The DOI matches its Crossref record; 121 of the 122 references it cites were found in a registry or an index.
Inositol pyrophosphates: between signalling and metabolism
Abstract
The present review will explore the insights gained into inositol pyrophosphates in the 20 years since their discovery in 1993. These molecules are defined by the presence of the characteristic 'high energy' pyrophosphate moiety and can be found ubiquitously in eukaryotic cells. The enzymes that synthesize them are similarly well distributed and can be found encoded in any eukaryote genome. Rapid progress has been made in characterizing inositol pyrophosphate metabolism and they have been linked to a surprisingly diverse range of cellular functions. Two decades of work is now beginning to present a view of inositol pyrophosphates as fundamental, conserved and highly important agents in the regulation of cellular homoeostasis. In particular it is emerging that energy metabolism, and thus ATP production, is closely regulated by these molecules. Much of the early work on these molecules was performed in the yeast Saccharomyces cerevisiae and the social amoeba Dictyostelium discoideum, but the development of mouse knockouts for IP6K1 and IP6K2 [IP6K is IP6 (inositol hexakisphosphate) kinase] in the last 5 years has provided very welcome tools to better understand the physiological roles of inositol pyrophosphates. Another recent innovation has been the use of gel electrophoresis to detect and purify inositol pyrophosphates. Despite the advances that have been made, many aspects of inositol pyrophosphate biology remain far from clear. By evaluating the literature, the present revi…
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“I(1,4,5)P3 is also a substrate for the synthesis of inositol polyphosphates including pyro-phosphates such as IP7 and IP8 which are recognised as signalling molecules, including metabolic messengers or energy sensors [50].”
From Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane (2020) · cites this paper as [50]
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Research works printed but not linked: 1
- Resnick, 2009, Inositol phosphates, 1
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Inositol Pyrophosphate InsP8 Acts as an Intracellular Phosphate Signal in Arabidopsis
Dong, J., Ma, G., Sui, L., Wei, M., Satheesh, V., Zhang, R., Ge, S., Li, J., Zhang, T., Wittwer, C., et al. (2019) · Molecular Plant · doi:10.1016/j.molp.2019.08.002 · Cited by 274
An inside-out origin for the eukaryotic cell
Baum, D., & Baum, B. (2014) · BMC Biology · doi:10.1186/s12915-014-0076-2 · Cited by 218
THOMAS, M. P., Mills, S. J., & Potter, B. V. L. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201502227 · Cited by 191
Protein Polyphosphorylation of Lysine Residues by Inorganic Polyphosphate
Azevedo, C., Livermore, T. M., & Saiardi, A. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.02.010 · Cited by 186
Self-citationPhosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane
Katan, M., & Cockcroft, S. (2020) · Essays in Biochemistry · doi:10.1042/ebc20200041 · Cited by 176
Metadata
- Authors
- Wilson, M. S. C., Livermore, T. M., & Saiardi, A.
- Affiliations
- MRC Laboratory for Molecular Cell Biology (GB)
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 2013-05-31
- Volume
- 452
- Issue
- 3
- Pages
- 369-379
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W1990899386
- Cited by
- 256
- References
- 122
- Citations by year
- 2026: 7 · 2025: 16 · 2024: 14 · 2023: 20 · 2022: 18 · 2021: 19 · 2020: 25 · 2019: 25 · 2018: 15 · 2017: 23 · 2016: 28 · 2015: 24 · 2014: 15 · 2013: 7
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical Journal (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Medical Research Council (MC_UU_12018/4)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Keywords
- inositol pyrophosphates, phytic acid, IP6K1, energy metabolism, cellular homeostasis, ATP production, Saccharomyces cerevisiae, Dictyostelium discoideum, mouse knockout models
- MeSH terms
- Animals, Energy Metabolism, Humans, Inositol Phosphates, Diphosphates, Signal Transduction, Phosphotransferases (Phosphate Group Acceptor)
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