NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS generation

The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology

Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989

NOX enzymes and the biology of reactive oxygen

Lambeth, J. D. (2004) · Nature Reviews Immunology · doi:10.1038/nri1312 · Cited by 3,125

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

Griendling, K. K., Minieri, C. A., Ollerenshaw, J. D., & Alexander, R. W. (1994) · Circulation Research · doi:10.1161/01.res.74.6.1141 · Cited by 2,735

Tetrazolium dyes as tools in cell biology: new insights into their cellular reduction

Berridge, M. V., Herst, P. M., & Tan, A. S. (2005) · Biotechnology Annual Review · doi:10.1016/s1387-2656(05)11004-7 · Cited by 2,222

Calcium phosphate-mediated gene transfer: a highly efficient transfection system for stably transforming cells with plasmid DNA.

Chen, C. A., & Okayama, H. (1990) · PubMed · Cited by 898

Identification of Renox, an NAD(P)H oxidase in kidney

Geiszt, M., Kopp, J. B., Várnai, P., & Leto, T. L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.130135897 · Cited by 840

NAD(P)H Oxidase 4 Mediates Transforming Growth Factor-β1–Induced Differentiation of Cardiac Fibroblasts Into Myofibroblasts

Cucoranu, I., Clempus, R., Dikalova, A., Phelan, P. J., Ariyan, S., Dikalov, S., & Sorescu, D. (2005) · Circulation Research · doi:10.1161/01.res.0000187457.24338.3d · Cited by 786

Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases

Martyn, K. D., Frederick, L. M., von Loehneysen, K., Dinauer, M. C., & Knaus, U. G. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2005.03.023 · Cited by 783

Characteristics of the Inhibition of NADPH Oxidase Activation in Neutrophils by Apocynin, a Methoxy-Substituted Catechol

Stolk, J. N., Hiltermann, T. J. N., Dijkman, J. H., & Verhoeven, A. J. (1994) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.11.1.8018341 · Cited by 650

A Ca2+-activated NADPH Oxidase in Testis, Spleen, and Lymph Nodes

Bánfi, B., Molnár, G., Maturana, A., Steger, K., Hegedûs, B., Demaurex, N., & Krause, K.-H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103034200 · Cited by 622

Sp3 transcription factor is crucial for transcriptional activation of the human NOX4 gene

Katsuyama, M., Hirai, H., Iwata, K., Ibi, M., Matsuno, K., Matsumoto, M., & Yabe‐Nishimura, C. (2011) · FEBS Journal · doi:10.1111/j.1742-4658.2011.08018.x · Cited by 25

Exposure to low- vs iso-osmolar contrast agents reduces NADPH-dependent reactive oxygen species generation in a cellular model of renal injury

Netti, G. S., Prattichizzo, C., Montemurno, E., Simone, S., Cafiero, C., Rascio, F., Stallone, G., Ranieri, E., Grandaliano, G., & Gesualdo, L. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.11.016 · Cited by 25

Prolonged fasting activates Nrf2 in postweaned elephant seals

Vázquez‐Medina, J. P., Soñanez‐Organis, J. G., Rodríguez, R., Viscarra, J. A., Nishiyama, A., Crocker, D. E., & Ortiz, R. M. (2013) · Journal of Experimental Biology · doi:10.1242/jeb.081927 · Cited by 25

Loss of Functional NADPH Oxidase 2 Protects Against Alcohol‐Induced Bone Resorption in Female p47phox −/− Mice

Mercer, K. E., Sims, C. R., Yang, C. S., Wynne, R. A., Moutos, C. P., Hogue, W. R., Lumpkin, C. K., Suva, L. J., Chen, J., Badger, T. M., et al. (2013) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12305 · Cited by 25

Role of Endothelial ADAM17 in Early Vascular Changes Associated with Diabetic Retinopathy

