A novel type of glutathione peroxidase: expression and regulation during wound repair
Open accessAbstract
We have previously identified and cloned a novel keratinocyte growth factor (KGF)-regulated gene in human keratinocytes that encodes the human homologue of a bovine non-selenium glutathione peroxidase (GPx). To gain insight into the regulation of this gene in vivo, we isolated the murine homologue from a mouse skin cDNA library. In vitro transcription/translation demonstrated that the cDNA encodes a 27 kDa protein. Furthermore, we amplified by PCR a partial cDNA that most likely corresponds to a related gene. RNase protection analysis revealed tissue-specific expression of both genes and the occurrence of alternative splicing or RNA editing of at least one of the primary transcripts. Similar to that of KGF, expression of GPx was strongly induced after cutaneous injury, and each isoform displayed unique kinetics of expression during the repair process. In situ hybridization studies demonstrated high levels of GPx mRNA in keratinocytes of the hyperproliferative epithelium at the wound edge. Since these cells express functional KGF receptors, induction of GPx expression by KGF might also occur in vivo. These data suggest a role for GPx in the protection of epithelial cells against oxidative stress, particularly during the inflammatory phase of wound repair.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Peroxiredoxin 6 is up-regulated by wound edge keratinocytes in early differential display screens.
“In early differential display screens, a reactive oxygen species (ROS)–detoxifying enzyme, peroxiredoxin 6, was seen to be up-regulated by wound edge keratinocytes (111).”
From Wound repair and regeneration: Mechanisms, signaling, and translation (2014) · cites this paper as [111]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,240 · see citing works
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
Feinberg, A. P., & Vogelstein, B. (1983) · Analytical Biochemistry · doi:10.1016/0003-2697(83)90418-9 · Cited by 24,512 · see citing works
Oxygen toxicity, oxygen radicals, transition metals and disease
Halliwell, B., & Gutteridge, J. M. C. (1984) · Biochemical Journal · doi:10.1042/bj2190001 · Cited by 5,330 · see citing works
Free Radicals in Biology and Medicine
Land, E. T. (1990) · International Journal of Radiation Biology · doi:10.1080/09553009014552071 · Cited by 4,868 · see citing works
Hayes, J. D., & Pulford, D. J. (1995) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409239509083491 · Cited by 3,471 · see citing works
Fridovich (1978) · doi:10.1126/science.210504 · Cited by 3,329 · see citing works
Wendel, A. (1981) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(81)77046-0 · Cited by 3,011 · see citing works
Prooxidant States and Tumor Promotion
Cerutti, P. (1985) · Science · doi:10.1126/science.2981433 · Cited by 2,513 · see citing works
Oxidative stress as a mediator of apoptosis
Buttke, T. M., & Sandstrom, P. A. (1994) · Immunology Today · doi:10.1016/0167-5699(94)90018-3 · Cited by 2,149 · see citing works
Human KGF is FGF-Related with Properties of a Paracrine Effector of Epithelial Cell Growth
Finch, P. W., Rubin, J. S., Miki, T., Ron, D., & Aaronson, S. A. (1989) · Science · doi:10.1126/science.2475908 · Cited by 984 · see citing works
Purification and characterization of a newly identified growth factor specific for epithelial cells.
Rubin, J. S., Osada, H., Finch, P. W., Taylor, W., Rudikoff, S., & Aaronson, S. A. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.3.802 · Cited by 832 · see citing works
Physiology, Biochemistry, and Molecular Biology of the Skin
Shelley, W. B. (1992) · JAMA · doi:10.1001/jama.1992.03490040129042 · Cited by 791 · see citing works
Miki, T., Bottaro, D., Fleming, T., Smith, C. L., Burgess, W., Chan, A., & Aaronson, S. (1992) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.89.1.246 · Cited by 757 · see citing works
Meier, B., Radeke, H. H., Selle, S., Younes, M., Sies, H., Resch, K., & Habermehl, G. (1989) · Biochemical Journal · doi:10.1042/bj2630539 · Cited by 650 · see citing works
Large induction of keratinocyte growth factor expression in the dermis during wound healing
Werner, S., Peters, K. G., Longaker, M. T., Fuller-Pace, F., Banda, M. J., & Williams, L. T. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.15.6896 · Cited by 612 · see citing works
Self-citationThe Function of KGF in Morphogenesis of Epithelium and Reepithelialization of Wounds
Werner, S., Smola, H., Liao, X., Longaker, M. T., Krieg, T. M., HOFSCHNEIDER, P. H., & Williams, L. T. (1994) · Science · doi:10.1126/science.7973639 · Cited by 604 · see citing works
Self-citationReappearance of an embryonic pattern of fibronectin splicing during wound healing in the adult rat.
