Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation

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    Christian Cortés‐Rojo, Manuel Alejandro Vargas-Vargas, Berenice Eridani Olmos‐Orizaba, Alain Raimundo Rodríguez-Orozco, Elizabeth Calderón‐Cortés · 2020 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
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    Kristen E. Boyle, Sean Alec Newsom, Rachel C. Janssen, Martha Lappas, Jacob E. Friedman · 2013 · The Journal of Clinical Endocrinology & Metabolism
  5. Extranuclear Sirtuins and Metabolic Stress
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  6. Reduced mitophagy is an early feature of NAFLD and liver-specific PARKIN knockout hastens the onset of steatosis, inflammation and fibrosis
    Ramya Undamatla, Olayemi Grace Fagunloye, J. Chen, L. R. Edmunds, A. Murali, A. Scott Mills, Bin Xie, Martha M. Pangburn, IAN J. SIPULA, Gregory A. Gibson et al. · 2023 · Scientific Reports
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    Nam Ho Jeoung, Chris R. Harris, Robert A. Harris · 2013 · Reviews in Endocrine and Metabolic Disorders
  8. Reduced mitochondrial function in obesity-associated fatty liver: SIRT3 takes on the fat
    Mahua Choudhury, Karen R. Jonscher, Jacob E. Friedman · 2011 · Aging
  9. Increased nitroxidative stress promotes mitochondrial dysfunction in alcoholic and nonalcoholic fatty liver disease
    Song, Byoung-Joon, Abdelmegeed, Mohamed A., Henderson, Lauren E., Yoo, Seong-Ho, Wan, Jie, Purohit, Vishnudutt, Hardwick, James P., Moon, Kwan-Hoon · 2013 · Oxidative Medicine and Cellular Longevity
  10. Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development
    Stephan H. Winnik, Daniel S. Gaul, Frédéric Preitner, Christine Lohmann, Julien Weber, Melroy X Miranda, Yilei Liu, Lambertus J. van Tits, José Marı́a Mateos, Chad E. Brokopp et al. · 2013 · Basic Research in Cardiology
  11. The Role of SIRT3 in the Brain Under Physiological and Pathological Conditions
    Elena Sidorova‐Darmos, Rosa Sommer, James H. Eubanks · 2018 · Frontiers in Cellular Neuroscience
  12. Regulation of mammalian mitochondrial translation by post-translational modifications
    Emine C. Koc, Hasan Koç · 2012 · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
  13. A Redox-resistant Sirtuin-1 Mutant Protects against Hepatic Metabolic and Oxidant Stress
    Di Shao, Jessica Fry, Jingyan Han, Xiuyun Hou, David Richard Pimentel, Reiko Matsui, Richard Alan Cohen, Markus Michael Bachschmid · 2014 · Journal of Biological Chemistry
  14. Sirt3 Deficiency Increased the Vulnerability of Pancreatic Beta Cells to Oxidative Stress-Induced Dysfunction
    Yu Zhou, Arthur C.K. Chung, Rongrong Fan, Heung Man Lee, Gang Xu, Brian Tomlinson, Juliana C.N. Chan, Alice P.S. Kong · 2017 · Antioxidants and Redox Signaling
  15. Palmitic acid induces ceramide accumulation, mitochondrial protein hyperacetylation, and mitochondrial dysfunction in porcine oocytes†
    Nobuhiko Itami, Koumei Shirasuna, Takehito Kuwayama, Hisataka Iwata · 2018 · Biology of Reproduction
  16. The role of SIRT3 in mitochondrial homeostasis and cardiac adaptation to hypertrophy and aging
    Michael N. Sack · 2011 · Journal of Molecular and Cellular Cardiology
  17. Sirtuin 3‐mediated deacetylation of acyl‐ CoA synthetase family member 3 by protocatechuic acid attenuates non‐alcoholic fatty liver disease
    Ruimin Sun, Xiaohui Kang, Yan Zhao, Zhanyu Wang, Ruiwen Wang, Rong Fu, Yang Li, Yan Wei Hu, Zhecheng Wang, Wen Shan et al. · 2020 · British Journal of Pharmacology
  18. Emerging characterization of the role of SIRT3-mediated mitochondrial protein deacetylation in the heart
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  19. Pyrroloquinoline quinone increases the expression and activity of Sirt1 and -3 genes in HepG2 cells
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  20. Role of SIRT3 in mitochondrial biology and its therapeutic implications in neurodegenerative disorders
