An essential role for functional lysosomes in ferroptosis of cancer cells

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691

Regulation of Ferroptotic Cancer Cell Death by GPX4

Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3064 · Cited by 3,732

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

DeNicola, G. M., Karreth, F. A., Humpton, T. J., Gopinathan, A., Wei, C., Frese, K., Mangal, D., Yu, K. H., Yeo, C. J., Calhoun, E. S., et al. (2011) · Nature · doi:10.1038/nature10189 · Cited by 2,277

Two to tango: Regulation of Mammalian iron metabolism

Hentze, M. W., Muckenthaler, M. U., Galy, B., & Camaschella, C. (2010) · Cell · doi:10.1016/j.cell.2010.06.028 · Cited by 2,120

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

Mancias, J. D., Wang, X., Gygi, S. P., Harper, J. W., & Kimmelman, A. C. (2014) · Nature · doi:10.1038/nature13148 · Cited by 2,084

A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology

Pagliarini, D. J., Calvo, S. E., Chang, B., Sheth, S. A., Vafai, S. B., Ong, S.-E., Walford, G. A., Sugiana, C., Boneh, A., Chen, W. K., et al. (2008) · Cell · doi:10.1016/j.cell.2008.06.016 · Cited by 1,994

Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells.

Yang, W. S., & Stockwell, B. R. (2008) · Chemistry & Biology · doi:10.1016/j.chembiol.2008.02.010 · Cited by 1,876

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

Weinberg, F., Hamanaka, R., Wheaton, W. W., Weinberg, S., Joseph, J., Lopez, M., Kalyanaraman, B., Mutlu, G. M., Budinger, G. R. S., & Chandel, N. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003428107 · Cited by 1,742

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

Berghe, T. V., Linkermann, A., Jouan-Lanhouet, S., Walczak, H., & Vandenabeele, P. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3737 · Cited by 1,735

Molecular mechanisms of ferroptosis and its antitumor applications in natural products

Yu, D., Wang, Q., Zhang, Q., Cai, M., Liu, S., & Zhang, W. (2023) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2023120 · Cited by 30

Insights Into Ferroptosis, a Novel Target for the Therapy of Cancer

Wang, H., Ju, J., Wang, S., Zhang, Y., Liu, C.-Y., Wang, T., Yu, X. M., Wang, F., Cheng, X.-R., Wang, K., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.812534 · Cited by 30

Epithelial-mesenchymal transition promotes metabolic reprogramming to suppress ferroptosis

Guo, W., Duan, Z., Wu, J., & Zhou, B. P. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.02.013 · Cited by 33

Iron Transporters and Ferroptosis in Malignant Brain Tumors

Zhao, J., Wang, Y., Tao, L., & Chen, L. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.861834 · Cited by 28

Emerging field: O-GlcNAcylation in ferroptosis

Zhang, H., Zhang, J., Dong, H., Kong, Y., & Guan, Y. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1203269 · Cited by 27

Recent Advances of Fluorescence Probes for Imaging of Ferroptosis Process

Li, H., An, Y., Gao, J., Yang, M., Luo, J., Li, X., Lv, J., Lv, J., Yuan, Z., & Ma, H. (2022) · Chemosensors · doi:10.3390/chemosensors10060233 · Cited by 27

Insight into the Double-Edged Role of Ferroptosis in Disease

Zhang, L., Jia, R., Li, H., Yu, H., Ren, K., Jia, S., Li, Y., & Wang, Q. (2021) · Biomolecules · doi:10.3390/biom11121790 · Cited by 26

Engaging the Lysosome and Lysosome-Dependent Cell Death in Cancer

Berg, A. L., Rowson-Hodel, A. R., Wheeler, M. R., Hu, M., Free, S. R., & Carraway, K. L. (2022) · Exon Publications eBooks · doi:10.36255/exon-publications-breast-cancer-lysosome · Cited by 26

The key roles of organelles and ferroptosis in Alzheimerʼs disease

Long, H., Cheng, Y., Zhou, Z., Luo, H., Wen, D., & Gao, L. (2022) · Journal of Neuroscience Research · doi:10.1002/jnr.25033 · Cited by 28

A comprehensive review of the relationship between autophagy and sorafenib-resistance in hepatocellular carcinoma: ferroptosis is noteworthy

Zhang, K., Zhang, Q., Jia, R., Xiang, S., & Xu, L. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1156383 · Cited by 25