ffrench‐Constant, C., Water, L. V. D., Dvorak, H. F., & Hynes, R. O. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.109.2.903 · Cited by 482 · see citing works
Human-tumor-derived cell lines contain common and different transforming genes
Perucho, M., Goldfarb, M. P., Shimizu, K., Lama, C., Fogh, J., & Wigler, M. H. (1981) · Cell · doi:10.1016/0092-8674(81)90388-3 · Cited by 447 · see citing works
Inflammation and Oxidative Stress in Carcinogenesis
Cerutti, P., & Amstad, P. (1993) · Springer eBooks · doi:10.1007/978-1-4615-3520-1_75 · Cited by 409 · see citing works
Wilkinson, D. G., Bailes, J. A., Champion, J. E., & McMahon, A. P. (1987) · Development · doi:10.1242/dev.99.4.493 · Cited by 293 · see citing works
Modulation of keratinocyte growth factor and its receptor in reepithelializing human skin.
Marchese, C., Chedid, M., Dirsch, O., Csaky, K. G., di Pompeo, F. S., Latini, C., LaRochelle, W. J., Torrisi, M. R., & Aaronson, S. A. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.5.1369 · Cited by 163 · see citing works
Oxidative stress in dermatology
Fuchs, J., & Packer, L. (1993) · Medical Entomology and Zoology · Cited by 154 · see citing works
Magnuson, V. L., Young, M. E., Schattenberg, D. G., Mancini, M. A., Chen, D. L., Steffensen, B., & Klebe, R. J. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98735-1 · Cited by 154 · see citing works
Primary Structure of Human Plasma Glutathione Peroxidase Deduced from eDNA Sequences1
Takahashi, K., Akasaka, M., Yamamoto, Y., Kobayashi, C., Mizoguchi, J., & Koyaxna, J. (1990) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a123172 · Cited by 153 · see citing works
Transforming growth factor‐β regulates the splicing pattern of fibronectin messenger RNA precursor
Borsi, L., Castellani, P., Risso, A. M., Leprini, A., & Zardi, L. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)80664-5 · Cited by 124 · see citing works
Frank, S., Munz, B., & Werner, S. (1997) · Oncogene · doi:10.1038/sj.onc.1200905 · Cited by 122 · see citing works
Self-citationcDNA sequence coding for human glutathione peroxidase
Sukenaga, Y., Ishida, K., Takeda, T., & Takagi, K. (1987) · Nucleic Acids Research · doi:10.1093/nar/15.17.7178 · Cited by 100 · see citing works
Hydrogen Peroxide Inhibits Human Keratinocyte Migration
O’Toole, E. A., GOEL, M., & Woodley, D. T. (1996) · Dermatologic Surgery · doi:10.1111/j.1524-4725.1996.tb00368.x · Cited by 91 · see citing works
Mullenbach, G. T., Tabrizi, A., Irvine, B. D., Bell, G. I., & Hallewell, R. A. (1987) · Nucleic Acids Research · doi:10.1093/nar/15.13.5484 · Cited by 90 · see citing works
Esworthy, R. S., Doan, K., Doroshow, J. H., & Chu, F. (1994) · Gene · doi:10.1016/0378-1119(94)90400-6 · Cited by 82 · see citing works
Shichi, H., & DeMar, J. C. (1990) · Experimental Eye Research · doi:10.1016/0014-4835(90)90040-2 · Cited by 64 · see citing works
Polarized regulation of fibronectin secretion and alternative splicing by transforming growth factor
Wang, A., Cohen, D. S., Palmer, E., & Sheppard, D. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98447-4 · Cited by 62 · see citing works
Flagged first, then by citations
Research works printed but not linked: 5
- Rubin, J. S., Osada, H., Finch, P. W., Taylor, W. G., Rudikoff, S. and Aaronson, S. A. (1989) Proc. Natl. Acad. Sci. U.S.A. 86, 802-806 Received 13 March 1997/6 May 1997 ; accepted 9 May 1997
- Werner, S., Peters, K. G., Longaker, M. T., Fuller-Pace, F., Banda, M. J. and Williams, L. T. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 6896-6900
