Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase
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Nitric oxide (NO) reversibly inhibited oxygen consumption of brain synaptosomes. Inhibition was reversible, occurred at the level of cytochrome oxidase, and was apparently competitive with oxygen, with half‐inhibition by 270 nM NO at oxygen concentrations around 145 μM and by 60 nM NO at around 30μM O 2 . Isolated cytochrome oxidase was inhibited by similar levels of NO. These levels of NO are within the measured physiological and pathological range for a number of tissues and conditions, suggesting that NO inhibition of cytochrome oxidase and the competion with oxygen may occur in vivo.
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The lack of difference in muscle pH indicates that there was no compensatory increased contribution of anaerobic glycolysis to energy turnover following nitrate supplementation.
“indicating that there was no ‘compensatory’ increased contribution of anaerobic glycolysis to energy turnover as may be the case if, for example, nitrate supplementation had resulted in an inhibition of respiration [62, 63].”
From Dietary Nitrate Supplementation and Exercise Performance (2014) · cites this paper as [62]
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Cites
Nitric oxide as a secretory product of mammalian cells
Nathan, C. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.12.1381691 · Cited by 4,350 · see citing works
NITRIC OXIDE: A Physiologic Messenger Molecule
Bredt, D. S., & Snyder, S. H. (1994) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.63.070194.001135 · Cited by 2,315 · see citing works
Stuehr, D. J., & Nathan, C. F. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.169.5.1543 · Cited by 1,744 · see citing works
Cleeter, M. W. J., Cooper, J. M., Darley-Usmar, V. M., Moncada, S., & Schapira, A. H. V. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00424-2 · Cited by 1,241 · see citing works
Nitric oxide release from a single cell measured in situ by a porphyrinic-based microsensor
Maliñski, T., & Taha, Z. (1992) · Nature · doi:10.1038/358676a0 · Cited by 1,071 · see citing works
Measurement of nitric oxide in biological models
Archer, S. L. (1993) · The FASEB Journal · doi:10.1096/fasebj.7.2.8440411 · Cited by 933 · see citing works
Endogenous nitric oxide release required for long-term synaptic depression in the cerebellum
Shibuki, K., & Okada, D. (1991) · Nature · doi:10.1038/349326a0 · Cited by 871 · see citing works
Nitric Oxide Synthase Inhibition and Cerebrovascular Regulation
Iadecola, C., Pelligrino, D. A., Moskowitz, M. A., & Lassen, N. A. (1994) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1994.25 · Cited by 649 · see citing works
Malinski, T., Bailey, F., Zhang, Z. G., & Chopp, M. (1993) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1993.48 · Cited by 625 · see citing works
Control of respiration and ATP synthesis in mammalian mitochondria and cells
Brown, G. C. (1992) · Biochemical Journal · doi:10.1042/bj2840001 · Cited by 598 · see citing works
Self-citationNitric oxide: A radical neurotransmitter in the central nervous system
Vincent, S. R. (1994) · Progress in Neurobiology · doi:10.1016/0301-0082(94)90023-x · Cited by 464 · see citing works
Diffusion of Nitric Oxide in the Aorta Wall Monitored in Situ by Porphyrinic Microsensors
Malinski, T., Taha, Z., Grunfeld, S., Patton, S. R., Kapturczak, M., & Tomboulian, P. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1735 · Cited by 417 · see citing works
An electrochemical microprobe for detecting nitric oxide release in brain tissue
Shibuki, K. (1990) · Neuroscience Research · doi:10.1016/0168-0102(90)90048-j · Cited by 413 · see citing works
Nitric Oxide‐Mediated Inhibition of the Mitochondrial Respiratory Chain in Cultured Astrocytes
Bolaños, J. P., Peuchen, S., Heales, S., Land, J. M., & Clark, J. B. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63030910.x · Cited by 413 · see citing works
Effect of exogenous and endogenous nitric oxide on mitochondrial respiration of rat hepatocytes
