Relative sensitivity of soluble guanylate cyclase and mitochondrial respiration to endogenous nitric oxide at physiological oxygen concentration
Open accessAbstract
Nitric oxide (NO) is a widespread biological messenger that has many physiological and pathophysiological roles. Most of the physiological actions of NO are mediated through the activation of sGC (soluble guanylate cyclase) and the subsequent production of cGMP. NO also binds to the binuclear centre of COX (cytochrome c oxidase) and inhibits mitochondrial respiration in competition with oxygen and in a reversible manner. Although sGC is more sensitive to endogenous NO than COX at atmospheric oxygen tension, the more relevant question is which enzyme is more sensitive at physiological oxygen concentration. Using a system in which NO is generated inside the cells in a finely controlled manner, we determined cGMP accumulation by immunoassay and mitochondrial oxygen consumption by high-resolution respirometry at 30 μM oxygen. In the present paper, we report that the NO EC50 of sGC was approx. 2.9 nM, whereas that required to achieve IC50 of respiration was 141 nM (the basal oxygen consumption in the absence of NO was 14±0.8 pmol of O2/s per 106 cells). In accordance with this, the NO–cGMP signalling transduction pathway was activated at lower NO concentrations than the AMPKs (AMP-activated protein kinase) pathway. We conclude that sGC is approx. 50-fold more sensitive than cellular respiration to endogenous NO under our experimental conditions. The implications of these results for cell physiology are discussed.
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In the bullseye model, CcOx is the next most sensitive target after sGC.
“In the next ring is the mitochondrial enzyme CcOx (43).”
From What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology (2010) · cites this paper as [43]
CcOx is considerably less sensitive to NO-mediated inhibition than sGC is to NO-dependent activation.
“Notably, CcOx is considerably less sensitive to NO-mediated inhibition than sGC is to NO-dependent activation (14, 43).”
From What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology (2010) · cites this paper as [43]
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Cites
Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589 · see citing works
Molecular cloning: A laboratory manual
Deininger, P. L. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90595-z · Cited by 84,684 · see citing works
Nitric oxide: physiology, pathophysiology, and pharmacology.
Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525 · see citing works
Hawley, S. A., Davison, M., Woods, A., Davies, S. P., Beri, R. K., Carling, D., & Hardie, D. G. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.44.27879 · Cited by 1,264 · see citing works
Cleeter, M. W. J., Cooper, J. M., Darley-Usmar, V. M., Moncada, S., & Schapira, A. H. V. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00424-2 · Cited by 1,241 · see citing works
Brown, G. C., & Cooper, C. E. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)01290-3 · Cited by 1,055 · see citing works
Cyclic GMP synthesis and function.
Waldman, S. A., & Murad, F. (1987) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06656-6 · Cited by 859 · see citing works
Mitochondrial threshold effects
Rossignol, R., Faustin, B., Rocher, C., Malgat, M., Mazat, J., & Letellier, T. (2003) · Biochemical Journal · doi:10.1042/bj20021594 · Cited by 802 · see citing works
Does nitric oxide modulate mitochondrial energy generation and apoptosis?