- Miki, T., Bottaro, D. P., Fleming, T. P., Smith, C. L., Burgess, W. H., Chan, A. M. L. and Aaronson, S. A. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 246-250
- Aviv, H. and Leder, P. (1972) Proc. Natl. Acad. Sci. U.S.A. 69, 6772-6774
- Ames, B. N. and Shigenaga, M. K. (1993) DNA and Free Radicals (Halliwell, B. and Aruoma, O. I., eds.), pp. 1-15, Ellis Harwood Publishers, Amsterdam 32
Cited by
Sorted by citations
Wound repair and regeneration: Mechanisms, signaling, and translation
Eming, S. A., Martin, P., & Tomic-Canic, M. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009337 · Cited by 3,562 · see citing works
Hayes, J. D., & McLellan, L. I. (1999) · Free Radical Research · doi:10.1080/10715769900300851 · Cited by 1,528 · see citing works
The expanding superfamily of phospholipase A2 enzymes: classification and characterization
Six, D. A., & Dennis, E. A. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00105-0 · Cited by 1,359 · see citing works
Selenium in global food systems
Combs, G. F. (2001) · British Journal of Nutrition · doi:10.1079/bjn2000280 · Cited by 1,129 · see citing works
Oxidative stress in normal and impaired wound repair
SCHAFER, M., & WERNER, S. (2008) · Pharmacological Research · doi:10.1016/j.phrs.2008.06.004 · Cited by 902 · see citing works
Self-citationHofmann, B., Hecht, H., & Flohé, L. (2002) · Biological Chemistry · doi:10.1515/bc.2002.040 · Cited by 620 · see citing works
Selenium, the Thyroid, and the Endocrine System
Köhrle, J., Jakob, F. J., Contempré, B., & Dumont, J. E. (2005) · Endocrine Reviews · doi:10.1210/er.2001-0034 · Cited by 527 · see citing works
Fisher, A. B. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3412 · Cited by 410 · see citing works
Manevich, Y., & Fisher, A. B. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.02.011 · Cited by 382 · see citing works
Advances in our understanding of peroxiredoxin, a multifunctional, mammalian redox protein
Fujii, J., & Ikeda, Y. (2002) · Redox Report · doi:10.1179/135100002125000352 · Cited by 369 · see citing works
Manevich, Y., Feinstein, S. I., & Fisher, A. B. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400181101 · Cited by 349 · see citing works
Keratinocyte Growth Factor: A Unique Player in Epithelial Repair Processes
Werner, S. (1998) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(98)00010-0 · Cited by 347 · see citing works
Self-citationWang, X., Phelan, S. A., Forsman‐Semb, K., Taylor, E. F., Petros, C., Brown, A. C., Lerner, C. P., & Paigen, B. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302706200 · Cited by 318 · see citing works
Phospholipid Hydroperoxides Are Substrates for Non-selenium Glutathione Peroxidase
Fisher, A. B., Dodia, C., Manevich, Y., Chen, J., & Feinstein, S. I. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.30.21326 · Cited by 295 · see citing works
The Ca2+-binding Proteins S100A8 and S100A9 Are Encoded by Novel Injury-regulated Genes
Thorey, I. S., Roth, J., Regenbogen, J., Halle, J.-P., Bittner, M., Vogl, T., Kaesler, S., Bugnon, P., Reitmaier, B., Durka, S., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104871200 · Cited by 233 · see citing works
Self-citationGlutathione and trypanothione in parasitic hydroperoxide metabolism
Flohé, L., Hecht, H., & Steinert, P. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00172-0 · Cited by 211 · see citing works
Cyclophilin A Binds to Peroxiredoxins and Activates Its Peroxidase Activity
Lee, S. P., Hwang, Y. S., Kim, Y. J., Kwon, K. S., Kim, H. J., Kim, K. H., & Chae, H. Z. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101822200 · Cited by 203 · see citing works