    Yogesh Mishra, Ravinder Kumar Kaundal · 2023 · Drug Discovery Today
  21. The therapeutic perspective of NAD+ precursors in age-related diseases
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  22. Prolonged Fasting Identifies Heat Shock Protein 10 as a Sirtuin 3 Substrate
    Zhongping Lu, Yong Chen, Angel M. Aponte, Valentina Battaglia, Marjan Guček, Michael N. Sack · 2014 · Journal of Biological Chemistry
  23. Sirtuin 3 (SIRT3) Regulates α-Smooth Muscle Actin (α-SMA) Production through the Succinate Dehydrogenase-G Protein-coupled Receptor 91 (GPR91) Pathway in Hepatic Stellate Cells
    Ying Hui Li, Dae Hee Choi, Eun Hye Lee, Su Ryeon Seo, Seungkoo Lee, Eun-Hee Cho · 2016 · Journal of Biological Chemistry
  24. Defining decreased protein succinylation of failing human cardiac myofibrils in ischemic cardiomyopathy
    Hadi Ali, Cole R. Michel, Ying H. Lin, Timothy A. McKinsey, Mark Y. Jeong, Amrut V. Ambardekar, Joseph C. Cleveland, Richard M. Reisdorph, Nichole A. Reisdorph, Kathleen C. Woulfe et al. · 2019 · Journal of Molecular and Cellular Cardiology
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  26. Acetyl-CoA from inflammation-induced fatty acids oxidation promotes hepatic malate-aspartate shuttle activity and glycolysis
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  27. OXPHOS-Mediated Induction of NAD+ Promotes Complete Oxidation of Fatty Acids and Interdicts Non-Alcoholic Fatty Liver Disease
    Thomas E. Akie, Lijun Liu, Minwoo Nam, Lei Shi, Marcus P. Cooper · 2015 · PLoS ONE
  28. Roles of sirtuins in the regulation of antioxidant defense and bioenergetic function of mitochondria under oxidative stress
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  29. Mitochondrial dysfunction in metabolism and ageing: shared mechanisms and outcomes?
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  30. The role of SIRT3 in homeostasis and cellular health
    Dennison Trinh, Lina Al Halabi, Harsimar Brar, Marie Kametani, Joanne E. Nash · 2024 · Frontiers in Cellular Neuroscience
  31. Myricetin Exerts Anti-Obesity Effects through Upregulation of SIRT3 in Adipose Tissue
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  32. NAD+: A key metabolic regulator with great therapeutic potential
    Ghazal Sultani, Azrah Samsudeen, Brenna Osborne, Nigel A. Turner · 2017 · Journal of Neuroendocrinology
  33. The sirtuin class of histone deacetylases: Regulation and roles in lipid metabolism
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  34. CD147: a small molecule transporter ancillary protein at the crossroad of multiple hallmarks of cancer and metabolic reprogramming
    Agnieszka A. Kendrick, Johnathon B. Schafer, Monika Dzieciątkowska, Travis G. Nemkov, Angelo D’Alessandro, Deepika Neelakantan, Heide L. Ford, Chad G. Pearson, Colin D. Weekes, Kirk Charles Hansen et al. · 2016 · Oncotarget
  35. SIRT3 regulates mitochondrial biogenesis in aging-related diseases
    Hongyan Li, Zhiyou Cai · 2022 · Journal of Biomedical Research
  36. Sirtuins-Mediated System-Level Regulation of Mammalian Tissues at the Interface between Metabolism and Cell Cycle: A Systematic Review
    Parcival Maissan, Eva Mooij, Matteo Barberis · 2021 · Biology
  37. Regulation of mitochondrial trifunctional protein modulates nonalcoholic fatty liver disease in mice
    Fatiha Nassir, Justin J. Arndt, Sarah A. Johnson, Jamal A. Ibdah · 2018 · Journal of Lipid Research
  38. Mono-(2-ethylhexyl) Phthalate Aggravates Inflammatory Response via Sirtuin Regulation and Inflammasome Activation in RAW 264.7 Cells
    Min Hi Park, Ana K. Gutiérrez-García, Mahua Choudhury · 2019 · Chemical Research in Toxicology
  39. EX-527 Prevents the Progression of High-Fat Diet-Induced Hepatic Steatosis and Fibrosis by Upregulating SIRT4 in Zucker Rats
    Amit B. Kundu, Prasanta Kumar Dey, Jae Hyeon Park, In Su Kim, Seung Jun Kwack, Hyung Sik Kim · 2020 · Cells
