Motor Speech Phenotypes of Frontotemporal Dementia, Primary Progressive Aphasia, and Progressive Apraxia of Speech
Abstract
Purpose: Our purpose was to create a comprehensive review of speech impairment in frontotemporal dementia (FTD), primary progressive aphasia (PPA), and progressive apraxia of speech in order to identify the most effective measures for diagnosis and monitoring, and to elucidate associations between speech and neuroimaging. Method: Speech and neuroimaging data described in studies of FTD and PPA were systematically reviewed. A meta-analysis was conducted for speech measures that were used consistently in multiple studies. Results: The methods and nomenclature used to describe speech in these disorders varied between studies. Our meta-analysis identified 3 speech measures which differentiate variants or healthy control-group participants (e.g., nonfluent and logopenic variants of PPA from all other groups, behavioral-variant FTD from a control group). Deficits within the frontal-lobe speech networks are linked to motor speech profiles of the nonfluent variant of PPA and progressive apraxia of speech. Motor speech impairment is rarely reported in semantic and logopenic variants of PPA. Limited data are available on motor speech impairment in the behavioral variant of FTD. Conclusions: Our review identified several measures of speech which may assist with diagnosis and classification, and consolidated the brain–behavior associations relating to speech in FTD, PPA, and progressive apraxia of speech.
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Individuals with FTD can present with a heterogeneous combination of speech and cognitive-linguistic impairments, ranging from motor-based apraxia-like symptoms to semantic, grammatic, and pragmatic deficits.
“Individuals with FTD can present with a heterogeneous combination of speech and cognitive‐linguistic impairments, ranging from motor‐based apraxia‐like symptoms, to semantic, grammatic, and pragmatic deficits. 44”
From Developing digital health technologies for frontotemporal degeneration (2025) · cites this paper as [44]
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- Authors
- Poole, M. L., Brodtmann, A., Darby, D., & Vogel, A. P.
- Affiliations
- The University of Melbourne (AU)
- Florey Institute of Neuroscience and Mental Health (AU)
- Venue
- Journal of Speech, Language, and Hearing Research
- Published
- 2017-04-14
- Volume
- 60
- Issue
- 4
- Pages
- 897-911
- ISSN
- 1092-4388 (ISSN-L)
- 1558-9102
- OpenAlex
- W2596578278
- Cited by
- 84
- References
- 89
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 9 · 2023: 12 · 2022: 9 · 2021: 13 · 2020: 23 · 2019: 3 · 2018: 3 · 2017: 1
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Speech Language and Hearing Research (publishedVersion)
- PubMed (publishedVersion)
- Minerva Access (University of Melbourne) (submittedVersion)
- Funders
- National Health and Medical Research Council
- National Medical Research Council
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Health Sciences › Medicine › Physiology › Voice and Speech Disorders
- Keywords
- frontotemporal dementia, primary progressive aphasia, motor speech disorders, logopenic variant PPA, behavioral variant FTD, neuroimaging, diagnosis and classification, semantic variant PPA
- MeSH terms
- Apraxias, Brain, Humans, Motor Skills, Phenotype, Speech, Aphasia, Primary Progressive, Frontotemporal Dementia
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