Different Types of ROS-Scavenging Enzymes Are Expressed during Cutaneous Wound Repair
Steiling, H., Munz, B., Werner, S., & Brauchle, M. A. (1999) · Experimental Cell Research · doi:10.1006/excr.1998.4366 · Cited by 169 · see citing works
Self-citationThe peroxiredoxin gene family in drosophila melanogaster
Radyuk, S. N., Klichko, V. I., Spinola, B., Sohal, R. S., & Orr, W. C. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00692-x · Cited by 165 · see citing works
Role of Se-dependent glutathione peroxidases in gastrointestinal inflammation and cancer
Chu, F., Esworthy, R. S., & Doroshow, J. H. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.04.010 · Cited by 157 · see citing works
Reactive Oxygen Species and Their Detoxification in Healing Skin Wounds
Keller, U. A. D., Kümin, A., Braun, S., & Werner, S. (2006) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1038/sj.jidsymp.5650001 · Cited by 150 · see citing works
Self-citationFrom Cytoprotection to Tumor Suppression: The Multifactorial Role of Peroxiredoxins
Butterfield, L. H., Merino, A., Golub, S. H., & Shau, H. (1999) · Antioxidants and Redox Signaling · doi:10.1089/ars.1999.1.4-385 · Cited by 137 · see citing works
Lee, C., Pugh, T. D., Klopp, R. G., Edwards, J. W., Allison, D. B., Weindruch, R. H., & Prolla, T. A. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.01.015 · Cited by 134 · see citing works
Fatma, N., Singh, D. P., Shinohara, T., & Chylack, L. T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100733200 · Cited by 134 · see citing works
EVOLUTION OF THE INNATE AND ADAPTIVE IMMUNE SYSTEMS
ller, W. E. G. M. U., Blumbach, B., & ller, I. M. M. (1999) · Transplantation · doi:10.1097/00007890-199911150-00001 · Cited by 132 · see citing works
Haem oxygenase-1: a novel player in cutaneous wound repair and psoriasis?
Hanselmann, C., Mauch, C., & Werner, S. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3530459 · Cited by 126 · see citing works
Self-citationBeer, H., Gassmann, M. G., Munz, B., Steiling, H., Engelhardt, F., Bleuel, K., & Werner, S. (2000) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1046/j.1087-0024.2000.00009.x · Cited by 126 · see citing works
Self-citationPeroxiredoxin 6 Is a Potent Cytoprotective Enzyme in the Epidermis
Kümin, A., Huber, C. W., Rülicke, T., Wolf, E., & Werner, S. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.060119 · Cited by 114 · see citing works
Self-citationKeratinocyte Growth Factor: Expression by Endometrial Epithelia of the Porcine Uterus
Ka, H., Spencer, T. E., Johnson, G. A., & Bazer, F. W. (2000) · Biology of Reproduction · doi:10.1095/biolreprod62.6.1772 · Cited by 99 · see citing works
Leyens, G., Donnay, I., & Knoops, B. (2003) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/s1096-4959(03)00290-2 · Cited by 98 · see citing works
Peroxiredoxin 6 is required for blood vessel integrity in wounded skin
Kümin, A., Schäfer, M., Epp, N., Bugnon, P., Born-Berclaz, C., Oxenius, A., Klippel, A., Bloch, W., & Werner, S. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200706090 · Cited by 96 · see citing works
Self-citationChhunchha, B., Fatma, N., Kubo, E., Rai, P., Singh, S. P., & Singh, D. P. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00345.2012 · Cited by 92 · see citing works
Evidence that peroxiredoxins are novel members of the thioredoxin fold superfamily
Schröder, E., & Ponting, C. P. (1998) · Protein Science · doi:10.1002/pro.5560071125 · Cited by 92 · see citing works
Fibroblast growth factors in epithelial repair and cytoprotection.