  40. Are sirtuin deacylase enzymes important modulators of mitochondrial energy metabolism?
    Brenna Osborne, Gregory James Cooney, Nigel A. Turner · 2013 · Biochimica et Biophysica Acta (BBA) - General Subjects
  41. Nutrient sensing by the mitochondrial transcription machinery dictates oxidative phosphorylation
    Lijun Liu, Minwoo Nam, Wei Fan, Thomas E. Akie, David C. Hoaglin, Guangping Gao, John F. Keaney, Marcus P. Cooper · 2014 · Journal of Clinical Investigation
  42. Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructose
    Jesse G. Meyer, Samir Softic, Nathan Basisty, Matthew J. Rardin, Eric M. Verdin, Bradford W. Gibson, Olga Ilkayeva, Christopher B. Newgard, C. Ronald Kahn, Birgit Schilling · 2018 · PLoS ONE
  43. Reduced hepatic mitochondrial respiration following acute high-fat diet is prevented by PGC-1α overexpression
    E. Matthew Morris, Matthew R. Jackman, Grace Margaret-Eleanor Meers, Ginger C. Johnson, Jordan L. Lopez, Paul S. MacLean, John P. Thyfault · 2013 · American Journal of Physiology-Gastrointestinal and Liver Physiology
  44. Chaperonin counteracts diet-induced non-alcoholic fatty liver disease by aiding sirtuin 3 in the control of fatty acid oxidation
    Shao‐Wen Weng, Jian‐Ching Wu, Feng‐Chih Shen, Yen‐Hsiang Chang, Yu‐Jih Su, Wei‐Shiung Lian, Ming‐Hong Tai, Chia‐Hao Su, Jiin‐Haur Chuang, Tsu‐Kung Lin et al. · 2023 · Diabetologia
  45. Targeting sirtuins for the treatment of diabetes
    Frank K. Huynh, Kathleen A. Hershberger, Matthew D. Hirschey · 2013 · Diabetes Management
  46. SIRT3 Overexpression Attenuates Palmitate-Induced Pancreatic β-Cell Dysfunction
    Min Kim, Ji Seon Lee, Joo En Oh, Jinyan Nan, Hakmo Lee, Hye Seung Jung, Sung Soo Chung, Kyong Soo Park · 2015 · PLoS ONE
  47. Sirtuin-3 Promotes Adipogenesis, Osteoclastogenesis, and Bone Loss in Aging Male Mice
    Linh Ho, Liping Wang, Theresa Roth, Yong Pan, Eric M. Verdin, Edward Chiaming Hsiao, Robert A. Nissenson · 2017 · Endocrinology
  48. NAD + -dependent deacetylase SIRT3 in adipocytes is dispensable for maintaining normal adipose tissue mitochondrial function and whole body metabolism
    Lane C. Porter, Michael P. Franczyk, Terri Pietka, Shintaro Yamaguchi, Jonathan B. Lin, Yo Sasaki, Eric M. Verdin, Rajendra S. Apte, Jun Yoshino · 2018 · American Journal of Physiology-Endocrinology and Metabolism
  49. Impact of nutrient overload on metabolic homeostasis
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  50. Mechanism of Action of Ketogenic Diet Treatment: Impact of Decanoic Acid and Beta—Hydroxybutyrate on Sirtuins and Energy Metabolism in Hippocampal Murine Neurons
    Partha Dabke, Anibh Martin Das · 2020 · Nutrients
  51. Regulation and protection of mitochondrial physiology by sirtuins
    Cláudia V. Pereira, Magdalena Lebiedzińska, Mariusz Roman Wieckowski, Paulo Jorge Oliveira · 2011 · Mitochondrion
  52. The interplay between oxidative stress and bioenergetic failure in neuropsychiatric illnesses: can we explain it and can we treat it?
