The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions
Abstract
The VEGF (vascular endothelial growth factor) family and its receptors are essential regulators of angiogenesis and vascular permeability. Currently, the VEGF family consists of VEGF-A, PlGF (placenta growth factor), VEGF-B, VEGF-C, VEGF-D, VEGF-E and snake venom VEGF. VEGF-A has at least nine subtypes due to the alternative splicing of a single gene. Although the VEGF165 isoform plays a central role in vascular development, recent studies have demonstrated that each VEGF isoform plays distinct roles in vascular patterning and arterial development. VEGF-A binds to and activates two tyrosine kinase receptors, VEGFR (VEGF receptor)-1 and VEGFR-2. VEGFR-2 mediates most of the endothelial growth and survival signals, but VEGFR-1-mediated signalling plays important roles in pathological conditions such as cancer, ischaemia and inflammation. In solid tumours, VEGF-A and its receptor are involved in carcinogenesis, invasion and distant metastasis as well as tumour angiogenesis. VEGF-A also has a neuroprotective effect on hypoxic motor neurons, and is a modifier of ALS (amyotrophic lateral sclerosis). Recent progress in the molecular and biological understanding of the VEGF/VEGFR system provides us with novel and promising therapeutic strategies and target proteins for overcoming a variety of diseases.
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Cited by
VEGF receptor signalling ? in control of vascular function
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The anti-cancer effect of quercetin: molecular implications in cancer metabolism
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“PI3K/Akt pathway activation concludes in metalloproteinase (MMP) synthesis, promoting cell invasion [111].”
BackgroundThe discovery of placenta growth factor and its biological activity
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Angiogenesis in the atherosclerotic plaque
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Metadata
- Authors
- Takahashi, H., & Shibuya, M.
- Venue
- Clinical Science
- Publisher
- Portland Press Ltd.
- Published
- 2005-08-24
- Volume
- 109
- Issue
- 3
- Pages
- 227-241
- ISSN
- 0143-5221 (ISSN-L)
- 1470-8736
- OpenAlex
- W1985043086
- Cited by
- 953
- References
- 16
- FWCI
- 14.17
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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