Differentiating primary progressive aphasias in a brief sample of connected speech
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OBJECTIVE: A brief speech expression protocol that can be administered and scored without special training would aid in the differential diagnosis of the 3 principal forms of primary progressive aphasia (PPA): nonfluent/agrammatic PPA, logopenic variant PPA, and semantic variant PPA. METHODS: We used a picture-description task to elicit a short speech sample, and we evaluated impairments in speech-sound production, speech rate, lexical retrieval, and grammaticality. We compared the results with those obtained by a longer, previously validated protocol and further validated performance with multimodal imaging to assess the neuroanatomical basis of the deficits. RESULTS: We found different patterns of impaired grammar in each PPA variant, and additional language production features were impaired in each: nonfluent/agrammatic PPA was characterized by speech-sound errors; logopenic variant PPA by dysfluencies (false starts and hesitations); and semantic variant PPA by poor retrieval of nouns. Strong correlations were found between this brief speech sample and a lengthier narrative speech sample. A composite measure of grammaticality and other measures of speech production were correlated with distinct regions of gray matter atrophy and reduced white matter fractional anisotropy in each PPA variant. CONCLUSIONS: These findings provide evidence that large-scale networks are required for fluent, grammatical expression; that these networks can be selectively disrupted in PPA syndromes; and that quantitative analysis of a brief speech sample can reveal the corresponding distinct speech characteristics.
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Across primary progressive aphasia variants, ASLA markers capture syndrome-specific patterns that predict underlying neuropathology years before death and correlate with variant-specific atrophy, even longitudinally.
“Across primary progressive aphasia variants, ASLA markers capture syndromespecific patterns 49-53 that predict underlying neuropathology years before death 7 and correlate with variant-specific atrophy, 53-56 even longitudinally. 57”
From Speech and language markers of neurodegeneration: a call for global equity (2023) · cites this paper as [56]
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Avants, B., Epstein, C. L., Grossman, M., & Gee, J. C. (2007) · Medical Image Analysis · doi:10.1016/j.media.2007.06.004 · Cited by 5,618 · see citing works
Self-citationThe cortical organization of speech processing
Hickok, G., & Poeppel, D. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2113 · Cited by 5,495 · see citing works
Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia
Rascovsky, K., Hodges, J. R., Knopman, D., Mendez, M. F., Kramer, J. H., Neuhaus, J., van Swieten, J. C., Seelaar, H., Dopper, E. G. P., Onyike, C. U., et al. (2011) · Brain · doi:10.1093/brain/awr179 · Cited by 5,221 · see citing works
Self-citationClassification of primary progressive aphasia and its variants
Gorno-Tempini, M. L., Hillis, A. E., Weintraub, S., Kertesz, A., Mendez, M., Cappa, S. F., Ogar, J. M., Rohrer, J. D., Black, S., Boeve, B. F., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e31821103e6 · Cited by 5,141 · see citing works
Self-citationThe assessment of aphasia and related disorders
Goodglass, H., & Kaplan, E. (1972) · Medical Entomology and Zoology · Cited by 3,258 · see citing works
Assessment of Aphasia and Related Disorders
Sarno, M. T. (1973) · Physical Therapy · doi:10.1093/ptj/53.2.225b · Cited by 2,256 · see citing works
The brain basis of language processing: from structure to function.
