Cited by 104Pharmacogenetics and Drug MetabolismPharmaceutical studies and practicesPharmaceutical Practices and Patient Outcomes

The DOI matches its Crossref record; 59 of the 60 references it cites were found in a registry or an index.

Pharmacokinetic properties of zolpidem in elderly and young adults: possible modulation by testosterone in men

Open access

Olubodun, Joel O., Ochs, Hermann R., Von Moltke, Lisa L., Roubenoff, Ronenn, Hesse, Leah M., Harmatz, Jerold S., Shader, Richard I., Greenblatt, David J.·2003·British Journal of Clinical Pharmacology

DOI 10.1046/j.0306-5251.2003.01852.xPMC PMC1884349

Open this paper in CoChat — free account Open PDF

Abstract

AIMS: The influence of ageing on the pharmacokinetics of zolpidem, an extensively prescribed hypnotic medication, was evaluated in healthy human volunteers. METHODS: A series of 16 elderly (age: 61-85 years) and 24 young (age: 22-42 years) volunteers received single 5 mg oral doses of zolpidem tartrate. Serum zolpidem concentrations were determined by HPLC with fluorescence detection in samples drawn during 8 h after dosage. The effect of testosterone on zolpidem biotransformation was evaluated in vitro using human liver microsomes. Possible induction of CYP3A protein expression and function was studied in cultured human hepatocytes. RESULTS: Among men, apparent oral clearance of zolpidem was decreased in elderly compared to young subjects (3.8 vs 11.0 ml min-1 kg-1, P < 0.01), Cmax was increased (93 vs 40 ng ml-1, P < 0.01), and half-life increased (2.7 vs 1.5 h, P < 0.03). Among women, zolpidem oral clearance was decreased in the elderly (3.0 vs 5.8 ml min-1 kg-1, P < 0.02), Cmax increased (108 vs 60 ng ml-1, P < 0.001), with no difference in t1/2 (2.3 vs 2.4 h). Among male subjects, free serum testosterone concentrations were lower in the elderly (10.5 vs 19.0 pg ml-1, P < 0.01), and were significantly correlated with zolpidem clearance (r2 = 0.46, P < 0.001). Multiple regression analysis indicated a greater relative contribution of serum testosterone than age to the oral clearance of zolpidem among men. In human liver microsomes, co-incubation of zolpidem (10 micro m) with varying concentrations of testosterone produced activation of biotransformation of zolpidem to its principal hydroxylated metabolite. Maximum activation was achieved at equimolar concentrations of testosterone (10 micro m). However, testosterone did not induce immunoactive CYP3A4 expression or catalytic function in cultured human hepatocytes. CONCLUSIONS: The increased Cmax and lower oral clearance of zolpidem in the elderly are consistent with recommendations of lower clinical doses of zolpidem in the elderly. Our clinical and in vitro data both suggest that reduced free serum testosterone may have a modulatory role in age-dependent changes in zolpidem pharmacokinetics in men.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1046/j.0306-5251.2003.01852.x

Cites

59 of 59 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The Triad of Sleep Apnea, Hypertension, and Chronic Kidney Disease: A Spectrum of Common Pathology
Aziz, F., & Chaudhary, K. R. (2016) · Cardiorenal Medicine · doi:10.1159/000450796 · Cited by 3,285
Psychopharmacology: The Fourth Generation of Progress
Bloom, F. E., & Kupfer, D. J. (1995) · Medical Entomology and Zoology · Cited by 2,985
Psychopharmacology: The Fourth Generation of Progress
Brophy, J. J. (1995) · JAMA · doi:10.1001/jama.1995.03530220079046 · Cited by 1,582
Age, Disease, and Changing Sex Hormone Levels in Middle-Aged Men: Results of the Massachusetts Male Aging Study*
Gray, A., Feldman, H. A., McKinlay, J. B., & Longcope, C. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-5-1016 · Cited by 1,104
Insomnia and Its Treatment: Prevalence and Correlates
Mellinger, G. D. (1985) · Archives of General Psychiatry · doi:10.1001/archpsyc.1985.01790260019002 · Cited by 1,071
Benzodiazepines of Long and Short Elimination Half-life and the Risk of Hip Fracture
Ray, W. A. (1989) · JAMA · doi:10.1001/jama.1989.03430230088031 · Cited by 536
Sex hormones and age: A cross-sectional study of testosterone and estradiol and their bioavailable fractions in community-dwelling men
Ferrini, R. L., & Barrett-Connor, E. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009519 · Cited by 473
Benzodiazepines and Zolpidem for Chronic Insomnia: A Meta-analysis of Treatment Efficacy
Nowell, P. D. (1997) · JAMA · doi:10.1001/jama.1997.03550240060035 · Cited by 451
Drug-Induced Cognitive Impairment in the Elderly
Moore, A. R., & O’Keeffe, S. T. (1999) · Drugs & Aging · doi:10.2165/00002512-199915010-00002 · Cited by 410
Incidence and remission of insomnia among elderly adults : An epidemiologic study of 6,800 persons over three years.
Monjan, Simonsick, & Wallace (1999) · SLEEP · Cited by 402

