Signalling through Class I PI3Ks in mammalian cells

TOR signaling in growth and metabolism

Wullschleger, S., Loewith, R., & Hall, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.01.016 · Cited by 5,787

The phosphoinositide 3-kinase pathway

Cantley, L. C. (2002) · Science · doi:10.1126/science.296.5573.1655 · Cited by 5,621

Cell Migration: Integrating Signals from Front to Back

Ridley, A. J., Schwartz, M. A., Burridge, K., Firtel, R., Ginsberg, M. H., Borisy, G. G., Parsons, J. T., & Horwitz, A. R. (2003) · Science · doi:10.1126/science.1092053 · Cited by 5,109

High Frequency of Mutations of the PIK3CA Gene in Human Cancers

Samuels, Y., Wang, Z., Bardelli, A., Silliman, N., Ptak, J., Szabo, S., Yan, H., Gazdar, A. F., Powell, S. M., Riggins, G. J., et al. (2004) · Science · doi:10.1126/science.1096502 · Cited by 3,448

Targeting RAS signalling pathways in cancer therapy

Downward, J. (2003) · Nature reviews. Cancer · doi:10.1038/nrc969 · Cited by 3,354

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

Engelman, J. A., Luo, J., & Cantley, L. C. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1879 · Cited by 3,330

Ras, PI(3)K and mTOR signalling controls tumour cell growth

Shaw, R. J., & Cantley, L. C. (2006) · Nature · doi:10.1038/nature04869 · Cited by 2,019

Phosphatidylinositol-3-OH kinase direct target of Ras

Rodriguez-Viciana, P., Warne, P. H., Dhand, R., Vanhaesebroeck, B., Gout, I., Fry, M. J., Waterfield, M. D., & Downward, J. (1994) · Nature · doi:10.1038/370527a0 · Cited by 1,954

Synthesis and Function of 3-Phosphorylated Inositol Lipids

Vanhaesebroeck, B., Leevers, S. J., Ahmadi, K., Timms, J., Katso, R., Driscoll, P. C., Woscholski, R., Parker, P. J., & Waterfield, M. D. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.535 · Cited by 1,535

Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis

Cully, M., You, H., Levine, A. J., & Mak, T. W. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1819 · Cited by 1,267

Pseudomonas aeruginosa interacts with epithelial cells rapidly forming aggregates that are internalized by a Lyn-dependent mechanism

Lepanto, P., Bryant, D. M., Rossello, J., Datta, A., Mostov, K. E., & Kierbel, A. (2011) · Cellular Microbiology · doi:10.1111/j.1462-5822.2011.01611.x · Cited by 42

Phosphoinositide 3-kinase signaling in the vertebrate retina

Rajala, R. (2010) · Journal of Lipid Research · doi:10.1194/jlr.r000232 · Cited by 46

Genetic alterations in oral squamous cell carcinoma progression detected by combining array-based comparative genomic hybridization and multiplex ligation-dependent probe amplification

Cha, J., Kim, H. J., & Cha, I. (2011) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1016/j.tripleo.2010.11.020 · Cited by 42

Glycyrrhizic acid and 18β-glycyrrhetinic acid recover glucocorticoid resistance via PI3K-induced AP1, CRE and NFAT activation

Kao, T.-C., Wu, C., & Yen, G. (2012) · Phytomedicine · doi:10.1016/j.phymed.2012.10.013 · Cited by 42

Phosphoinositide 3-kinase γ mediates microglial phagocytosis via lipid kinase-independent control of cAMP

Schmidt, C., Schneble, N., Müller, J., Bauer, R., Perino, A., Marone, R., Rybalkin, S. D., Wymann, M. P., Hirsch, E., & Wetzker, R. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.12.036 · Cited by 40

In-depth PtdIns(3,4,5)P3 signalosome analysis identifies DAPP1 as a negative regulator of GPVI-driven platelet function

Durrant, T. N., Hutchinson, J. L., Heesom, K. J., Anderson, K. E., Stephens, L., Hawkins, P. T., Marshall, A. J., Moore, S., & Hers, I. (2017) · Blood Advances · doi:10.1182/bloodadvances.2017005173 · Cited by 41

Intraventricular injections of mesenchymal stem cells activate endogenous functional remyelination in a chronic demyelinating murine model