Moncada, S., & Erusalimsky, J. D. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm762 · Cited by 789 · see citing works
Control of respiration and ATP synthesis in mammalian mitochondria and cells
Brown, G. C. (1992) · Biochemical Journal · doi:10.1042/bj2840001 · Cited by 598 · see citing works
NO-independent regulatory site on soluble guanylate cyclase
Stasch, J., Becker, E. M., Alonso‐Alija, C., Apeler, H., Dembowsky, K., Feurer, A., Gerzer, R., Minuth, T., Perzborn, E., Pleiß, U., et al. (2001) · Nature · doi:10.1038/35065611 · Cited by 546 · see citing works
Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase
Brown, G. C. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00763-y · Cited by 540 · see citing works
Signal transduction mechanisms involving nitric oxide
Ignarro, L. J. (1991) · Biochemical Pharmacology · doi:10.1016/0006-2952(91)90618-f · Cited by 524 · see citing works
AMP-activated protein kinase, super metabolic regulator
Kemp, B. E., Stapleton, D., Campbell, D. J., Chen, Z.-P., Murthy, S., Walter, M., Gupta, A., Adams, J. J., Katsis, F., van Denderen, B., et al. (2003) · Biochemical Society Transactions · doi:10.1042/bst0310162 · Cited by 474 · see citing works
Inducible Nitric-oxide Synthase Generates Superoxide from the Reductase Domain
Xia, Y., Roman, L. J., Masters, B. S. S., & Zweier, J. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.35.22635 · Cited by 388 · see citing works
Hypoxia inhibits expression of eNOS via transcriptional and posttranscriptional mechanisms
McQuillan, L. P., Leung, G., Marsden, P. A., Kostyk, S. K., & Kourembanas, S. (1994) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1994.267.5.h1921 · Cited by 382 · see citing works
Lee, J.-H., Ryu, H., Ferrante, R. J., Morris, S. M., & Ratan, R. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0735876100 · Cited by 358 · see citing works
Gladwin, M. T., Raat, N. J. H., Shiva, S., Dezfulian, C., Hogg, N., Kim-Shapiro, D. B., & Patel, R. P. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00407.2006 · Cited by 329 · see citing works
Mitochondrial Oxygen Affinity, Respiratory Flux Control And Excess Capacity Of Cytochrome c Oxidase
Gnaiger, E., Lassnig, B., Kuznetsov, A. V., Rieger, G. E., & Margreiter, R. (1998) · Journal of Experimental Biology · doi:10.1242/jeb.201.8.1129 · Cited by 318 · see citing works
Spectral and Kinetic Studies on the Activation of Soluble Guanylate Cyclase by Nitric Oxide
Stone, J. R., & Marletta, M. A. (1996) · Biochemistry · doi:10.1021/bi9519718 · Cited by 307 · see citing works
On the mechanism by which vascular endothelial cells regulate their oxygen consumption
Clementi, E., Brown, G. C., Foxwell, N., & Moncada, S. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1559 · Cited by 296 · see citing works
Gnaiger, E. (2001) · Respiration Physiology · doi:10.1016/s0034-5687(01)00307-3 · Cited by 280 · see citing works
Mateo, J., García‐Lecea, M., Cadenas, S., HERNÁNDEZ, C., & Moncada, S. (2003) · Biochemical Journal · doi:10.1042/bj20031155 · Cited by 256 · see citing works
Self-citationCras, T. D. L., Xue, C., Rengasamy, A., & Johns, R. A. (1996) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1996.270.1.l164 · Cited by 254 · see citing works
Borutaitė, V., & Brown, G. C. (1996) · Biochemical Journal · doi:10.1042/bj3150295 · Cited by 243 · see citing works
CONTROL OF ELECTRON FLUX THROUGH THE RESPIRATORY CHAIN IN MITOCHONDRIA AND CELLS
Brand, M. D., & Murphy, M. P. (1987) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.1987.tb01265.x · Cited by 240 · see citing works
Inhibition of Soluble Guanylate Cyclase by ODQ
Zhao, Y., Brandish, P. E., Valentin, M. D., Schelvis, J. P. M., Babcock, Ǵ., & Marletta, M. A. (2000) · Biochemistry · doi:10.1021/bi9929296 · Cited by 234 · see citing works
NO activation of guanylyl cyclase
Russwurm, M., & Koesling, D. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600422 · Cited by 222 · see citing works
Functional properties of a naturally occurring isoform of soluble guanylyl cyclase
Russwurm, M., Behrends, S., Harteneck, C., & Koesling, D. (1998) · Biochemical Journal · doi:10.1042/bj3350125 · Cited by 210 · see citing works
Nitric oxide produced by activated astrocytes rapidly and reversibly inhibits cellular respiration
Brown, G. C., Bolaños, J. P., Heales, S., & Clark, J. B. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11703-y · Cited by 205 · see citing works
Regulation of bovine endothelial constitutive nitric oxide synthase by oxygen.