Stadler, J., Billiar, T. R., CURRAN, R. D., Stuehr, D. J., Ochoa, J. B., & Simmons, R. L. (1991) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1991.260.5.c910 · Cited by 396 · see citing works
A rapid method for preparing synaptosomes: Comparison, with alternative procedures
Dodd, P. R., Hardy, J., Oakley, A. E., Edwardson, J. A., Perry, E. K., & Delaunoy, J. (1981) · Brain Research · doi:10.1016/0006-8993(81)91086-6 · Cited by 392 · see citing works
Kuboyama, M., Yong, F. C., & King, T. E. (1972) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)44703-0 · Cited by 308 · see citing works
Intracellular diffusion gradients of O2 and ATP
Jones, D. P. (1986) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1986.250.5.c663 · Cited by 273 · see citing works
Reactions of nitric oxide with cytochrome c oxidase
Brudvig, G. W., Stevens, T. H., & Chan, S. I. (1980) · Biochemistry · doi:10.1021/bi00564a020 · Cited by 237 · see citing works
Direct Electrochemical Measurement of Nitric Oxide Released from Human Platelets
Maliñski, T., Radomski, M. W., Taha, Z., et al. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1914 · Cited by 197 · see citing works
Continuous Monitoring of Nitric Oxide Release from Human Umbilical Vein Endothelial Cells
Tsukahara, H., Gordienko, D. V., & Goligorsky, M. S. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1685 · Cited by 188 · see citing works
Photodegradation of Sodium Nitroprusside
Arnold, W. P., Longnecker, D. E., & Epstein, R. (1984) · Anesthesiology · doi:10.1097/00000542-198409000-00004 · Cited by 133 · see citing works
Inhibition of hepatic gluconeogenesis by nitric oxide: a comparison with endotoxic shock
Horton, R. A., CEPPI, E. D., Knowles, R. G., et al. (1994) · Biochemical Journal · doi:10.1042/bj2990735 · Cited by 87 · see citing works
Inhibitors of cytochrome c oxidase
Erecińska, M., & Wilson, D. F. (1980) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(80)90057-1 · Cited by 57 · see citing works
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Cited by
Sorted by citations
How mitochondria produce reactive oxygen species
Murphy, M. P. (2009) · Biochemical Journal · doi:10.1042/bj20081386 · Cited by 8,207 · see citing works
Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release
Zorov, D. B., Juhaszova, M., & Sollott, S. J. (2014) · Physiological Reviews · doi:10.1152/physrev.00026.2013 · Cited by 5,383 · see citing works
The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics
Lundberg, J. O., Weitzberg, E., & Gladwin, M. T. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2466 · Cited by 2,739 · see citing works
Mitochondria and reactive oxygen species
Kowaltowski, A. J., de Souza-Pinto, N. C., Castilho, R. F., & Vercesi, A. E. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.05.004 · Cited by 1,162 · see citing works
Clementi, E., Brown, G. C., Feelisch, M., & Moncada, S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7631 · Cited by 863 · see citing works
Self-citationCalorie Restriction Increases Muscle Mitochondrial Biogenesis in Healthy Humans
Civitarese, A. E., Carling, S., Heilbronn, L. K., Hulver, M. H., Ukropcova, B., Deutsch, W. A., Smith, S. R., & Ravussin, E. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040076 · Cited by 790 · see citing works
Thomas, D. D., Liu, X., Kantrow, S. P., & Lancaster, J. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.1.355 · Cited by 760 · see citing works
Bailey, S. J., Winyard, P., Vanhatalo, A., Blackwell, J. R., DiMenna, F. J., Wilkerson, D. P., Tarr, J., Benjamin, N., & Jones, A. M. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00722.2009 · Cited by 759 · see citing works
Nitric oxide and mitochondrial respiration
Brown, G. C. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00025-0 · Cited by 702 · see citing works
Self-citationDietary Inorganic Nitrate Improves Mitochondrial Efficiency in Humans
Larsen, F. J., Schiffer, T. A., Borniquel, S., Sahlin, K., Ekblom, B., Lundberg, J. O., & Weitzberg, E. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.004 · Cited by 689 · see citing works
Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver
Duranski, M. R., Greer, J. J. M., Dejam, A., Jaganmohan, S., Hogg, N., Langston, W., Patel, R. P., Yet, S.-F., Wang, X., Kevil, C. G., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22493 · Cited by 674 · see citing works
The mitochondrial energy transduction system and the aging process
Navarro, A., & Boveris, A. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00213.2006 · Cited by 646 · see citing works
Effects of dietary nitrate on oxygen cost during exercise
Larsen, F. J., Weitzberg, E., Lundberg, J. O., & Ekblom, B. (2007) · Acta Physiologica · doi:10.1111/j.1748-1716.2007.01713.x · Cited by 637 · see citing works
Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome c oxidase
Brown, G. C. (2001) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(00)00238-3 · Cited by 602 · see citing works
Self-citationStrategies to increase nitric oxide signalling in cardiovascular disease
Lundberg, J. O., Gladwin, M. T., & Weitzberg, E. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4623 · Cited by 576 · see citing works
Shiva, S., Sack, M. N., Greer, J. J., Duranski, M., Ringwood, L. A., Burwell, L., Wang, X., MacArthur, P. H., Shoja, A., Raghavachari, N., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070198 · Cited by 555 · see citing works
Nitric oxide and iron proteins
Cooper, C. E. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00021-3 · Cited by 510 · see citing works
Self-citationMitochondrial biogenesis by NO yields functionally active mitochondria in mammals
Nisoli, E., Falcone, S., Tonello, C., Cozzi, V., Palomba, L., Fiorani, M., Pisconti, A., Brunelli, S., Cardile, A., Francolini, M., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405432101 · Cited by 495 · see citing works
Dietary Nitrate Supplementation and Exercise Performance
Jones, A. M. (2014) · Sports Medicine · doi:10.1007/s40279-014-0149-y · Cited by 442 · see citing works
Nitrite as Regulator of Hypoxic Signaling in Mammalian Physiology
van Faassen, E. E., Bahrami, S., Feelisch, M., Hogg, N., Kelm, M., Kim‐Shapiro, D. B., Kozlov, A. V., Li, H., Lundberg, J. O., Mason, R., et al. (2009) · Medicinal Research Reviews · doi:10.1002/med.20151 · Cited by 435 · see citing works
Hypoxia. 2. Hypoxia regulates cellular metabolism
Wheaton, W. W., & Chandel, N. S. (2011) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00485.2010 · Cited by 426 · see citing works
Mitochondrial defects in acute multiple sclerosis lesions
Mahad, D., Ziabreva, I., Lassmann, H., & Turnbull, D. (2008) · Brain · doi:10.1093/brain/awn105 · Cited by 406 · see citing works
Maia, L. B., & Moura, J. J. G. (2014) · Chemical Reviews · doi:10.1021/cr400518y · Cited by 401 · see citing works
Carlström, M., Larsen, F. J., Nyström, T., Hezel, M., Borniquel, S., Weitzberg, E., & Lundberg, J. O. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008872107 · Cited by 382 · see citing works
What is the real physiological NO concentration in vivo?
Hall, C. N., & Garthwaite, J. (2009) · Nitric Oxide · doi:10.1016/j.niox.2009.07.002 · Cited by 378 · see citing works
Nitric oxide inhibition of mitochondrial respiration and its role in cell death
Brown, G. C., & Borutaite, V. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01112-7 · Cited by 377 · see citing works
Self-citationCytochrome c Nitration by Peroxynitrite
Cassina, A. M., Hodara, R., Souza, J. M., Thomson, L., Castro, L., Ischiropoulos, H., Freeman, B. A., & Radi, R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m909978199 · Cited by 354 · see citing works
Inhibition of mitochondrial respiratory complex I by nitric oxide, peroxynitrite and S-nitrosothiols
Brown, G. C., & Borutaite, V. (2004) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2004.03.016 · Cited by 344 · see citing works
Self-citationNon-Heme Iron Nitrosyls in Biology
Butler, A. R., & Megson, I. L. (2002) · Chemical Reviews · doi:10.1021/cr000076d · Cited by 343 · see citing works
The chemistry of nitroxyl (HNO) and implications in biology
Miranda, K. M. (2005) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2004.08.010 · Cited by 339 · see citing works
