The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
The Warburg effect: 80 years on
Open accessAbstract
Influential research by Warburg and Cori in the 1920s ignited interest in how cancer cells' energy generation is different from that of normal cells. They observed high glucose consumption and large amounts of lactate excretion from cancer cells compared with normal cells, which oxidised glucose using mitochondria. It was therefore assumed that cancer cells were generating energy using glycolysis rather than mitochondrial oxidative phosphorylation, and that the mitochondria were dysfunctional. Advances in research techniques since then have shown the mitochondria in cancer cells to be functional across a range of tumour types. However, different tumour populations have different bioenergetic alterations in order to meet their high energy requirement; the Warburg effect is not consistent across all cancer types. This review will discuss the metabolic reprogramming of cancer, possible explanations for the high glucose consumption in cancer cells observed by Warburg, and suggest key experimental practices we should consider when studying the metabolism of cancer.
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Cites
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Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425
Why Do Cancers Have High Aerobic Glycolysis?
Gatenby, R. A., & Gillies, R. J. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1478 · Cited by 4,784
The metabolism of tumors in the body
Warburg, O., Wind, F., & Negelein, E. (1927) · Journal of General Physiology · doi:10.1085/jgp.8.6.519 · Cited by 4,416
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
Dang, L., White, D. W., Gross, S., Bennett, B. D., Bittinger, M. A., Driggers, E. M., Fantin, V. R., Jang, H. G., Jin, S., Keenan, M. C., et al. (2009) · Nature · doi:10.1038/nature08617 · Cited by 4,154
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On Respiratory Impairment in Cancer Cells
Warburg, O. (1956) · Science · doi:10.1126/science.124.3215.269 · Cited by 3,468
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Cellular and developmental control of O 2 homeostasis by hypoxia-inducible factor 1α
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Cited by
Borst, P. (2020) · IUBMB Life · doi:10.1002/iub.2367 · Cited by 252
Mechanisms driving the lactate switch in Chinese hamster ovary cells
Hartley, F., Walker, T., Chung, V., & Morten, K. (2018) · Biotechnology and Bioengineering · doi:10.1002/bit.26603 · Cited by 108
Self-citationThe Warburg Effect is the result of faster ATP production by glycolysis than respiration
Kukurugya, M. A., Rosset, S., & Titov, D. V. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2409509121 · Cited by 81
APOE and metabolic dysfunction in Alzheimer's disease
(2020) · International Review of Neurobiology · doi:10.1016/bs.irn.2020.02.002 · Cited by 31
Metadata
- Authors
- Potter, M., Newport, E., & Morten, K. J.
- Venue
- Biochemical Society Transactions
- Publisher
- Portland Press Ltd.
- Published
- 2016-10-15
- Volume
- 44
- Issue
- 5
- Pages
- 1499-1505
- ISSN
- 0300-5127 (ISSN-L)
- 1470-8752
- OpenAlex
- W2537551256
- Cited by
- 499
- References
- 58
- FWCI
- 12.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
