Quantification of motor speech impairment and its anatomic basis in primary progressive aphasia
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OBJECTIVE: To evaluate whether a quantitative speech measure is effective in identifying and monitoring motor speech impairment (MSI) in patients with primary progressive aphasia (PPA) and to investigate the neuroanatomical basis of MSI in PPA. METHODS: Sixty-four patients with PPA were evaluated at baseline, with a subset (n = 39) evaluated longitudinally. Articulation rate (AR), a quantitative measure derived from spontaneous speech, was measured at each time point. MRI was collected at baseline. Differences in baseline AR were assessed across PPA subtypes, separated by severity level. Linear mixed-effects models were conducted to assess groups differences across PPA subtypes in rate of decline in AR over a 1-year period. Cortical thickness measured from baseline MRIs was used to test hypotheses about the relationship between cortical atrophy and MSI. RESULTS: Baseline AR was reduced for patients with nonfluent variant PPA (nfvPPA) compared to other PPA subtypes and controls, even in mild stages of disease. Longitudinal results showed a greater rate of decline in AR for the nfvPPA group over 1 year compared to the logopenic and semantic variant subgroups. Reduced baseline AR was associated with cortical atrophy in left-hemisphere premotor and supplementary motor cortices. CONCLUSIONS: The AR measure is an effective quantitative index of MSI that detects MSI in mild disease stages and tracks decline in MSI longitudinally. The AR measure also demonstrates anatomic localization to motor speech-specific cortical regions. Our findings suggest that this quantitative measure of MSI might have utility in diagnostic evaluation and monitoring of MSI in PPA.
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Across primary progressive aphasia variants, ASLA markers capture syndrome-specific patterns that predict underlying neuropathology years before death and correlate with variant-specific atrophy, even longitudinally.
“Across primary progressive aphasia variants, ASLA markers capture syndromespecific patterns 49-53 that predict underlying neuropathology years before death 7 and correlate with variant-specific atrophy, 53-56 even longitudinally. 57”
From Speech and language markers of neurodegeneration: a call for global equity (2023) · cites this paper as [54]
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Barcelona scale for buccophonatory apraxia: Quantitative assessment tool
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Sprechmotorische Störungen bei primär progredienter Aphasie
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Advances in Primary Progressive Aphasia
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Neural and Behavioral Predictors of Speech Motor Sequence Learning in Primary Progressive Aphasia
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- Authors
- Cordella, C., Quimby, M., Touroutoglou, A., Brickhouse, M., Dickerson, B. C., & Green, J. R.
- Affiliations
- Harvard University (US)
- Corresponding author
- Green, Jordan R.
- ORCID
- Venue
- Neurology
- Published
- 2019-04-23
- Volume
- 92
- Issue
- 17
- Pages
- e1992-e2004
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC6511075
- OpenAlex
- W2932996615
- Cited by
- 49
- References
- 52
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 9 · 2023: 6 · 2022: 8 · 2021: 12 · 2020: 5
- FWCI
- 4.97
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Neurology (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Massachusetts General Hospital
- National Institutes of Health
- MGH Institute of Health Professions
- National Institute on Aging (P30AG062421)
- National Institute on Deafness and Other Communication Disorders (R01DC013547, R01DC014296, K24DC016312, R01DC002852, F31DC015703, R01DC007683)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Health Sciences › Medicine › Physiology › Voice and Speech Disorders
- Keywords
- primary progressive aphasia, motor speech disorders, articulation rate, cortical atrophy, premotor cortex, supplementary motor area, cortical thickness, longitudinal decline, disease severity
- MeSH terms
- Aged, Atrophy, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Motor Cortex, Speech, Aphasia, Primary Progressive, Comprehension
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