The DOI matches its Crossref record.
Synthesis and function of hepatic very-low-density lipoprotein
Abstract
Most of the triacylglycerol (TAG) utilized for the assembly of very-low-density lipoprotein (VLDL) in the secretory apparatus of the hepatocyte is mobilized by lipolysis of the cytosolic TAG pool, followed by re-esterification. The lipases involved include arylacetamide deacetylase and/or triacylglycerol hydrolase. Some of the re-esterified products of lipolysis gain access to an apolipoprotein-B-rich VLDL precursor to form mature VLDL. Some, however, are returned to the cytosolic pool in a process that is stimulated by insulin and inhibited by microsomal triacylglycerol transfer protein (MTP). Phospholipids also contribute to VLDL TAG in a process which involves ADP-ribosylation factor-1 (ARF-1)-mediated activation of phospholipase D. The temporary storage of TAG in the liver, followed by its mobilization and secretion as VLDL, form part of a process by which the liver protects vulnerable body tissues from excess lipotoxic non-esterified (‘free’) fatty acids in the plasma.
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Metadata
- Authors
- Gibbons, G. F., Wiggins, D., Brown, A.-M., & Hebbachi, A.-M.
- Venue
- Biochemical Society Transactions
- Publisher
- Portland Press Ltd.
- Published
- 2004-02-01
- Volume
- 32
- Issue
- 1
- Pages
- 59-64
- ISSN
- 0300-5127 (ISSN-L)
- 1470-8752
- OpenAlex
- W2085645589
- Cited by
- 254
- References
- 0
- FWCI
- 10.74
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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