Live-cell imaging with fluorogenic radical-trapping antioxidant probes reveals the onset and progression of ferroptosis

Xu, L., Zhang, W., Sánchez-Tejeda, J. F., Holovan, D., McCain, J., Lovell, T. C., & Cosa, G. (2025) · Nature Chemistry · doi:10.1038/s41557-025-01966-x · Cited by 25

Ferroptosis in Glioma Immune Microenvironment: Opportunity and Challenge

Wang, K., Wang, J., Zhang, J., Zhang, A., Liu, Y., Zhou, J., Wang, X., & Zhang, J. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.917634 · Cited by 27

Heterogeneity of ferrous iron‐containing endolysosomes and effects of endolysosome iron on endolysosome numbers, sizes, and localization patterns

Halcrow, P. W., Kumar, N., Afghah, Z., Fischer, J. P., Khan, N., Chen, X., Meucci, O., & Geiger, J. D. (2022) · Journal of Neurochemistry · doi:10.1111/jnc.15583 · Cited by 23

Autophagy-modulating biomembrane nanostructures: A robust anticancer weapon by modulating the inner and outer cancer environment

Zhang, X., Zhang, M., Cui, H., Zhang, T., Wu, L., Xu, C., Yin, C., & Gao, J. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.12.032 · Cited by 25

Clozapine-N-oxide protects dopaminergic neurons against rotenone-induced neurotoxicity by preventing ferritinophagy-mediated ferroptosis

Sun, Q., Wang, Y., Hou, L., Li, S., Hong, J.-S., Wang, Q., & Zhao, J. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.12.045 · Cited by 25

Defining a pharmacological inhibitor fingerprint for oxytosis/ferroptosis

Soriano‐Castell, D., Currais, A. J. M., & Maher, P. A. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.05.023 · Cited by 22

Identification of novel neuroprotective N,N-dimethylaniline derivatives that prevent oxytosis/ferroptosis and localize to late endosomes and lysosomes

Hirata, Y., Tsunekawa, Y., Takahashi, M., Oh‐hashi, K., Kawaguchi, K., Hayazaki, M., Watanabe, M., Koga, K.-I., Hattori, Y., Takemori, H., et al. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.08.015 · Cited by 22

Die hard: cell death mechanisms and their implications in nanotoxicology

Lomphithak, T., & Fadeel, B. (2023) · Toxicological Sciences · doi:10.1093/toxsci/kfad008 · Cited by 24

High-Dose Exposure to Polymer-Coated Iron Oxide Nanoparticles Elicits Autophagy-Dependent Ferroptosis in Susceptible Cancer Cells

Lomphithak, T., Helvacioglu, S., Armenia, I., Keshavan, S., Ovejero, J. G., Baldi, G., Ravagli, C., Grazú, V., & Fadeel, B. (2023) · Nanomaterials · doi:10.3390/nano13111719 · Cited by 23

LC3-associated phagocytosis of neutrophils triggers tumor ferroptotic cell death in glioblastoma

Lu, T., Yee, P. P., Chih, S. Y., Tang, M., Chen, H., Aregawi, D. G., Glantz, M., Zacharia, B. E., Wang, H., & Li, W. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00130-4 · Cited by 20

Susceptibility to erastin‐induced ferroptosis decreases during maturation in a human oligodendrocyte cell line

Hoshino, T., Yamakado, H., Takahashi, R., & Matsuzawa, S. (2020) · FEBS Open Bio · doi:10.1002/2211-5463.12923 · Cited by 20

Emerging Role of Autophagy in the Development and Progression of Oral Squamous Cell Carcinoma

El-Aziz, Y. S. A., Leck, L. Y. W., Jansson, P. J., & Sahni, S. (2021) · Cancers · doi:10.3390/cancers13246152 · Cited by 22

Ferroptosis and its implications in bone-related diseases

Wang, Z., Yan, Q., Wang, Z., Hu, Z., Wang, C., Zhang, X., Gao, X., Bai, X., Chen, X., Zhang, L., et al. (2024) · PeerJ · doi:10.7717/peerj.18626 · Cited by 23

Targeting ferroptosis as a cell death pathway in Melanoma: From molecular mechanisms to skin cancer treatment

Tavakoli, G. M., Mirzapour, M. H., Razi, S., & Rezaei, N. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110215 · Cited by 20

