The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Formation of hydroxyl radicals from hydrogen peroxide in the presence of iron. Is haemoglobin a biological Fenton reagent?
Open accessAbstract
The ability of oxyhaemoglobin and methaemoglobin to generate hydroxyl radicals (OH.) from H2O2 has been investigated using deoxyribose and phenylalanine as ‘detector molecules’ for OH.. An excess of H2O2 degrades methaemoglobin, releasing iron ions that react with H2O2 to form a species that appears to be OH.. Oxyhaemoglobin reacts with low concentrations of H2O2 to form a ‘reactive species’ that degrades deoxyribose but does not hydroxylate phenylalanine. This ‘reactive species’ is less amenable to scavenging by certain scavengers (salicylate, phenylalanine, arginine) than is OH., but it appears more reactive than OH. is to others (Hepes, urea). The ability of haemoglobin to generate not only this ‘reactive species’, but also OH. in the presence of H2O2 may account for the damaging effects of free haemoglobin in the brain, the eye, and at sites of inflammation.
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Cites
Gutteridge, J. M. C. (1986) · FEBS Letters · doi:10.1016/0014-5793(86)80626-3 · Cited by 629
Biemond, P., van Eijk, H. G., Swaak, A. J., & Koster, J. F. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111364 · Cited by 380
Cited by
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Halliwell, B., & Gutteridge, J. M. C. (1990) · Methods in Enzymology · doi:10.1016/0076-6879(90)86093-b · Cited by 4,994
Self-citationReactive Oxygen Species and the Central Nervous System
Halliwell, B. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10990.x · Cited by 2,947
Self-citationOxidative stress and neurodegeneration: where are we now?
Halliwell, B. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03907.x · Cited by 2,614
Self-citationWink, D. A., & Mitchell, J. B. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00092-6 · Cited by 1,606
Antioxidant defence mechanisms: From the beginning to the end (of the beginning)
Halliwell, B. (1999) · Free Radical Research · doi:10.1080/10715769900300841 · Cited by 1,020
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Metadata
- Authors
- Puppo, A., & Halliwell, B.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1988-01-01
- Volume
- 249
- Issue
- 1
- Pages
- 185-190
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W1841695296
- Cited by
- 399
- References
- 2
- FWCI
- 9.02
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Puppo, A., & Halliwell, B. (1988). Formation of hydroxyl radicals from hydrogen peroxide in the presence of iron. Is haemoglobin a biological Fenton reagent? Biochemical Journal. https://doi.org/10.1042/bj2490185
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
