The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Stress-induced transcription of the clusterin/apoJ gene
Open accessAbstract
Clusterin/apoJ is an intriguing gene frequently isolated by differential screening in laboratories from different areas of molecular biology, since it is overexpressed in numerous cases of degenerative diseases such as Alzheimer's disease and scrapie. While the dramatic increase of clusterin expression in injured tissues is well established, the molecular basis of the gene induction remains unclear. In this study, we have focused our attention on the only DNA region strictly conserved between clusterin gene proximal promoters from different vertebrate classes. We show that this 14-bp DNA element is specifically recognized by the HSF1 transcription factor and can mediate heat-shock-induced transcription in transient expression assays. Conversely, the avian clusterin proximal promoter, point-mutated at the level of this element, no longer transmits heat-shock activation. These findings provide a possible explanation for the high sensitivity of clusterin expression to environmental changes and allow the classification of clusterin as an extracellular version of heat-shock protein.
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Cites
Apolipoprotein J: structure and tissue distribution
De Silva, H. V., Harmony, J. A. K., Stuart, W. D., Gil, C. M., & Robbins, J. (1990) · Biochemistry · doi:10.1021/bi00474a025 · Cited by 353
May, P. C., Lampert-Etchells, M., Johnson, S. A., Poirier, J., Masters, J. N., & Finch, C. E. (1990) · Neuron · doi:10.1016/0896-6273(90)90342-d · Cited by 339
Distribution of clusterin in Alzheimer brain tissue
McGeer, P. L., Kawamata, T., & Walker, D. G. (1992) · Brain Research · doi:10.1016/0006-8993(92)90071-g · Cited by 212
Cited by
Clusterin Has Chaperone-like Activity Similar to That of Small Heat Shock Proteins
Humphreys, D. T., Carver, J. A., Easterbrook-Smith, S. B., & Wilson, M. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.11.6875 · Cited by 455
Synthesis and Functional Analyses of Nuclear Clusterin, a Cell Death Protein
Leskov, K. S., Klokov, D. Y., Li, J., Kinsella, T. J., & Boothman, D. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209233200 · Cited by 395
Clusterin in Alzheimer’s Disease: Mechanisms, Genetics, and Lessons From Other Pathologies
Foster, E. M., Dangla-Valls, A., Lovestone, S., Ribe, E. M., & Buckley, N. J. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00164 · Cited by 381
The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE
Guerreiro, R. J., Gustafson, D. R., & Hardy, J. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.03.025 · Cited by 285
Clusterin: A forgotten player in Alzheimer's disease
Nuutinen, T., Suuronen, T., Kauppinen, A., & Salminen, A. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.05.007 · Cited by 267
Metadata
- Authors
- MICHEL, D., CHATELAIN, G., NORTH, S., & BRUN, G.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 1997-11-15
- Volume
- 328
- Issue
- 1
- Pages
- 45-50
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W2166575679
- Cited by
- 194
- References
- 3
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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