Shalaby, L., Thounaojam, M. C., Tawfik, A. M., Li, J., Hussein, K. A., Jahng, W. J., Al‐Shabrawey, M., Kwok, H. F., Bartoli, M., & Gutsaeva, D. R. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020400 · Cited by 24

Redox-Regulated Growth Factor Survival Signaling

Woolley, J. F., Corcoran, A., Groeger, G., Landry, W. D., & Cotter, T. G. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.5028 · Cited by 24

Acute Changes in NADPH Oxidase 4 in Early Post‐Traumatic Osteoarthritis

Wegner, A. M., Campos, N. R., Robbins, M. A., Haddad, A. F., Cunningham, H. C., Yik, J. H. N., Christiansen, B., & Haudenschild, D. R. (2019) · Journal of Orthopaedic Research® · doi:10.1002/jor.24417 · Cited by 23

NADPH Oxidases in Neurodegenerative Disorders: Mechanisms and Therapeutic Opportunities

Fiadeiro, M. B., Diogo, J. C., Silva, A., Kim, Y., & Cristóvão, A. C. (2024) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0002 · Cited by 25

Abrogation of transforming growth factor-β-induced tissue fibrosis in mice with a global genetic deletion of Nox4

Wermuth, P. J., Mendoza, F. A., & Jiménez, S. A. (2018) · Laboratory Investigation · doi:10.1038/s41374-018-0161-1 · Cited by 23

Engulfment and cell motility protein 1 potentiates diabetic cardiomyopathy via Rac-dependent and Rac-independent ROS production

Kakoki, M., Bahnson, E. M., Hagaman, J. R., Siletzky, R. M., Grant, R., Kayashima, Y., Li, F., Lee, E. Y., Sun, M., Taylor, J. M., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.127660 · Cited by 23

Involvement of superoxide and nitric oxide in BRAFV600E inhibitor PLX4032-induced growth inhibition of melanoma cells

Yu, L. D., Gao, L. X., Ma, X. Q., Hu, F., Li, C. M., & Lu, Z. (2014) · Integrative Biology · doi:10.1039/c4ib00170b · Cited by 23

Mitochondrial Regulation of NADPH Oxidase in Hindlimb Unweighting Rat Cerebral Arteries

Zhang, R., Ran, H., Peng, L., Xu, F., Sun, J., Lan-ning, Z., Fan, Y., Li, P., & Cui, G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095916 · Cited by 23

Molecular Roles of NADPH Oxidase-Mediated Oxidative Stress in Alzheimer’s Disease: Isoform-Specific Contributions

Kim, J., & Moon, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212299 · Cited by 26

NOX4 is the main NADPH oxidase involved in the early stages of hematopoietic differentiation from human induced pluripotent stem cells

Brault, J., Vigne, B., Meunier, M., Beaumel, S., Mollin, M., Park, S., & Stasia, M. J. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.10.005 · Cited by 23

Complexities of the chemogenetic toolkit: Differential mDAAO activation by d-amino substrates and subcellular targeting

Erdogan, Y. C., Altun, H. Y., Seçilmiş, M., Ata, B. N., Sevimli, G., Çokluk, Z., Zaki, A. G., Sezen, S., Çağlar, T. A., Sevgen, İ., et al. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.10.023 · Cited by 22

SIRT7 Deficiency Protects against Aβ42-Induced Apoptosis through the Regulation of NOX4-Derived Reactive Oxygen Species Production in SH-SY5Y Cells

Mizutani, H., Sato, Y., Yamazaki, M., Yoshizawa, T., Ando, Y., Ueda, M., & Yamagata, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169027 · Cited by 22

Cyclic stretch stimulates nitric oxide synthase-1-dependent peroxynitrite formation by neonatal rat pulmonary artery smooth muscle

Dick, A. S., Ivanovska, J., Kantores, C., Belcastro, R., Tanswell, A. K., & Jankov, R. P. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.04.027 · Cited by 22

