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Mesenchymal stem cell infusion therapy in a carbon tetrachloride‐induced liver fibrosis model affects matrix metalloproteinase expression
Abstract
In order to investigate the effects of bone marrow‐derived MSCs (mesenchymal stem cells) in reversing liver fibrosis and to determine their possible mechanism of action, mouse MSCs were infused into the tail vein of a CCl 4 injection mouse chronic model. MSCs caused a decrease in liver fibrosis histopathologically, 4 weeks after transplantation. The reduction in liver collagen was confirmed by quantitative analysis. Moreover, lipid peroxidation in the CCl 4/MSC group decreased significantly. Quantitative RT (reverse transcription)‐PCR analysis showed administration of MSCs has a significant antifibrotic effect as evidenced by the decrease in expression of liver collagen and increase in MMP13 (matrix metalloproteinase 13) in the CCl 4/MSC group when compared with the CCl 4 group, 4 weeks after transplantation. The expression of αSMA (smooth muscle actin) and TIMP1 was also down‐regulated in the CCl 4/MSC group. Additionally, the expression of MMP9 was significantly up‐regulated in the CCl 4‐treated group; however, there was no significant change after MSC injection. Few engrafted cells in the recipient liver and were able to differentiate into albumin‐positive cells. In conclusion, MSCs can enhance recovery of a CCl 4‐injured mouse liver through their influence in reducing collagen deposition by possibly affecting expression of MMPs.
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“Moreover, MSCs can modulate fibrosis by enhancing the expression of matrix metalloproteinases (MMPs) and downregulating the expression of tissue inhibitors of MMPs, resulting in the regression of liver fibrosis [202], [203].”
From Mesenchymal stem cell secretome for regenerative medicine: Where do we stand? (2025) · cites this paper as [202]
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Mesenchymal stem cell secretome for regenerative medicine: Where do we stand?
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Metadata
- Authors
- Rabani, V., Shahsavani, M., Gharavi, M., Piryaei, A., Azhdari, Z., & Baharvand, H.
- Affiliations
- Royan Institute (IR)
- Iranian Legal Medicine Organization (IR)
- University of Science and Culture (IR)
- Corresponding author
- Baharvand, Hossein
- Venue
- Cell Biology International
- Publisher
- Wiley
- Published
- 2010-06
- Volume
- 34
- Issue
- 6
- Pages
- 601-605
- ISSN
- 1065-6995 (ISSN-L)
- 1095-8355
- OpenAlex
- W2040041350
- Cited by
- 112
- References
- 27
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 5 · 2022: 3 · 2021: 7 · 2020: 7 · 2019: 8 · 2018: 7 · 2017: 12 · 2016: 5 · 2015: 14 · 2014: 16 · 2013: 6 · 2012: 7
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cell Biology International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Keywords
- mesenchymal stem cells, liver fibrosis, carbon tetrachloride, matrix metalloproteinases, MMP-13, MMP-9, collagen deposition, lipid peroxidation, alpha-smooth muscle actin, TIMP-1, stem cell engraftment, antifibrotic therapy, bone marrow-derived stem cells
- MeSH terms
- Actins, Animals, Bone Marrow Cells, Carbon Tetrachloride, Collagen, Disease Models, Animal, Female, Liver Cirrhosis, Down-Regulation, Up-Regulation, Tissue Inhibitor of Metalloproteinase-1, Matrix Metalloproteinase 9, Mesenchymal Stem Cell Transplantation, Mice, Matrix Metalloproteinase 13, Mesenchymal Stem Cells
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