A CRISPR-Cas9 library screening identifies CARM1 as a critical inhibitor of ferroptosis in hepatocellular carcinoma cells

Cheng, Y., Wang, X., Huang, S., Zhang, L., Lan, B., Li, X., Chen, X., Liu, Z., Su, Y., Xi, L., et al. (2023) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2023.102063 · Cited by 20

Mechanisms of Action of AGuIX as a Pan-Cancer Nano-Radiosensitizer: A Comprehensive Review

Aubrun, C., Doussineau, T., Carmès, L., Meyzaud, A., Boux, F., Dufort, S., Delfour, A., de Beaumont, O., Mirjolet, C., & Duc, G. L. (2025) · Pharmaceuticals · doi:10.3390/ph18040519 · Cited by 19

Ferroptosis: opening up potential targets for gastric cancer treatment

Li, Y., Liu, J., Wu, S., Xiao, J., & Zhang, Z. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04886-x · Cited by 18

Can diallyl trisulfide, a dietary garlic-derived compound, activate ferroptosis to overcome therapy resistance in prostate cancer?

Samy, A. L. P. A., Shah, D., Shahagadkar, P., Shah, H., & Munirathinam, G. (2021) · Nutrition and Health · doi:10.1177/02601060211018360 · Cited by 18

Mechanism of ferroptosis in heart failure: The role of the RAGE/TLR4-JNK1/2 pathway in cardiomyocyte ferroptosis and intervention strategies

Zhang, Z., Yang, Z., Wang, S., Wang, X., & Mao, J. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102770 · Cited by 18

Targeting FSP1 to induce ferroptosis in chromophobe renal cell carcinoma

Salem, S., Han, T., Alchoueiry, M., Mahmoud, N., Bzeih, W., Chami, J., Khabibullin, D., Mansour, H., Tang, Y., Ho, T. H., et al. (2025) · Oncogene · doi:10.1038/s41388-025-03562-2 · Cited by 20

2,2,6,6-Tetramethylpiperidine-1-oxyl acts as a volatile inhibitor of ferroptosis and neurological injury

Mizuno, H., Kubota, C., Takigawa, Y., Shintoku, R., Kannari, N., Muraoka, T., Obinata, H., Yoshimoto, Y., Kanazawa, M., Koshiishi, I., et al. (2022) · The Journal of Biochemistry · doi:10.1093/jb/mvac044 · Cited by 17

Surveying the landscape of emerging and understudied cell death mechanisms

Leak, L. B., & Dixon, S. J. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2023.119432 · Cited by 18

Carboranyl-1,8-naphthalimide intercalators induce lysosomal membrane permeabilization and ferroptosis in cancer cell lines

Rykowski, S., Gurda, D., Fedoruk‐Wyszomirska, A., Orlicka-Płocka, M., Kowalczyk, A., Stączek, P., Denel‐Bobrowska, M., Biniek-Antosiak, K., Rypniewski, W. R., Wyszko, E., et al. (2023) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2023.2171028 · Cited by 17

Natural products and ferroptosis: A novel approach for heart failure management

Zhang, Z., Yang, Z., Wang, S., Wang, X., & Mao, J. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156783 · Cited by 17

The mechanism and progress of ferroptosis in pancreatic cancer

Bao, Z., Hou, X.-B., Li, H.-L., Mao, Y., & Wang, W. (2022) · Acta Histochemica · doi:10.1016/j.acthis.2022.151919 · Cited by 17

Discovery of a NCOA4 Degrader for Labile Iron-Dependent Ferroptosis Inhibition

Ji, J., Jin, Y., Ma, S., Zhu, Y., Bi, X., You, Q., & Jiang, Z. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c00403 · Cited by 18

Botanical sulfane sulfur donors inhibit ferroptotic cell death caused by the depletion of cysteine

Nagai, S., Yoshida, M., Takigawa, Y., Torii, S., & Koshiishi, I. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.128511 · Cited by 16

Imaging of Mitophagy Enabled by an Acidity-Reporting Probe Anchored on the Mitochondrial Inner Membrane

Wen, S., Hu, X. X., Shi, Y., Han, J., & Han, S. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c03881 · Cited by 16

Current insights into the functional roles of ferroptosis in musculoskeletal diseases and therapeutic implications

Zhang, F., Yan, Y., Cai, Y., Liang, Q., Liu, Y., Peng, B., Xu, Z., & Liu, W. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1112751 · Cited by 16

