Back in the Water: The Return of the Inositol Phosphates
Abstract
Following the discovery of inositol-1,4,5-trisphosphate as a second messenger, many other inositol phosphates were discovered in quick succession, with some understanding of their synthesis pathways and a few guesses at their possible functions. But then it all seemed to go comparatively quiet, with an explosion of interest in the inositol lipids. Now the water-soluble phase is once again becoming a focus of interest. Old and new data point to a new vista of inositol phosphates, with functions in many diverse aspects of cell biology, such as ion-channel physiology, membrane dynamics and nuclear signalling.
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Traditionally, InsP3 derived from PIP2 by PLC has been considered the primary precursor for InsP4 production.
“Traditionally, InsP3, derived from Phosphatidylinositol 4,5-bisphosphate (PIP2) by phospholipase C (PLC), has been considered the primary precursor for InsP4 (InsP 1,4,5,6) production [37].”
From From Obscurity to Prominence: IPMK’s Expanding Role in Cellular Signaling, Physiology, and Disease (2025) · cites this paper as [37]
Cites
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Mechanism of auxin perception by the TIR1 ubiquitin ligase
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Single‐Cell Insights Into Macrophage Subtypes in Pulmonary Infections
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From Obscurity to Prominence: IPMK’s Expanding Role in Cellular Signaling, Physiology, and Disease
Mishra, S. H., Chatterjee, S., Viera-Preval, L., & Guha, P. (2025) · Biomolecules · doi:10.3390/biom15091266 · Cited by 1 · see citing works
“Traditionally, InsP3, derived from Phosphatidylinositol 4,5-bisphosphate (PIP2) by phospholipase C (PLC), has been considered the primary precursor for InsP4 (InsP 1,4,5,6) production [37].”
- Authors
- Irvine, R. F., & Schell, M. J.
- Affiliations
- University of Cambridge (GB)
- ORCID
- Schell, Michael J.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2001-05
- Volume
- 2
- Issue
- 5
- Pages
- 327-338
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2146718650
- Cited by
- 659
- References
- 3
- Citations by year
- 2026: 7 · 2025: 22 · 2024: 16 · 2023: 19 · 2022: 16 · 2021: 30 · 2020: 30 · 2019: 30 · 2018: 18 · 2017: 24 · 2016: 24 · 2015: 31 · 2014: 22 · 2013: 29 · 2012: 25
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- inositol phosphates, inositol 1,4,5-trisphosphate, second messengers, inositol lipid signaling, ion channel modulation, membrane dynamics, nuclear signalling
- MeSH terms
- Animals, Eukaryotic Cells, Humans, Inositol Phosphates, Water, Signal Transduction
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