Braun, S., Keller, U. A. D., Steiling, H., & Werner, S. (2004) · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · doi:10.1098/rstb.2004.1464 · Cited by 88 · see citing works
Self-citationFibroblast growth factors: key players in epithelial morphogenesis, repair and cytoprotection
Steiling, H., & Werner, S. (2003) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2003.08.003 · Cited by 86 · see citing works
Self-citationAntioxidant System within Yeast Peroxisome
Horiguchi, H., Yurimoto, H., Kato, N., & Sakai, Y. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011661200 · Cited by 79 · see citing works
Loss of PKC-δ alters cardiac metabolism
Mayr, M., Chung, Y., Mayr, U., McGregor, E., Troy, H., Baier, G., Leitges, M., Dunn, M. J., Griffiths, J. R., & Xu, Q. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00877.2003 · Cited by 77 · see citing works
Keratinocyte growth factor: effects on keratinocytes and mechanisms of action
Keller, U. A. D., Krampert, M., Kümin, A., Braun, S., & Werner, S. (2004) · European Journal of Cell Biology · doi:10.1078/0171-9335-00389 · Cited by 76 · see citing works
Self-citationKruse, M., Steffen, R., Batel, R., Müller, I. M., & Müller, W. E. G. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.23.4305 · Cited by 76 · see citing works
Fujii, T., Fujii, J., & Taniguchi, N. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2001.01843.x · Cited by 75 · see citing works
Beer, H., Vindevoghel, L., Gait, M., Revest, J., Duan, D. R., Mason, I. J., Dickson, C., & Werner, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.21.16091 · Cited by 75 · see citing works
Self-citationMontemartini, M., Kalisz, H. M., Hecht, H., Steinert, P., & Flohé, L. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00656.x · Cited by 73 · see citing works
Nonselenium Glutathione Peroxidase in Human Brain
Power, J. H. T., Shannon, J. M., Blumbergs, P. C., & Gai, W. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64249-6 · Cited by 70 · see citing works
Esworthy, R. S., Mann, J. R., Sam, M., & Chu, F. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.279.2.g426 · Cited by 69 · see citing works
Peroxiredoxins in the Lung with Emphasis on Peroxiredoxin VI
Schremmer, B., Manevich, Y., Feinstein, S. I., & Fisher, A. B. (2007) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-1-4020-6051-9_15 · Cited by 68 · see citing works
Dual Role of the Antioxidant Enzyme Peroxiredoxin 6 in Skin Carcinogenesis
Rolfs, F., Huber, M., Грубер, Ф., Böhm, F., Pfister, H., Bochkov, V. N., Tschachler, E., Dummer, R., Hohl, D., Schäfer, M., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4369 · Cited by 67 · see citing works
Self-citationMitochondrial Peroxiredoxin III is a Potential Target for Cancer Therapy
Song, I.-S., Kim, H.-K., Jeong, S., Lee, S.-R., Kim, N., Rhee, B., Ko, K., & Han, J. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12107163 · Cited by 60 · see citing works
Neuroprotective effect of peroxiredoxin 6 against hypoxia-induced retinal ganglion cell damage
Tulsawani, R., Kelly, L. S., Fatma, N., Chhunchha, B., Kubo, E., Kumar, A., & Singh, D. P. (2010) · BMC Neuroscience · doi:10.1186/1471-2202-11-125 · Cited by 65 · see citing works
Mu, C., Zhao, J., Wang, L., Song, L., Zhang, H., Li, C., Qiu, L., & Gai, Y. (2008) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2008.10.006 · Cited by 65 · see citing works
Lack of Myoglobin Causes a Switch in Cardiac Substrate Selection
Flögel, U., Laußmann, T., Gödecke, A., Abanador-Kamper, N., Schäfers, M. A., Fingas, C. D., Metzger, S. U., Levkau, B., Jacoby, C., & Schrader, J. (2005) · Circulation Research · doi:10.1161/01.res.0000165481.36288.d2 · Cited by 64 · see citing works