Nitric Oxide and Mitochondrial Signaling: From Physiology to Pathophysiology
Erusalimsky, J. D., & Moncada, S. (2007) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.107.151167 · Cited by 336 · see citing works
Ferguson, S. K., Hirai, D. M., Copp, S. W., Holdsworth, C. T., Allen, J. D., Jones, A. M., Musch, T. I., & Poole, D. C. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.243121 · Cited by 333 · see citing works
Nitrate Supplementation’s Improvement of 10-km Time-Trial Performance in Trained Cyclists
Cermak, N. M., Gibala, M. J., & van Loon, L. J. C. (2012) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.22.1.64 · Cited by 326 · see citing works
Macrophage Polarization and Reprogramming in Acute Inflammation: A Redox Perspective
Pérez, S., & Rius-Pérez, S. (2022) · Antioxidants · doi:10.3390/antiox11071394 · Cited by 312 · see citing works
Recchia, F. A., McConnell, P. I., Bernstein, R. D., Vogel, T. R., Xu, X., & Hintze, T. H. (1998) · Circulation Research · doi:10.1161/01.res.83.10.969 · Cited by 302 · see citing works
Nitric Oxide in Vascular Biology
Walford, G., & Loscalzo, J. (2003) · Journal of Thrombosis and Haemostasis · doi:10.1046/j.1538-7836.2003.00345.x · Cited by 302 · see citing works
Mitochondria: regulators of signal transduction by reactive oxygen and nitrogen species
Brookes, P. S., Levonen, A.-L., Shiva, S., Sarti, P., & Darley-Usmar, V. M. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00901-2 · Cited by 298 · see citing works
On the mechanism by which vascular endothelial cells regulate their oxygen consumption
Clementi, E., Brown, G. C., Foxwell, N., & Moncada, S. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1559 · Cited by 296 · see citing works
Self-citationBioenergetics and redox adaptations of astrocytes to neuronal activity
Bolaños, J. P. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13486 · Cited by 262 · see citing works
Nitrite in nitric oxide biology: Cause or consequence?
Bryan, N. S. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.05.019 · Cited by 260 · see citing works
Doulias, P.-T., Tenopoulou, M., Greene, J. L., Raju, K., & Ischiropoulos, H. (2013) · Science Signaling · doi:10.1126/scisignal.2003252 · Cited by 250 · see citing works
Antioxidant and bioenergetic coupling between neurons and astrocytes
Fernandez-Fernandez, S., Almeida, A., & Bolaños, J. P. (2012) · Biochemical Journal · doi:10.1042/bj20111943 · Cited by 247 · see citing works
Kapil, V., Khambata, R. S., Jones, D. A., Rathod, K., Primus, C., Massimo, G., Fukuto, J. M., & Ahluwalia, A. (2020) · Pharmacological Reviews · doi:10.1124/pr.120.019240 · Cited by 248 · see citing works
Nitric Oxide in Macrophage Immunometabolism: Hiding in Plain Sight
Palmieri, E. M., McGinity, C., Wink, D. A., & McVicar, D. W. (2020) · Metabolites · doi:10.3390/metabo10110429 · Cited by 237 · see citing works
“At an O2 concentration of 145 μM (approximately same as arterial concentration), the IC50 for NO inhibition is 270 nM, whereas at 30 μM (approximately the tissue concentration of O2) the IC50 falls to 60 nM [38].”
BackgroundMason, M. G., Nicholls, P., Wilson, M. T., & Cooper, C. E. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506562103 · Cited by 233 · see citing works
Self-citationDietary nitrate reduces muscle metabolic perturbation and improves exercise tolerance in hypoxia
Vanhatalo, A., Fulford, J., Bailey, S. J., Blackwell, J. R., Winyard, P. G., & Jones, A. M. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.216341 · Cited by 233 · see citing works
Prime, T. A., Blaikie, F. H., Evans, C., Nadtochiy, S. M., James, A. M., Dahm, C. C., Vitturi, D. A., Patel, R. P., Hiley, C. R., Abakumova, I., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903250106 · Cited by 222 · see citing works
Dietary Nitrate and Physical Performance
Jones, A. M., Thompson, C., Wylie, L. J., & Vanhatalo, A. (2018) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-082117-051622 · Cited by 206 · see citing works
Role of the anion nitrite in ischemia-reperfusion cytoprotection and therapeutics