Friederici, A. D. (2011) · Physiological Reviews · doi:10.1152/physrev.00006.2011 · Cited by 2,140 · see citing works
Cognition and anatomy in three variants of primary progressive aphasia
Gorno‐Tempini, M. L., Dronkers, N. F., Rankin, K. P., Ogar, J. M., Phengrasamy, L., Rosen, H. J., Johnson, J. K., Weiner, M. W., & Miller, B. L. (2004) · Annals of Neurology · doi:10.1002/ana.10825 · Cited by 1,608 · see citing works
Clinical and Pathological Diagnosis of Frontotemporal Dementia
McKhann, G. M. (2001) · Archives of Neurology · doi:10.1001/archneur.58.11.1803 · Cited by 1,475 · see citing works
A new brain region for coordinating speech articulation
Dronkers, N. F. (1996) · Nature · doi:10.1038/384159a0 · Cited by 1,192 · see citing works
Grammatical structures written at three grade levels
Hunt, K. W. (1965) · Cited by 996 · see citing works
Mayer, M. (1969) · Medical Entomology and Zoology · Cited by 979 · see citing works
Semantic dementia: a unique clinicopathological syndrome
Hodges, J. R., & Patterson, K. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70266-1 · Cited by 772 · see citing works
The logopenic/phonological variant of primary progressive aphasia
Gorno‐Tempini, M., Brambati, S. M., Ginex, V., Ogar, J., Dronkers, N. F., Marcone, A., Perani, D., Garibotto, V., Cappa, S. F., & Miller, B. L. (2008) · Neurology · doi:10.1212/01.wnl.0000320506.79811.da · Cited by 700 · see citing works
Connected speech production in three variants of primary progressive aphasia
Wilson, S. M., Henry, M. L., Besbris, M., Ogar, J. M., Dronkers, N. F., Jarrold, W., Miller, B. L., & Gorno-Tempini, M. L. (2010) · Brain · doi:10.1093/brain/awq129 · Cited by 546 · see citing works
Alzheimer and frontotemporal pathology in subsets of primary progressive aphasia
Mesulam, M., Wicklund, A., Johnson, N., Rogalski, E., Léger, G. C., Rademaker, A., Weintraub, S., & Bigio, E. H. (2008) · Annals of Neurology · doi:10.1002/ana.21388 · Cited by 513 · see citing works
Primary progressive aphasia: clinicopathological correlations
Grossman, M. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2009.216 · Cited by 414 · see citing works
Self-citationClinical and pathological characterization of progressive aphasia
Knibb, J., Xuereb, J., Patterson, K., & Hodges, J. R. (2006) · Annals of Neurology · doi:10.1002/ana.20700 · Cited by 346 · see citing works
Quantitative classification of primary progressive aphasia at early and mild impairment stages
Mesulam, M. M., Wieneke, C., Thompson, C. K., Rogalski, E., & Weıntraub, S. (2012) · Brain · doi:10.1093/brain/aws080 · Cited by 342 · see citing works
The Rise and Fall of Frequency and Imageability: Noun and Verb Production in Semantic Dementia
Bird, H., Ralph, M. A. L., Patterson, K. E., & Hodges, J. R. (2000) · Brain and Language · doi:10.1006/brln.2000.2293 · Cited by 277 · see citing works
MRI atlas of human white matter
Oishi, K., & Crain, B. J. (2010) · Cited by 272 · see citing works
Clinical and Pathological Continuum of Multisystem TDP-43 Proteinopathies
Geser, F., Martinez-Lage, M., Robinson, J., Uryu, K., Neumann, M., Brandmeir, N. J., Xie, S. X., Kwong, L. K., Elman, L., McCluskey, L., et al. (2009) · Archives of Neurology · doi:10.1001/archneurol.2008.558 · Cited by 267 · see citing works
Self-citationEvaluation of volume-based and surface-based brain image registration methods
Klein, A., Ghosh, S. S., Avants, B., Yeo, B. T. T., Fischl, B., Ardekani, B., Gee, J. C., Mann, J. J., & Parsey, R. V. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.01.091 · Cited by 255 · see citing works
The non-fluent/agrammatic variant of primary progressive aphasia
Grossman, M. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70099-6 · Cited by 231 · see citing works
Self-citationSajjadi, S. A., Patterson, K. E., Arnold, R. J., Watson, P., & Nestor, P. J. (2012) · Neurology · doi:10.1212/wnl.0b013e3182574f79 · Cited by 228 · see citing works
Grossman, M., Mickanin, J., Onishi, K., Hughes, E., D’Esposito, M., Xin-sheng, D., Alavi, A. A., & Reivich, M. (1996) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1996.8.2.135 · Cited by 216 · see citing works
Self-citationAnatomy of Language Impairments in Primary Progressive Aphasia
