Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation
Kendrick, Agnieszka A., Choudhury, Mahua, Rahman, Shaikh M., McCurdy, Carrie E., Friederich, Marisa, Van Hove, Johan L. K., Watson, Peter A., Birdsey, Nicholas, Bao, Jianjun, Gius, David, Sack, Michael N., Jing, Enxuan, Kahn, C. Ronald, Friedman, Jacob E., Jonscher, Karen R.·2011·Biochemical Journal
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Items 101–200 of 382
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- Interplay between NADH oxidation by complex I, glutathione redox state and sirtuin-3, and its role in the development of insulin resistanceChristian Cortés‐Rojo, Manuel Alejandro Vargas-Vargas, Berenice Eridani Olmos‐Orizaba, Alain Raimundo Rodríguez-Orozco, Elizabeth Calderón‐Cortés · 2020 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
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- Reduced mitophagy is an early feature of NAFLD and liver-specific PARKIN knockout hastens the onset of steatosis, inflammation and fibrosisRamya Undamatla, Olayemi Grace Fagunloye, J. Chen, L. R. Edmunds, A. Murali, A. Scott Mills, Bin Xie, Martha M. Pangburn, IAN J. SIPULA, Gregory A. Gibson et al. · 2023 · Scientific Reports
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- Increased nitroxidative stress promotes mitochondrial dysfunction in alcoholic and nonalcoholic fatty liver diseaseSong, Byoung-Joon, Abdelmegeed, Mohamed A., Henderson, Lauren E., Yoo, Seong-Ho, Wan, Jie, Purohit, Vishnudutt, Hardwick, James P., Moon, Kwan-Hoon · 2013 · Oxidative Medicine and Cellular Longevity
- Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor developmentStephan H. Winnik, Daniel S. Gaul, Frédéric Preitner, Christine Lohmann, Julien Weber, Melroy X Miranda, Yilei Liu, Lambertus J. van Tits, José Marı́a Mateos, Chad E. Brokopp et al. · 2013 · Basic Research in Cardiology
- The Role of SIRT3 in the Brain Under Physiological and Pathological ConditionsElena Sidorova‐Darmos, Rosa Sommer, James H. Eubanks · 2018 · Frontiers in Cellular Neuroscience
- Regulation of mammalian mitochondrial translation by post-translational modificationsEmine C. Koc, Hasan Koç · 2012 · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
- A Redox-resistant Sirtuin-1 Mutant Protects against Hepatic Metabolic and Oxidant StressDi Shao, Jessica Fry, Jingyan Han, Xiuyun Hou, David Richard Pimentel, Reiko Matsui, Richard Alan Cohen, Markus Michael Bachschmid · 2014 · Journal of Biological Chemistry
- Sirt3 Deficiency Increased the Vulnerability of Pancreatic Beta Cells to Oxidative Stress-Induced DysfunctionYu Zhou, Arthur C.K. Chung, Rongrong Fan, Heung Man Lee, Gang Xu, Brian Tomlinson, Juliana C.N. Chan, Alice P.S. Kong · 2017 · Antioxidants and Redox Signaling
- Palmitic acid induces ceramide accumulation, mitochondrial protein hyperacetylation, and mitochondrial dysfunction in porcine oocytes†Nobuhiko Itami, Koumei Shirasuna, Takehito Kuwayama, Hisataka Iwata · 2018 · Biology of Reproduction
- The role of SIRT3 in mitochondrial homeostasis and cardiac adaptation to hypertrophy and agingMichael N. Sack · 2011 · Journal of Molecular and Cellular Cardiology
- Sirtuin 3‐mediated deacetylation of acyl‐ CoA synthetase family member 3 by protocatechuic acid attenuates non‐alcoholic fatty liver diseaseRuimin Sun, Xiaohui Kang, Yan Zhao, Zhanyu Wang, Ruiwen Wang, Rong Fu, Yang Li, Yan Wei Hu, Zhecheng Wang, Wen Shan et al. · 2020 · British Journal of Pharmacology