NADPH Oxidase 4 Deficiency Reduces Aquaporin-2 mRNA Expression in Cultured Renal Collecting Duct Principal Cells via Increased PDE3 and PDE4 Activity

Féraille, E., Dizin, É., Roth, I., Derouette, J.-P., Szántó, I., Martin, P., de Seigneux, S., & Hasler, U. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087239 · Cited by 22

The dehydrogenase region of the NADPH oxidase component Nox2 acts as a protein disulfide isomerase (PDI) resembling PDIA3 with a role in the binding of the activator protein p67phox

Bechor, E., Dahan, I. M., Fradin, T., Berdichevsky, Y., Zahavi, A., Gross, A. F., Rafalowski, M., & Pick, E. (2015) · Frontiers in Chemistry · doi:10.3389/fchem.2015.00003 · Cited by 22

Protective effect of allicin on high glucose/hypoxia-induced aortic endothelial cells via reduction of oxidative stress

WANG, S.-L., Liu, D., Liang, E., GAO, Y.-H., CUI, Y., Liu, Y.-Z., & Gao, W. (2015) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2015.2708 · Cited by 22

Differential endothelial hydrogen peroxide signaling via Nox isoforms: Critical roles for Rac1 and modulation by statins

Waldeck‐Weiermair, M., Yadav, S., Kaynert, J. T., Thulabandu, V., Pandey, A. K., Spyropoulos, F., Covington, T. A., Das, A. A., Krüger, C., & Michel, T. M. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102539 · Cited by 21

Empagliflozin alleviates diabetes-induced cognitive impairments by lowering nicotinamide adenine dinucleotide phosphate oxidase-4 expression and potentiating the antioxidant defense system in brain tissue of diabetic rats

Yaribeygi, H., Hemmati, M. A., Nasimi, F. S., Pakdel, R., Jamialahmadi, T., & Sahebkar, A. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114830 · Cited by 22

Group VIA Phospholipase A 2 Mediates Enhanced Macrophage Migration in Diabetes Mellitus by Increasing Expression of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4

Tan, C., Day, R. T., Bao, S. S., TURK, J. W., & Zhao, Q. D. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.302847 · Cited by 21

The NADPH oxidase inhibitor diphenyleneiodonium activates the human TRPA1 nociceptor

Suzuki, H., Hatano, N., Muraki, Y., Itoh, Y., Kimura, S., Hayashi, H., Onozaki, K., Ohi, Y., Haji, A., & Muraki, K. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00182.2013 · Cited by 21

Reactive oxygen species and the structural remodeling of the visual system after ocular enucleation

Hernandes, M. S., Britto, L. R. G., Real, C. C., Martins, D. O., & Lopes, L. R. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.07.065 · Cited by 21

Alterations in pectoralis muscle cell characteristics after radiation of the human breast in situ

Wallner, C., Drysch, M., Hahn, S. A., Becerikli, M., Puscz, F., Wagner, J. M., Sacher, M., Sogorski, A., Dadras, M., Lehnhardt, M., et al. (2019) · Journal of Radiation Research · doi:10.1093/jrr/rrz067 · Cited by 21

Fulvene-5 inhibition of Nadph oxidases attenuates activation of epithelial sodium channels in A6 distal nephron cells

Trac, D. Q., Liu, B., Pao, A. C., Thomas, S. V., Park, M., Downs, C. A., Ma, H., & Helms, M. N. (2013) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00098.2013 · Cited by 20

TLR4 regulates pulmonary vascular homeostasis and remodeling via redox signaling

Chen, Y. (2015) · Frontiers in bioscience · doi:10.2741/4396 · Cited by 21

NADPH oxidase 4 attenuates cerebral artery changes during the progression of Marfan syndrome

Onetti, Y., Meirelles, T., Dantas, A. P., Schröder, K., Vila, E., Egea, G., & Jiménez‐Altayó, F. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00770.2015 · Cited by 20