Rogalski, E. J., Cobia, D. J., Harrison, T. M., Wieneke, C. A., Thompson, C. K., Weıntraub, S., & Mesulam, M. M. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5544-10.2011 · Cited by 209 · see citing works
Ash, S., Moore, P., Antani, S., McCawley, G., Work, M., & Grossman, M. (2006) · Neurology · doi:10.1212/01.wnl.0000210435.72614.38 · Cited by 204 · see citing works
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Bozeat, S., Ralph, M. A. L., PATTERSON, K., & Hodges, J. R. (2002) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/cabn.2.3.236 · Cited by 165 · see citing works
Reversal of the concreteness effect in semantic dementia
Bonner, M., Vesely, L., Price, C. C., Anderson, C., Richmond, L. L., Farag, C., Avants, B., & Grossman, M. (2009) · Cognitive Neuropsychology · doi:10.1080/02643290903512305 · Cited by 161 · see citing works
Self-citationNon-fluent speech in frontotemporal lobar degeneration
Ash, S., Moore, P., Vesely, L., Gunawardena, D., McMillan, C. T., Anderson, C., Avants, B., & Grossman, M. (2009) · Journal of Neurolinguistics · doi:10.1016/j.jneuroling.2008.12.001 · Cited by 140 · see citing works
Self-citationSPEECH ERRORS IN PROGRESSIVE NON-FLUENT APHASIA
Ash, S., McMillan, C., Gunawardena, D., Avants, B., Morgan, B. E., Khan, A., Moore, P., Gee, J., & Grossman, M. (2010) · Brain and Language · doi:10.1016/j.bandl.2009.12.001 · Cited by 129 · see citing works
Self-citationKERTESZ, A. E., Jesso, S., Harciarek, M., Blair, M., & McMonagle, P. (2010) · Archives of Neurology · doi:10.1001/archneurol.2010.55 · Cited by 109 · see citing works
Why are patients with progressive nonfluent aphasia nonfluent?
Gunawardena, D., Ash, S., McMillan, C. T., Avants, B., Gee, J. C., & Grossman, M. (2010) · Neurology · doi:10.1212/wnl.0b013e3181ed9c7d · Cited by 95 · see citing works
Self-citationSpears, W. M., Hamann, J., Maxim, P. M., Kunkel, T., Heil, R., Zarzhitsky, D. V., Spears, D. F., & Karlsson, C. (2007) · Springer eBooks · doi:10.1007/978-3-540-71541-2_9 · Cited by 94 · see citing works
Grossman, M., Powers, J., Ash, S., McMillan, C. T., Burkholder, L., Irwin, D. J., & Trojanowski, J. Q. (2012) · Brain and Language · doi:10.1016/j.bandl.2012.10.005 · Cited by 91 · see citing works
Self-citationSweet nothings: Narrative speech in semantic dementia
Patterson, K. E., & MacDonald, M. C. (2010) · doi:10.4324/9780203841211-22 · Cited by 26 · see citing works
Disruption of Large-scale Neural Networks in Non-Fluent/Agrammatic Primary Progressive Aphasia
Grossman, M., Charles, D., Ash, S., Powers, J., Olm, C. A., McMillan, C. T., Rascovsky, K., Irwin, D. J., & Trojanowski, J. Q. (2013) · Procedia - Social and Behavioral Sciences · doi:10.1016/j.sbspro.2013.09.069 · Cited by 2 · see citing works
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Montembeault, M., Brambati, S. M., Gorno‐Tempini, M. L., & Migliaccio, R. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00692 · Cited by 174 · see citing works
Clinical marker for Alzheimer disease pathology in logopenic primary progressive aphasia
Giannini, L. A. A., Irwin, D. J., McMillan, C. T., Ash, S., Rascovsky, K., Wolk, D. A., Van Deerlin, V. M., Lee, E. B., Trojanowski, J. Q., & Grossman, M. (2017) · Neurology · doi:10.1212/wnl.0000000000004034 · Cited by 144 · see citing works
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Speech and language markers of neurodegeneration: a call for global equity
García, A. M., de Leon, J., Tee, B. L., Blasi, D. E., & Gorno-Tempini, M. L. (2023) · Brain · doi:10.1093/brain/awad253 · Cited by 102 · see citing works
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Butts, A. M., Machulda, M. M., Duffy, J. R., Strand, E. A., Whitwell, J. L., & Josephs, K. A. (2015) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617715000399 · Cited by 98 · see citing works
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Berube, S. K., Nonnemacher, J., Demsky, C., Glenn, S., Saxena, S., Wright, A. E., Tippett, D. C., & Hillis, A. E. (2018) · American Journal of Speech-Language Pathology · doi:10.1044/2018_ajslp-17-0131 · Cited by 91 · see citing works
Yeung, A., Iaboni, A., Rochon, E. A., Lavoie, M., Santiago, C., Yancheva, M., Novikova, J., Xu, M., Robin, J., Kaufman, L. D., et al. (2021) · Alzheimer s Research & Therapy · doi:10.1186/s13195-021-00848-x · Cited by 90 · see citing works