Show all 60 references

Research works printed but not linked: 3

Von Moltke LL, 1999, Pharmacokinetics of psychotropic drugs in the elderly, Annu Rev Gerontol Geriatr, 19, 53
Mäenpää J, 1998, Human cytochrome P4503A (CYP3A) mediated midazolam metabolism: the effect of assay conditions and regioselective stimulation by alpha–naphthoflavone, terfenadine and testosterone, Pharmacogenetics, 8, 137
Ruegg CE, 1997, Cytochrome‐P450 induction and conjugated metabolism in primary human hepatocytes after cryopreservation, In Vitro Toxicol, 10, 217

Sorted by citations

Zolpidem
Harrison, T., & Keating, G. (2005) · CNS Drugs · doi:10.2165/00023210-200519010-00008 · Cited by 303
Sex and gender differences research design for basic, clinical, and population studies: essentials for investigators
Rich-Edwards, J. W., Kaiser, U. B., Chen, G. L., Manson, J. E., & Goldstein, J. M. (2018) · Endocrine Reviews · doi:10.1210/er.2017-00246 · Cited by 273
The Influence of Age and Sex on the Clearance of Cytochrome P450 3A Substrates
Cotreau, M. M., Moltke, L. L., & Greenblatt, D. J. (2005) · Clinical Pharmacokinetics · doi:10.2165/00003088-200544010-00002 · Cited by 291
Self-citation
Zolpidem for insomnia
Greenblatt, D. J., & Roth, T. G. (2012) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2012.667074 · Cited by 284
Self-citation
Prediction of in vivo drug clearance from in vitro data. I: Impact of inter-individual variability
Howgate, E. M., Rowland Yeo, K., Proctor, N. J., Tucker, G. T., & Rostami-Hodjegan, A. (2006) · Xenobiotica · doi:10.1080/00498250600683197 · Cited by 223
Postural Instability and Consequent Falls and Hip Fractures Associated with Use of Hypnotics in the Elderly: A Comparative Review
Allain, H., Bentu??-Ferrer, D., Polard, E., Akwa, Y., & Patat, A. (2005) · Drugs & Aging · doi:10.2165/00002512-200522090-00004 · Cited by 214
Aging and Clinical Pharmacology: Implications for Antidepressants
Lotrich, F. E., & Pollock, B. G. (2005) · The Journal of Clinical Pharmacology · doi:10.1177/0091270005280297 · Cited by 110
Gender differences in pharmacokinetics and pharmacodynamics of zolpidem following sublingual administration
Greenblatt, D. J., Harmatz, J. S., Singh, N. N., Steinberg, F., Roth, T., Moline, M. L., Harris, S. C., & Kapil, R. P. (2014) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.220 · Cited by 107
Self-citation
Effects of Vitamin D Supplementation in Atorvastatin-Treated Patients: A New Drug Interaction With an Unexpected Consequence
Schwartz, J. B. (2008) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2008.165 · Cited by 103
Hypnotics in Insomnia: The Experience of Zolpidem
MacFarlane, J., Morin, C. M., & Montplaisir, J. (2014) · Clinical Therapeutics · doi:10.1016/j.clinthera.2014.09.017 · Cited by 94
Zolpidem: Efficacy and Side Effects for Insomnia
Edinoff, A. N., Wu, N. W., Ghaffar, Y. T., Prejean, R., Gremillion, R., Cogburn, M., Chami, A. A., Kaye, A. M., & Kaye, A. D. (2021) · Health Psychology Research · doi:10.52965/001c.24927 · Cited by 89
Effect of CYP3A4 metabolism on sex differences in the pharmacokinetics and pharmacodynamics of zolpidem
Yoon, S., Jeong, S., Jung, E., Kim, K. S., Jeon, I., Lee, Y., Cho, J., Oh, W. Y., & Chung, J. (2021) · Scientific Reports · doi:10.1038/s41598-021-98689-z · Cited by 80
