Redox activation of Nrf2 & NF-κB: A double end sword?

Buelna-Chontal, Mabel; Zazueta, Cecilia

doi:10.1016/j.cellsig.2013.08.007

Cited by 239Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stressNF-κB Signaling Pathways

Redox activation of Nrf2 & NF-κB: A double end sword?

Buelna-Chontal, Mabel, Zazueta, Cecilia·2013·Cellular Signalling

DOI 10.1016/j.cellsig.2013.08.007

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Abstract

Moderate concentrations of reactive oxygen species (ROS) are produced by diverse sources under physiological conditions. At such low levels, these molecules may act as upstream mediators of relevant signaling pathways; however an increase in their concentration with respect to the antioxidant system activity, changes their redox signaling function into a deleterious role. Thus, cell health depends, at least in part, on redox balance. This review includes global aspects of oxygen chemistry, ROS generation, antioxidant system, and redox signaling. It is also focused on the description of two relevant redox-sensitive transcription factors: nuclear factor erythroid 2-related factor 2 (Nrf2), which may be a potential target to confer cell protection, and nuclear factor κB (NF-κB), which is involved in deleterious effects in the cell. Finally, recent findings on the interplay between both factors for the development of different pathologies are discussed.

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The interplay between oxidative stress and inflammation is partly governed by reciprocal interactions between the transcription factors Nrf2 and NF-kB.
“The complex interplay between oxidative stress and inflammation is in part governed by the reciprocal interactions between the transcription factors Nrf2 (whose nuclear translocation induces antioxidant phase II gene transcription) and NF-kB (whose translocation to the nucleus promotes transcription of many pro-inflammatory genes) (Buelna-Chontal and Zazueta, 2013).”
From Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A “central hub” in schizophrenia pathophysiology? (2016) · cites this paper as Buelna-Chontal and Zazueta, 2013
Disruption of NFE2L2 induces NF-κB activation, probably by modifying NFKB1A degradation and NF-κB binding to DNA.
“At the molecular level, the antagonism between antioxidant-promoting NFE2L2 and inflammatory gene-regulating NF-κB may control the balance between oxidative stress and inflammation 94 : disruption of NFE2L2 induces NF-κB activation, probably by modifying NF-κB inhibitor α (NFKB1A, also known as IkBα) degradation and NF-κB binding to DNA 95,96”
From Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis (2016) · cites this paper as [96]

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Authors: Buelna-Chontal, M., & Zazueta, C.
Affiliations: Instituto Nacional de Cardiología (MX)
Corresponding author: Zazueta, Cecilia
ORCID: Zazueta, Cecilia
Venue: Cellular Signalling
Publisher: Elsevier BV
Published: 2013-12
Volume: 25
Issue: 12
Pages: 2548-2557
ISSN: 0898-6568 (ISSN-L)
DOI: 10.1016/j.cellsig.2013.08.007
OpenAlex: W2058792844
Cited by: 239
References: 121
Citations by year: 2026: 9 · 2025: 12 · 2024: 6 · 2023: 12 · 2022: 14 · 2021: 27 · 2020: 21 · 2019: 22 · 2018: 31 · 2017: 26 · 2016: 20 · 2015: 25 · 2014: 13 · 2013: 1
FWCI: 1.85
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cellular Signalling (publishedVersion)
PubMed (publishedVersion)
Funders: National Council of Science and Technology (CONACyT), Mexico (177527)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: Nrf2, NF-κB, reactive oxygen species, redox signaling, redox homeostasis, antioxidant defense, oxidative stress, transcription factors, cytoprotection, oxygen chemistry
MeSH terms: Animals, Humans, Oxidation-Reduction, Signal Transduction, NF-kappa B, Reactive Oxygen Species, NF-E2-Related Factor 2

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Redox activation of Nrf2 & NF-κB: A double end sword?

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