Circulating microRNAs as emerging non-invasive biomarkers for gliomas
Open accessAbstract
No single circulating biomarker has been put to practice for malignant gliomas so far, the most lethal primary brain tumors. Many promising protein biomarkers such as the mutant EGFRvIII or glial fibrillary acidic protein (GFAP) have already been detected in the blood and cerebrospinal fluid (CSF) of patients with gliomas, but their clinical value is still pending validation. Furthermore, these and other proteins seem to lack sufficient sensitivity and specificity required for a successful biomarker in this clinical setting. The expression profiling of microRNAs (miRNAs) has already entered cancer clinics as diagnostic and prognostic biomarkers, for assessing tumor initiation, progression and response to treatment. Large-scale miRNA expression analyses reported both up-regulation and down-regulation of several miRNAs in tumour tissues from patients with gliomas compared to normal brain tissue, thus supporting the development of miRNA-based biomarkers. Using comprehensive high-throughput approaches, such as microarrays, different circulating miRNAs were proposed as potential biomarkers of gliomas. This review is aimed to summarize the clinical evidence about circulating miRNA biomarkers discovered to date. Mandatory issues to develop clinically validated biomarkers to improve time of diagnosis, predicting response to treatment and prognosis of patients with gliomas are also herein addresses.
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Non-invasive serum-based liquid biopsies are emerging as practical alternatives for glioma diagnosis and monitoring across all grades.
“Given these constraints, non-invasive serum-based liquid biopsies are emerging as practical alternatives for glioma diagnosis and monitoring across all grades [5].”
From miR-21 as a diagnostic and prognostic biomarker in glioma: tissue and serum expression analysis in a Pakistani cohort (2026) · cites this paper as [5]
The extracellular-vesicles section says a blood-derived exosomal miRNA liquid biopsy may be a practical alternative to tumor biopsy for monitoring recurrence and treatment response. The proposed-biomarkers section also discusses serum miRNAs for diagnosis and follow-up, but does not establish their use across all four grades. The Conclusions say larger prospective studies are needed before routine clinical use, so the claim overstates how practical and broadly applicable these biopsies currently are. (LLM, conf=0.87)
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- Authors
- Santangelo, A., Tamanini, A., Cabrini, G., & Dechecchi, M. C.
- Affiliations
- University of Verona (IT)
- Corresponding author
- Dechecchi, Maria Cristina
- Venue
- Annals of Translational Medicine
- Publisher
- AME Publishing Company
- Published
- 2017-07
- Volume
- 5
- Issue
- 13
- Pages
- 277-277
- ISSN
- 2305-5839 (ISSN-L)
- 2305-5847
- PMC
- PMC5515812
- OpenAlex
- W2626072141
- Cited by
- 36
- References
- 37
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 5 · 2019: 7 · 2018: 7 · 2017: 4
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Annals of Translational Medicine (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Brain Research Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
- Keywords
- circulating microRNAs, glioma, non-invasive biomarkers, liquid biopsy, EGFRvIII, glial fibrillary acidic protein, cerebrospinal fluid, miRNA expression profiling, diagnosis, prognosis, treatment response prediction
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