Improving ferroptosis-mediated immunotherapy for colorectal cancer through lysosome-targeted photodynamic therapy

Chen, Z., Wang, Y., Li, Z., Chen, M., Li, Y., Lu, C., Lin, Z., Zheng, H., Chen, L., & Zhang, Q. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101552 · Cited by 15

A Novel Ferroptosis-Related Gene Model for Overall Survival Predictions of Bladder Urothelial Carcinoma Patients

Zhang, M., Zhang, X., Yu, M., Zhang, W., Zhang, D., Zeng, S., Wang, X., & Hu, X. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.698856 · Cited by 15

Role of CELF2 in ferroptosis: Potential targets for cancer therapy (Review)

Li, J., Xian, L., Zhu, Z., Wang, Y., Zhang, W., Zheng, R., Wang, X., & Li, J. (2023) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2023.5291 · Cited by 15

PPT1 Promotes Growth and Inhibits Ferroptosis of Oral Squamous Cell Carcinoma Cells

Luo, Q., Hu, S., Tang, Y., Yang, D., & Chen, Q. (2024) · Current Cancer Drug Targets · doi:10.2174/0115680096294098240123104657 · Cited by 15

Iron Dyshomeostasis in Neurodegeneration with Brain Iron Accumulation (NBIA): Is It the Cause or the Effect?

Agostini, F., Sgalletta, B., & Bisaglia, M. (2024) · Cells · doi:10.3390/cells13161376 · Cited by 17

Deferiprone ameliorates cisplatin induced peripheral neurotoxicity via ferritinophagy adjustment

Seddiek, H., Hanna, M., Hamoud, A., Elbaset, M. A., Akabawy, A. M. A., Kotb, M. Z., & Khalifa, M. M. (2025) · Scientific Reports · doi:10.1038/s41598-025-87628-x · Cited by 15

Development and validation of a ferroptosis-related prognostic model in pancreatic cancer

Qiu, C., Wang, X., Zheng, Z., Yang, C., Lin, K., Zhang, K., Tu, M., Jiang, K., & Gao, W. (2021) · Investigational New Drugs · doi:10.1007/s10637-021-01114-5 · Cited by 15

Exploring therapeutic strategies for infantile neuronal axonal dystrophy (INAD/PARK14)

Lin, G., Tepe, B., McGrane, G., Tipon, R. C., Croft, G. F., Panwala, L., Hope, A., Liang, A. J., Zuo, Z., Byeon, S. K., et al. (2023) · eLife · doi:10.7554/elife.82555 · Cited by 16

Mechanisms of Ferroptosis and Application to Head and Neck Squamous Cell Carcinoma Treatments

Li, S., Liu, Y., Li, J., Zhao, X. B., & Yu, D. (2021) · DNA and Cell Biology · doi:10.1089/dna.2021.0023 · Cited by 16

Lactoferrin Nanoparticle-Vanadium Complex: A Promising High-Efficiency Agent against Glioblastoma by Triggering Autophagy and Ferroptosis

Gai, S., Yan, Q., Li, S., Zhong, X., Qin, Y., & Jiang, M. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c02696 · Cited by 14

1,4-dihydroxy quininib activates ferroptosis pathways in metastatic uveal melanoma and reveals a novel prognostic biomarker signature

Tonelotto, V., Costa-García, M., O’Reilly, E., Smith, K. F., Slater, K., Dillon, E., Pendino, M., Higgins, C., Sist, P., Bosch, R., et al. (2024) · Cell Death Discovery · doi:10.1038/s41420-023-01773-8 · Cited by 16

Lysosomes as hubs of metabolic sensing and cellular homeostasis

Jain, A., & Zoncu, R. (2026) · Molecular Cell · doi:10.1016/j.molcel.2026.01.011 · Cited by 15

Cell death mechanisms in retinal phototoxicity

Françon, A., & Torriglia, A. (2023) · Journal of Photochemistry and Photobiology · doi:10.1016/j.jpap.2023.100185 · Cited by 13

Sulfiredoxin-1 accelerates erastin-induced ferroptosis in HT-22 hippocampal neurons by driving heme Oxygenase-1 activation

Guo, S., Zhang, D., Dong, Y.-Y., Shu, Y., Wu, X., Ni, Y., Zhao, R., & Ma, W. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.08.008 · Cited by 13

