Cited by 153Neuroinflammation and Neurodegeneration MechanismsIntensive Care Unit Cognitive DisordersDementia and Cognitive Impairment Research

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Systemic inflammation and delirium: important co-factors in the progression of dementia

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Cunningham, Colm·2011·Biochemical Society Transactions

DOI 10.1042/bst0390945PMC PMC4157218

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Abstract

It is widely accepted that inflammation plays some role in the progression of chronic neurodegenerative diseases such as AD (Alzheimer's disease), but its precise role remains elusive. It has been known for many years that systemic inflammatory insults can signal to the brain to induce changes in CNS (central nervous system) function, typically grouped under the syndrome of sickness behaviour. These changes are mediated via systemic and CNS cytokine and prostaglandin synthesis. When patients with dementia suffer similar systemic inflammatory insults, delirium is a frequent consequence. This profound and acute exacerbation of cognitive dysfunction is associated with poor prognosis: accelerating cognitive decline and shortening time to permanent institutionalization and death. Therefore a better understanding of how delirium occurs during dementia and how these episodes impact on existing neurodegeneration are now important priorities. The current review summarizes the relationship between dementia, systemic inflammation and episodes of delirium and addresses the basic scientific approaches currently being pursued with respect to understanding acute cognitive dysfunction during aging and dementia. In addition, despite there being limited studies on this subject, it is becoming increasingly clear that infections and other systemic inflammatory conditions do increase the risk of AD and accelerate the progression of established dementia. These data suggest that systemic inflammation is a major contributor to the progression of dementia and constitutes an important clinical target.

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Authors: Cunningham, C.
Affiliations: Trinity College Dublin (IE)
Corresponding author: Cunningham, Colm
ORCID: Cunningham, Colm
Venue: Biochemical Society Transactions
Publisher: Portland Press Ltd.
Published: 2011-07-20
Volume: 39
Issue: 4
Pages: 945-953
ISSN: 0300-5127 (ISSN-L)
1470-8752
DOI: 10.1042/bst0390945
PMC: PMC4157218
OpenAlex: W2105065969
Cited by: 153
References: 74
Citations by year: 2026: 13 · 2025: 7 · 2024: 4 · 2023: 11 · 2022: 13 · 2021: 16 · 2020: 17 · 2019: 8 · 2018: 9 · 2017: 10 · 2016: 5 · 2015: 7 · 2014: 9 · 2013: 10 · 2012: 12
FWCI: 0.93
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Biochemical Society Transactions (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Arrow@dit (Dublin Institute of Technology) (submittedVersion, cc-by-nc-sa)
Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
Funders: Wellcome Trust (090907)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: systemic inflammation, delirium, dementia progression, Alzheimer's disease, sickness behavior, cytokines, prostaglandins, cognitive decline, infection, neurodegeneration, aging
MeSH terms: Animals, Anti-Inflammatory Agents, Non-Steroidal, Central Nervous System, Delirium, Dementia, Humans, Inflammation, Disease Progression

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Systemic inflammation and delirium: important co-factors in the progression of dementia

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