Extracellular vesicles: translational challenges and opportunities
Abstract
Extracellular vesicles (EVs) are a heterogeneous group of small lipid-enclosed structures with myriad roles in physiology and disease. The recent surge of interest in EVs has led to greater understanding of their biology and appreciation of how they might be utilised as diagnostic and therapeutic tools. There remain, however, a number of challenges that must be overcome before EVs may be used routinely in the clinic. In this review we will discuss the translational potential of EVs and the current technologies available to isolate, purify and analyse EVs and their contents.
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EVs often lack the long-lasting stability, potency, and targeting precision needed for effective disease diagnosis and treatment.
“While EVs offer promising potential for CNS theranostics, EVs often lack the long-lasting stability, potency, and targeting precision needed for effective disease diagnosis and treatment [227].”
From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [227]
Cites
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Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions
Choi, H. K., Chen, M., Goldston, L. L., & Lee, K.-B. (2024) · Nano Convergence · doi:10.1186/s40580-024-00426-5 · Cited by 26 · see citing works
- Authors
- Clemmens, H., & Lambert, D. W.
- Affiliations
- University of Sheffield (GB)
- Corresponding author
- Clemmens, Hannah
- Venue
- Biochemical Society Transactions
- Publisher
- Portland Press Ltd.
- Published
- 2018-09-21
- Volume
- 46
- Issue
- 5
- Pages
- 1073-1082
- ISSN
- 0300-5127 (ISSN-L)
- 1470-8752
- OpenAlex
- W2890650452
- Cited by
- 70
- References
- 8
- Citations by year
- 2026: 1 · 2025: 9 · 2024: 16 · 2023: 18 · 2022: 9 · 2021: 7 · 2020: 6 · 2019: 4
- FWCI
- 0.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical Society Transactions (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
- Keywords
- extracellular vesicles, translational medicine, EV isolation, EV purification, diagnostic biomarkers, therapeutic applications
- MeSH terms
- Extracellular Vesicles, Animals, Cell Communication, Extracellular Matrix, Heart Diseases, Humans, Lipids, Models, Biological, Neoplasms, Nervous System Diseases, Phagocytosis, Biomarkers, Drug Delivery Systems, Apoptosis, Cell Transplantation, Proteomics, Exosomes, Translational Research, Biomedical
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