Cruz-Martinez, P., González-Granero, S., Molina‐Navarro, M. M., Pacheco‐Torres, J., García‐Verdugo, J. M., Geijo‐Barrientos, E., Jones, J., & Martı́nez, S. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.130 · Cited by 43

Molecular Mechanisms of Insulin Resistance Development

Va, T., & Vorotnikov, A. V. (2014) · Diabetes Mellitus · doi:10.14341/dm2014229-40 · Cited by 48

PI3K class IB controls the cell cycle checkpoint promoting cell proliferation in hepatocellular carcinoma

Dituri, F., Mazzocca, A., Lupo, L., Edling, C. E., Azzariti, A., Antonaci, S., Falasca, M., & Giannelli, G. (2011) · International Journal of Cancer · doi:10.1002/ijc.26319 · Cited by 41

The neuronal Arf GAP centaurin α1 modulates dendritic differentiation

Moore, C. D., Thacker, E. E., Larimore, J., Gaston, D., Underwood, A., Kearns, B., Patterson, S. I., Jackson, T., Chapleau, C., Pozzo-Miller, L., et al. (2007) · Journal of Cell Science · doi:10.1242/jcs.006346 · Cited by 40

Caspase-3 is Involved in Aluminum-Induced Impairment of Long-Term Potentiation in Rats Through the Akt/GSK-3β Pathway

Zhang, H., Yang, X., Qin, X., & Niu, Q. L. (2016) · Neurotoxicity Research · doi:10.1007/s12640-016-9597-5 · Cited by 41

PI3Kγ Protects from Myocardial Ischemia and Reperfusion Injury through a Kinase-Independent Pathway

Haubner, B. J., Neely, G. G., Voelkl, J. G. J., Damilano, F., Kuba, K., Imai, Y., Komnenovic, V., Mayr, A., Pachinger, O. M., Hirsch, E., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009350 · Cited by 40

Superoxide and Non-ionotropic Signaling in Neuronal Excitotoxicity

Wang, J., & Swanson, R. A. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00861 · Cited by 40

Cryptotanshinone inhibits chemotactic migration in macrophages through negative regulation of the PI3K signaling pathway

Don, M., Liao, J., Lin, L., & Chiou, W. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707271 · Cited by 40

The p110δ subunit of PI3K regulates bone marrow-derived eosinophil trafficking and airway eosinophilia in allergen-challenged mice

Kang, B. N., Ha, S. G., Ge, X. N., Hosseinkhani, M. R., Bahaie, N. S., Greenberg, Y. G., Blumenthal, M. N., Puri, K. D., Sriramarao, P., & Sriramarao, P. (2012) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00005.2012 · Cited by 39

mTOR-dependent alterations of Kv1.1 subunit expression in the neuronal subset-specific Pten knockout mouse model of cortical dysplasia with epilepsy

Nguyen, L. H., & Anderson, A. E. (2018) · Scientific Reports · doi:10.1038/s41598-018-21656-8 · Cited by 39

The Phosphoinositide-3 Kinase Survival Signaling Mechanism in Sepsis

Manukyan, M. C., Weil, B. R., Wang, Y., Abarbanell, A. M., Herrmann, J. L., Poynter, J. A., & Meldrum, D. R. (2010) · Shock · doi:10.1097/shk.0b013e3181e14ea9 · Cited by 38

LY294002 enhances boswellic acid-induced apoptosis in colon cancer cells.

Liu, J., & Duan, R. (2009) · PubMed · Cited by 39

Upstream signaling events leading to elevated production of pro-survival nitric oxide in photodynamically-challenged glioblastoma cells

Fahey, J. M., Korytowski, W., & Girotti, A. W. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.04.013 · Cited by 38

PI3K at the crossroads of tumor angiogenesis signaling pathways

Soler, A., Angulo‐Urarte, A., & Graupera, M. (2015) · Molecular & Cellular Oncology · doi:10.4161/23723556.2014.975624 · Cited by 39

Maternal Subclinical Hypothyroidism Impairs Neurodevelopment in Rat Offspring by Inhibiting the CREB Signaling Pathway

Zhang, Y., Fan, Y., Yu, X., Wang, X., Bao, S., Li, J., Fan, C., Shan, Z., & Teng, W. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8855-x · Cited by 38

