblast MigrationMounir Joseph Haurani, Eugenia Cifuentes-Pagano, Alexander Duncan Shepard, Patrick J. Pagano · 2008 · Hypertension
- ROS signalling, NADPH oxidases and cancerWilliam D. Landry, Thomas G. Cotter · 2014 · Biochemical Society Transactions
- Antioxidants and vascular healthAlessandra Bielli, Maria Giovanna Scioli, Donatella Mazzaglia, Elena Doldo, Augusto Orlandi · 2015 · Life Sciences
- The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-β-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoformsPatricia Sancho, Esther Bertrán, Laia Caja, Irene Carmona‐Cuenca, Miguel Manuel Murillo, Isabel Fabregat · 2008 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- The NADPH Oxidase Nox4 and Aging in the HeartTetsuro Ago, Shouji Matsushima, Junya Kuroda, Daniela Zablocki, Takanari Kitazono, Junichi Sadoshima · 2010 · Aging
- Erlotinib-Mediated Inhibition of EGFR Signaling Induces Metabolic Oxidative Stress through NOX4Kevin P. Orcutt, Arlene D. Parsons, Zita A. Sibenaller, Peter M. Scarbrough, Yueming Zhu, Arya Sobhakumari, Werner W. Wilke, Amanda L. Kalen, Prabhat C. Goswami, Francis J. Miller et al. · 2011 · Cancer Research
- A novel bifunctional mitochondria-targeted anticancer agent with high selectivity for cancer cellsHuan He, Dong-Wei Li, Liyun Yang, Li Fu, Xunjin Zhu, Wai‐Kwok Wong, Feng‐Lei Jiang, Yi Liu · 2015 · Scientific Reports
- Inhibition of Nox4‐dependent ROS signaling attenuates prostate fibroblast activation and abrogates stromal‐mediated protumorigenic interactionsNatalie Sampson, Elena Brunner, Anja Weber, Martin Puhr, Georg Schäfer, Cédric Szyndralewiez, Helmut Klocker · 2018 · International Journal of Cancer
- Hsp90 Regulates NADPH Oxidase Activity and Is Necessary for Superoxide but Not Hydrogen Peroxide ProductionFeng Chen, D. Pandey, A. Chadli, J. Catravas, Teng Chen, D. Fulton · 2011 · Antioxidants and Redox Signaling
- Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury.Lijian Shao, Yingying Wang, Jianhui Chang, Yi Luo, Aimin Meng, Daohong Zhou · 2013 · PubMed