Liao, J. K., Zulueta, J. J., Yu, F. S., Peng, H., Côté, C., & Hassoun, P. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118332 · Cited by 204 · see citing works
Borutaitė, V., Jekabsone, A., & Brown, G. C. (2000) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(00)00178-x · Cited by 197 · see citing works
Palacios‐Callender, M., Quintero, M., Hollis, V., Springett, R., & Moncada, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401723101 · Cited by 181 · see citing works
Bellamy, T. C., Wood, J. G., Goodwin, D. A., & Garthwaite, J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.6.2928 · Cited by 158 · see citing works
Mitochondrial nitric oxide synthase
Brookes, P. S. (2003) · Mitochondrion · doi:10.1016/j.mito.2003.10.001 · Cited by 154 · see citing works
Regulation of Mitochondrial Respiration by Oxygen and Nitric Oxide
BOVERIS, A., Costa, L. E., Poderoso, J. J., Carreras, M. C., & Cadenas, E. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06181.x · Cited by 148 · see citing works
Distribution of NOS in normoxic vs. hypoxic rat lung: upregulation of NOS by chronic hypoxia
Xue, C., Rengasamy, A., Cras, T. D. L., Koberna, P. A., Dailey, G. C., & Johns, R. A. (1994) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1994.267.6.l667 · Cited by 145 · see citing works
Mitochondrial respiration at low levels of oxygen and cytochrome c
Gnaiger, E., & Kuznetsov, A. V. (2002) · Biochemical Society Transactions · doi:10.1042/bst0300252 · Cited by 138 · see citing works
Moncada, S. (1997) · Biochemical Society Transactions · doi:10.1042/bst025383sc · Cited by 137 · see citing works
Xue, C., & Johns, R. A. (1996) · Hypertension · doi:10.1161/01.hyp.28.5.743 · Cited by 128 · see citing works
Kinetics of the inhibition of mitochondrial respiration by NO
Koivisto, A., Matthias, A., Bronnikov, G. E., & Nedergaard, J. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01258-1 · Cited by 126 · see citing works
Müllershausen, F., Russwurm, M., Thompson, W. J., Liu, L., Koesling, D., & Friebe, A. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200107001 · Cited by 125 · see citing works
Bellamy, T. C., Griffiths, C., & Garthwaite, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205936200 · Cited by 124 · see citing works
Control of Mitochondrial Respiration by NO., Effects of Low Oxygen and Respiratory State
Brookes, P. S., Kraus, D. W., Shiva, S., Doeller, J. E., Barone, M.-C., Patel, R. P., Lancaster, J. R., & Darley-Usmar, V. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211784200 · Cited by 118 · see citing works
Santolini, J., Meade, A. L., & Stuehr, D. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m108666200 · Cited by 116 · see citing works
Bellamy, T. C., & Garthwaite, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006677200 · Cited by 111 · see citing works
Nitric oxide and the respiratory enzyme
Brunori, M., Forte, E., Arese, M., Mastronicola, D., Giuffrè, A., & Sarti, P. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.05.011 · Cited by 74 · see citing works
Deguchi, A., Soh, J., Li, H., Pamukcu, R., Thompson, W. J., & Weinstein, I. B. (2002) · PubMed · Cited by 74 · see citing works
Cooper, C. E., Davies, N. A., Psychoulis, M., Canevari, L., Bates, T. E., Dobbie, M. S., Casley, C. S., & Sharpe, M. A. (2003) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2003.08.003 · Cited by 70 · see citing works
The shaping of nitric oxide signals by a cellular sink
Griffiths, C., & Garthwaite, J. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.00855.x · Cited by 70 · see citing works
cGMP-dependent protein kinases in drug discovery
Schlossmann, J., & Hofmann, F. B. (2005) · Drug Discovery Today · doi:10.1016/s1359-6446(05)03406-9 · Cited by 69 · see citing works
Artz, J. D., Toader, V., Zavorin, S. I., Bennett, B. M., & Thatcher, G. R. J. (2001) · Biochemistry · doi:10.1021/bi002885x · Cited by 66 · see citing works
Chronic hypoxia impairs soluble guanylyl cyclase-mediated pulmonary arterial relaxation in the rat
Crawley, D. E., Zhao, L., Giembycz, M. A., Liu, S., Barnes, P. J., Winter, R. J. D., & Evans, T. W. (1992) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1992.263.3.l325 · Cited by 65 · see citing works
Soluble guanylate cyclase gene expression and localization in rat lung after exposure to hypoxia
Li, D., Zhou, N., & Johns, R. A. (1999) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1999.277.4.l841 · Cited by 63 · see citing works
