Cited by 108Atherosclerosis and Cardiovascular DiseasesAdipokines, Inflammation, and Metabolic DiseasesLipid metabolism and disorders

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Postprandial inflammation and endothelial dysfuction

Alipour, A., Elte, J.W.F., van Zaanen, H.C.T., Rietveld, A.P., Cabezas, M. Castro·2007·Biochemical Society Transactions

DOI 10.1042/bst0350466

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Abstract

Postprandial hyperlipidaemia is a common metabolic disturbance in atherosclerosis. During the postprandial phase, chylomicrons and their remnants can penetrate the intact endothelium and cause foam cell formation. These particles are highly atherogenic after modification. People in the Western world are non-fasting for most of the day, which consequently leads to a continuous challenge of the endothelium by atherogenic lipoproteins and their remnants. Furthermore, atherosclerosis is considered a low-grade chronic inflammatory disease. Many studies have shown that the process of atherogenesis in part starts with the interaction between the activated leucocytes and activated endothelium. Postprandial lipoproteins can activate leucocytes in the blood and up-regulate the expression of leucocyte adhesion molecules on the endothelium, facilitating adhesion and migration of inflammatory cells into the subendothelial space. Another inflammatory process associated with postprandial lipaemia is the activation of the complement system. Its central component C3 has been associated with obesity, coronary sclerosis, the metabolic syndrome and fasting and postprandial TAGs (triacylglycerols). Moreover, chylomicrons are the strongest stimulators of adipocyte C3 production via activation of the alternative complement cascade. A postprandial C3 increment has been shown in healthy subjects and in patients with CAD (coronary artery disease) and with FCHL (familial combined hyperlipidaemia). Postprandial lipaemia has been related to TAG and free fatty acid metabolism. All of these mechanisms provide an alternative explanation for the atherogenicity of the postprandial period.

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Produits laitiers et inflammation métabolique : quels liens en phase postprandiale et à long terme ?
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“In the postprandial phase, lipoproteins, including chylomicrons and high-density lipoprotein (HDL), lead to C3 activation in the blood (Alipour et al., 2007).”
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Elevated Circulating Endocan Levels Are Associated with Increased Levels of Endothelial and Inflammation Factors in Postprandial Lipemia
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Polyphenol-rich fruits attenuate impaired endothelial function induced by glucose and free fatty acids in vitro in human endothelial cells
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L’inflammation postprandiale : les données récentes suggèrent un rôle préventif des protéines alimentaires et de leur nature
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“…et en sucres simples entrainent l’apparition transitoire de manifestations d’inflammation a bas bruit et de dysfonction endoth eliale (par exemple : (Alipour et al., 2007; Bae et al., 2003; Blackburn et al., 2006; Burdge and Calder, 2005; Ceriello, 2000; de Koning and Rabelink, 2002; Lee et al.,…”
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Serum Lipid Changes after Short Term SIPC Therapy for Lower Limb Lymphedema
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Selectina-E, VCAM-1, FNT-α, IL-6, PCR y Fibrinógeno plasmático como marcadores de inflamación en la aterosclerosis, en conejos machos Nueva Zelanda, expuestos a una dieta hiperlipidémica.
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“Vascular endothelial dysfunction is generally associated with an increase in the proinflammatory markers (1,7).”
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Observational Study of ChondroT's Improvement of Blood Metabolites in High-fat Diet-induced Hyperlipidemia
Yoon, C. S., Kim, D. H., Na, C. S., Jeong, J. W., Kim, J. H., Kim, S. G., Choi, J. M., & Kim, S. J. (2021) · Journal of Korean Medicine Rehabilitation · doi:10.18325/jkmr.2021.31.1.81 · Cited by 1
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Adhesion Molecules in Obesity and Metabolic Syndrome
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Author's response
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Intestinal postprandial chylomicrons: state of the union between liver, gut and dyslipidemia?
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“as a contributing factor to chronic disease, such as diabetes and atherosclerosis((19,20)).”
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Disorders in Postprandial Lipid Metabolism and the Risk of Atherogenesis
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Dairy Whey Proteins and Obesity
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Comparação da Lipemia Pós-Prandial de Mulheres que Utilizam e Não Utilizam Contraceptivo Oral Comparison of Postprandial Lipemia between Women who are on Oral Contraceptive Methods and Those who are not
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“Microarrays were analysed using the reorganized oligonucleotide probes, which combines all individual probes for a gene [8].”
BackgroundMethodInfluential

Authors: Alipour, A., Elte, J. W. F., van Zaanen, H. C. T., Rietveld, A. P., & Cabezas, M. C.
Affiliations: Sint Franciscus Gasthuis (NL)
Department of Internal Medicine, St Franciscus Gasthuis, Center for Diabetes and Vascular Medicine, PO Box 10900, 3004 BA Rotterdam, The Netherlands
ORCID: Alipour, A.
Cabezas, M. Castro
Venue: Biochemical Society Transactions
Publisher: Portland Press Ltd.
Published: 2007-05-22
Volume: 35
Issue: 3
Pages: 466-469
ISSN: 0300-5127 (ISSN-L)
1470-8752
DOI: 10.1042/bst0350466
OpenAlex: W2102556811
Cited by: 108
References: 47
Citations by year: 2025: 4 · 2024: 2 · 2023: 1 · 2021: 3 · 2020: 4 · 2019: 7 · 2018: 4 · 2017: 6 · 2016: 7 · 2015: 6 · 2014: 11 · 2013: 6 · 2012: 4
FWCI: 0.77
Type: journal article
Language: en
Open access: closed
Locations: Biochemical Society Transactions (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords: endothelial dysfunction, postprandial inflammation, atherosclerosis, chylomicrons, chylomicron remnants, foam cell formation, complement C3, alternative complement pathway, adipocytes, leukocyte activation, coronary artery disease, familial combined hyperlipidaemia, triglycerides, free fatty acids, low-grade inflammation
MeSH terms: Animals, Chylomicrons, Complement C3, Endothelium, Vascular, Humans, Hyperlipidemias, Inflammation, Models, Cardiovascular, Postprandial Period, Atherosclerosis

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