Cited by 447Ubiquitin and proteasome pathwaysRedox biology and oxidative stressHeat shock proteins research

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Comparative resistance of the 20S and 26S proteasome to oxidative stress

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REINHECKEL, Thomas, SITTE, Nicolle, ULLRICH, Oliver, KUCKELKORN, Ulrike, DAVIES, Kelvin J. A., GRUNE, Tilman·1998·Biochemical Journal

DOI 10.1042/bj3350637PMC PMC1219826

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Abstract

Oxidatively modified ferritin is selectively recognized and degraded by the 20S proteasome. Concentrations of hydrogen peroxide (H2O2) higher than 10 µmol/mg of protein are able to prevent proteolytic degradation. Exposure of the protease to high amounts of oxidants (H2O2, peroxynitrite and hypochlorite) inhibits the enzymic activity of the 20S proteasome towards the fluorogenic peptide succinyl-leucine-leucine-valine-tyrosine-methylcoumarylamide (Suc-LLVY-MCA), as well as the proteolytic degradation of normal and oxidant-treated ferritin. Fifty per cent inhibition of the degradation of the protein substrates was achieved using 40 µmol of H2O2/mg of proteasome. No change in the composition of the enzyme was revealed by electrophoretic analysis up to concentrations of 120 µmol of H2O2/mg of proteasome. In further experiments, it was found that the 26S proteasome, the ATP- and ubiquitin-dependent form of the proteasomal system, is much more susceptible to oxidative stress. Whereas degradation of the fluorogenic peptide, Suc-LLVY-MCA, by the 20S proteasome was inhibited by 50% with 12 µmol of H2O2/mg, 3 µmol of H2O2/mg was enough to inhibit ATP-stimulated degradation by the 26S proteasome by 50%. This loss in activity could be followed by the loss of band intensity in the non-denaturing gel. Therefore we concluded that the 20S proteasome was more resistant to oxidative stress than the ATP- and ubiquitin-dependent 26S proteasome. Furthermore, we investigated the activity of both proteases in K562 cells after H2O2 treatment. Lysates from K562 cells are able to degrade oxidized ferritin at a higher rate than non-oxidized ferritin, in an ATP-independent manner. This effect could be followed even after treatment of the cells with H2O2 up to a concentration of 2 mM. The lactacystin-sensitive ATP-stimulated degradation of the fluorogenic peptide Suc-LLVY-MCA declined, after treatment of the cells with 1 mM H2O2, to the same level as that obtained without ATP stimulation. Therefore, we conclude that the regulation of the 20 S proteasome by various regulators takes place during oxidative stress. This provides further evidence for the role of the 20S proteasome in the secondary antioxidative defences of mammalian cells.

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Authors: REINHECKEL, T., SITTE, N., ULLRICH, O., KUCKELKORN, U., DAVIES, K. J. A., & GRUNE, T.
Affiliations: Humboldt-Universität zu Berlin (DE)
University of Southern California (US)
Corresponding author: REINHECKEL, Thomas
SITTE, Nicolle
ULLRICH, Oliver
GRUNE, Tilman
ORCID: REINHECKEL, Thomas
ULLRICH, Oliver
KUCKELKORN, Ulrike
DAVIES, Kelvin J. A.
GRUNE, Tilman
Venue: Biochemical Journal
Publisher: Portland Press Ltd.
Published: 1998-11-01
Volume: 335
Issue: 3
Pages: 637-642
ISSN: 0264-6021 (ISSN-L)
1470-8728
DOI: 10.1042/bj3350637
PMC: PMC1219826
OpenAlex: W2237167760
Cited by: 447
References: 24
Citations by year: 2026: 6 · 2025: 4 · 2024: 8 · 2023: 9 · 2022: 7 · 2021: 15 · 2020: 19 · 2019: 11 · 2018: 13 · 2017: 11 · 2016: 25 · 2015: 16 · 2014: 17 · 2013: 19 · 2012: 19
FWCI: 5.35
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Biochemical Journal (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft
National Institutes of Health (ES-03598)
National Institute of Environmental Health Sciences (ES03598)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
Keywords: 20S proteasome, 26S proteasome, oxidative stress, hydrogen peroxide, ATP-dependent proteolysis, ubiquitin, peroxynitrite, hypochlorite, K562 cells, proteasome inhibition, lactacystin
MeSH terms: Coumarins, Cysteine Endopeptidases, Erythrocytes, Ferritins, Fluorescent Dyes, Humans, Hydrogen Peroxide, Kinetics, Multienzyme Complexes, Nitrates, Oligopeptides, Peptide Hydrolases, Sodium Hypochlorite, Substrate Specificity, Oxidants, Oxidative Stress, K562 Cells, Proteasome Endopeptidase Complex

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Comparative resistance of the 20S and 26S proteasome to oxidative stress

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