Cited by 256Metabolism, Diabetes, and CancerCalcium signaling and nucleotide metabolismBiochemical and Molecular Research

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Inositol pyrophosphates: between signalling and metabolism

Wilson, Miranda S. C., Livermore, Thomas M., Saiardi, Adolfo·2013·Biochemical Journal

DOI 10.1042/bj20130118

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Abstract

The present review will explore the insights gained into inositol pyrophosphates in the 20 years since their discovery in 1993. These molecules are defined by the presence of the characteristic 'high energy' pyrophosphate moiety and can be found ubiquitously in eukaryotic cells. The enzymes that synthesize them are similarly well distributed and can be found encoded in any eukaryote genome. Rapid progress has been made in characterizing inositol pyrophosphate metabolism and they have been linked to a surprisingly diverse range of cellular functions. Two decades of work is now beginning to present a view of inositol pyrophosphates as fundamental, conserved and highly important agents in the regulation of cellular homoeostasis. In particular it is emerging that energy metabolism, and thus ATP production, is closely regulated by these molecules. Much of the early work on these molecules was performed in the yeast Saccharomyces cerevisiae and the social amoeba Dictyostelium discoideum, but the development of mouse knockouts for IP6K1 and IP6K2 [IP6K is IP6 (inositol hexakisphosphate) kinase] in the last 5 years has provided very welcome tools to better understand the physiological roles of inositol pyrophosphates. Another recent innovation has been the use of gel electrophoresis to detect and purify inositol pyrophosphates. Despite the advances that have been made, many aspects of inositol pyrophosphate biology remain far from clear. By evaluating the literature, the present revi…

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Authors: Wilson, M. S. C., Livermore, T. M., & Saiardi, A.
Affiliations: MRC Laboratory for Molecular Cell Biology (GB)
ORCID: Wilson, Miranda S. C.
Saiardi, Adolfo
Venue: Biochemical Journal
Publisher: Portland Press Ltd.
Published: 2013-05-31
Volume: 452
Issue: 3
Pages: 369-379
ISSN: 0264-6021 (ISSN-L)
1470-8728
DOI: 10.1042/bj20130118
OpenAlex: W1990899386
Cited by: 256
References: 122
Citations by year: 2026: 7 · 2025: 16 · 2024: 14 · 2023: 20 · 2022: 18 · 2021: 19 · 2020: 25 · 2019: 25 · 2018: 15 · 2017: 23 · 2016: 28 · 2015: 24 · 2014: 15 · 2013: 7
FWCI: 2.32
Type: journal article
Language: en
Open access: closed
Locations: Biochemical Journal (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: Medical Research Council (MC_UU_12018/4)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
Keywords: inositol pyrophosphates, phytic acid, IP6K1, energy metabolism, cellular homeostasis, ATP production, Saccharomyces cerevisiae, Dictyostelium discoideum, mouse knockout models
MeSH terms: Animals, Energy Metabolism, Humans, Inositol Phosphates, Diphosphates, Signal Transduction, Phosphotransferases (Phosphate Group Acceptor)

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Inositol pyrophosphates: between signalling and metabolism

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