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  53. Nicotinamide Adenine Dinucleotide in Aging Biology: Potential Applications and Many Unknowns
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  54. Mitochondrion as a Target for Heart Failure Therapy – Role of Protein Lysine Acetylation –
    Chi Fung Lee, Rong Tian · 2015 · Circulation Journal
  55. Caffeine ameliorates high energy diet-induced hepatic steatosis: sirtuin 3 acts as a bridge in the lipid metabolism pathway
    Shijie Zhang, Yi-Fang Li, Guo-En Wang, Ruirong Tan, Bun Tsoi, Gaowei Mao, Yu-Jia Zhai, Lingfang Cao, Min Chen, Hiroshi Kurihara et al. · 2015 · Food & Function
  56. Post-Translational Modification of Proteins in Toxicological Research: Focus on Lysine Acylation
    Sangkyu Lee · 2013 · Toxicological Research
  57. Hepatic NAD+ levels and NAMPT abundance are unaffected during prolonged high-fat diet consumption in C57BL/6JBomTac mice
    Morten Dall, Melanie Penke, Karolina Sulek, Madlen Matz‐Soja, Birgitte Holst, Antje Garten, Wieland Kieß, Jonas T. Treebak · 2018 · Molecular and Cellular Endocrinology
  58. Uridine prevents tamoxifen-induced liver lipid droplet accumulation
    Thuc T. Le, Yasuyo Urasaki, Giuseppe Pizzorno · 2014 · BMC Pharmacology and Toxicology
  59. Sirtuins: The NAD + -Dependent Multifaceted Modulators of Inflammation
    Leonardo Santos, Andrés Benítez-Rosendo, Mariana Bresque, Juliana Camacho-Pereira, Aldo J. Calliari, Carlos Escande · 2023 · Antioxidants and Redox Signaling
  60. PFOS Modulates Interactive Epigenetic Regulation in First-Trimester Human Trophoblast Cell Line HTR-8/SVneo
    Ravi Sonkar, Matthew Kay, Mahua Choudhury · 2019 · Chemical Research in Toxicology
  61. Protein acetylation in mitochondria plays critical functions in the pathogenesis of fatty liver disease
    Zhang Le-tian, Hu Cheng-zhang, Xuan Zhang, Qin Zhang, Zhengui Yan, Qingqing Wei, Wang Sheng-xuan, Zhongjin Xu, Ranran Li, Liu Ting-jun et al. · 2020 · BMC Genomics
  62. Metabolic effects of lactoferrin during energy restriction and weight regain in diet-induced obese mice
    Jin Ping Shi, Piet Finckenberg, Essi Martonen, Anu Ahlroos-Lehmus, Taru K. Pilvi, Riitta Korpela, Eero M. A. Mervaala · 2011 · Journal of Functional Foods
  63. Cardiomyocyte-specific deletion of GCN5L1 in mice restricts mitochondrial protein hyperacetylation in response to a high fat diet
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  64. The mitochondrial NAD+ transporter SLC25A51 is a fasting-induced gene affecting SIRT3 functions
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  65. Role of Argininosuccinate Synthase 1 ‐Dependent L‐Arginine Biosynthesis in the Protective Effect of Endothelial Sirtuin 3 Against Atherosclerosis
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  72. Gut microbiota and sirtuins in obesity-related inflammation and bowel dysfunction
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  74. Mitochondrial General Control of Amino Acid Synthesis 5 Like 1 Regulates Glutaminolysis, Mammalian Target of Rapamycin Complex 1 Activity, and Murine Liver Regeneration
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