The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Polyunsaturated fatty acids and inflammation
Abstract
The n–6 polyunsaturated fatty acid, arachidonic acid, is a precursor of prostaglandins, leukotrienes and related compounds that have important roles as mediators and regulators of inflammation. Consuming increased amounts of long chain n–3 polyunsaturated fatty acids (found in oily fish and fish oils) results in a partial replacement of the arachidonic acid in cell membranes by eicosapentaenoic and docosahexaenoic acids. This leads to decreased production of arachidonic acid-derived mediators. This alone is a potentially beneficial anti-inflammatory effect of n–3 fatty acids. However, n–3 fatty acids have a number of other effects that might occur downstream of altered eicosanoid production or are independent of this. For example, they result in suppressed production of pro-inflammatory cytokines and can modulate adhesion molecule expression. These effects occur at the level of altered gene expression.
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Cites
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Self-citationOh, D. Y., Talukdar, S., Bae, E. J., Imamura, T., Morinaga, H., Fan, W., Li, P., Lu, W. J., Watkins, S. M., & Olefsky, J. M. (2010) · Cell · doi:10.1016/j.cell.2010.07.041 · Cited by 2,428
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Effects of Omega-3 Fatty Acids on Immune Cells
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Modulation of inflammation in brain: A matter of fat
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(n-3) Fatty Acids and Cardiovascular Health: Are Effects of EPA and DHA Shared or Complementary?
Mozaffarian, D., & Wu, J. H. Y. (2012) · The Journal of Nutrition · doi:10.3945/jn.111.149633 · Cited by 368
Dietary α-linolenic acid and health-related outcomes: a metabolic perspective
Burdge, G. C., & Calder, P. C. (2006) · Nutrition Research Reviews · doi:10.1079/nrr2005113 · Cited by 281
Self-citationEffect of fish oil on arrhythmias and mortality: systematic review.
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Apolipoprotein D takes center stage in the stress response of the aging and degenerative brain
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Metadata
- Authors
- Calder, P. C.
- Venue
- Biochemical Society Transactions
- Publisher
- Portland Press Ltd.
- Published
- 2005-04-01
- Volume
- 33
- Issue
- 2
- Pages
- 423-427
- ISSN
- 0300-5127 (ISSN-L)
- 1470-8752
- OpenAlex
- W3023533824
- Cited by
- 327
- References
- 7
- FWCI
- 18.80
- Type
- journal article
- Language
- en
- Open access
- closed
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