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Aromatic hydroxylation as a potential measure of hydroxyl-radical formation in vivo. Identification of hydroxylated derivatives of salicylate in human body fluids
Open accessAbstract
Attack by .OH radicals, generated by a Fenton system, upon salicylate produces 2,3-dihydroxybenzoate and 2,5-dihydroxybenzoate as major products and catechol as a minor product. H.p.l.c. separation combined with electrochemical detection was used to identify and quantify 2,3-dihydroxybenzoate and 2,5-dihydroxybenzoate in human plasma and synovial fluid. We propose that conversion of salicylate into 2,3-dihydroxybenzoate, or of other aromatic compounds into specific hydroxylated products, may be a useful assay for .OH formation in the human body.
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Cited by
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[1] Role of free radicals and catalytic metal ions in human disease: An overview
Halliwell, B., & Gutteridge, J. M. C. (1990) · Methods in Enzymology · doi:10.1016/0076-6879(90)86093-b · Cited by 4,994
Self-citationHalliwell, B., & Whiteman, M. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705776 · Cited by 2,238
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Metadata
- Authors
- Grootveld, M., & Halliwell, B.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1986-07-15
- Volume
- 237
- Issue
- 2
- Pages
- 499-504
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W1825467595
- Cited by
- 373
- References
- 0
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Aromatic hydroxylation as a potential measure of hydroxyl-radical formation in vivo. Identification of hydroxylated derivatives of salicylate in human body fluids. https://app.cochat.ai/papers/10.1042/bj2370499
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- Grootveld, M., & Halliwell, B. (1986). Aromatic hydroxylation as a potential measure of hydroxyl-radical formation in vivo. Identification of hydroxylated derivatives of salicylate in human body fluids. Biochemical Journal. https://doi.org/10.1042/bj2370499
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