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Muscle wasting in emphysema
Abstract
1. We have investigated arteriovenous exchanges of tyrosine and 3-methylhistidine across leg tissue in the postabsorptive state as specific indicators of net protein balance and myofibrillar protein breakdown, respectively, in eight patients with emphysema and in 11 healthy controls. Whole-body protein turnover was measured using l-[1-13C]leucine. 2. Leg efflux of tyrosine was increased by 47% in emphysematous patients compared with normal control subjects, but 3-methylhistidine efflux was not significantly altered. 3. In emphysema, whole-body leucine flux was normal, whole-body leucine oxidation was increased, and whole-body protein synthesis was depressed. 4. These results indicate that the predominant mechanism of muscle wasting in emphysema is a fall in muscle protein synthesis, which is accompanied by an overall fall in whole-body protein turnover.
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“Anorexia developed in long-term smokers also contributes to muscle wasting, especially in those with chronic obstructive pulmonary disease (Morrison et al., 1988; Jagoe and Engelen, 2003).”
From Cigarette Smoking and Brain Regulation of Energy Homeostasis (2012) · cites this paper as Morrison et al., 1988
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Cited by
Complex chronic comorbidities of COPD
Fabbri, L. M., Luppi, F., Beghé, B., & Rabe, K. F. (2008) · European Respiratory Journal · doi:10.1183/09031936.00114307 · Cited by 660
Inflammation induced loss of skeletal muscle
Londhe, P., & Guttridge, D. C. (2015) · Bone · doi:10.1016/j.bone.2015.03.015 · Cited by 276
Muscle Wasting and Changes in Muscle Protein Metabolism in Chronic Obstructive Pulmonary Disease
Jagoe, R. T., & Engelen, M. P. K. J. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00004608 · Cited by 134
Skeletal muscle protein balance and metabolism in the elderly
S. Fry, C., & B. Rasmussen, B. (2011) · Current Aging Sciencee · doi:10.2174/1874609811104030260 · Cited by 111
Schena, F., Guerrini, F., Tregnaghi, P., & Kayser, B. (1992) · European Journal of Applied Physiology and Occupational Physiology · doi:10.1007/bf00243503 · Cited by 70
Cigarette Smoking and Brain Regulation of Energy Homeostasis
Chen, H., Saad, S., Sandow, S. L., & Bertrand, P. P. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00147 · Cited by 69
Metadata
- Authors
- Morrison, W. L., Gibson, J. N. A., Scrimgeour, C., & Rennie, M. J.
- Affiliations
- Departments of Physiology and Medicine, University of Dundee, Dundee, U.K.
- Venue
- Clinical Science
- Publisher
- Portland Press Ltd.
- Published
- 1988-10-01
- Volume
- 75
- Issue
- 4
- Pages
- 415-420
- ISSN
- 0143-5221
- 1470-8736
- Cited by
- 87
- References
- 0
- Language
- en
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