Poole, M. L., Brodtmann, A., Darby, D., & Vogel, A. P. (2017) · Journal of Speech, Language, and Hearing Research · doi:10.1044/2016_jslhr-s-16-0140 · Cited by 84 · see citing works
Speech and language impairments in behavioral variant frontotemporal dementia: A systematic review
Geraudie, A., Battista, P., García, A. M., Allen, I. E., Miller, Z. A., Gorno-Tempini, M. L., & Montembeault, M. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.10.015 · Cited by 80 · see citing works
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Classification of the primary progressive aphasias: principles and review of progress since 2011
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Putcha, D., Dickerson, B. C., Brickhouse, M. J., Johnson, K. A., Sperling, R. A., & Papp, K. V. (2020) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2020.107391 · Cited by 25 · see citing works
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Gallée, J., Cordella, C., Fedorenko, E. G., Hochberg, D., Touroutoglou, A., Quimby, M., & Dickerson, B. C. (2021) · Brain Sciences · doi:10.3390/brainsci11020130 · Cited by 24 · see citing works
Digital Speech Analysis in Progressive Supranuclear Palsy and Corticobasal Syndromes
Parjane, N., Cho, S., Ash, S., Cousins, K. A. Q., Shellikeri, S., Liberman, M., Shaw, L. M., Irwin, D. J., Grossman, M., & Nevler, N. (2021) · Journal of Alzheimer's Disease · doi:10.3233/jad-201132 · Cited by 24 · see citing works
Self-citationLavoie, M., Black, S. E., Tang‐Wai, D. F., Graham, N. L., Stewart, S., Léonard, C., & Rochon, E. A. (2021) · International Journal of Language & Communication Disorders · doi:10.1111/1460-6984.12660 · Cited by 24 · see citing works
Mack, J. E., Barbieri, E., Weıntraub, S., Mesulam, M. M., & Thompson, C. K. (2020) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2020.107713 · Cited by 23 · see citing works
Linguistic changes in neurodegenerative diseases relate to clinical symptoms
Gumus, M., Koo, M., Studzinski, C. M., Bhan, A., Robin, J., & Black, S. E. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1373341 · Cited by 23 · see citing works
Santi, G. C., Conca, F., Esposito, V., Polito, C., Caminiti, S. P., Boccalini, C., Morinelli, C., Berti, V., Mazzeo, S., Bessi, V., et al. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01403-0 · Cited by 21 · see citing works
Beales, A., Whitworth, A., & Cartwright, J. (2018) · Aphasiology · doi:10.1080/02687038.2018.1491192 · Cited by 20 · see citing works
Added value of multimodal MRI to the clinical diagnosis of primary progressive aphasia variants
Canu, E., Agosta, F., Imperiale, F., Fontana, A., Caso, F., Spinelli, E. G., Magnani, G., Falini, A., Comı, G., & Filippi, M. (2018) · Cortex · doi:10.1016/j.cortex.2018.11.025 · Cited by 22 · see citing works
SECT and MAST: new tests to assess grammatical abilities in primary progressive aphasia
Billette, O. V., Sajjadi, S., Patterson, K., & Nestor, P. (2015) · Aphasiology · doi:10.1080/02687038.2015.1037822 · Cited by 22 · see citing works
Meyer, A. M., Faria, A. V., Tippett, D. C., Hillis, A. E., & Friedman, R. B. (2017) · Aphasiology · doi:10.1080/02687038.2017.1296557 · Cited by 20 · see citing works
Clinical and neuroimaging characteristics of primary progressive aphasia
Tippett, D. C., & Keser, Z. (2022) · Handbook of clinical neurology · doi:10.1016/b978-0-12-823384-9.00016-5 · Cited by 19 · see citing works
Wu, W., Morales, M., Patel, T., Pickering, M. J., & Hoffman, P. (2022) · Cortex · doi:10.1016/j.cortex.2022.08.002 · Cited by 22 · see citing works
Determining stability in connected speech in primary progressive aphasia and Alzheimer’s disease
Beales, A., Whitworth, A., Cartwright, J., Panegyres, P. K., & Kane, R. T. (2018) · International Journal of Speech-Language Pathology · doi:10.1080/17549507.2018.1442498 · Cited by 19 · see citing works
Lukic, S., Fan, Z., García, A. M., Welch, A. E., Ratnasiri, B. M., Wilson, S. M., Henry, M. L., Vonk, J., Deleon, J., Miller, B. L., et al. (2024) · Cortex · doi:10.1016/j.cortex.2023.12.013 · Cited by 19 · see citing works
Frontotemporal dementia. How to deal with its diagnostic complexity?
