The DOI matches its Crossref record; 155 of the 157 references it cites were found in a registry or an index.
Brown adipose tissue: development, metabolism and beyond
Open accessAbstract
Obesity represents a major risk factor for the development of several of our most common medical conditions, including Type 2 diabetes, dyslipidaemia, non-alcoholic fatty liver, cardiovascular disease and even some cancers. Although increased fat mass is the main feature of obesity, not all fat depots are created equal. Adipocytes found in white adipose tissue contain a single large lipid droplet and play well-known roles in energy storage. By contrast, brown adipose tissue is specialized for thermogenic energy expenditure. Owing to its significant capacity to dissipate energy and regulate triacylglycerol (triglyceride) and glucose metabolism, and its demonstrated presence in adult humans, brown fat could be a potential target for the treatment of obesity and metabolic syndrome. Undoubtedly, fundamental knowledge about the formation of brown fat and regulation of its activity is imperatively needed to make such therapeutics possible. In the present review, we integrate the recent advancements on the regulation of brown fat formation and activity by developmental and hormonal signals in relation to its metabolic function.
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“Three types of adipose tissues have been identified so far: The WAT [218], the BAT [219,220], and the beige or brite (brown in white) adipose tissue (BIWAT) [220].”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [219]
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“Interestingly, this study also demonstrated the presence of a common lineage of progenitor cells that expresses the myogenic transcription factor Myf5 and that can give rise to interscapular cBAT as well as skeletal muscle [30].”
BackgroundInfluential
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Cited by
Sorted by citations
Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases
Demine, S., Renard, P., & Arnould, T. (2019) · Cells · doi:10.3390/cells8080795 · Cited by 476
Peirce, V. J., Carobbio, S., & Vidal‐Puig, A. (2014) · Nature · doi:10.1038/nature13477 · Cited by 430
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Metadata
- Authors
- Schulz, T. J., & Tseng, Y.-H.
- Affiliations
- German Institute of Human Nutrition (DE)
- Joslin Diabetes Center (US)
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 2013-06-28
- Volume
- 453
- Issue
- 2
- Pages
- 167-178
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- PMC
- PMC3887508
- OpenAlex
- W2023674811
- Cited by
- 173
- References
- 157
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 11 · 2023: 10 · 2022: 8 · 2021: 18 · 2020: 19 · 2019: 18 · 2018: 15 · 2017: 14 · 2016: 11 · 2015: 12 · 2014: 14 · 2013: 4
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biochemical Journal (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK077097, P30DK036836)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- brown adipose tissue, thermogenesis, energy expenditure, obesity, metabolic syndrome, white adipose tissue, hormonal regulation, glucose metabolism, triglyceride metabolism, obesity treatment
- MeSH terms
- Animals, Adipose Tissue, Brown, Humans, Metabolic Diseases, Obesity, Stem Cells, Thermogenesis
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