DEZFULIAN, C., RAAT, N., SHIVA, S., & GLADWIN, M. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.05.001 · Cited by 198 · see citing works
Review: Mitochondria and disease progression in multiple sclerosis
Mahad, D., Lassmann, H., & Turnbull, D. (2008) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2008.00987.x · Cited by 193 · see citing works
Sex differences in mitochondrial (dys)function: Implications for neuroprotection
Demarest, T. G., & McCarthy, M. M. (2015) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-014-9583-7 · Cited by 192 · see citing works
The Redox Activity of Hemoglobins: From Physiologic Functions to Pathologic Mechanisms
Reeder, B. J. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2974 · Cited by 189 · see citing works
Cooper, C. E., & Giulivi, C. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00310.2006 · Cited by 176 · see citing works
Self-citationTherapeutic effects of inorganic nitrate and nitrite in cardiovascular and metabolic diseases
Omar, S. A., Webb, A. J., Lundberg, J. O., & Weitzberg, E. (2016) · Journal of Internal Medicine · doi:10.1111/joim.12441 · Cited by 175 · see citing works
Wightman, E. L., Haskell-Ramsay, C. F., Thompson, K. G., Blackwell, J. R., Winyard, P. G., Forster, J., Jones, A. M., & Kennedy, D. O. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.05.035 · Cited by 170 · see citing works
Nitrate-Nitrite-Nitric Oxide Pathway: Implications for Anesthesiology and Intensive Care
Weitzberg, E., Hezel, M., Lundberg, J. O., & Warner, D. S. (2010) · Anesthesiology · doi:10.1097/aln.0b013e3181fcf3cc · Cited by 145 · see citing works
Jones, A. M. (2014) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2014-0036 · Cited by 144 · see citing works
DILISA, F., & BERNARDI, P. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.02.009 · Cited by 139 · see citing works
Effects of nitric oxide on the contraction of skeletal muscle
Maréchal, G., & Gailly, P. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050359 · Cited by 135 · see citing works
Interaction of Peroxynitrite with Mitochondrial Cytochrome Oxidase
Sharpe, M. A., & Cooper, C. E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.47.30961 · Cited by 133 · see citing works
Self-citationZhao, Z., Zhao, C., Zhang, X. H., Zheng, F., Cai, W., Vlassara, H., & Ma, Z. A. (2009) · Endocrinology · doi:10.1210/en.2008-1342 · Cited by 132 · see citing works
Nitric Oxide in Skeletal Muscle: Role on Mitochondrial Biogenesis and Function
Tengan, C., Rodrigues, G., & Godinho, R. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms131217160 · Cited by 123 · see citing works
Nitrite Reduction and Cardiovascular Protection
Omar, S. A., & Webb, A. J. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.01.012 · Cited by 121 · see citing works
Whitfield, J., Ludzki, A., Heigenhauser, G. J. F., Senden, J. M. G., Verdijk, L. B., van Loon, L. J. C., Spriet, L. L., & Holloway, G. P. (2016) · The Journal of Physiology · doi:10.1113/jp270844 · Cited by 115 · see citing works
The redox interplay between nitrite and nitric oxide: From the gut to the brain
Pereira, C., Ferreira, N. R., Rocha, B. S., Barbosa, R. M., & Laranjinha, J. (2013) · Redox Biology · doi:10.1016/j.redox.2013.04.004 · Cited by 92 · see citing works
Thomas, D. D., Miranda, K. M., Colton, C. A., Citrin, D., Espey, M. G., & Wink, D. A. (2003) · Antioxidants & Redox Signaling · doi:10.1089/152308603322110887 · Cited by 89 · see citing works
Mitochondria as metabolizers and targets of nitrite
Shiva, S. (2010) · Nitric Oxide · doi:10.1016/j.niox.2009.09.002 · Cited by 87 · see citing works
Regulation of mitochondrial function and energetics by reactive nitrogen oxides
Larsen, F. J., Schiffer, T. A., Weitzberg, E., & Lundberg, J. O. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.08.580 · Cited by 87 · see citing works
Effects of nitrite on modulating ROS generation following ischemia and reperfusion
Raat, N. J. H., Shiva, S., & Gladwin, M. T. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.02.002 · Cited by 79 · see citing works