Antonioni, A., Raho, E. M., Granieri, E., & Koch, G. (2025) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2025.2461758 · Cited by 21 · see citing works
Neuropsychological Assessment of Primary Progressive Aphasia (PPA)
Bettcher, B. M., & Sturm, V. E. (2014) · Perspectives on Neurophysiology and Neurogenic Speech and Language Disorders · doi:10.1044/nnsld24.4.128 · Cited by 18 · see citing works
Silent Pauses and Speech Indices as Biomarkers for Primary Progressive Aphasia
Potagas, C. M., Nikitopoulou, Z., Angelopoulou, G., Kasselimis, D. S., Laskaris, N., Kourtidou, E., Constantinides, V. C., Bougea, A. M., Paraskevas, G. P., Papageorgiou, G., et al. (2022) · Medicina · doi:10.3390/medicina58101352 · Cited by 17 · see citing works
Cordella, C., Filippo, L. D., Kolachalama, V. B., & Kiran, S. (2024) · American Journal of Speech-Language Pathology · doi:10.1044/2024_ajslp-23-00208 · Cited by 16 · see citing works
Lack of Frank Agrammatism in the Nonfluent Agrammatic Variant of Primary Progressive Aphasia
Graham, N. L., Léonard, C., Tang‐Wai, D. F., Black, S. E., Chow, T. W., Scott, C. J. M., McNeely, A. A., Masellis, M., & Rochon, E. A. (2016) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000448944 · Cited by 16 · see citing works
Verb-argument integration in primary progressive aphasia: Real-time argument access and selection
Mack, J. E., Mesulam, M. M., Rogalski, E. J., & Thompson, C. K. (2019) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2019.107192 · Cited by 16 · see citing works
Connected speech markers of amyloid burden in primary progressive aphasia
Slegers, A., Chafouleas, G., Montembeault, M., Bedetti, C., Welch, A. E., Rabinovici, G. D., Langlais, P., Gorno‐Tempini, M. L., & Brambati, S. M. (2021) · Cortex · doi:10.1016/j.cortex.2021.09.010 · Cited by 14 · see citing works
Ramanan, S., Halai, A. D., García‐Pentón, L., Perry, A., Patel, N., Peterson, K. A., Ingram, R. U., Storey, I., Cappa, S. F., Catricalà, E., et al. (2023) · Alzheimer s Research & Therapy · doi:10.1186/s13195-023-01350-2 · Cited by 12 · see citing works
Beber, B. C., Mandelli, M. L., Santos‐Santos, M., Binney, R. J., Miller, B. L., Chaves, M. L. F., Gorno‐Tempini, M. L., & Shapiro, K. A. (2018) · Aphasiology · doi:10.1080/02687038.2018.1461799 · Cited by 14 · see citing works
Pausing before verb production is associated with mild cognitive impairment in Parkinson’s disease
Andrade, E. I. N., Manxhari, C., & Smith, K. M. (2023) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2023.1102024 · Cited by 13 · see citing works
Bilingualism in a Case of the Non-fluent/agrammatic Variant of Primary Progressive Aphasia
Karpathiou, N., Papatriantafyllou, J. D., & Kambanaros, M. (2018) · Frontiers in Communication · doi:10.3389/fcomm.2018.00052 · Cited by 13 · see citing works
Hohlbaum, K., Dressel, K., Lange, I., Wellner, B., Sáez, L. E., Huber, W., Grande, M., Amunts, K., Grodzinsky, Y., & Heim, S. (2018) · Aphasiology · doi:10.1080/02687038.2017.1423271 · Cited by 13 · see citing works
Carthery‐Goulart, M. T., de Oliveira, R., de Almeida, I. J., Campanha, A. C., Souza, D. D. S., Zana, Y., Caramelli, P., & Machado, T. H. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.815227 · Cited by 11 · see citing works
Catricalà, E., Santi, G. C., Polito, C., Conca, F., Esposito, V., Caminiti, S. P., Boccalini, C., Berti, V., Bessi, V., Marcone, A., et al. (2022) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2022.09.001 · Cited by 11 · see citing works