- Emerging characterization of the role of SIRT3-mediated mitochondrial protein deacetylation in the heartMichael N. Sack · 2011 · American Journal of Physiology-Heart and Circulatory Physiology
- Pyrroloquinoline quinone increases the expression and activity of Sirt1 and -3 genes in HepG2 cellsJian Zhang, Sunitha Meruvu, Yudhishtar S. Bedi, Jason Chau, Andrix O. Arguelles, Robert B. Rucker, Mahua Choudhury · 2015 · Nutrition Research
- Role of SIRT3 in mitochondrial biology and its therapeutic implications in neurodegenerative disordersYogesh Mishra, Ravinder Kumar Kaundal · 2023 · Drug Discovery Today
- The therapeutic perspective of NAD+ precursors in age-related diseasesTooba Iqbal, Takashi Nakagawa · 2024 · Biochemical and Biophysical Research Communications
- Prolonged Fasting Identifies Heat Shock Protein 10 as a Sirtuin 3 SubstrateZhongping Lu, Yong Chen, Angel M. Aponte, Valentina Battaglia, Marjan Guček, Michael N. Sack · 2014 · Journal of Biological Chemistry
- Sirtuin 3 (SIRT3) Regulates α-Smooth Muscle Actin (α-SMA) Production through the Succinate Dehydrogenase-G Protein-coupled Receptor 91 (GPR91) Pathway in Hepatic Stellate CellsYing Hui Li, Dae Hee Choi, Eun Hye Lee, Su Ryeon Seo, Seungkoo Lee, Eun-Hee Cho · 2016 · Journal of Biological Chemistry
- Defining decreased protein succinylation of failing human cardiac myofibrils in ischemic cardiomyopathyHadi Ali, Cole R. Michel, Ying H. Lin, Timothy A. McKinsey, Mark Y. Jeong, Amrut V. Ambardekar, Joseph C. Cleveland, Richard M. Reisdorph, Nichole A. Reisdorph, Kathleen C. Woulfe et al. · 2019 · Journal of Molecular and Cellular Cardiology
- SIRT3 Activation a Promise in Drug Development? New Insights into SIRT3 Biology and Its Implications on the Drug Discovery ProcessChiara Lambona, Clemens Zwergel, Sérgio Valente, Antonello Mai · 2024 · Journal of Medicinal Chemistry
- Acetyl-CoA from inflammation-induced fatty acids oxidation promotes hepatic malate-aspartate shuttle activity and glycolysisTongxin Wang, Weilei Yao, Ji Li, Qiongyu He, Yafei Shao, Feiruo Huang · 2018 · American Journal of Physiology-Endocrinology and Metabolism
- OXPHOS-Mediated Induction of NAD+ Promotes Complete Oxidation of Fatty Acids and Interdicts Non-Alcoholic Fatty Liver DiseaseThomas E. Akie, Lijun Liu, Minwoo Nam, Lei Shi, Marcus P. Cooper · 2015 · PLoS ONE
- Roles of sirtuins in the regulation of antioxidant defense and bioenergetic function of mitochondria under oxidative stressYuting Wu, Shi‐Bei Wu, Yau‐Huei Wei · 2014 · Free Radical Research
- Mitochondrial dysfunction in metabolism and ageing: shared mechanisms and outcomes?Guillermo López‐Lluch, Juan Diego Hernández‐Camacho, Daniel J.M. Fernández‐Ayala, Plácido Navas · 2018 · Biogerontology
- The role of SIRT3 in homeostasis and cellular healthDennison Trinh, Lina Al Halabi, Harsimar Brar, Marie Kametani, Joanne E. Nash · 2024 · Frontiers in Cellular Neuroscience
- Myricetin Exerts Anti-Obesity Effects through Upregulation of SIRT3 in Adipose TissueSeun Akindehin, Young-Suk Jung, Sang-Nam Kim, Yeon-Ho Son, Icksoo Lee, Je Kyung Seong, Hyun Woo Jeong, Yun-Hee Lee · 2018 · Nutrients
- NAD+: A key metabolic regulator with great therapeutic potentialGhazal Sultani, Azrah Samsudeen, Brenna Osborne, Nigel A. Turner · 2017 · Journal of Neuroendocrinology
- The sirtuin class of histone deacetylases: Regulation and roles in lipid metabolismErika Fiorino, Marco Giudici, Alessandra Ferrari, Nico Mitro, Donatella Caruso, Emma De Fabiani, Maurizio Crestani · 2014 · IUBMB Life
