Cited by 84Dementia and Cognitive Impairment ResearchNeurobiology of Language and BilingualismVoice and Speech Disorders

Motor Speech Phenotypes of Frontotemporal Dementia, Primary Progressive Aphasia, and Progressive Apraxia of Speech

Poole, Matthew L., Brodtmann, Amy, Darby, David, Vogel, Adam P.·2017·Journal of Speech, Language, and Hearing Research

Abstract

Purpose: Our purpose was to create a comprehensive review of speech impairment in frontotemporal dementia (FTD), primary progressive aphasia (PPA), and progressive apraxia of speech in order to identify the most effective measures for diagnosis and monitoring, and to elucidate associations between speech and neuroimaging. Method: Speech and neuroimaging data described in studies of FTD and PPA were systematically reviewed. A meta-analysis was conducted for speech measures that were used consistently in multiple studies. Results: The methods and nomenclature used to describe speech in these disorders varied between studies. Our meta-analysis identified 3 speech measures which differentiate variants or healthy control-group participants (e.g., nonfluent and logopenic variants of PPA from all other groups, behavioral-variant FTD from a control group). Deficits within the frontal-lobe speech networks are linked to motor speech profiles of the nonfluent variant of PPA and progressive apraxia of speech. Motor speech impairment is rarely reported in semantic and logopenic variants of PPA. Limited data are available on motor speech impairment in the behavioral variant of FTD. Conclusions: Our review identified several measures of speech which may assist with diagnosis and classification, and consolidated the brain–behavior associations relating to speech in FTD, PPA, and progressive apraxia of speech.

Integrity signals

Registry

Crossref · 10.1044/2016_jslhr-s-16-0140

Cites

89 of 89 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Individuals with FTD can present with a heterogeneous combination of speech and cognitive-linguistic impairments, ranging from motor-based apraxia-like symptoms to semantic, grammatic, and pragmatic deficits.

    “Individuals with FTD can present with a heterogeneous combination of speech and cognitive‐linguistic impairments, ranging from motor‐based apraxia‐like symptoms, to semantic, grammatic, and pragmatic deficits. 44”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Poole, M. L., Brodtmann, A., Darby, D., & Vogel, A. P.
Affiliations
  • The University of Melbourne (AU)
  • Florey Institute of Neuroscience and Mental Health (AU)
Venue
Journal of Speech, Language, and Hearing Research
Published
2017-04-14
Volume
60
Issue
4
Pages
897-911
ISSN
  • 1092-4388 (ISSN-L)
  • 1558-9102
OpenAlex
W2596578278
Cited by
84
References
89
Citations by year
2026: 6 · 2025: 5 · 2024: 9 · 2023: 12 · 2022: 9 · 2021: 13 · 2020: 23 · 2019: 3 · 2018: 3 · 2017: 1
FWCI
1.25
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Speech Language and Hearing Research (publishedVersion)
  • PubMed (publishedVersion)
  • Minerva Access (University of Melbourne) (submittedVersion)
Funders
  • National Health and Medical Research Council
  • National Medical Research Council
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
  • Health Sciences › Medicine › Physiology › Voice and Speech Disorders
Keywords
frontotemporal dementia, primary progressive aphasia, motor speech disorders, logopenic variant PPA, behavioral variant FTD, neuroimaging, diagnosis and classification, semantic variant PPA
MeSH terms
Apraxias, Brain, Humans, Motor Skills, Phenotype, Speech, Aphasia, Primary Progressive, Frontotemporal Dementia

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review