Worms, Fat, and Death: Caenorhabditis elegans Lipid Metabolites Regulate Cell Death

Perez, M. A., & Watts, J. L. (2021) · Metabolites · doi:10.3390/metabo11020125 · Cited by 14

Ferroptosis in glioma treatment: Current situation, prospects and drug applications

Zhou, Y., Fang, C., Xu, H., Yuan, L., Liu, Y., Wang, X., Zhang, A., Shao, A., & Zhou, D. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.989896 · Cited by 16

Deciphering the molecular mechanistic paths describing the chemotherapeutic potential and epigenetic regulation of curcumin in lung cancer: a mini review

Karati, D., Mukherjee, S., & Roy, S. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02838-2 · Cited by 11

Ferroptosis: Regulatory mechanisms and potential targets for bone metabolism: A review

Zhang, Y., Hu, K., Shang, Z., Yang, X., & Cao, L. X. (2024) · Medicine · doi:10.1097/md.0000000000039158 · Cited by 12

Exogenous dihomo-γ-linolenic acid triggers ferroptosis via ACSL4-mediated lipid metabolic reprogramming in acute myeloid leukemia cells

Jiang, X., Huang, Y., Hong, X., Wu, W., Lin, Y., Lin, L., Xue, Y., & Lin, D. (2024) · Translational Oncology · doi:10.1016/j.tranon.2024.102227 · Cited by 12

The Role of AMP-activated Protein Kinase in Oxytosis/Ferroptosis: Protector or Potentiator?

Currais, A. J. M., Kepchia, D., Liang, Z., & Maher, P. A. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0013 · Cited by 12

The Organelle-Specific Regulations and Epigenetic Regulators in Ferroptosis

Zhang, Y., Li, M., Guo, Y., Liu, S., & Tao, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.905501 · Cited by 12

Burgeoning Strategies for Cancer Therapy Based on Ferroptosis Induced by Nanomaterials

Gao, F., Liu, H., Liu, J., & Chen, C. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202511199 · Cited by 11

Iron–Sulfur Cluster Metabolism Impacts Iron Homeostasis, Ferroptosis Sensitivity, and Human Disease

Sviderskiy, V. O., Terzi, E. M., & Possemato, R. (2019) · Springer eBooks · doi:10.1007/978-3-030-26780-3_12 · Cited by 12

Progress in the study of ferroptosis in cancer treatment: State-of-the-Art

Wang, D. (2023) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2023.110348 · Cited by 11

Detection and structural analysis of lipid-derived radicals in vitro and in vivo

Matsuoka, Y., & Yamada, K. (2021) · Free Radical Research · doi:10.1080/10715762.2021.1881500 · Cited by 11

To Betray or to Fight? The Dual Identity of the Mitochondria in Cancer

Zhang, X., Su, Q., Zhou, J., Yang, Z., Liu, Z., Ji, L., Gao, H., & Jiang, G. (2021) · Future Oncology · doi:10.2217/fon-2020-0362 · Cited by 11

Natural Agents Modulating Ferroptosis in Cancer: Molecular Pathways and Therapeutic Perspectives

Amin, M. A., Zehravi, M., Sweilam, S. H., Jahnavi, P., Gupta, J. K., Rajashakar, V., Vodeti, R., Billah, A. A. M., Dharmamoorthy, G., Arjun, U. V. N. V., et al. (2025) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70834 · Cited by 11

Ferroptosis in cardiovascular diseases: molecular mechanisms and a novel therapeutic target

Yu, S., Pang, Z., Fang, H., & Liu, C. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00420-9 · Cited by 13

From mitochondrial dysregulation to ferroptosis: Exploring new strategies and challenges in radioimmunotherapy (Review)

Wang, T., Zhou, X., Yin, X., Zhang, A., Fan, Y., Chen, K., Tao, H., Tang, Z., Zhang, P., He, X., et al. (2025) · International Journal of Oncology · doi:10.3892/ijo.2025.5781 · Cited by 12

Ferroptosis as a New Type of Cell Death and its Role in Cancer Treatment

Skoupilová, H., Michalová, E., & Hrstka, R. (2018) · Klinicka onkologie · doi:10.14735/amko20182s21 · Cited by 11

Cell–cell contacts prevent t-BuOOH-triggered ferroptosis and cellular damage in vitro by regulation of intracellular calcium