Hypoxia inhibits expression of eNOS via transcriptional and posttranscriptional mechanisms
McQuillan, L. P., Leung, G. K. C., Marsden, P. A., Kostyk, S. K., & Kourembanas, S. (1995) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1995.268.2.1-a · Cited by 62 · see citing works
Guanylyl cyclase: NO hits its target
Russwurm, M., & Koesling, D. (2004) · Biochemical Society Symposia · doi:10.1042/bss0710051 · Cited by 45 · see citing works
Kinetics of nitric oxide‐cyclic GMP signalling in CNS cells and itspossible regulation by cyclic GMP
Wykes, V., Bellamy, T. C., & Garthwaite, J. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01106.x · Cited by 43 · see citing works
Weaver, J. M. R., Porasuphatana, S., Tsai, P., Pou, S., Roman, L. J., & Rosen, G. M. (2005) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2005.08.012 · Cited by 37 · see citing works
Hassoun, P. M., Filippov, G., Fogel, M. A., Donaldson, C., Kayyali, U. S., Shimoda, L. A., & Bloch, K. D. (2004) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2003-0287oc · Cited by 29 · see citing works
André, M., Latado, H., & Felley‐Bosco, E. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.11.007 · Cited by 15 · see citing works
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Schon, E. A., DiMauro, S., & Hirano, M. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3275 · Cited by 757 · see citing works
Complex I Is the Major Site of Mitochondrial Superoxide Production by Paraquat
Cochemé, H. M., & Murphy, M. P. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m708597200 · Cited by 563 · see citing works
Tello, D., Balsa, E., Acosta‐Iborra, B., Fuertes-Yebra, E., Elorza, A., Ordóñez, Á., Corral-Escariz, M., Soro-Arnáiz, I., López-Bernardo, E., Perales‐Clemente, E., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.10.008 · Cited by 369 · see citing works
Self-citationNitric oxide signaling: Classical, less classical, and nonclassical mechanisms
Martı́nez-Ruiz, A., Cadenas, S., & Lamas, S. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.010 · Cited by 336 · see citing works
Self-citationDranka, B. P., Hill, B. G., & Darley-Usmar, V. M. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.01.015 · Cited by 329 · see citing works
Chen, K., Pittman, R. N., & Popel, A. S. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1959 · Cited by 325 · see citing works
What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology
Hill, B. G., Dranka, B. P., Bailey, S. M., Lancaster, J. R., & Darley-Usmar, V. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.r110.101618 · Cited by 310 · see citing works
From synaptically localized to volume transmission by nitric oxide
Garthwaite, J. (2015) · The Journal of Physiology · doi:10.1113/jp270297 · Cited by 119 · see citing works
Halligan, K. E., Jourd’heuil, F. L., & Jourd’heuil, D. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808231200 · Cited by 115 · see citing works
Mitochondrial reprogramming through cardiac oxygen sensors in ischaemic heart disease
Cadenas, S., Aragonés, J., & Landázuri, M. O. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq256 · Cited by 101 · see citing works
Self-citationNanomolar nitric oxide concentrations quickly and reversibly modulate astrocytic energy metabolism
Martín, A. S., Arce‐Molina, R., Galaz, A., Pérez-Guerra, G., & Barros, L. F. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.777243 · Cited by 60 · see citing works
Regulation of carbohydrate metabolism by nitric oxide and hydrogen sulfide: Implications in diabetes
Gheibi, S., Samsonov, A. P., Gheibi, S., Vazquez, A. B., & Kashfi, K. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.113819 · Cited by 63 · see citing works
Recent advances on endogenous gasotransmitters in inflammatory dermatological disorders
Wang, L., Xie, X., Ke, B., Huang, W., Jiang, X. L., & He, G. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2021.08.012 · Cited by 62 · see citing works
Targeting the NO/superoxide ratio in adipose tissue: relevance to obesity and diabetes management
Janković, A., Korać, A., Buzadžić, B., Stančić, A., Otašević, V., Ferdinándy, P., Daiber, A., & Korać, B. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13498 · Cited by 60 · see citing works
Assessing the physiological concentration and targets of nitric oxide in brain tissue