Specific NOX4 Inhibition Preserves Mitochondrial Function and Dampens Kidney Dysfunction Following Ischemia–Reperfusion-Induced Kidney Injury

Schiffer, T. A., Carvalho, L. R. R. A., Guimarães, D. D., Boeder, A. M., Wikström, P., & Carlström, M. (2024) · Antioxidants · doi:10.3390/antiox13040489 · Cited by 20

BIAM switch assay coupled to mass spectrometry identifies novel redox targets of NADPH oxidase 4

Löwe, O., Rezende, F., Heidler, J., Wittig, I., Helfinger, V., Brandes, R. P., & Schröder, K. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101125 · Cited by 20

NADPH oxidase 4 is required for interleukin-1β-mediated activation of protein kinase Cδ and downstream activation of c-jun N-terminal kinase signaling in smooth muscle

Ginnan, R. G., Jourd’heuil, F. L., Guikema, B. J., Simons, M., Singer, H. A., & Jourd’heuil, D. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.09.026 · Cited by 20

The Expression of NADPH Oxidases and Production of Reactive Oxygen Species by Human Lung Adenocarcinoma Epithelial Cell Line A549

Kolářová, H., Binó, L., Pejchalová, K., & Kubala, L. (2010) · Folia Biologica · doi:10.14712/fb2010056050211 · Cited by 20

Cardiac Fibrosis Is a Risk Factor for Severe COVID-19

Mustroph, J., Hupf, J., Baier, M. J., Evert, K., Brochhausen, C., Broeker, K. A. E., Meindl, C., Seither, B., Jungbauer, C. G., Evert, M., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.740260 · Cited by 19

Nox4 promotes endothelial differentiation through chromatin remodeling

Hahner, F., Moll, F., Warwick, T., Hebchen, D. M., Buchmann, G., Epah, J., Abplanalp, W. T., Schader, T., Günther, S., Gilsbach, R., et al. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102381 · Cited by 19

GLX351322, a Novel NADPH Oxidase 4 Inhibitor, Attenuates TMJ Osteoarthritis by Inhibiting the ROS/MAPK/NF-κB Signaling Pathways

Zhen, J., Chen, X., Ma, H., Xie, X., Chen, X., Xu, W., & Zhang, S. (2023) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2023/1952348 · Cited by 19

Upregulation of NOX-2 and Nrf-2 Promotes 5-Fluorouracil Resistance of Human Colon Carcinoma (HCT-116) Cells

Waghela, B. N., Vaidya, F. U., & Pathak, C. (2021) · Biochemistry (Moscow) · doi:10.1134/s0006297921030044 · Cited by 19

Cells redox environment modulates BRCA1 expression and DNA homologous recombination repair

Wilson, A., & Yakovlev, V. A. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.10.015 · Cited by 19

Endothelial NADPH oxidases: friends or foes?

Morawietz, H. (2011) · Basic Research in Cardiology · doi:10.1007/s00395-011-0188-6 · Cited by 19

NADPH Oxidase 4

Miller, F. J. (2009) · Circulation Research · doi:10.1161/circresaha.109.202986 · Cited by 19

Óxido nítrico y factores relacionados a oxidación e inflamación como posibles biomarcadores de insuficiencia cardíaca

Bonafede, R. J., & Manucha, W. A. (2018) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/j.arteri.2017.12.004 · Cited by 25

NADPH Oxidase 3: Beyond the Inner Ear

Herb, M. (2024) · Antioxidants · doi:10.3390/antiox13020219 · Cited by 19

Functional Heterogeneity of Nadph Oxidases in Atherosclerotic and Aneurysmal Diseases

Kigawa, Y., Miyazaki, T., Lei, X., Kim‐Kaneyama, J., & Miyazaki, A. (2016) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.33431 · Cited by 18

NADPH oxidase 4 is involved in the triethylene glycol dimethacrylate-induced reactive oxygen species and apoptosis in human embryonic palatal mesenchymal and dental pulp cells

