In Vitro and In Vivo Models of Non-Alcoholic Fatty Liver Disease: A Critical Appraisal
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Non-alcoholic fatty liver disease (NAFLD), including non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH), represents the hepatic manifestation of obesity and metabolic syndrome. Due to the spread of the obesity epidemic, NAFLD is becoming the most common chronic liver disease and one of the principal indications for liver transplantation. However, no pharmacological treatment is currently approved to prevent the outbreak of NASH, which leads to fibrosis and cirrhosis. Preclinical research is required to improve our knowledge of NAFLD physiopathology and to identify new therapeutic targets. In the present review, we summarize advances in NAFLD preclinical models from cellular models, including new bioengineered platforms, to in vivo models, with a particular focus on genetic and dietary mouse models. We aim to discuss the advantages and limits of these different models.
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Limited translation of preclinical data from animal models due to interspecies differences increases the importance of human-oriented in vitro platforms compatible with controlled design and high-throughput screening.
“Against the background of the limited translation of preclinical data from animal models due to interspecies differences, the importance of human-oriented in vitro platforms compatible with controlled design and high-throughput screening is increasing.”
From The HepG2 Cell Line as a Model for Studying Metabolic Dysfunction-Associated Steatotic Liver Disease (2026) · cites this paper as [26]
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- Authors
- Soret, P.-A., Magusto, J., Housset, C., & Gautheron, J.
- Affiliations
- Inserm (FR)
- Corresponding author
- Gautheron, Jérémie
- Venue
- Journal of Clinical Medicine
- Publisher
- MDPI AG
- Published
- 2020-12-24
- Volume
- 10
- Issue
- 1
- Pages
- 36
- ISSN
- 2077-0383 (ISSN-L)
- PMC
- PMC7794936
- OpenAlex
- W3116089396
- Cited by
- 121
- References
- 174
- Citations by year
- 2026: 13 · 2025: 15 · 2024: 25 · 2023: 26 · 2022: 34 · 2021: 8
- FWCI
- 2.48
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Clinical Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Fondation pour la Recherche Médicale (EQU2020-03010517, ARF20170938613)
- Société Nationale Française de Gastro-Entérologie
- Société Francophone du Diabète
- Institut de Cardiométabolisme et Nutrition
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- non-alcoholic fatty liver disease, nonalcoholic steatohepatitis, in vitro model, in vivo models, cell model, mouse model, genetic mouse models, obesity, metabolic syndrome, liver fibrosis, liver cirrhosis, therapeutic target
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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