The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

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Items 101–200 of 1,001

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2. Early activation of mTORC1 signalling in response to mechanical overload is independent of phosphoinositide 3‐kinase/Akt signalling
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3. Loss of Tsc2 in Purkinje cells is associated with autistic-like behavior in a mouse model of tuberous sclerosis complex
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4. Regulation of mTOR Complex 1 (mTORC1) by Raptor Ser863 and Multisite Phosphorylation
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5. Molecular Mechanisms of Cardiovascular Toxicity of Targeted Cancer Therapeutics
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6. Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity
   Carroll, Bernadette, Maetzel, Dorothea, Maddocks, Oliver DK, Otten, Gisela, Ratcliff, Matthew, Smith, Graham R, Dunlop, Elaine A, Passos, João F, Davies, Owen R, Jaenisch, Rudolf et al. · 2016 · eLife
7. Downregulation of AMPK Accompanies Leucine- and Glucose-Induced Increases in Protein Synthesis and Insulin Resistance in Rat Skeletal Muscle
   Asish K. Saha, X. Julia Xu, Ebony Lawson, Rosangela Deoliveira, Amanda E. Brandon, Edward W. Kraegen, Neil B. Ruderman · 2010 · Diabetes
8. mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
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9. Lipid signalling drives proteolytic rewiring of mitochondria by YME1L
   Thomas MacVicar, Yohsuke Ohba, Hendrik Nolte, Fiona Carola Mayer, Takashi Tatsuta, Hans‐Georg Sprenger, Barbara Lindner, Yue Zhao, Jiahui Li, Christiane J. Bruns et al. · 2019 · Nature
10. nab -Sirolimus for Patients With Malignant Perivascular Epithelioid Cell Tumors
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11. Differentiating the mTOR inhibitors everolimus and sirolimus in the treatment of tuberous sclerosis complex
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12. Chronic Activation of mTOR Complex 1 Is Sufficient to Cause Hepatocellular Carcinoma in Mice
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13. The Role of the Mammalian Target of Rapamycin (mTOR) in Pulmonary Fibrosis
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14. Insulin Receptor Substrates Irs1 and Irs2 Coordinate Skeletal Muscle Growth and Metabolism via the Akt and AMPK Pathways
    Yun Chau Long, Zhiyong Cheng, Kyle D. Copps, Morris F. White · 2010 · Molecular and Cellular Biology
15. Metabolic Heterogeneity of Cancer Cells: An Interplay between HIF-1, GLUTs, and AMPK
    Nurbubu T. Moldogazieva, Innokenty M. Mokhosoev, Alexander A. Terentiev · 2020 · Cancers
16. Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney
    Laura R. Pearce, Eeva M. Sommer, Kei Sakamoto, Stephan Wullschleger, Dario R. Alessi · 2011 · Biochemical Journal
17. PTEN-opathies: from biological insights to evidence-based precision medicine
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18. ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Intracellular signaling pathways: tyrosine kinase and mTOR inhibitors)
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19. Insulin Inhibits Lipolysis in Adipocytes via the Evolutionarily Conserved mTORC1-Egr1-ATGL-Mediated Pathway
    Partha Chakrabarti, Ju Youn Kim, Maneet Singh, Yu‐Kyong Shin, Jessica Kim, Joerg Kumbrink, Yuanyuan Wu, Mi‐Jeong Lee, Kathrin H. Kirsch, Susan K. Fried et al. · 2013 · Molecular and Cellular Biology
20. Making a good egg: human oocyte health, aging, and in vitro development
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21. Everolimus for subependymal giant cell astrocytoma: 5‐year final analysis
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22. PI3K-AKT-mTOR and NFκB Pathways in Ovarian Cancer: Implications for Targeted Therapeutics
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23. Mechanotransduction and the regulation of mTORC1 signaling in skeletal muscle
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24. Take your PIK
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25. Caloric restriction: From soup to nuts
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26. The emerging role of mTORC1 signaling in placental nutrient-sensing
    Thomas Jansson, Irving L.M.H. Aye, Deborah C. I. Goberdhan · 2012 · Placenta
27. Site-Specific mTOR Phosphorylation Promotes mTORC1-Mediated Signaling and Cell Growth
    Hugo A. Acosta-Jaquez, Jennifer A. Keller, Kathryn G. Foster, Bilgen Ekim Üstünel, Ghada A. Soliman, Edward P. Feener, Bryan A. Ballif, Diane C. Fingar · 2009 · Molecular and Cellular Biology
28. The Lysosome Signaling Platform: Adapting With the Times
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29. State of the Science: An Update on Renal Cell Carcinoma
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30. Transcriptional Control of Cellular Metabolism by mTOR Signaling
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31. Lysosomal recruitment of TSC2 is a universal response to cellular stress
    Demetriades, Constantinos, Plescher, Monika, Teleman, Aurelio A. · 2016 · Nature Communications