Inhibitors of Glioma Growth that Reveal the Tumour to the Immune System

Nieto‐Sampedro, M., Valle‐Argos, B., Gómez‐Nicola, D., Fernández‐Mayoralas, A., & Nieto‐Díaz, M. (2011) · Clinical Medicine Insights Oncology · doi:10.4137/cmo.s7685 · Cited by 39

A new class of cancer-associated PTEN mutations defined by membrane translocation defects

Nguyen, H.-N., Yang, J.-M., Jr., Rahdar, M., Keniry, M. E., Swaney, K. F., Parsons, R. E., Park, B. H., Sesaki, H., Devreotes, P. N., & Iijima, M. (2014) · Oncogene · doi:10.1038/onc.2014.293 · Cited by 38

Distinct inactivation of PI3K signalling by PTEN and 5-phosphatases

Leslie, N. R., Dixon, M. J., Schenning, M., Gray, A., & Batty, I. H. (2011) · Advances in Biological Regulation · doi:10.1016/j.advenzreg.2011.09.010 · Cited by 39

Reciprocal regulation among TRPV1 channels and phosphoinositide 3-kinase in response to nerve growth factor

Stratiievska, A., Nelson, S., Senning, E. N., Lautz, J. D., Smith, S. E. P., & Gordon, S. E. (2018) · eLife · doi:10.7554/elife.38869 · Cited by 37

The Effect of Deleting p110δ on the Phenotype and Function of PTEN-Deficient B Cells

Janas, M. L., Hodson, D. J., Stamataki, Z., Hill, S., Welch, K. A., Gambardella, L., Trotman, L. C., Pandolfi, P. P., Vigorito, E., & Turner, M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.2.739 · Cited by 37

Src-family-tyrosine kinase Lyn is critical for TLR2-mediated NF-κB activation through the PI 3-kinase signaling pathway

Toubiana, J., Rossi, A.-L., Belaïdouni, N., Grimaldi, D., Pène, F., Chafey, P., Comba, B., Camoin, L., Bismuth, G., Claessens, Y.-É., et al. (2015) · Innate Immunity · doi:10.1177/1753425915586075 · Cited by 37

Quantitative Measurement of Phosphatidylinositol 3,4,5-trisphosphate

Guillou, H., Stephens, L., & Hawkins, P. T. (2007) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(07)34007-x · Cited by 36

Multiple Phosphatidylinositol 3-Kinases Regulate Vaccinia Virus Morphogenesis

McNulty, S., Bornmann, W. G., Schriewer, J. M., Werner, C., Smith, S. K., Olson, V. A., Damon, I. K., Buller, R. M. L., Heuser, J., & Kalman, D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010884 · Cited by 36

Suppression of mTOR complex 2-dependent AKT phosphorylation in melanoma cells by combined treatment with rapamycin and LY294002

Werzowa, J. M., Cejka, D., Fuereder, T., Dekrout, B., Thallinger, C., Pehamberger, H., Wacheck, V., & Pratscher, B. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08991.x · Cited by 36

PI3-Kinase Regulates Eosinophil and Neutrophil Degranulation in Patients with Allergic Rhinitis and Allergic Asthma Irrespective of Allergen Challenge Model

Kämpe, M., Lampinen, M., Stolt, I., Janson, C., Stålenheim, G., & Carlson, M. (2011) · Inflammation · doi:10.1007/s10753-011-9309-5 · Cited by 36

P-Rex1 Cooperates with PDGFRβ to Drive Cellular Migration in 3D Microenvironments

Campbell, A. D., Lawn, S. O., McGarry, L., Welch, H. C. E., Ozanne, B. W., & Norman, J. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053982 · Cited by 35

Discovery of Highly Isoform Selective Thiazolopiperidine Inhibitors of Phosphoinositide 3-Kinase γ

Collier, P. N., Messersmith, D., LeTiran, A., Bandarage, U. K., Boucher, C., Come, J. H., Cottrell, K. M., Damagnez, V., Doran, J., Griffith, J. P., et al. (2015) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b00498 · Cited by 35

PDK1 Regulates Chemotaxis in Human Neutrophils

Yagi, M., Kantarcı, A., Iwata, T., Omori, K., Ayilavarapu, S., Ito, K., Hastürk, H., & Dyke, T. E. V. (2009) · Journal of Dental Research · doi:10.1177/0022034509349402 · Cited by 35

Assembly of Membrane-Bound Protein Complexes: Detection and Analysis by Single Molecule Diffusion

