Mechanotransduction and the regulation of mTORC1 signaling in skeletal muscle

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Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

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Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways

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Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1

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The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

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Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

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Phosphatidic Acid-Mediated Mitogenic Activation of mTOR Signaling

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Molecular mechanisms of translational control

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mTOR Controls Cell Cycle Progression through Its Cell Growth Effectors S6K1 and 4E-BP1/Eukaryotic Translation Initiation Factor 4E

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Signaling in Muscle Atrophy and Hypertrophy

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Signaling functions of phosphatidic acid

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S6K1 −/− / S6K2 −/− Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway

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<i>Physiology of a Microgravity Environment</i> Invited Review: Microgravity and skeletal muscle

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Expanding mTOR signaling

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Phospholipase A2

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Novel insights into the regulation of skeletal muscle protein synthesis as revealed by a new nonradioactive in vivo technique

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Selective activation of AMPK‐PGC‐1α or PKB‐TSC2‐mTOR signaling can explain specific adaptive responses to endurance or resistance training‐like electrical muscle stimulation

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Rapamycin administration in humans blocks the contraction‐induced increase in skeletal muscle protein synthesis

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A protein kinase B-dependent and rapamycin-sensitive pathway controls skeletal muscle growth but not fiber type specification

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Fast/Glycolytic Muscle Fiber Growth Reduces Fat Mass and Improves Metabolic Parameters in Obese Mice

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Atrophy of S6K1(−/−) skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control

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Rheb Activates mTOR by Antagonizing Its Endogenous Inhibitor, FKBP38

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Leucine Regulates Translation of Specific mRNAs in L6 Myoblasts through mTOR-mediated Changes in Availability of eIF4E and Phosphorylation of Ribosomal Protein S6*

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Amino acid regulation of TOR complex 1

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Localized infusion of IGF-I results in skeletal muscle hypertrophy in rats

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Amino Acids Activate mTOR Complex 1 via Ca2+/CaM Signaling to hVps34

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The benefits of strength training for older adults

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Stress and mTORture signaling

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Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase

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Insulin Controls Subcellular Localization and Multisite Phosphorylation of the Phosphatidic Acid Phosphatase, Lipin 1

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Space travel directly induces skeletal muscle atrophy

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A Phosphatidylinositol 3-Kinase/Protein Kinase B-independent Activation of Mammalian Target of Rapamycin Signaling Is Sufficient to Induce Skeletal Muscle Hypertrophy

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Changes in muscle mass with mechanical load: possible cellular mechanismsThis paper is one of a selection of papers published in this Special Issue, entitled 14th International Biochemistry of Exercise Conference – Muscles as Molecular and Metabolic Machines, and has undergone the Journal’s usual peer review process.

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