Yeh, C., Chang, J. Z., Yang, W., Chang, H., Lai, E. H., & Kuo, M. Y. (2014) · Clinical Oral Investigations · doi:10.1007/s00784-014-1370-7 · Cited by 19

A novel NADPH oxidase inhibitor targeting Nox4 in TGFβ-induced lens epithelial to mesenchymal transition

Das, S. J., Wikström, P., Walum, E., & Lovicu, F. J. (2019) · Experimental Eye Research · doi:10.1016/j.exer.2019.107692 · Cited by 21

Characterisation of Nox4 Inhibitors from Edible Plants

Kofler, P., Pircher, H., von Grafenstein, S., Diener, T., Höll, M., Liedl, K. R., Siems, K., & Jansen‐Dürr, P. (2013) · Planta Medica · doi:10.1055/s-0032-1328129 · Cited by 18

Leptin-depended NLRP3 inflammasome activation in osteoarthritic chondrocytes is mediated by ROS

Mourmoura, E., Papathanasiou, I. V., Trachana, V., Konteles, V., Tsoumpou, A., Goutas, A., Papageorgiou, A.-A., Stefanou, N., & Tsezou, A. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111730 · Cited by 17

Time dependent changes in the intestinal Ca2+ absorption in rats with type I diabetes mellitus are associated with alterations in the intestinal redox state

Rivoira, M. A., Rodríguez, V. A., López, M. P., & de Talamoni, N. T. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.11.018 · Cited by 17

Hypo-CpG methylation controls PTEN expression and cell apoptosis in irradiated lung

Zhang, X., Hadley, C. C., Jackson, I. L., Zhang, Y., Zhang, A., Spasojević, I., Batinic̈‐Haberle, I., & Vujašković, Ž. (2016) · Free Radical Research · doi:10.1080/10715762.2016.1189078 · Cited by 17

Nuclear membrane-localised NOX4D generates pro-survival ROS in FLT3-ITD-expressing AML

Moloney, J. N., Jayavelu, A. K., Stanicka, J., Roche, S. L., O’Brien, R. L., Scholl, S., Böhmer, F.-D., & Cotter, T. G. (2017) · Oncotarget · doi:10.18632/oncotarget.22241 · Cited by 19

Inhibition of insulin-stimulated hydrogen peroxide production prevents stimulation of sodium transport in A6 cell monolayers

Markadieu, N., Crutzen, R., Boom, A., Erneux, C., & Beauwens, R. (2009) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.90397.2008 · Cited by 16

The Dual Role of NOX4 in Cardiovascular Diseases: Driver of Oxidative Stress and Mediator of Adaptive Remodeling

Labbé, P., Thorin, É., & Thorin‐Trescases, N. (2025) · Antioxidants · doi:10.3390/antiox14091137 · Cited by 16

Stimulation of vasculogenesis and leukopoiesis of embryonic stem cells by extracellular transfer RNA and ribosomal RNA

Sharifpanah, F., Silva, S. D., Bekhite, M. M., Hurtado-Oliveros, J., Preissner, K. T., Wartenberg, M., & Sauer, H. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.10.423 · Cited by 17

NADPH Oxidase 4 Mediates TGFβ1-induced CCN2 in Gingival Fibroblasts

Yang, W., Deng, Y., Hsieh, Y. P., Wu, K., & Kuo, M. Y. (2015) · Journal of Dental Research · doi:10.1177/0022034515580986 · Cited by 16

Intrahepatic microcirculatory disorder, parenchymal hypoxia and NOX4 upregulation result in zonal differences in hepatocyte apoptosis following lipopolysaccharide- and D-galactosamine-induced acute liver failure in rats

Tanaka, M., TANAKA, K., MASAKI, Y., MIYAZAKI, M., Kato, M., Kotoh, K., Enjoji, M., Nakamuta, M., & Takayanagi, R. (2013) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2013.1573 · Cited by 16