32. Bone and skeletal muscle: Key players in mechanotransduction and potential overlapping mechanisms
    Craig A. Goodman, Troy Alan Hornberger, Alexander G. Robling · 2015 · Bone
33. mTORC1 pathway in DNA damage response
    Yinxing Ma, Yegor S Vassetzky, Svetlana Dokudovskaya · 2018 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
34. Nitazoxanide Stimulates Autophagy and Inhibits mTORC1 Signaling and Intracellular Proliferation of Mycobacterium tuberculosis
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35. FoxO Transcription Factors Promote AKT Ser473 Phosphorylation and Renal Tumor Growth in Response to Pharmacologic Inhibition of the PI3K–AKT Pathway
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36. The role of mTOR signaling in the regulation of protein synthesis and muscle mass during immobilization in mice
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37. mTOR links oncogenic signaling to tumor cell metabolism
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38. Calorie Restriction and Dietary Restriction Mimetics: A Strategy for Improving Healthy Aging and Longevity
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39. G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling
    Mirja Tamara Prentzell, Ulrike Rehbein, Marti Cadena Sandoval, Ann‐Sofie De Meulemeester, Ralf Baumeister, Laura Brohée, Bianca Berdel, Mathias Bockwoldt, Bernadette Carroll, Suvagata Roy Chowdhury et al. · 2021 · Cell
40. Glucose Regulation of Load‐Induced mTOR Signaling and ER Stress in Mammalian Heart
    Shiraj Sen, Bijoy K. Kundu, Henry C. Wu, S. Shahrukh Hashmi, Patrick H. Guthrie, Landon W. Locke, Rahul Roy, G. Paul Matherne, Stuart S. Berr, Matthew D. Terwelp et al. · 2013 · Journal of the American Heart Association
41. Cancer and mTOR Inhibitors in Transplant Recipients
    Johan Willem de Fijter · 2016 · Transplantation
42. TORC 1 signaling inhibition by rapamycin and caffeine affect lifespan, global gene expression, and cell proliferation of fission yeast
    Charalampos Rallis, Sandra Codlin, Jürg Bähler · 2013 · Aging Cell
43. mTORC1 signaling: what we still don't know
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44. FoxOs Enforce a Progression Checkpoint to Constrain mTORC1-Activated Renal Tumorigenesis
    Boyi Gan, Carol Lim, Gerald Chu, Sujun Hua, Zhihu Ding, Michael P. Collins, JIAN LI HU, Shan Jiang, Eliot Fletcher-Sananikone, Li Zhuang et al. · 2010 · Cancer Cell
45. TSC1 regulates the balance between effector and regulatory T cells
    Yoon Park, Hyung‐seung Jin, Justine M Lopez, Chris Elly, Gisen Kim, Masako Murai, Mitchell Kronenberg, Yun‐Cai Liu · 2013 · Journal of Clinical Investigation
46. Dopaminergic pathway reconstruction by Akt/Rheb‐induced axon regeneration
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47. mTOR Cross-Talk in Cancer and Potential for Combination Therapy
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48. The Opposing Actions of Target of Rapamycin and AMP-Activated Protein Kinase in Cell Growth Control
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49. Ras activation revisited: role of GEF and GAP systems
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50. Regulation of Autophagy and Its Associated Cell Death by “Sphingolipid Rheostat”
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51. Evolving neurobiology of tuberous sclerosis complex
    Peter B. Crino · 2013 · Acta Neuropathologica
52. The Role of mTORC1 in Regulating Protein Synthesis and Skeletal Muscle Mass in Response to Various Mechanical Stimuli
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53. Activation of mTOR Signaling Pathway in Hepatocellular Carcinoma
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54. Host Cell Autophagy Is Induced by Toxoplasma gondii and Contributes to Parasite Growth
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55. Long-term Follow-up Assessing Renal Angiomyolipoma Treatment Patterns, Morbidity, and Mortality: An Observational Study in Tuberous Sclerosis Complex Patients in the Netherlands
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56. Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi
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57. Ral and Rheb GTPase Activating Proteins Integrate mTOR and GTPase Signaling in Aging, Autophagy, and Tumor Cell Invasion
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58. The long and winding road to rational treatment of cancer associated with LKB1/AMPK/TSC/mTORC1 signaling
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59. mTORC1 signalling and mRNA translation
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60. Genetics of tuberous sclerosis complex: implications for clinical practice
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61. TOR‐mediated regulation of metabolism in aging
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62. Targeting PI3K/Akt/mTOR in AML: Rationale and Clinical Evidence
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63. Negative regulation of autophagy
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64. Targeting PI3K-AKT/mTOR signaling in the prevention of autism
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65. Fetal Brain Lesions in Tuberous Sclerosis Complex: TORC1 Activation and Inflammation
