Chemerin and CMKLR1 expression in human arteries and periadventitial fat: a possible role for local chemerin in atherosclerosis?
Open accessAbstract
BACKGROUND: Depending on their anatomical location, different fat depots have a different capacity to produce bioactive peptides, called adipokines. Adipokines produced by periadventitial fat have been implicated in the pathogenesis of vascular disease, including atherosclerosis. Chemerin is an adipokine with an established role in immunity, adipose tissue function and metabolism, acting in autocrine, paracrine and endocrine manners. We investigated the protein expression of chemerin and its receptor, CMKLR1, in human aortas, coronary vessels and the respective periadventitial adipose tissue and correlated their expression with the presence of atherosclerosis. METHODS: Immunohistochemistry for chemerin and CMKLR1 was performed on human aortic and coronary artery samples including the periadventitial adipose tissue. Aortic and coronary atherosclerotic lesions were assessed using the AHA classification. RESULTS: Chemerin immunopositivity was noticed in both periadventitial fat depots, in vascular smooth muscle cells and foam cells in atherosclerotic lesions. Periadventitial fat and foam cell chemerin immunopositivity was statistically significantly correlated with the severity of atherosclerosis in both locations. CMKLR1 was expressed in vascular smooth muscle cells and foam cells in aortic and coronary vessels with atherosclerotic lesions. CMKLR1 immunostaining in foam cells was statistically significantly correlated with aortic atherosclerosis. CONCLUSIONS: Our results lend some support to a presumable role of locally produced chemerin in the progression of atherosclerotic lesions, possibly acting through its CMKLR1 receptor. Further research will elucidate the role of chemerin signaling in atherosclerosis.
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ALX/FPR2 and ChemR23 are expressed in human aortic, coronary, and carotid atherosclerotic lesions, indicating that their pro-resolving ligands act locally within the vascular wall.
“These receptors are expressed in human aortic, coronary and carotid atherosclerotic lesions104–106, indicating that their pro-resolving ligands exert local effects within the vascular wall (TABLE 1).”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [106]
Chemerin is a ChemR23 ligand present in human atherosclerotic lesions and correlates with disease severity.
“The adipokine chemerin is another ChemR23 ligand116 that is present in human atherosclerotic lesions and correlates with disease severity106.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [106]
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- Authors
- Kostopoulos, C. G., Spiroglou, S. G., Varakis, J. N., Apostolakis, E., & Papadaki, H. H.
- Affiliations
- University of Patras (GR)
- University of Ioannina (GR)
- Corresponding author
- Kostopoulos, Christos G
- Venue
- BMC Cardiovascular Disorders
- Published
- 2014-04-30
- Volume
- 14
- Issue
- 1
- Pages
- 56-56
- ISSN
- 1471-2261 (ISSN-L)
- PMC
- PMC4022413
- OpenAlex
- W1984836036
- Cited by
- 82
- References
- 31
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 7 · 2023: 9 · 2022: 4 · 2021: 9 · 2020: 10 · 2019: 10 · 2018: 6 · 2017: 6 · 2016: 5 · 2015: 4 · 2014: 2 · 2013: 1
- FWCI
- 3.89
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Cardiovascular Disorders (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- University of Patras
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- chemerin, CMKLR1, atherosclerosis, adipokines, coronary arteries, aorta, foam cells, vascular smooth muscle cells, atherosclerotic lesion severity
- MeSH terms
- Adipose Tissue, Adolescent, Adult, Aged, Aged, 80 and over, Aorta, Abdominal, Aortic Diseases, Autopsy, Coronary Artery Disease, Coronary Vessels, Foam Cells, Humans, Immunohistochemistry, Middle Aged, Muscle, Smooth, Vascular, Disease Progression, Chemokines, Receptors, Chemokine, Intercellular Signaling Peptides and Proteins, Atherosclerosis, Young Adult, Adventitia
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