Ziemba, B. P., Knight, J. D., & Falke, J. J. (2012) · Biochemistry · doi:10.1021/bi201743a · Cited by 35

Microbial inositol polyphosphate metabolic pathway as drug development target

Saiardi, A., Azevedo, C., Desfougères, Y., Portela-Torres, P., & Wilson, M. (2017) · Advances in Biological Regulation · doi:10.1016/j.jbior.2017.09.007 · Cited by 32

Aberrant expression of LncRNA‐MIR31HG regulates cell migration and proliferation by affecting miR‐31 and miR‐31* in Hirschsprung's disease

Cai, P., Li, H., Huo, W., Zhu, H., Xu, C., Zang, R., Lv, W., Xia, Y., & Tang, W. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26830 · Cited by 34

eIF4E3 forms an active eIF4F complex during stresses (eIF4FS) targeting mTOR and re-programs the translatome

Weiss, B., Allen, G. E., Kloehn, J., Abid, K., Jaquier-Gubler, P., & Curran, J. A. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab267 · Cited by 34

The vitamin D receptor‐mediated activation of phosphatidylinositol 3‐kinase (PI3Kα) plays a role in the 1α,25‐dihydroxyvitamin D3‐stimulated increase in steroid sulphatase activity in myeloid leukaemic cell lines

Hughes, P., Lee, J. S. I., Reiner, N., & Brown, G. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21545 · Cited by 38

Liver Regeneration and Immunity: A Tale to Tell

Di-Iacovo, N., Pieroni, S., Piobbico, D., Castelli, M., Scopetti, D., Ferracchiato, S., Fazia, M. A. D., & Servillo, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021176 · Cited by 37

Protective Effects of Keratinocyte Growth Factor-2 on Ischemia–Reperfusion–Induced Lung Injury in Rats

Fang, X., Wang, L., Shi, L., Chen, C., Wang, Q., Bai, C., & Wang, X. (2014) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2013-0268oc · Cited by 33

Phosphatidylinositol 3′-Kinase Activity Is Critical for Initiating the Oxidative Burst and Bacterial Destruction during CEACAM3-mediated Phagocytosis

Buntru, A., Kopp, K., Voges, M., Frank, R., Bachmann, V. A., & Hauck, C. R. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.216085 · Cited by 33

Cellular stress-induced up-regulation of FMRP promotes cell survival by modulating PI3K-Akt phosphorylation cascades

Jeon, S. J., Seo, J. E., Yang, S., Choi, J. W., Wells, D. G., Shin, C. Y., & Ko, K. H. (2011) · Journal of Biomedical Science · doi:10.1186/1423-0127-18-17 · Cited by 32

From the Bench to the Bed Side: PI3K Pathway Inhibitors in Clinical Development

Maira, S.-M., Finan, P. M., & Garcı́a-Echeverrı́a, C. (2010) · Current topics in microbiology and immunology · doi:10.1007/82_2010_60 · Cited by 32

Odorant-Specific Modes of Signaling in Mammalian Olfaction

Ache, B. W. (2010) · Chemical Senses · doi:10.1093/chemse/bjq045 · Cited by 32

The role of PI3K/protein kinase B (PKB/c-akt) in migration and homing of hematopoietic stem and progenitor cells

Buitenhuis, M. (2011) · Current Opinion in Hematology · doi:10.1097/moh.0b013e32834760e5 · Cited by 32

Molecular Basis for Membrane Recruitment by the PX and C2 Domains of Class II Phosphoinositide 3-Kinase-C2α

Chen, K., Tillu, V. A., Chandra, M., & Collins, B. M. (2018) · Structure · doi:10.1016/j.str.2018.08.010 · Cited by 32

Out, in and back again: PtdIns(4,5)P2 regulates cadherin trafficking in epithelial morphogenesis

Schill, N. J., & Anderson, R. A. (2009) · Biochemical Journal · doi:10.1042/bj20081844 · Cited by 32

Signal Transduction Pathways in Chronic Inflammatory Autoimmune Disease: Small GTPases

Reedquist, K. A., & Tak, P. P. (2012) · The Open Rheumatology Journal · doi:10.2174/1874312901206010259 · Cited by 31

Evaluating PI3 Kinase Isoforms Using Transcreener™ ADP Assays

Klink, T. A., Kleman-Leyer, K. M., Kopp, A. L., Westermeyer, T. A., & Lowery, R. G. (2008) · SLAS DISCOVERY · doi:10.1177/1087057108319864 · Cited by 32