Hall, C. N., & Attwell, D. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.154724 · Cited by 52 · see citing works
Matsuda, S., Harada, K., Ito, M., Takizawa, M., Wongso, D., Tsuboi, T., & Kitaguchi, T. (2016) · ACS Sensors · doi:10.1021/acssensors.6b00582 · Cited by 52 · see citing works
Rukoyatkina, N., Walter, U., Friebe, A., & Gambaryan, S. P. (2011) · Thrombosis and Haemostasis · doi:10.1160/th11-05-0319 · Cited by 48 · see citing works
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Aguirre, E., Rodríguez-Juárez, F., Bellelli, A., Gnaiger, E., & Cadenas, S. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.01.033 · Cited by 47 · see citing works
Self-citationDynamic and interacting profiles of ⋅NO and O2 in rat hippocampal slices
Ledo, A., Barbosa, R. M., Cadenas, E., & Laranjinha, J. A. N. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.01.024 · Cited by 27 · see citing works
Dynnik, V. V., Grishina, E. V., & Fedotcheva, N. I. (2019) · FEBS Journal · doi:10.1111/febs.15090 · Cited by 23 · see citing works
Mannino, M. H., Patel, R. S., Eccardt, A. M., Perez-Magnelli, R., Robinson, C. L. C., Janowiak, B. E., Warren, D. E., & Fisher, J. S. (2019) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2019.04.005 · Cited by 22 · see citing works
Aguirre, E., López-Bernardo, E., & Cadenas, S. (2011) · Mitochondrion · doi:10.1016/j.mito.2011.05.010 · Cited by 19 · see citing works
Self-citationThe role of nitric oxide in diabetic skin (patho)physiology
Stančić, A., Janković, A., Korać, A., Buzadžić, B., Otašević, V., & Korać, B. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.08.018 · Cited by 10 · see citing works
N‐nitrosomelatonin enhances photic synchronization of mammalian circadian rhythms
Baidanoff, F. M., Plano, S. A., Doctorovich, F. A., Suárez, S., Golombek, D. A., & Chiesa, J. J. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12613 · Cited by 9 · see citing works
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Agurto, A., Vielma, A. H., Cádiz, B., Couve, E., & Schmachtenberg, O. (2017) · Experimental Eye Research · doi:10.1016/j.exer.2017.05.013 · Cited by 8 · see citing works
Landar, A. L., & Darley-Usmar, V. M. (2007) · Biochemical Journal · doi:10.1042/bj20070590 · Cited by 7 · see citing works
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Rőszer, T. (2012) · Springer eBooks · doi:10.1007/978-94-007-2819-6_10 · Cited by 4 · see citing works
Maione, D., Cicero, A. F. G., Bacchelli, S., Cosentino, E. R., Esposti, D. D., Manners, D. N., Rinaldi, E., Rosticci, M., Senaldi, R., Ambrosioni, E., et al. (2015) · Physiological Research · doi:10.33549/physiolres.932833 · Cited by 1 · see citing works
Dynnik, V. V., Grishina, E. V., & Fedotcheva, N. I. (2019) · Biochemistry (Moscow) Supplement Series A Membrane and Cell Biology · doi:10.1134/s1990747819040056 · Cited by 1 · see citing works
Dynnik, V. V., Grishina, E. V., & Fedotcheva, N. I. (2021) · Biochemistry (Moscow) Supplement Series A Membrane and Cell Biology · doi:10.1134/s1990747820050050
- Authors
- Rodríguez-Juárez, F., Aguirre, E., & Cadenas, S.
- Affiliations
- Spanish National Centre for Cardiovascular Research (ES)
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 2007-06-27
- Volume
- 405
- Issue
- 2
- Pages
- 223-231
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- PMC
- PMC1904527
- OpenAlex
- W2033968800
- Cited by
- 31
- References
- 60
- Citations by year
- 2021: 2 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 2 · 2013: 1 · 2012: 2
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biochemical Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion, other-oa)
- Funders
- Centro Nacional de Investigaciones Cardiovasculares
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hemoglobin structure and function
- Keywords
- nitric oxide, soluble guanylate cyclase, cytochrome c oxidase, mitochondrial respiration, cGMP signaling, AMPK, oxygen consumption
- MeSH terms
- Vasodilator-Stimulated Phosphoprotein, Cells, Cultured, Electron Transport Complex IV, Guanylate Cyclase, Humans, Hydrazines, Microfilament Proteins, Mitochondria, Multienzyme Complexes, Nitric Oxide, Oxygen, Oxygen Consumption, Phosphoproteins, Phosphorylation, Signal Transduction, Cell Adhesion Molecules, Protein Serine-Threonine Kinases, Nitric Oxide Synthase Type II, AMP-Activated Protein Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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