Differential effects of NOX2 and NOX4 inhibition after rodent spinal cord injury

Khayrullina, G., Bermudez, S., Hopkins, D., Yauger, Y. J., & Byrnes, K. R. (2023) · PLoS ONE · doi:10.1371/journal.pone.0281045 · Cited by 15

Oxidative DNA Damage and NOX4 Levels in Children with Undescended Testes

Avcı, V., Ayengin, K., & Hakan, H. (2019) · European Journal of Pediatric Surgery · doi:10.1055/s-0039-1692167 · Cited by 15

Epigenetic plasticity and redox regulation of neural stem cell state and fate

Tay, E. X. Y., Chia, K., & Ong, D. S. T. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.02.030 · Cited by 15

PI 3Kγ contributes to MEK 1/2 activation in oxidative glutamate toxicity via PDK 1

Ha, J. S., Kwon, K., & Park, S. S. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12364 · Cited by 15

Oxidative Stress and Nuclear Factor κB (NF-κB) Increase Peritoneal Filtration and Contribute to Ascites Formation in Nephrotic Syndrome

Udwan, K., Brideau, G., Fila, M., Edwards, A., Vogt, B., & Doucet, A. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.724690 · Cited by 15

NADPH Oxidase Accounts for Changes in Cerebrovascular Redox Status in Hindlimb Unweighting Rats

Peng, L., Ran, H., Zhang, Y., Yu, Z. H. A. O., Fan, Y., Peng, L., Zhang, R., & Cao, F. (2015) · Biomedical and Environmental Sciences · doi:10.1016/s0895-3988(15)30110-0 · Cited by 15

Glutamine protects intestinal calcium absorption against oxidative stress and apoptosis

Moine, L., de Barboza, G. D., Pérez, A., Benedetto, M. M., & de Talamoni, N. T. (2017) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2017.07.006 · Cited by 15

Ferroptosis in schizophrenia: Mechanisms and therapeutic potentials (Review)

Lv, S., & Luo, C. (2024) · Molecular Medicine Reports · doi:10.3892/mmr.2024.13402 · Cited by 14

Redox-Dependent Calpain Signaling in Airway and Pulmonary Vascular Remodeling in COPD

Kovács, L., & Su, Y. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-63245-2_9 · Cited by 14

Binding of p67phox to Nox2 is stabilized by disulfide bonds between cysteines in the 369Cys-Gly-Cys371 triad in Nox2 and in p67phox

Fradin, T., Bechor, E., Berdichevsky, Y., Dahan, I. M., & Pick, E. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.4a0418-173r · Cited by 14

Estradiol and NADPH oxidase crosstalk regulates responses to high fat feeding in female mice

Ronis, M. J. J., Blackburn, M. L., Shankar, K., Ferguson, M. E., Cleves, M. A., & Badger, T. M. (2019) · Experimental Biology and Medicine · doi:10.1177/1535370219853563 · Cited by 14

Naringin prevents diabetic nephropathy in rats through blockage of oxidative stress and attenuation of the mitochondrial dysfunction

Pérez, A., Mukdsi, J. H., Valdez, L. B., Rukavina-mikusic, I. A., de Barboza, G. D., de Talamoni, N. T., & Rivoira, M. A. (2023) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2022-0449 · Cited by 13

Neuroprotective Effects and Therapeutic Potential of Dichloroacetate: Targeting Metabolic Disorders in Nervous System Diseases

Zhang, Y., Sun, M., Zhao, H., Wang, Z., Shi, Y., Dong, J., Wang, K., Wang, X., Li, X., Qi, H., et al. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s439728 · Cited by 13

Epoetin beta pegol prevents endothelial dysfunction as evaluated by flow-mediated dilation in chronic kidney disease rats

Serizawa, K., Yogo, K., Tashiro, Y., Aizawa, K., Kawasaki, R., Hirata, M., & Endo, K. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.09.034 · Cited by 13

