Cited by 76Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationCancer-related Molecular Pathways

Co-ordination of cell cycle and differentiation in the developing nervous system

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Hindley, Christopher, Philpott, Anna·2012·Biochemical Journal

Abstract

During embryonic development, cells must divide to produce appropriate numbers, but later must exit the cell cycle to allow differentiation. How these processes of proliferation and differentiation are co-ordinated during embryonic development has been poorly understood until recently. However, a number of studies have now given an insight into how the cell cycle machinery, including cyclins, CDKs (cyclin-dependent kinases), CDK inhibitors and other cell cycle regulators directly influence mechanisms that control cell fate and differentiation. Conversely, examples are emerging of transcriptional regulators that are better known for their role in driving the differentiated phenotype, which also play complementary roles in controlling cell cycle progression. The present review will summarise our current understanding of the mechanisms co-ordinating the cell cycle and differentiation in the developing nervous system, where these links have been, perhaps, most extensively studied.

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  • DYRK1A can phosphorylate and possibly regulate Cyclin D1 (G1-to-S phase transition and cell proliferation) and p27 (neuronal differentiation and cell cycle exit).

    “This mechanism of action could be attributed to the ability of DYRK1A to phosphorylate and possibly regulate Cyclin D1 (G1-to-S phase transition and cell proliferation) and p27 (neuronal differentiation and cell cycle exit) (Frank and Tsai, 2009; Hindley and Philpott, 2012; Najas et al., 2015; Tejedor and Hammerle, 2011).”

    From Sex-specific developmental alterations in DYRK1A expression in the brain of a Down syndrome mouse model (2024) · cites this paper as Hindley and Philpott, 2012

    The Cyclins and CDKis sections (page numbers unavailable) link cyclin D1 to proliferation and p27kip1 to neuronal differentiation and cell-cycle exit. They do not say that DYRK1A phosphorylates or regulates either protein, so the proposed mechanism is not supported by this source. (LLM, conf=0.85)

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  1. [20]Sun W. Lee D. K. Lee C. C. Kim K. Differential expression of D-type G1 cyclins during mouse development and liver regeneration in vivo Mol. Reprod. Dev. 1996 43 414 420 9052931

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Authors
Hindley, C., & Philpott, A.
Affiliations
University of Cambridge (GB)
Corresponding author
Philpott, Anna
Venue
Biochemical Journal
Published
2012-05-29
Volume
444
Issue
3
Pages
375-382
ISSN
  • 0264-6021 (ISSN-L)
  • 1470-8728
OpenAlex
W1993112528
Cited by
76
References
95
Citations by year
2026: 1 · 2025: 4 · 2024: 7 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 1 · 2019: 4 · 2018: 7 · 2017: 6 · 2016: 4 · 2015: 5 · 2014: 12 · 2013: 10 · 2012: 1
FWCI
1.15
Type
journal article
Language
en
Open access
Locations
  • Biochemical Journal (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
  • Cancer Research UK
  • Medical Research Council
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords
cell cycle, neuronal differentiation, brain development, cyclins, cyclin-dependent kinases, cyclin-dependent kinase inhibitors, cell cycle regulators, cell fate, transcription factors, cell proliferation, neurogenesis
MeSH terms
Animals, Cell Cycle, Cell Differentiation, Humans, Nervous System, Embryonic Development, Neurogenesis

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