Cited by 173Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic DiseasesPeroxisome Proliferator-Activated Receptors

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Brown adipose tissue: development, metabolism and beyond

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Schulz, Tim J., Tseng, Yu-Hua·2013·Biochemical Journal

DOI 10.1042/bj20130457PMC PMC3887508

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Abstract

Obesity represents a major risk factor for the development of several of our most common medical conditions, including Type 2 diabetes, dyslipidaemia, non-alcoholic fatty liver, cardiovascular disease and even some cancers. Although increased fat mass is the main feature of obesity, not all fat depots are created equal. Adipocytes found in white adipose tissue contain a single large lipid droplet and play well-known roles in energy storage. By contrast, brown adipose tissue is specialized for thermogenic energy expenditure. Owing to its significant capacity to dissipate energy and regulate triacylglycerol (triglyceride) and glucose metabolism, and its demonstrated presence in adult humans, brown fat could be a potential target for the treatment of obesity and metabolic syndrome. Undoubtedly, fundamental knowledge about the formation of brown fat and regulation of its activity is imperatively needed to make such therapeutics possible. In the present review, we integrate the recent advancements on the regulation of brown fat formation and activity by developmental and hormonal signals in relation to its metabolic function.

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Authors: Schulz, T. J., & Tseng, Y.-H.
Affiliations: German Institute of Human Nutrition (DE)
Joslin Diabetes Center (US)
ORCID: Schulz, Tim J.
Tseng, Yu-Hua
Venue: Biochemical Journal
Publisher: Portland Press Ltd.
Published: 2013-06-28
Volume: 453
Issue: 2
Pages: 167-178
ISSN: 0264-6021 (ISSN-L)
1470-8728
DOI: 10.1042/bj20130457
PMC: PMC3887508
OpenAlex: W2023674811
Cited by: 173
References: 157
Citations by year: 2026: 6 · 2025: 13 · 2024: 11 · 2023: 10 · 2022: 8 · 2021: 18 · 2020: 19 · 2019: 18 · 2018: 15 · 2017: 14 · 2016: 11 · 2015: 12 · 2014: 14 · 2013: 4
FWCI: 1.50
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Biochemical Journal (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R01DK077097, P30DK036836)
Topics: Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords: brown adipose tissue, thermogenesis, energy expenditure, obesity, metabolic syndrome, white adipose tissue, hormonal regulation, glucose metabolism, triglyceride metabolism, obesity treatment
MeSH terms: Animals, Adipose Tissue, Brown, Humans, Metabolic Diseases, Obesity, Stem Cells, Thermogenesis

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Brown adipose tissue: development, metabolism and beyond

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