Naringin prevents the inhibition of intestinal Ca 2+ absorption induced by a fructose rich diet

Rodríguez, V. A., Rivoira, M. A., Guizzardi, S., & de Talamoni, N. T. (2017) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2017.11.002 · Cited by 13

Efficacy of Obcordata A from Aspidopterys obcordata on Kidney Stones by Inhibiting NOX4 Expression

Li, Y., Ma, G., Lv, Y., Su, J., Li, G., & Chen, X. (2019) · Molecules · doi:10.3390/molecules24101957 · Cited by 13

Combined treatment of menadione and calcitriol increases the antiproliferative effect by promoting oxidative/nitrosative stress, mitochondrial dysfunction, and autophagy in breast cancer MCF-7 cells

Guizzardi, S., Picotto, G., Rodríguez, V. A., Welsh, J., Narvaez, C. J., Bohl, L. P., & de Talamoni, N. T. (2020) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2019-0585 · Cited by 13

Exercise Training‐Enhanced, Endothelium‐Dependent Dilation Mediated by Altered Regulation of BK Ca Channels in Collateral‐Dependent Porcine Coronary Arterioles

Xie, W., Parker, J. L., & Heaps, C. L. (2012) · Microcirculation · doi:10.1111/micc.12016 · Cited by 13

Importance of insulin resistance to vascular repair and regeneration

Cubbon, R. M., Mercer, B. N., Sengupta, A., & Kearney, M. T. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.02.028 · Cited by 12

Oxidative Stress and Cell Dysfunction in Diabetes: Role of ROS Produced by Mitochondria and NAD(P)H Oxidase

Kim, S. S., & Son, S. M. (2008) · Korean Diabetes Journal · doi:10.4093/kdj.2008.32.5.389 · Cited by 12

Characterization of a murine model of endothelial dysfunction induced by chronic intraperitoneal administration of angiotensin II

Trejo-Moreno, C., Jiménez‐Ferrer, E., Castro-Martínez, G., Méndez-Martínez, M., Santana, M. A., Arrellín, G., Pedraza‐Chaverrí, J., Medina‐Campos, O. N., Hernández‐Téllez, B., Ramírez-Pliego, O., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-00676-x · Cited by 12

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Pang, J., Zhu, D., Liu, Y., Liu, D., Zhao, C., Zhang, J., Li, S., Liu, Z., Li, X., Huang, P., et al. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202203011 · Cited by 12

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Nguyen, M. V. C., Zhang, L., Lhomme, S., Mouz, N., Lenormand, J., Lardy, B., & Morel, F. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.01.136 · Cited by 12

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Serizawa, K., Yogo, K., Tashiro, Y., Takeda, S., Kawasaki, R., Aizawa, K., & Endo, K. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0332 · Cited by 12

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Buchmann, G., Schürmann, C., Spaeth, M., Abplanalp, W. T., Tombor, L. S., John, D., Warwick, T., Rezende, F., Weigert, A., Shah, A. M., et al. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102050 · Cited by 12

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Aminzadehanboohi, M., Makridakis, M., Rasti, D., Cambet, Y., Krause, K., Vlahou, A., & Jaquet, V. (2025) · Antioxidants · doi:10.3390/antiox14040486 · Cited by 11

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Areco, V. A., Rodríguez, V. A., Marchionatti, A. M. E., Carpentieri, A. R., & de Talamoni, N. T. (2016) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2016.03.005 · Cited by 11

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Yan, X., Xun, M., Wu, L., Du, X., Zhang, F., & Zheng, J. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.04.030 · Cited by 11

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Morel, F., Rousset, F., Nguyen, M. V. C., Trocmé, C., Grange, L., & Lardy, B. (2015) · Bulletin de l Académie Nationale de Médecine · doi:10.1016/s0001-4079(19)30941-0 · Cited by 11