Zhang, S., Wang, W., Gu, Q., Xue, J., Cao, H., Tang, Y., Xu, X., Cao, J., Zhou, J., Wu, J., et al. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.01.019 · Cited by 64 · see citing works
Spontaneous skin damage and delayed wound healing in SOD1-deficient mice
Iuchi, Y., Roy, D., Okada, F., Kibe, N., Tsunoda, S., Suzuki, S., Takahashi, M., Yokoyama, H., Yoshitake, J., Kondo, S., et al. (2010) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-010-0449-y · Cited by 61 · see citing works
Investigating transcriptional regulation of Prdx6 in mouse liver cells
Gallagher, B. M., & Phelan, S. A. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.01.023 · Cited by 58 · see citing works
Peroxiredoxins in antioxidant defense and redox regulation
Flohé, L., Budde, H., & Hofmann, B. (2003) · BioFactors · doi:10.1002/biof.5520190102 · Cited by 58 · see citing works
Phelan, S. A., Wang, X., Wallbrandt, P., Forsman‐Semb, K., & Paigen, B. J. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00462-3 · Cited by 57 · see citing works
Singh, S. P., Chhunchha, B., Fatma, N., Kubo, E., Singh, S. P., & Singh, D. P. (2015) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00229.2015 · Cited by 56 · see citing works
Kubo, E., Miyazawa, T., Fatma, N., Akagi, Y., & Singh, D. P. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.10.003 · Cited by 54 · see citing works
Peshenko, I. V., Novoselov, V. I., Va, E., Nikolaev, Y. V., Kamzalov, S., Shuvaeva, T. M., Липкин, В. М., & Fesenko, E. E. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00111-7 · Cited by 53 · see citing works
Chhunchha, B., Kubo, E., & Singh, D. P. (2019) · Cells · doi:10.3390/cells8101159 · Cited by 51 · see citing works
Bustamante‐Filho, I. C., Pederzolli, C. D., Sgaravatti, Â. M., Gregory, R. M., Filho, C. S. D., Jobim, M. I. M., & Mattos, R. C. (2009) · Animal Reproduction · Cited by 50 · see citing works
Mei, L., Chen, Y., Chen, P., Chen, H., He, S., Jin, C., Wang, Y., Hu, Z., Li, W., Jin, L., et al. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102468 · Cited by 49 · see citing works
David, É., Tanguy, A., & Moraga, D. (2007) · Aquatic Toxicology · doi:10.1016/j.aquatox.2007.06.017 · Cited by 49 · see citing works
Antioxidant protein 2 prevents methemoglobin formation in erythrocyte hemolysates
Stuhlmeier, K. M., Kao, J. J., Wallbrandt, P., Lindberg, M., Hammarström, B., BROELL, H., & Paigen, B. J. (2003) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2003.03393.x · Cited by 47 · see citing works
Phelan, S. A., Johnson, K. A., Beier, D. R., & Paigen, B. J. (1998) · Genomics · doi:10.1006/geno.1998.5568 · Cited by 43 · see citing works
Lee, T., Yu, S., Kim, S.-U., Kim, Y.-M., Choi, I., Kang, S. W., Rhee, S. G., & Yu, D. (1999) · Gene · doi:10.1016/s0378-1119(99)00190-0 · Cited by 40 · see citing works
CTGF and chronic kidney fibrosis
Chen, X. (2009) · Frontiers in Bioscience-Elite · doi:10.2741/e13 · Cited by 39 · see citing works
AOP2 (Antioxidant Protein 2): Structure and Function of a Unique Thiol-Specific Antioxidant
Phelan, S. A. (1999) · Antioxidants and Redox Signaling · doi:10.1089/ars.1999.1.4-571 · Cited by 38 · see citing works
Pak, J. H., Son, W., Seo, S., Hong, S., Sohn, W., Na, B., & Kim, T. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.08.016 · Cited by 37 · see citing works
Wiens, M., Krasko, A., Blumbach, B., Müller, I. M., & Müller, W. E. G. (2000) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400671 · Cited by 37 · see citing works
Peroxiredoxins as multifunctional enzymes