Lexical markers of disordered speech in primary progressive aphasia and ‘Parkinson-plus’ disorders
Henderson, S. K., Ramanan, S., Patterson, K. E., Garrard, P., Patel, N., Peterson, K. A., Halai, A. D., Cappa, S. F., Rowe, J. B., & Ralph, M. A. L. (2024) · Brain Communications · doi:10.1093/braincomms/fcae433 · Cited by 10 · see citing works
Northwestern Anagram Test-Italian (Nat-I) for primary progressive aphasia
Canu, E., Agosta, F., Imperiale, F., Ferraro, P. M., Fontana, A., Magnani, G., Mesulam, M. M., Thompson, C. K., Weıntraub, S., Moro, A., et al. (2019) · Cortex · doi:10.1016/j.cortex.2019.08.007 · Cited by 10 · see citing works
Predicting Cognitive Impairment in Cerebrovascular Disease Using Spoken Discourse Production
Roberts, A., Aveni, K., Basque, S. R., Orange, J. B., McLaughlin, P. M., Ramirez, J., Troyer, A. K., Gutierrez, S., Chen, A., Bartha, R., et al. (2021) · Topics in Language Disorders · doi:10.1097/tld.0000000000000242 · Cited by 10 · see citing works
Auditory Verb Generation Performance Patterns Dissociate Variants of Primary Progressive Aphasia
Lukic, S., Licata, A. E., Weis, E., Bogley, R., Ratnasiri, B. M., Welch, A. E., Hinkley, L. B. N., Miller, Z., García, A. M., Houde, J. F., et al. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.887591 · Cited by 11 · see citing works
Patel, N., Peterson, K. A., Ingram, R. U., Storey, I., Cappa, S. F., Catricalà, E., Patterson, K. E., Ralph, M. A. L., Rowe, J. B., & Garrard, P. (2020) · medRxiv · doi:10.1101/2020.06.02.20119974 · Cited by 10 · see citing works
Coppieters, R., Bouzigues, A., Jiskoot, L. C., Montembeault, M., Tee, B. L., Rohrer, J. D., Bruffaerts, R., Russell, L. L., Foster, P. H., Ferry‐Bolder, E., et al. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105909 · Cited by 9 · see citing works
Diversity of language symptoms in Alzheimrʼs disease
Matsuda, M. (2015) · Higher Brain Function Research · doi:10.2496/hbfr.35.312 · Cited by 3 · see citing works
Meyer, A., Snider, S., Tippett, D., Saloma, R., Turkeltaub, P., Hillis, A., & Friedman, R. (2023) · Aphasiology · doi:10.1080/02687038.2023.2183075 · Cited by 9 · see citing works
Gallée, J., & Volkmer, A. (2021) · Perspectives of the ASHA Special Interest Groups · doi:10.1044/2021_persp-21-00021 · Cited by 7 · see citing works
Language in behavioral variant frontotemporal dementia: Another stone to be turned in Latin America
Geraudie, A., Díaz Rivera, M., Montembeault, M., & García, A. M. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.702770 · Cited by 7 · see citing works
Neural mechanisms of sentence production: a volumetric study of primary progressive aphasia
Barbieri, E., Lukic, S., Rogalski, E. J., Weıntraub, S., Mesulam, M. M., & Thompson, C. K. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhad470 · Cited by 7 · see citing works
Cordella, C., Gutz, S. E., Eshghi, M., Stipancic, K. L., Schliep, M. E., Dickerson, B. C., & Green, J. R. (2022) · Journal of Speech Language and Hearing Research · doi:10.1044/2022_jslhr-22-00177 · Cited by 7 · see citing works
Mehrsprachige Pflegebedürftige in deutschen Pflegeheimen und das Projekt UnVergessen
Karl, K. B. (2021) · Springer eBooks · doi:10.1007/978-3-658-33868-8 · Cited by 6 · see citing works
Connected Speech Alterations and Progression in Patients With Primary Progressive Aphasia Variants
Canu, E., Agosta, F., Lumaca, L., Basaia, S., Castelnovo, V., Santicioli, S., Pisano, S., Gatti, E., Lamanuzzi, A., Spinelli, E. G., et al. (2025) · Neurology · doi:10.1212/wnl.0000000000213524 · Cited by 6 · see citing works