Mechanisms of the interaction of nitroxyl with mitochondria
SHIVA, S., CRAWFORD, J. H., RAMACHANDRAN, A., CEASER, E. K., HILLSON, T., BROOKES, P. S., PATEL, R. P., & DARLEY-USMAR, V. M. (2004) · Biochemical Journal · doi:10.1042/bj20031758 · Cited by 78 · see citing works
Nitric oxide is the primary mediator of cytotoxicity induced by GSH depletion in neuronal cells
Aquilano, K., Baldelli, S., Cardaci, S., Rotilio, G., & Ciriolo, M. R. (2011) · Journal of Cell Science · doi:10.1242/jcs.077149 · Cited by 67 · see citing works
Kindig, C. A., McDonough, P., Erickson, H. H., & Poole, D. C. (2002) · Respiratory Physiology & Neurobiology · doi:10.1016/s1569-9048(02)00068-x · Cited by 62 · see citing works
Rassaf, T., Ferdinandy, P., & Schulz, R. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12291 · Cited by 62 · see citing works
McAndrew, J., Patel, R. P., Jo, H., Cornwell, T., Lincoln, T., Moellering, D., White, C. R., Matalon, S., & Darley-Usmar, V. (1997) · Seminars in Perinatology · doi:10.1016/s0146-0005(97)80002-x · Cited by 56 · see citing works
Thompson, C., Wylie, L. J., Blackwell, J. R., Fulford, J., Black, M. I., Kelly, J., McDonagh, S. T. J., Carter, J., Bailey, S. J., Vanhatalo, A., et al. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00909.2016 · Cited by 51 · see citing works
Cooper, C. (2003) · IUBMB Life · doi:10.1080/15216540310001628663 · Cited by 46 · see citing works
Hendgen-Cotta, U. B., Kelm, M., & Rassaf, T. (2010) · Nitric Oxide · doi:10.1016/j.niox.2009.10.003 · Cited by 46 · see citing works
Jaber, S. M., Bordt, E. A., Bhatt, N. M., Lewis, D. M., Gerecht, S., Fiskum, G., & Polster, B. M. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2017.09.003 · Cited by 40 · see citing works
NO-ferroheme is a signaling entity in the vasculature
Kleschyov, A. L., Zhuge, Z., Schiffer, T. A., Guimarães, D. D., Zhang, G., Montenegro, M. F., Tesse, A., Weitzberg, E., Carlström, M., & Lundberg, J. O. (2023) · Nature Chemical Biology · doi:10.1038/s41589-023-01411-5 · Cited by 36 · see citing works
ORSI, A., BELTRÁN, B., CLEMENTI, E., HALLÉN, K., FEELISCH, M., & MONCADA, S. (2000) · Biochemical Journal · doi:10.1042/bj3460407 · Cited by 37 · see citing works
Rodríguez-Juárez, F., Aguirre, E., & Cadenas, S. (2007) · Biochemical Journal · doi:10.1042/bj20070033 · Cited by 31 · see citing works
Enzymatic/non-enzymatic formation of nitric oxide
Meyer, D. J. (1995) · Nature Medicine · doi:10.1038/nm1195-1103a · Cited by 20 · see citing works
Nitrite reduction: a ubiquitous function from a pre-aerobic past
Cutruzzolà, F., Rinaldo, S., Castiglione, N., Giardina, G., Pecht, I., & Brunori, M. (2009) · BioEssays · doi:10.1002/bies.200800235 · Cited by 13 · see citing works
Institute of Biology, P. U. I. S., Tkaczenko, H., Lukash, O., Kamiński, P., & Kurhaluk, N. (2024) · Cellular Physiology and Biochemistry · doi:10.33594/000000716 · Cited by 7 · see citing works
Shepherd, A. I., Wilkerson, D. P., Dobson, L., Kelly, J., Winyard, P. G., Jones, A. M., Benjamin, N., Shore, A. C., & Gilchrist, M. (2015) · Nitric Oxide · doi:10.1016/j.niox.2015.01.002 · Cited by 88 · see citing works
- Authors
- Brown, G. C., & Cooper, C. E.
- Affiliations
- University College London (GB)
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1994-12-19
- Volume
- 356
- Issue
- 2-3
- Pages
- 295-298
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2047545717
- Cited by
- 1,055
- References
- 24
- Citations by year
- 2026: 20 · 2025: 19 · 2024: 20 · 2023: 14 · 2022: 18 · 2021: 21 · 2020: 31 · 2019: 19 · 2018: 22 · 2017: 36 · 2016: 27 · 2015: 25 · 2014: 29 · 2013: 36 · 2012: 52
- FWCI
- 12.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- nitric oxide, cytochrome c oxidase, synaptosomes, oxygen consumption, competitive inhibition, respiration inhibition, brain mitochondria, reversible inhibition, oxygen
- MeSH terms
- Animals, Binding, Competitive, Brain, Electron Transport Complex IV, Kinetics, Light, Microchemistry, Nitric Oxide, Nitroprusside, Oxygen, Oxygen Consumption, Synaptosomes, Rats
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