Sharapov, M. G., Ravin, V., & Novoselov, V. (2014) · Molecular Biology · doi:10.1134/s0026893314040128 · Cited by 26 · see citing works
Fatma, N., Kubo, E., Takamura, Y., Ishihara, K., Garcia, C. M., Beebe, D. C., & Singh, D. P. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.016071 · Cited by 35 · see citing works
Parallels between wound repair and morphogenesis in the embryo
Grose, R. P., & Martin, P. B. (1999) · Seminars in Cell and Developmental Biology · doi:10.1006/scdb.1999.0326 · Cited by 33 · see citing works
Lee, J. E., Kwon, B. D., Lee, J.-B., Won, Y., Kim, Y. P., Lee, S., Chae, H. Z., & Ahn, K. Y. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00177.x · Cited by 31 · see citing works
AuNP-peptide probe for caspase-3 detection in living cells by SERS
Zhao, C., Qiu, L., Lv, P., Han, A., Fang, G., Liu, J., & Wang, S. (2018) · The Analyst · doi:10.1039/c8an02145g · Cited by 29 · see citing works
Peroxiredoxin6 in Endothelial Signaling
Patel, P., & Chatterjee, S. (2019) · Antioxidants · doi:10.3390/antiox8030063 · Cited by 28 · see citing works
Shayman, J. A., Abe, A., & Hiraoka, M. (2003) · Glycoconjugate Journal · doi:10.1023/b:glyc.0000016739.32089.55 · Cited by 28 · see citing works
Neu differentiation factor/heregulin induction by hepatocyte and keratinocyte growth factors
Castagnino, P. A., Lorenzi, M. V., Yeh, J., Breckenridge, D., Sakata, H., Munz, B., Werner, S., & Bottaro, D. P. (2000) · Oncogene · doi:10.1038/sj.onc.1203357 · Cited by 28 · see citing works
Self-citationPeroxiredoxins in Cell Signaling and HIV Infection
Jin, D., & Jeang, K. (2000) · Elsevier eBooks · doi:10.1016/b978-012636670-9/50019-2 · Cited by 26 · see citing works
Catechol Redox Reaction: Reactive Oxygen Species Generation, Regulation, and Biomedical Applications
Forooshani, P. K., Meng, H., & Lee, B. P. (2017) · ACS symposium series · doi:10.1021/bk-2017-1252.ch010 · Cited by 24 · see citing works
Identification and characterization of the peroxiredoxin gene family in chickens
Han, J. Y., Song, K. D., Shin, J. H., Han, B. K., Park, T. S., Park, H. J., Kim, J.-K., Lillehoj, H. S., Lim, J. M., & Kim, H. (2005) · Poultry Science · doi:10.1093/ps/84.9.1432 · Cited by 24 · see citing works
Müller, W. E. G., Wiens, M., Müller, I. M., & Schröder, H. C. (2003) · Progress in molecular and subcellular biology · doi:10.1007/978-3-642-18670-7_5 · Cited by 24 · see citing works
Analysis of Glutathione‐Related Enzymes
Esworthy, R. S., Chu, F., & Doroshow, J. H. (1999) · Current Protocols in Toxicology · doi:10.1002/0471140856.tx0701s00 · Cited by 23 · see citing works
Jonas, C. R., Farrell, C. L., Scully, S. A., Eli, A., Estívariz, C. F., Gu, L. H., Jones, D. P., & Ziegler, T. R. (2000) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860710002400267 · Cited by 23 · see citing works
Beaven, A., & Shea, T. C. (2006) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.7.16.2287 · Cited by 22 · see citing works
Das, S. J., & Olsen, I. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4621 · Cited by 22 · see citing works
Fadriquela, A., Sajo, M. E. J., Bajgai, J., Kim, D.-H., Kim, C.-S., Kim, S., & Lee, K. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/2459826 · Cited by 21 · see citing works
Kim, H., Cho, H. J., Ishihara, A., Kim, B.-K., & Kim, O. (2018) · BMB Reports · doi:10.5483/bmbrep.2018.51.4.209 · Cited by 21 · see citing works
Peroxiredoxins, a new family of antioxidant proteins
Shuvaeva, T. M., Novoselov, V. I., Fesenko, E. E., & Липкин, В. М. (2009) · Russian Journal of Bioorganic Chemistry · doi:10.1134/s106816200905001x · Cited by 19 · see citing works
Zhang, W., Shen, H., Ma, L., Shen, B., Xu, Z., & Wang, X. (2007) · Toxicology · doi:10.1016/j.tox.2007.07.021 · Cited by 18 · see citing works