Targeting the Akt-pathway to Improve Radiosensitivity in Glioblastoma

Narayan, R. S., Fedrigo, C. A., Stalpers, L. J. A., Baumert, B. G., & Sminia, P. (2012) · Current Pharmaceutical Design · doi:10.2174/138161213804547286 · Cited by 32

Enhanced FGF23 production in mice expressing PI3K‐insensitive GSK3 is normalized by β‐blocker treatment

Fajol, A., Chen, H., Umbach, A. T., Quarles, L. D., Lang, H., & Föller, M. (2015) · The FASEB Journal · doi:10.1096/fj.15-279943 · Cited by 32

Gαi2 and Gαi3 Differentially Regulate Arrest from Flow and Chemotaxis in Mouse Neutrophils

Kuwano, Y., Adler, M., Zhang, H., Groisman, A., & Ley, K. F. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1500532 · Cited by 31

Phosphoinositide signaling in sperm development

Brill, J. A., Yildirim, S., & Fabian, L. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.06.010 · Cited by 31

Differential Distribution of PI3K Isoforms in Spinal Cord and Dorsal Root Ganglia: Potential Roles in Acute Inflammatory Pain

Leinders, M., Koehrn, F., Bartok, B., Boyle, D., Shubayev, V., Kalcheva, I., Yu, N.-K., Park, J., Kaang, B., Hefferan, M., et al. (2014) · Pain · doi:10.1016/j.pain.2014.03.003 · Cited by 29

Proteasome Inactivation Promotes p38 Mitogen-activated Protein Kinase-dependent Phosphatidylinositol 3-kinase Activation and Increases Interleukin-8 Production in Retinal Pigment Epithelial Cells

Fernandes, A. F., Bian, Q., Jiang, J., Thomas, C. J., Taylor, A., Pereira, P., & Shang, F. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-10-1068 · Cited by 31

New insights into transcription elongation control of HIV-1 latency and rebound

Mbonye, U. R., Kizito, F., & Karn, J. (2022) · Trends in Immunology · doi:10.1016/j.it.2022.11.003 · Cited by 28

Genetic syndromes with vascular malformations – update on molecular background and diagnostics

Ustaszewski, A., Janowska-Głowacka, J., Wołyńska, K., Pietrzak, A., & Badura‐Stronka, M. (2020) · Archives of Medical Science · doi:10.5114/aoms.2020.93260 · Cited by 30

Platelet lipid metabolism in vascular thrombo-inflammation

Manke, M.-C., Ahrends, R., & Borst, O. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108258 · Cited by 30

The pharmacological effects of Berberine and its therapeutic potential in different diseases: Role of the phosphatidylinositol 3‐kinase/ AKT signaling pathway

Khezri, M. R., Mohammadipanah, S., & Ghasemnejad‐Berenji, M. (2023) · Phytotherapy Research · doi:10.1002/ptr.8040 · Cited by 32

Stromal cell-derived factor 1α and CXCR4: newly defined requirements for efficient thymic β-selection

Janas, M. L., & Turner, M. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.07.002 · Cited by 30

The Pace of Prostatic Intraepithelial Neoplasia Development Is Determined by the Timing of Pten Tumor Suppressor Gene Excision

Luchman, H. A., Benediktsson, H., Villemaire, M. L., Peterson, A. C., & Jirik, F. R. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003940 · Cited by 30

The PI(3)P interactome from a colon cancer cell

Catimel, B., Kapp, E. A., Yin, M.-X., Gregory, M. A., Wong, L. S. ‐., Condron, M. M., Church, N., Kershaw, N. J., Holmes, A. B., & Burgess, A. W. (2013) · Journal of Proteomics · doi:10.1016/j.jprot.2013.01.031 · Cited by 30

Arginine ADP-ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway

Yang, L., XIAO, M., Li, X., Tang, Y., & Wang, Y. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2473 · Cited by 30

Reelin modulates cytoskeletal organization by regulating Rho GTPases

Leemhuis, J., & Bock, H. H. (2011) · Communicative & Integrative Biology · doi:10.4161/cib.4.3.14890 · Cited by 29

Correction: Corrigendum: Intraventricular injections of mesenchymal stem cells activate endogenous functional remyelination in a chronic demyelinating murine model