Faust, D., Wenz, C., Holm, S., Harms, G. S., Greffrath, W., & Dietrich, C. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03792-5 · Cited by 10

Potential application of traditional Chinese medicine in cerebral ischemia—Focusing on ferroptosis

Zhao, F., Peng, C., Sun, Y., Li, H., Du, K., & Liu, F. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.963179 · Cited by 10

Regulation of apoptosis, ferroptosis, and pyroptosis mediated by acetylation

Lu, W., Deng, Y., Liu, M., Hu, Y., Yang, K., Wang, B., Li, Y., wang, G., Ma, L., LIU, J., et al. (2026) · Cell Death Discovery · doi:10.1038/s41420-025-02859-1 · Cited by 9

Pan-Inhibition of Protein Disulfide Isomerase Caused Cell Death through Disrupting Cellular Proteostasis in Pancreatic Ductal Adenocarcinoma Cells

Hung, C.-S., Lee, K.-L., Huang, W., Su, F.-H., & Liang, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216467 · Cited by 8

Ferroptosis defense mechanisms: The future and hope for treating osteosarcoma

Ma, Y., Cong, L., Shen, W., Yang, C., & Ye, K. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.4080 · Cited by 10

Application of extracellular vesicles in diabetic osteoporosis

Jia, X., Zhang, G., & Yu, D. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1466775 · Cited by 11

The Emerging Scenario of Ferroptosis in Pancreatic Cancer Tumorigenesis and Treatment

Lyu, H., Kong, J., Chen, J., Zhang, R., Xiao, S., Guo, D. S., Zhang, Q., Chen, X., Tang, J., & Zhou, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413334 · Cited by 12

Silencing ribosome biogenesis regulator 1 homolog (RRS1) inhibits angiogenesis and cisplatin resistance of lung cancer cells by activating ferroptosis mediated by p53 pathway

Lin, L., Zou, Y., & Zhang, D. (2025) · Tissue and Cell · doi:10.1016/j.tice.2025.102796 · Cited by 7

Ferroptosis contributes to lead-induced cochlear spiral ganglion neurons injury

Huang, H., Mei, L., Wang, L., Bai, Y., Gao, K., Song, J., Jiang, M., Chen, Y., Zhang, S., Pang, B., et al. (2024) · Toxicology · doi:10.1016/j.tox.2024.153938 · Cited by 8

Natural products and the balancing act of autophagy-dependent/independent ferroptosis in cancer therapy

Anaraki, S. R., Farzami, P., Nasab, S. S. H., Kousari, A., Naghibi, A. F., Zadeh, M. S., Barati, R., Taha, S. R., Karimian, A., Nabi‐Afjadi, M., et al. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02782-1 · Cited by 7

Ferroptosis and its modulators: A raising target for cancer and Alzheimer’s disease

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Lysosome: a critical hub for ferroptosis regulation

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TGF-β1 induces ROS to activate ferroptosis via the ERK1/2-WISP1 pathway to promote the progression of renal tubular epithelial cell fibrosis

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Regulation of Ferroptosis Through the Cysteine-Glutathione Redox Axis

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Emerging role of copper in the pathophysiology of spinal cord injury

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Ferroptosis: The Pivotal Link in Cardiovascular Diseases Pathogenesis and Therapy

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The Role of Ferroptosis in Diabetes Pathogenesis: Therapeutic Implications of Hydrogen Sulfide and Its Reactive Metabolites

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Regulation and Function of Autophagy During Ferroptosis

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Organelle-specific regulation of ferroptosis

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Quercetin Targets HSP90α and Regulates Keap1/Nrf2 Pathway to Inhibit Crosstalk between Apoptosis and Ferroptosis in Oxidatively Stressed Neurons

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Phospholipase PAFAH2 Mediates Ferroptosis Surveillance and Lipid Remodeling to Promote Resistance in KEAP1 Mutant Cancers

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Ferroptosis in Cardiovascular Disease

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A Multifunctional Fe‐Based Metal–Organic Framework With Ferroptosis for Synergistic Therapy

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The role of ferroptosis in the side effects of dexamethasone

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Dual effects of erastin on aggressive osteosarcoma cells: ferroptosis sensitization and anti-ferroptotic gene activation

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Activation of lysosomal iron triggers ferroptosis in cancer

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Lipoxygenase‐mediated generation of lipid peroxides enhances ferroptosis induced by erastin and RSL3

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The lysosome as a master regulator of iron metabolism

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