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Kang, D. H., Kim, Y., Min, S., Lee, S. Y., Chung, K. Y., Baek, I., Kwon, K., Jo, H., & Kang, S. W. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113361 · Cited by 10

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Kano, R., Shirakawa, H., Poole, D. C., Hoshino, D., & Kano, Y. (2025) · Redox Biochemistry and Chemistry · doi:10.1016/j.rbc.2025.100056 · Cited by 10

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He, X., Shi, Y., Zeng, Z., Tang, B., Xiao, X., Yu, J., Zou, P., Liu, J., Xiao, Y., Luo, Y., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.929289 · Cited by 10

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Granato, D. C., Costa, R. A. P. E., Kawahara, R., Yokoo, S., Aragão, A. Z. B., Domingues, R. R., Pauletti, B. A., Honorato, R. V., Fattori, J., Figueira, A. C. M., et al. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7297 · Cited by 10

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Nisimoto, Y., Ogawa, H., Kadokawa, Y., & Qiao, S. (2018) · The Journal of Biochemistry · doi:10.1093/jb/mvy014 · Cited by 10

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Chen, Y., Ding, S., Zhang, H., Sun, Z., Shen, X., Sun, L., Yin, Y., Qun, S., & Li, W. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103713 · Cited by 10

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Yamanaka, K., Nakamura, K., Shibahara, T., Takashima, M., Takaki, H., Hidaka, M., Komori, M., Yoshikawa, Y., Wakisaka, Y., Ago, T., et al. (2022) · Glia · doi:10.1002/glia.24292 · Cited by 10

Redox processes inform multivariate transdifferentiation trajectories associated with TGFβ-induced epithelial–mesenchymal transition

Prasanphanich, A. F., Arencibia, C. A., & Kemp, M. L. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.07.032 · Cited by 9

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Pereira, B. P., do Valle, G. T., Salles, B. C. C., Costa, K. C. M., Ângelo, M. L., Torres, L. H., Novaes, R. D., Ruginsk, S. G., Tirapelli, C. R., Paula, F. B. D. A., et al. (2020) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-020-01906-1 · Cited by 9

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Rivoira, M. A., Rigalli, A., Corball, L., de Talamoni, N. T., & Rodríguez, V. A. (2021) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2021-0473 · Cited by 9

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Mainali, N., Ayyadevara, S., Ganne, A., Reis, R. J. S., & Mehta, J. L. (2023) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2023.4 · Cited by 10

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Drummond, S. E., Burns, D. P., Maghrani, S. E., Ziegler, O., Healy, V., & O’Halloran, K. D. (2023) · Cells · doi:10.3390/cells12141834 · Cited by 10

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Joachim, J., Maselli, D., Petsolari, E., Aman, J., Swiatlowska, P., Killock, D., Chaudhry, H., Zarban, A. A., Sarker, M. H., Fraser, P. A., et al. (2024) · Science Advances · doi:10.1126/sciadv.adk6583 · Cited by 9

Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases

Martyn, K. D., Frederick, L. M., von Loehneysen, K., Dinauer, M. C., & Knaus, U. G. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2005.03.023 · Cited by 783

Identification of novel Nox4 splice variants with impact on ROS levels in A549 cells

Goyal, P., Weißmann, N., Rose, F., Grimminger, F., Schäfers, H., Seeger, W., & Hänze, J. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.01.089 · Cited by 107

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von Löhneysen, K., Noack, D., Wood, M. R., Friedman, J. S., & Knaus, U. G. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01393-09 · Cited by 127

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Helmcke, I., Heumüller, S., Tikkanen, R., Schröder, K., & Brandes, R. P. (2009) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2383 · Cited by 145

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Schmidt, H. H. H. W., Wingler, K., Kleinschnitz, C., & Dusting, G. J. (2012) · Circulation Research · doi:10.1161/circresaha.112.271957 · Cited by 21