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Rapid formation of inositol 1,3,4,5-tetrakisphosphate following muscarinic receptor stimulation of rat cerebral cortical slices
Open accessAbstract
Carbachol stimulation of muscarinic receptors in rat cortical slices prelabelled with myo-[2-3H]inositol caused the rapid formation of a novel inositol polyphosphate. Evidence derived from its chromatographic behaviour, and from the structure of the products formed in partial dephosphorylation experiments, suggests that it is probably D-myo-inositol 1,3,4,5-tetrakisphosphate. An enzyme in human red cell membranes specifically removes the 5-phosphate from it to form inositol 1,3,4-trisphosphate. It is suggested that inositol 1,3,4,5-tetrakisphosphate is likely to be a second messenger, and that it is the precursor of inositol 1,3,4-trisphosphate and possibly of inositol 1,4,5-trisphosphate.
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Cited by
Back in the Water: The Return of the Inositol Phosphates
Irvine, R. F., & Schell, M. J. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35073015 · Cited by 659
Self-citationDamen, J. E., Liu, L., Rosten, P., Humphries, R. K., Jefferson, A. B., Majerus, P. W., & Krystal, G. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.4.1689 · Cited by 633
The Inositol Phosphate Signalling Network in Physiology and Disease
Kim, S., Bhandari, R., Brearley, C. A., & Saiardi, A. (2024) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2024.08.005 · Cited by 70
Inositol Polyphosphate Multikinase: Metabolic Architect of Nuclear Inositides
Resnick, A. C. (2008) · Frontiers in Bioscience · doi:10.2741/2726 · Cited by 39
Metadata
- Authors
- Batty, I. R., Nahorski, S. R., & Irvine, R. F.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1985-11-15
- Volume
- 232
- Issue
- 1
- Pages
- 211-215
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W2214267384
- Cited by
- 643
- References
- 0
- FWCI
- 43.33
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Rapid formation of inositol 1,3,4,5-tetrakisphosphate following muscarinic receptor stimulation of rat cerebral cortical slices. https://app.cochat.ai/papers/10.1042/bj2320211
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- Batty, I. R., Nahorski, S. R., & Irvine, R. F. (1985). Rapid formation of inositol 1,3,4,5-tetrakisphosphate following muscarinic receptor stimulation of rat cerebral cortical slices. Biochemical Journal. https://doi.org/10.1042/bj2320211
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