Speech Motor Profiles in Primary Progressive Aphasia
Staiger, A., Schroeter, M. L., Ziegler, W., Pino, D., Regenbrecht, F., Schölderle, T., Rieger, T., Riedl, L., Müller‐Sarnowski, F., & Diehl‐Schmid, J. (2023) · American Journal of Speech-Language Pathology · doi:10.1044/2023_ajslp-22-00319 · Cited by 6 · see citing works
Discourse and Conversation Impairments in Patients with Dementia
Themistocleous, C. K. (2023) · Springer eBooks · doi:10.1007/978-3-031-45190-4_3 · Cited by 7 · see citing works
Automatic Analysis of Phonetic Speech Style Dimensions
Ryant, N., & Liberman, M. (2016) · Interspeech (USB) · doi:10.21437/interspeech.2016-1355 · Cited by 6 · see citing works
Utianski, R. L., Botha, H., Duffy, J. R., Clark, H. M., Martin, P. R., Butts, A. M., Machulda, M. M., Whitwell, J. L., & Josephs, K. A. (2018) · The Journal of the Acoustical Society of America · doi:10.1121/1.5082210 · Cited by 6 · see citing works
The Discourse Profile in Corticobasal Syndrome: A Comprehensive Clinical and Biomarker Approach
de Almeida, I. J., Silagi, M. L., Carthery‐Goulart, M. T., Parmera, J. B., Cecchini, M. A., Coutinho, A. M., Brucki, S. M. D., Nitríni, R., & Schochat, E. (2022) · Brain Sciences · doi:10.3390/brainsci12121705 · Cited by 5 · see citing works
Apraxia of Speech in the Spontaneous Speech of Nonfluent/Agrammatic Primary Progressive Aphasia
Ash, S., Nevler, N., Irwin, D. J., Shellikeri, S., Rascovsky, K., Shaw, L. M. J., Lee, E. B., Trojanowski, J. Q., & Grossman, M. (2023) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-220089 · Cited by 5 · see citing works
Self-citationMeyer, A. M., Snider, S. F., Tippett, D. C., Saloma, R., Faria, A. V., Turkeltaub, P. E., Hillis, A. E., & Friedman, R. B. (2024) · Aphasiology · doi:10.1080/02687038.2024.2361961 · Cited by 5 · see citing works
Beber, S., Bontempi, G., Miceli, G., & Tettamanti, M. (2024) · Neuropsychology Review · doi:10.1007/s11065-024-09648-0 · Cited by 7 · see citing works
- Authors
- Ash, S., Evans, E., O'Shea, J., Powers, J., Boller, A., Weinberg, D., Haley, J., McMillan, C., Irwin, D. J., Rascovsky, K., & Grossman, M.
- Affiliations
- University of Pennsylvania (US)
- Venue
- Neurology
- Published
- 2013-07-23
- Volume
- 81
- Issue
- 4
- Pages
- 329-336
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC3772830
- OpenAlex
- W2100387103
- Cited by
- 171
- References
- 38
- Citations by year
- 2026: 14 · 2025: 18 · 2024: 16 · 2023: 16 · 2022: 22 · 2021: 18 · 2020: 11 · 2019: 5 · 2018: 16 · 2017: 12 · 2016: 9 · 2015: 10 · 2014: 3 · 2013: 1
- FWCI
- 5.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wyncote Foundation
- National Institutes of Health
- National Institute on Aging (R01AG038490, R01AG015116, P01AG017586, AG038490, AG032953, AG-017586, AG015116, P01AG032953, T32AG000255)
- National Institute of Neurological Disorders and Stroke (NS053488, P50NS053488, NS044266, R01NS044266)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- primary progressive aphasia, differential diagnosis, logopenic variant PPA, semantic variant PPA, picture description task, speech production, grammaticality, speech rate, word retrieval, disfluency, false starts, gray matter atrophy, white matter fractional anisotropy
- MeSH terms
- Aged, Aged, 80 and over, Atrophy, Brain, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Semantics, Speech, Aphasia, Primary Progressive, Frontotemporal Dementia
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