Bidooki, S. H., Sánchez-Marco, J., Martínez‐Beamonte, R., Herrero‐Continente, T., Navarro, M. Á., Rodriguez‐Yoldi, M. J., & Osada, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417131 · Cited by 17 · see citing works
Insight into the Regulatory Function of Human Hair Keratins in Wound Healing Using Proteomics
Gao, F., Li, W., Kan, J., Ding, Y., Wang, Y., Deng, J., Qing, R., Wang, B., & Hao, S. (2020) · Advanced Biosystems · doi:10.1002/adbi.201900235 · Cited by 17 · see citing works
Koh, C. H. V., Peng, Z. F., Ou, K., Melendez, A. J., Manikandan, J., Qi, R. Z., & Cheung, N. S. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.20912 · Cited by 17 · see citing works
Tchah, H., Kim, M. J., Kim, T., Choi, H.-J., Kim, J. Y., Kim, M. J., & Pak, J. H. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-0107 · Cited by 16 · see citing works
Brigelius‐Flohé, R., Maiorino, M., Flohé, L., & Ursini, F. (2001) · CRC Press eBooks · doi:10.1201/9780203904046.pt9 · Cited by 16 · see citing works
Yara İyileşmesi ve Oksidatif Stress
Aksoy, H. (2014) · MARMARA PHARMACEUTCAL JOURNAL · doi:10.12991/mpj.2014187243 · Cited by 14 · see citing works
Wagner, G., Stettmaier, K., Bors, W., Sies, H., Wagner, E.-M., Reuter, A., & Weiher, H. (2001) · Biological Chemistry · doi:10.1515/bc.2001.128 · Cited by 14 · see citing works
Transcripts associated with Prdx6 (Peroxiredoxin 6) and related genes in mouse
Simeone, M., & Phelan, S. A. (2005) · Mammalian Genome · doi:10.1007/s00335-004-2429-6 · Cited by 14 · see citing works
Pak, J. H., Yi, J., Ryu, S., Kim, I. K., Kim, J.-W., Baek, H., & Chung, J. W. (2019) · Antioxidants · doi:10.3390/antiox8090399 · Cited by 11 · see citing works
Xu, Y., Ge, J., Zhang, M., Sun, W., Zhang, J., Yu, P., Zheng, Y.-F., Yang, J. J., & Zhu, X. (2016) · International Journal of Toxicology · doi:10.1177/1091581816653363 · Cited by 11 · see citing works
Modulation of the Wound Healing Response Through Oxidation Active Materials
Wattamwar, P. P., & Dziubla, T. D. (2011) · Springer eBooks · doi:10.1007/978-1-4614-1080-5_7 · Cited by 9 · see citing works
- Authors
- MUNZ, B., FRANK, S., HÜBNER, G., OLSEN, E., & WERNER, S.
- Affiliations
- Max Planck Institute of Biochemistry (DE)
- Danish Centre for Human Genome Research, Ole Worms Alle 170, DK-8000 Aarhus C, Denmark
- Corresponding author
- MUNZ, Barbara
- FRANK, Stefan
- WERNER, Sabine
- ORCID
- WERNER, Sabine
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1997-09-01
- Volume
- 326
- Issue
- 2
- Pages
- 579-585
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- PMC
- PMC1218708
- OpenAlex
- W2267571706
- Cited by
- 118
- References
- 32
- Citations by year
- 2026: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 5 · 2013: 4 · 2012: 1
- FWCI
- 10.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biochemical Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eli Lilly and Company
- Verband der Chemischen Industrie
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- glutathione peroxidase, keratinocyte growth factor, keratinocytes, wound healing, skin wounds, gene expression regulation, alternative splicing, RNA editing, tissue-specific gene expression, oxidative stress, inflammatory phase, mouse skin
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, Cattle, Cell Division, Cloning, Molecular, Epithelial Cells, Epithelium, Female, Gene Expression Regulation, Multigene Family, Glutathione Peroxidase, Humans, Mice, Inbred BALB C, Molecular Sequence Data, Molecular Weight, Organ Specificity, Wound Healing, Keratinocytes, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review