Zolpidem and Gender: Are Women Really At Risk?
Greenblatt, D. J., Harmatz, J. S., & Roth, T. G. (2019) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000001026 · Cited by 75
Self-citation
Mechanistic investigation of the negative food effect of modified release zolpidem
Andreas, C. J., Pepin, X. J. H., Markopoulos, C., Vertzoni, M., Reppas, C. I., & Dressman, J. (2017) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2017.03.011 · Cited by 74
Age-Related Differences in CYP3A Expression and Activity in the Rat Liver, Intestine, and Kidney
Warrington, J. S., Greenblatt, D. J., & Moltke, L. L. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.061077 · Cited by 65
Self-citation
Concentrations of Scheduled Prescription Drugs in Blood of Impaired Drivers: Considerations for Interpreting the Results
Jones, A. W., Holmgren, A., & Kugelberg, F. C. (2007) · Therapeutic Drug Monitoring · doi:10.1097/ftd.0b013e31803d3c04 · Cited by 64
Age and Gender Effects on the Pharmacokinetics and Pharmacodynamics of Ramelteon, a Hypnotic Agent Acting via Melatonin Receptors MT1and MT2
Greenblatt, D. J., Harmatz, J. S., & Karim, A. (2007) · The Journal of Clinical Pharmacology · doi:10.1177/0091270006298602 · Cited by 64
Self-citation
Dynamics and Kinetics of a Modified‐Release Formulation of Zolpidem: Comparison With Immediate‐Release Standard Zolpidem and Placebo
Greenblatt, D. J., Legangneux, E., Harmatz, J. S., Weinling, E., Freeman, J., Rice, K., & Zammit, G. K. (2006) · The Journal of Clinical Pharmacology · doi:10.1177/0091270006293303 · Cited by 57
Self-citation
Acute effects of zolpidem extended-release on cognitive performance and sleep in healthy males after repeated nightly use.
Kleykamp, B. A., Griffiths, R. R., McCann, U. D., Smith, M. T., & Mintzer, M. Z. (2011) · Experimental and Clinical Psychopharmacology · doi:10.1037/a0025237 · Cited by 52
The efficacy and safety of zolpidem and zopiclone to treat insomnia in Alzheimer’s disease: a randomized, triple-blind, placebo-controlled trial
Louzada, L. L., Machado, F. V., Quintas, J. L., Ribeiro, G. A., Silva, M. V., da Silva, D. L. M., Gonçalves, B. S. B., Nóbrega, O. D. T., & Camargos, E. F. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01191-3 · Cited by 47
Zolpidem and zopiclone impair similarly monotonous driving performance after a single nighttime intake in aged subjects
Bocca, M., Marie, S., Lelong‐Boulouard, V., Bertran, F., Couque, C., Desfemmes, T., Berthelon, C., Amato, J.-N., Moessinger, M., Paillet‐Loilier, M., et al. (2010) · Psychopharmacology · doi:10.1007/s00213-010-2075-5 · Cited by 46
Residual Effects of Low-Dose Sublingual Zolpidem on Highway Driving Performance the Morning after Middle-of-the-Night Use
Vermeeren, A., Vuurman, E. F. P. M., Leufkens, T., van Leeuwen, C. J., Oers, A. C. M. V., LASKA, E. M., Rico, S., Steinberg, F. J., & Roth, T. G. (2014) · SLEEP · doi:10.5665/sleep.3482 · Cited by 45
Comparison of Pharmacokinetic Profiles of Zolpidem Buffered Sublingual Tablet and Zolpidem Oral Immediate-Release Tablet: Results from a Single-Center, Single-Dose, Randomized, Open-Label Crossover Study in Healthy Adults