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66. Chapter 3 Ribosomal Protein S6 Kinase
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67. The Multifaceted Role of Nutrient Sensing and mTORC1 Signaling in Physiology and Aging
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68. Phosphorylation and Signal Transduction Pathways in Translational Control
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69. mTOR Kinase Domain Phosphorylation Promotes mTORC1 Signaling, Cell Growth, and Cell Cycle Progression
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70. Signaling Events Downstream of Mammalian Target of Rapamycin Complex 2 Are Attenuated in Cells and Tumors Deficient for the Tuberous Sclerosis Complex Tumor Suppressors
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71. The kinase triad, AMPK, mTORC1 and ULK1, maintains energy and nutrient homoeostasis
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72. mTor Signaling in Skeletal Muscle During Sepsis and Inflammation: Where Does It All Go Wrong?
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73. Synergistic Effects of Metformin Treatment in Combination with Gefitinib, a Selective EGFR Tyrosine Kinase Inhibitor, in LKB1 Wild-type NSCLC Cell Lines
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74. The journey of metformin from glycaemic control to mTOR inhibition and the suppression of tumour growth
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75. TGFβ-Stimulated MicroRNA-21 Utilizes PTEN to Orchestrate AKT/mTORC1 Signaling for Mesangial Cell Hypertrophy and Matrix Expansion
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76. Purkinje cells derived from TSC patients display hypoexcitability and synaptic deficits associated with reduced FMRP levels and reversed by rapamycin
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77. Are neuroendocrine tumours a feature of tuberous sclerosis? A systematic review
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78. mTOR-Mediated Activation of p70 S6K Induces Differentiation of Pluripotent Human Embryonic Stem Cells
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79. Regulation of mTORC1 Signaling by pH
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80. mTORC1 coordinates an immediate unfolded protein response-related transcriptome in activated B cells preceding antibody secretion
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81. How does mTOR sense glucose starvation? AMPK is the usual suspect
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82. Effects of dietary isoleucine on growth, the digestion and absorption capacity and gene expression in hepatopancreas and intestine of juvenile Jian carp (Cyprinus carpio var. Jian)
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83. Fetal Brain mTOR Signaling Activation in Tuberous Sclerosis Complex
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84. mTOR inhibition modulates epileptogenesis, seizures and depressive behavior in a genetic rat model of absence epilepsy
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85. At a glance: A history of autophagy and cancer
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86. TRIM31 is upregulated in hepatocellular carcinoma and promotes disease progression by inducing ubiquitination of TSC1–TSC2 complex
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87. PI3K inhibitors for cancer treatment: where do we stand?
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88. A nexus for cellular homeostasis: the interplay between metabolic and signal transduction pathways
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89. Amino acid management in cancer
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90. Regulation of mTOR Complex 2 Signaling in Neurofibromatosis 2–Deficient Target Cell Types
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91. Snf1/AMPK promotes the formation of Kog1/Raptor-bodies to increase the activation threshold of TORC1 in budding yeast
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92. The Many Faces of Rap1 GTPase
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93. Altered Glutamine Metabolism and Therapeutic Opportunities for Lung Cancer
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94. R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein
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95. Seizing the moment: Zebrafish epilepsy models
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96. Dopaminergic Dysregulation in Syndromic Autism Spectrum Disorders: Insights From Genetic Mouse Models
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97. Swimming exercise training-induced left ventricular hypertrophy involves microRNAs and synergistic regulation of the PI3K/AKT/mTOR signaling pathway
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98. Hypothalamic mTOR pathway mediates thyroid hormone‐induced hyperphagia in hyperthyroidism
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99. Influence of mTOR in energy and metabolic homeostasis
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100. Sensitive time-windows for susceptibility in neurodevelopmental disorders
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