- CD147: a small molecule transporter ancillary protein at the crossroad of multiple hallmarks of cancer and metabolic reprogrammingAgnieszka A. Kendrick, Johnathon B. Schafer, Monika Dzieciątkowska, Travis G. Nemkov, Angelo D’Alessandro, Deepika Neelakantan, Heide L. Ford, Chad G. Pearson, Colin D. Weekes, Kirk Charles Hansen et al. · 2016 · Oncotarget
- SIRT3 regulates mitochondrial biogenesis in aging-related diseasesHongyan Li, Zhiyou Cai · 2022 · Journal of Biomedical Research
- Sirtuins-Mediated System-Level Regulation of Mammalian Tissues at the Interface between Metabolism and Cell Cycle: A Systematic ReviewParcival Maissan, Eva Mooij, Matteo Barberis · 2021 · Biology
- Regulation of mitochondrial trifunctional protein modulates nonalcoholic fatty liver disease in miceFatiha Nassir, Justin J. Arndt, Sarah A. Johnson, Jamal A. Ibdah · 2018 · Journal of Lipid Research
- Mono-(2-ethylhexyl) Phthalate Aggravates Inflammatory Response via Sirtuin Regulation and Inflammasome Activation in RAW 264.7 CellsMin Hi Park, Ana K. Gutiérrez-García, Mahua Choudhury · 2019 · Chemical Research in Toxicology
- EX-527 Prevents the Progression of High-Fat Diet-Induced Hepatic Steatosis and Fibrosis by Upregulating SIRT4 in Zucker RatsAmit B. Kundu, Prasanta Kumar Dey, Jae Hyeon Park, In Su Kim, Seung Jun Kwack, Hyung Sik Kim · 2020 · Cells
- Are sirtuin deacylase enzymes important modulators of mitochondrial energy metabolism?Brenna Osborne, Gregory James Cooney, Nigel A. Turner · 2013 · Biochimica et Biophysica Acta (BBA) - General Subjects
- Nutrient sensing by the mitochondrial transcription machinery dictates oxidative phosphorylationLijun Liu, Minwoo Nam, Wei Fan, Thomas E. Akie, David C. Hoaglin, Guangping Gao, John F. Keaney, Marcus P. Cooper · 2014 · Journal of Clinical Investigation
- Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructoseJesse G. Meyer, Samir Softic, Nathan Basisty, Matthew J. Rardin, Eric M. Verdin, Bradford W. Gibson, Olga Ilkayeva, Christopher B. Newgard, C. Ronald Kahn, Birgit Schilling · 2018 · PLoS ONE
- Reduced hepatic mitochondrial respiration following acute high-fat diet is prevented by PGC-1α overexpressionE. Matthew Morris, Matthew R. Jackman, Grace Margaret-Eleanor Meers, Ginger C. Johnson, Jordan L. Lopez, Paul S. MacLean, John P. Thyfault · 2013 · American Journal of Physiology-Gastrointestinal and Liver Physiology
- Chaperonin counteracts diet-induced non-alcoholic fatty liver disease by aiding sirtuin 3 in the control of fatty acid oxidationShao‐Wen Weng, Jian‐Ching Wu, Feng‐Chih Shen, Yen‐Hsiang Chang, Yu‐Jih Su, Wei‐Shiung Lian, Ming‐Hong Tai, Chia‐Hao Su, Jiin‐Haur Chuang, Tsu‐Kung Lin et al. · 2023 · Diabetologia
- Targeting sirtuins for the treatment of diabetesFrank K. Huynh, Kathleen A. Hershberger, Matthew D. Hirschey · 2013 · Diabetes Management
- SIRT3 Overexpression Attenuates Palmitate-Induced Pancreatic β-Cell DysfunctionMin Kim, Ji Seon Lee, Joo En Oh, Jinyan Nan, Hakmo Lee, Hye Seung Jung, Sung Soo Chung, Kyong Soo Park · 2015 · PLoS ONE
- Sirtuin-3 Promotes Adipogenesis, Osteoclastogenesis, and Bone Loss in Aging Male MiceLinh Ho, Liping Wang, Theresa Roth, Yong Pan, Eric M. Verdin, Edward Chiaming Hsiao, Robert A. Nissenson · 2017 · Endocrinology
- NAD + -dependent deacetylase SIRT3 in adipocytes is dispensable for maintaining normal adipose tissue mitochondrial function and whole body metabolismLane C. Porter, Michael P. Franczyk, Terri Pietka, Shintaro Yamaguchi, Jonathan B. Lin, Yo Sasaki, Eric M. Verdin, Rajendra S. Apte, Jun Yoshino · 2018 · American Journal of Physiology-Endocrinology and Metabolism
