Cited by 112Mesenchymal stem cell researchLiver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

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Mesenchymal stem cell infusion therapy in a carbon tetrachloride‐induced liver fibrosis model affects matrix metalloproteinase expression

Rabani, Vahideh, Shahsavani, Mansoureh, Gharavi, Marzieh, Piryaei, Abbas, Azhdari, Zahra, Baharvand, Hossein·2010·Cell Biology International

DOI 10.1042/cbi20090386

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Abstract

In order to investigate the effects of bone marrow‐derived MSCs (mesenchymal stem cells) in reversing liver fibrosis and to determine their possible mechanism of action, mouse MSCs were infused into the tail vein of a CCl 4 injection mouse chronic model. MSCs caused a decrease in liver fibrosis histopathologically, 4 weeks after transplantation. The reduction in liver collagen was confirmed by quantitative analysis. Moreover, lipid peroxidation in the CCl 4/MSC group decreased significantly. Quantitative RT (reverse transcription)‐PCR analysis showed administration of MSCs has a significant antifibrotic effect as evidenced by the decrease in expression of liver collagen and increase in MMP13 (matrix metalloproteinase 13) in the CCl 4/MSC group when compared with the CCl 4 group, 4 weeks after transplantation. The expression of αSMA (smooth muscle actin) and TIMP1 was also down‐regulated in the CCl 4/MSC group. Additionally, the expression of MMP9 was significantly up‐regulated in the CCl 4‐treated group; however, there was no significant change after MSC injection. Few engrafted cells in the recipient liver and were able to differentiate into albumin‐positive cells. In conclusion, MSCs can enhance recovery of a CCl 4‐injured mouse liver through their influence in reducing collagen deposition by possibly affecting expression of MMPs.

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Authors: Rabani, V., Shahsavani, M., Gharavi, M., Piryaei, A., Azhdari, Z., & Baharvand, H.
Affiliations: Royan Institute (IR)
Iranian Legal Medicine Organization (IR)
University of Science and Culture (IR)
Corresponding author: Baharvand, Hossein
ORCID: Shahsavani, Mansoureh
Piryaei, Abbas
Baharvand, Hossein
Venue: Cell Biology International
Publisher: Wiley
Published: 2010-06
Volume: 34
Issue: 6
Pages: 601-605
ISSN: 1065-6995 (ISSN-L)
1095-8355
DOI: 10.1042/cbi20090386
OpenAlex: W2040041350
Cited by: 112
References: 27
Citations by year: 2026: 1 · 2025: 2 · 2024: 5 · 2023: 5 · 2022: 3 · 2021: 7 · 2020: 7 · 2019: 8 · 2018: 7 · 2017: 12 · 2016: 5 · 2015: 14 · 2014: 16 · 2013: 6 · 2012: 7
FWCI: 2.85
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1581 d)
Locations: Cell Biology International (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
Keywords: mesenchymal stem cells, liver fibrosis, carbon tetrachloride, matrix metalloproteinases, MMP-13, MMP-9, collagen deposition, lipid peroxidation, alpha-smooth muscle actin, TIMP-1, stem cell engraftment, antifibrotic therapy, bone marrow-derived stem cells
MeSH terms: Actins, Animals, Bone Marrow Cells, Carbon Tetrachloride, Collagen, Disease Models, Animal, Female, Liver Cirrhosis, Down-Regulation, Up-Regulation, Tissue Inhibitor of Metalloproteinase-1, Matrix Metalloproteinase 9, Mesenchymal Stem Cell Transplantation, Mice, Matrix Metalloproteinase 13, Mesenchymal Stem Cells

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Mesenchymal stem cell infusion therapy in a carbon tetrachloride‐induced liver fibrosis model affects matrix metalloproteinase expression

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