Cited by 265Cardiovascular Disease and AdiposityCardiovascular, Neuropeptides, and Oxidative Stress ResearchApelin-related biomedical research

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Perivascular adipose tissue: more than just structural support

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Szasz, Theodora, Webb, R. Clinton·2012·Clinical Science

DOI 10.1042/cs20110151PMC PMC3966487

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Abstract

PVAT (perivascular adipose tissue) has recently been recognized as a novel factor in vascular biology, with implications in the pathophysiology of cardiovascular disease. Composed mainly of adipocytes, PVAT releases a wide range of biologically active molecules that modulate vascular smooth muscle cell contraction, proliferation and migration. PVAT exerts an anti-contractile effect in various vascular beds which seems to be mediated by an as yet elusive PVRF [PVAT-derived relaxing factor(s)]. Considerable progress has been made on deciphering the nature and mechanisms of action of PVRF, and the PVRFs proposed until now are reviewed here. However, complex pathways seem to regulate PVAT function and more than one mechanism is probably responsible for PVAT actions in vascular biology. The present review describes our current knowledge on the structure and function of PVAT, with a focus on its role in modulating vascular tone. Potential involvements of PVAT dysfunction in obesity, hypertension and atherosclerosis will be highlighted.

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Authors: Szasz, T., & Webb, R. C.
Affiliations: Department of Physiology, Georgia Health Sciences University, Augusta, GA 30912, U.S.A.
ORCID: Webb, R. Clinton
Venue: Clinical Science
Publisher: Portland Press Ltd.
Published: 2011-09-12
Volume: 122
Issue: 1
Pages: 1-12
ISSN: 0143-5221 (ISSN-L)
1470-8736
DOI: 10.1042/cs20110151
PMC: PMC3966487
OpenAlex: W2052860092
Cited by: 265
References: 102
Citations by year: 2026: 18 · 2025: 15 · 2024: 14 · 2023: 21 · 2022: 19 · 2021: 20 · 2020: 28 · 2019: 23 · 2018: 16 · 2017: 18 · 2016: 20 · 2015: 15 · 2014: 13 · 2013: 18 · 2012: 6
FWCI: 2.00
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Clinical Science (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (HL-71138, R01HL071138, T32HL066993)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK083685, DK-83685)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
Health Sciences › Medicine › Pharmacology (medical) › Apelin-related biomedical research
Keywords: perivascular adipose tissue, vascular smooth muscle contraction, vascular tone, adipocytes, obesity, hypertension, atherosclerosis, cardiovascular disease
MeSH terms: Adipose Tissue, Animals, Blood Vessels, Cardiovascular Diseases, Endothelium, Vascular, Humans, Models, Biological, Nitric Oxide, Vasoconstriction, Adipokines

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Perivascular adipose tissue: more than just structural support

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