Cruz-Martinez, P., González-Granero, S., Molina‐Navarro, M. M., Pacheco‐Torres, J., García‐Verdugo, J. M., Geijo‐Barrientos, E., Jones, J., & Martínez, S. (2017) · Cell Death and Disease · doi:10.1038/cddis.2016.340 · Cited by 30

Regulation of CD38 Expression in Human Airway Smooth Muscle Cells

Jude, J. A., Tirumurugaan, K. G., Kang, B. N., Panettieri, R. A., Walseth, T. F., & Kannan, M. (2012) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2012-0025oc · Cited by 30

The Phosphoinositide 3‐Kinase Isoform PI3Kβ Regulates Osteoclast‐Mediated Bone Resorption in Humans and Mice

Győri, D., Csete, D., Benkő, S., Kulkarni, S., Mandl, P., Dobó‐Nagy, C., Vanhaesebroeck, B., Stephens, L., Hawkins, P. T., & Mócsai, A. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38660 · Cited by 28

Mitochondrial Neuroglobin Is Necessary for Protection Induced by Conditioned Medium from Human Adipose-Derived Mesenchymal Stem Cells in Astrocytic Cells Subjected to Scratch and Metabolic Injury

Báez-Jurado, E., Guio-Vega, G. P., Hidalgo‐Lanussa, O., González, J., Echeverrı́a, V., Ashraf, G. M., Sahebkar, A., & Barreto, G. E. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1442-9 · Cited by 29

Towards Kinase Inhibitor Therapies for Fragile X Syndrome: Tweaking Twists in the Autism Spectrum Kinase Signaling Network

D’Incal, C., Broos, J., Torfs, T., Kooy, R. F., & Vanden Berghe, W. (2022) · Cells · doi:10.3390/cells11081325 · Cited by 29

Modulation of μ-opioid receptor desensitization in peripheral sensory neurons by phosphoinositide 3-kinase γ

König, C., Gavrilova-Ruch, O., von Banchet, G. S., Bauer, R., Grün, M., Hirsch, E., Rubio, I., Schulz, S., Heinemann, S. H., Schaible, H.-G., et al. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.04.068 · Cited by 29

The Phosphatidylinositol 3-Kinase/mTor Pathway as a Therapeutic Target for Brain Aging and Neurodegeneration

Heras-Sandoval, D., Ávila-Muñoz, E., & Arias, C. (2011) · Pharmaceuticals · doi:10.3390/ph4081070 · Cited by 30

TrkC Promotes Survival and Growth of Leukemia Cells Through Akt-mTOR-Dependent Up-Regulation of PLK-1 and Twist-1

Kim, M. S., Kim, G. M., Choi, Y.-J., Kim, H. J., Kim, Y., & Jin, W. (2013) · Molecules and Cells · doi:10.1007/s10059-013-0061-6 · Cited by 27

Phosphatidylinositol 3-Kinase p110δ Isoform Regulates CD8+ T Cell Responses during Acute Viral and Intracellular Bacterial Infections

Gracias, D. T., Boesteanu, A. C., Fraietta, J. A., Hope, J. L., Carey, A. J., Mueller, Y. M., Kawalekar, O. U., Fike, A. J., June, C. H., & Katsikis, P. D. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501890 · Cited by 28

Cryptotanshinone exhibits therapeutical effects on cerebral stroke through the PI3K/AKT-eNOS signaling pathway

Zhu, W., Qiu, W., & Lu, A. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7824 · Cited by 28

BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein regulates neurite development via PI3K–AKT and ERK signaling pathways

Zhou, C., Li, C., Li, D., Wang, Y., Shao, W., You, Y., Peng, J., Zhang, X., Lu, L., & Shen, X. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.09.045 · Cited by 28

Treponema denticola Major Outer Sheath Protein Induces Actin Assembly at Free Barbed Ends by a PIP2-Dependent Uncapping Mechanism in Fibroblasts

Visser, M. B., Koh, A., Glogauer, M., & Ellen, R. P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023736 · Cited by 28

Phosphatidylinositol 3‐kinase/protein kinase Cδ activation induces close homolog of adhesion molecule L1 (CHL1) expression in cultured astrocytes

Wu, J., Wrathall, J. R., & Schachner, M. (2009) · Glia · doi:10.1002/glia.20925 · Cited by 28

A Screen for Novel Phosphoinositide 3-kinase Effector Proteins

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