The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Polyunsaturated fatty acids and inflammation
Abstract
The n–6 polyunsaturated fatty acid, arachidonic acid, is a precursor of prostaglandins, leukotrienes and related compounds that have important roles as mediators and regulators of inflammation. Consuming increased amounts of long chain n–3 polyunsaturated fatty acids (found in oily fish and fish oils) results in a partial replacement of the arachidonic acid in cell membranes by eicosapentaenoic and docosahexaenoic acids. This leads to decreased production of arachidonic acid-derived mediators. This alone is a potentially beneficial anti-inflammatory effect of n–3 fatty acids. However, n–3 fatty acids have a number of other effects that might occur downstream of altered eicosanoid production or are independent of this. For example, they result in suppressed production of pro-inflammatory cytokines and can modulate adhesion molecule expression. These effects occur at the level of altered gene expression.
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Cites
Lipid mediator class switching during acute inflammation: signals in resolution
Levy, B. D., Clish, C. B., Schmidt, B., Gronert, K., & Serhan, C. N. (2001) · Nature Immunology · doi:10.1038/89759 · Cited by 1,453
Lee, T. H., Hoover, R. L., Williams, J. D., Sperling, R. I., Ravalese, J., Spur, B. W., Robinson, D. R., Corey, E. J., Lewis, R. A., & Austen, K. F. (1985) · New England Journal of Medicine · doi:10.1056/nejm198505093121903 · Cited by 1,333
Serhan, C. N., Clish, C. B., Brannon, J., Colgan, S. P., Chiang, N., & Gronert, K. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.8.1197 · Cited by 1,189
Hong, S., Gronert, K., Devchand, P. R., Moussignac, R.-L., & Serhan, C. N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300218200 · Cited by 1,000
Marcheselli, V. L., Hong, S., Lukiw, W. J., Tian, X. H., Gronert, K., Musto, A., Hardy, M., Gimenez, J. M., Chiang, N., Serhan, C. N., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305841200 · Cited by 802
Mukherjee, P. K., Marcheselli, V. L., Serhan, C. N., & Bazan, N. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402531101 · Cited by 753
Trebble, T. M., Wootton, S. A., Miles, E. A., Mullee, M., Arden, N. K., Ballinger, A. B., Stroud, M. A., Burdge, G. C., & Calder, P. C. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.3.376 · Cited by 179
Cited by
n−3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases
Calder, P. C. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1505s · Cited by 2,525
Self-citationOh, D. Y., Talukdar, S., Bae, E. J., Imamura, T., Morinaga, H., Fan, W., Li, P., Lu, W. J., Watkins, S. M., & Olefsky, J. M. (2010) · Cell · doi:10.1016/j.cell.2010.07.041 · Cited by 2,428
Schaeffer, L., Gohlke, H., Müller, M., Heid, I. M., Palmer, L. J., Kompauer, I., Demmelmair, H., Illig, T., Koletzko, B., & Heinrich, J. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl117 · Cited by 561
Effects of Omega-3 Fatty Acids on Immune Cells
Gutiérrez, S., Svahn, S. L., & Johansson, M. E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205028 · Cited by 525
Modulation of inflammation in brain: A matter of fat
Farooqui, A. A., Horrocks, L. A., & Farooqui, T. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04371.x · Cited by 460
Metadata
- Authors
- Calder, P. C.
- Venue
- Biochemical Society Transactions
- Publisher
- Portland Press Ltd.
- Published
- 2005-04-01
- Volume
- 33
- Issue
- 2
- Pages
- 423-427
- ISSN
- 0300-5127 (ISSN-L)
- 1470-8752
- OpenAlex
- W3023533824
- Cited by
- 327
- References
- 7
- FWCI
- 18.80
- Type
- journal article
- Language
- en
- Open access
- closed
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