Inositol Polyphosphate Multikinase: Metabolic Architect of Nuclear Inositides
Open accessAbstract
The inositides are key cellular second messengers with well established roles in signal transduction pathways initiated by cell surface receptor activation. The recent identification of an evolutionarily conserved nuclear signaling pathway for higher inositol polyphosphates has defined a new signaling paradigm for this diverse class of molecules whose biosynthesis and regulation is mediated by what are likely some of the earliest ancestors of the inositide kinase families. Inositol polyphosphate multikinase (IPMK) represents the most catalytically diverse member of this family with critical roles in nuclear functions including mRNA export, transcriptional regulation, and chromatin remodeling.
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IPMK functions as both an inositol kinase and a lipid kinase, converting PIP2 to PIP3.
“It functions as both an inositol kinase and a lipid kinase, capable of converting PIP2 (Phosphoinositide 4,5 bi phosphate) to PIP3 (Phosphoinositide 3,4,5 triphosphate) [26,27].”
From From Obscurity to Prominence: IPMK’s Expanding Role in Cellular Signaling, Physiology, and Disease (2025) · cites this paper as [27]
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Cites
A Role for Nuclear Inositol 1,4,5-Trisphosphate Kinase in Transcriptional Control
Odom, A. R., Stahlberg, A., Wente, S. R., & York, J. D. (2000) · Science · doi:10.1126/science.287.5460.2026 · Cited by 394 · see citing works
Modulation of ATP-Dependent Chromatin-Remodeling Complexes by Inositol Polyphosphates
Shen, X., Xiao, H., Ranallo, R., Wu, W.-H., & Wu, C. (2003) · Science · doi:10.1126/science.1078068 · Cited by 338 · see citing works
Saiardi, A., Nagata, E., Luo, H. R., Sawa, A., Luo, X., Snowman, A. M., & Snyder, S. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.041614598 · Cited by 110 · see citing works
NALASKOWSKI, M. M., DESCHERMEIER, C., FANICK, W., & MAYR, G. W. (2002) · Biochemical Journal · doi:10.1042/bj20020327 · Cited by 89 · see citing works
El Alami, M., Messenguy, F., Scherens, B., & Dubois, E. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03562.x · Cited by 83 · see citing works
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Research works printed but not linked: 3
- T. Zhang, J.J. Caffrey & S.B. Shears: The transcriptional regulator, Arg82, is a hybrid kinase with both monophosphoinositol and diphosphoinositol polyphosphate synthase activity. FEBS Letters, 208-212 (2001).
- A. Saiardi, J.J. Caffrey, S.H. Snyder & S.B. Shears: Inositol polyphosphate multikinase (ArgRIII) determines nuclear mRNA export in Saccharomyces cerevisiae. FEBS Letters, 28-32 (2000).
- E. Dubois, V. Dewaste, C. Erneux & F. Messenguy: Inositol polyphosphate kinase activity of Arg82/ArgRIII is not required for the regulation of the arginine metabolism in yeast. FEBS Letters, 300-304 (2000).
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Insights into the activation mechanism of class I HDAC complexes by inositol phosphates
Watson, P. J., Millard, C. J., Riley, A. M., Robertson, N. S., Wright, L. C., Godage, H. Y., Cowley, S. M., Jamieson, A. G., Potter, B. V. L., & Schwabe, J. W. R. (2016) · Nature Communications · doi:10.1038/ncomms11262 · Cited by 244 · see citing works
From Obscurity to Prominence: IPMK’s Expanding Role in Cellular Signaling, Physiology, and Disease
Mishra, S. H., Chatterjee, S., Viera-Preval, L., & Guha, P. (2025) · Biomolecules · doi:10.3390/biom15091266 · Cited by 1 · see citing works
“It functions as both an inositol kinase and a lipid kinase, capable of converting PIP2 (Phosphoinositide 4,5 bi phosphate) to PIP3 (Phosphoinositide 3,4,5 triphosphate) [26,27].”
- Authors
- Resnick, A. C.
- Affiliations
- Children's Hospital of Philadelphia (US)
- Corresponding author
- Resnick, Adam Cain
- ORCID
- Resnick, Adam Cain
- Venue
- Frontiers in Bioscience
- Publisher
- IMR Press
- Published
- 2008
- Volume
- 13
- Issue
- 13
- Pages
- 856
- ISSN
- 1093-4715 (ISSN-L)
- 1093-9946
- DOI
- 10.2741/2726
- OpenAlex
- W2064091112
- Cited by
- 39
- References
- 5
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2021: 1 · 2020: 3 · 2019: 2 · 2017: 3 · 2016: 4 · 2015: 1 · 2014: 2 · 2012: 3
- FWCI
- 0.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Frontiers in bioscience (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Children's Hospital of Philadelphia
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- inositol polyphosphate multikinase, inositol polyphosphates, nuclear signaling, second messengers, mRNA export, transcriptional regulation, chromatin remodeling, signal transduction
- MeSH terms
- Animals, Arginine, Cell Nucleus, Chromatin, Fungal Proteins, Humans, Inositol, Lipids, Models, Biological, Transcription, Genetic, Signal Transduction, Phosphotransferases (Alcohol Group Acceptor), Phosphatidylinositol 3-Kinases
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