- Impact of nutrient overload on metabolic homeostasisHaowen Qiu, Vicki L. Schlegel · 2018 · Nutrition Reviews
- Mechanism of Action of Ketogenic Diet Treatment: Impact of Decanoic Acid and Beta—Hydroxybutyrate on Sirtuins and Energy Metabolism in Hippocampal Murine NeuronsPartha Dabke, Anibh Martin Das · 2020 · Nutrients
- Regulation and protection of mitochondrial physiology by sirtuinsCláudia V. Pereira, Magdalena Lebiedzińska, Mariusz Roman Wieckowski, Paulo Jorge Oliveira · 2011 · Mitochondrion
- The interplay between oxidative stress and bioenergetic failure in neuropsychiatric illnesses: can we explain it and can we treat it?Gerwyn Morris, Ken R. Walder, M. Berk, Wolfgang Marx, Adam J. Walker, Michael H. J. Maes, Basant K. Puri · 2020 · Molecular Biology Reports
- Nicotinamide Adenine Dinucleotide in Aging Biology: Potential Applications and Many UnknownsShalender Bhasin, Douglas R. Seals, Marie E. Migaud, Nicolas Musi, Joseph A. Baur · 2023 · Endocrine Reviews
- Mitochondrion as a Target for Heart Failure Therapy – Role of Protein Lysine Acetylation –Chi Fung Lee, Rong Tian · 2015 · Circulation Journal
- Caffeine ameliorates high energy diet-induced hepatic steatosis: sirtuin 3 acts as a bridge in the lipid metabolism pathwayShijie Zhang, Yi-Fang Li, Guo-En Wang, Ruirong Tan, Bun Tsoi, Gaowei Mao, Yu-Jia Zhai, Lingfang Cao, Min Chen, Hiroshi Kurihara et al. · 2015 · Food & Function
- Post-Translational Modification of Proteins in Toxicological Research: Focus on Lysine AcylationSangkyu Lee · 2013 · Toxicological Research
- Hepatic NAD+ levels and NAMPT abundance are unaffected during prolonged high-fat diet consumption in C57BL/6JBomTac miceMorten Dall, Melanie Penke, Karolina Sulek, Madlen Matz‐Soja, Birgitte Holst, Antje Garten, Wieland Kieß, Jonas T. Treebak · 2018 · Molecular and Cellular Endocrinology
- Uridine prevents tamoxifen-induced liver lipid droplet accumulationThuc T. Le, Yasuyo Urasaki, Giuseppe Pizzorno · 2014 · BMC Pharmacology and Toxicology
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- PFOS Modulates Interactive Epigenetic Regulation in First-Trimester Human Trophoblast Cell Line HTR-8/SVneoRavi Sonkar, Matthew Kay, Mahua Choudhury · 2019 · Chemical Research in Toxicology
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- Metabolic effects of lactoferrin during energy restriction and weight regain in diet-induced obese miceJin Ping Shi, Piet Finckenberg, Essi Martonen, Anu Ahlroos-Lehmus, Taru K. Pilvi, Riitta Korpela, Eero M. A. Mervaala · 2011 · Journal of Functional Foods
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- The mitochondrial NAD+ transporter SLC25A51 is a fasting-induced gene affecting SIRT3 functionsZhiyao Fu, Hyunbae Kim, Paul T. Morse, Mu‐Jie Lu, Maik Hüttemann, Xiaolu A. Cambronne, Kezhong Zhang, Ren Zhang · 2022 · Metabolism
- Role of Argininosuccinate Synthase 1 ‐Dependent L‐Arginine Biosynthesis in the Protective Effect of Endothelial Sirtuin 3 Against AtherosclerosisXiaoyun Cao, Vivian Wei Yan Wu, Yumeng Han, Huiling Hong, Yalan Wu, Alice P.S. Kong, Kathy O. Lui, Xiao Yu Tian · 2024 · Advanced Science
- Genetic Ablation of CD38 Protects against Western Diet-Induced Exercise Intolerance and Metabolic InflexibilityShian-Huey Chiang, W. Wallace Harrington, Guizhen Luo, Naphtali O. Milliken, John C. Ulrich, Jing Chen, Deepak K. Rajpal, Ying Qian, Tiffany Y. Carpenter, Rusty Murray et al. · 2015 · PLoS ONE
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