Greenblatt, D. J., Harmatz, J. S., Roth, T. G., Singh, N., Moline, M. L., Harris, S., & Kapil, R. P. (2013) · Clinical Therapeutics · doi:10.1016/j.clinthera.2013.03.007 · Cited by 43
Self-citation
Erythromycin breath test results in elderly, very elderly, and frail elderly persons
Schwartz, J. B. (2006) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2006.01.006 · Cited by 41
Age-related changes in slow wave activity rise time and NREM sleep EEG with and without zolpidem in healthy young and older adults
Chinoy, E. D., Frey, D. J., Kaslovsky, D. N., Meyer, F. G., & Wright, K. P. (2014) · Sleep Medicine · doi:10.1016/j.sleep.2014.05.007 · Cited by 40
Zolpidem prescribing practices before and after Food and Drug Administration required product labeling changes
Norman, J. L., Fixen, D. R., Saseen, J. J., Saba, L. M., & Linnebur, S. A. (2017) · SAGE Open Medicine · doi:10.1177/2050312117707687 · Cited by 38
Making a ‘sex-difference fact’: Ambien dosing at the interface of policy, regulation, women’s health, and biology
Zhao, H. H., DiMarco, M., Ichikawa, K., Boulicault, M., Perret, M., Jillson, K., Fair, A., DeJesus, K., & Richardson, S. S. (2023) · Social Studies of Science · doi:10.1177/03063127231168371 · Cited by 42
Risk of Falling and Hypnotic Drugs: Retrospective Study of Inpatients
Obayashi, K., Araki, T., Nakamura, K., Kurabayashi, M., Nojima, Y., Hara, K., Nakamura, T., & Yamamoto, K. (2013) · Drugs in R&D · doi:10.1007/s40268-013-0019-3 · Cited by 37
Zolpidem abuse, dependence and withdrawal syndrome: sex as susceptibility factor for adverse effects
Cubała, W. J., Landowski, J., & Wichowicz, H. M. (2008) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2007.03028.x · Cited by 34
Ritonavir Greatly Impairs CYP3A Activity in HIV Infection With Chronic Viral Hepatitis
Knox, T. A., Oleson, L. E., Moltke, L. L., Kaufman, R. C., WANKE, C. A., & Greenblatt, D. J. (2008) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31818c7efe · Cited by 34
Self-citation
A systematic review on sex differences in adverse drug reactions related to psychotropic, cardiovascular, and analgesic medications
Shan, Y., Cheung, L., Zhou, Y., Huang, Y., & Huang, R. S. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1096366 · Cited by 32
Central Nervous System Medications: Pharmacokinetic and Pharmacodynamic Considerations for Older Adults
Gronich, N. (2024) · Drugs & Aging · doi:10.1007/s40266-024-01117-w · Cited by 41
Non-Benzodiazepine Receptor Agonists for Insomnia.
Becker, P., & Somiah, M. (2015) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2014.11.002 · Cited by 32
Cortical oscillatory dynamics and benzodiazepine-site modulation of tonic inhibition in fast spiking interneurons
Prokic, E. J., Weston, C. A., Yamawaki, N., Hall, S. D., Jones, R. S. G., Stanford, I. M., Ladds, G., & Woodhall, G. L. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.03.006 · Cited by 31
Use of Zolpidem and Risk of Acute Pyelonephritis in Women: A Population‐Based Case‐Control Study in Taiwan
Hsu, F., Sheu, M., Lin, C., Hsieh, Y., & Lai, S. (2016) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.815 · Cited by 28
A Multimodal Perspective on the Composition of Cortical Oscillations
Rönnqvist, K. C., McAllister, C. J., Woodhall, G. L., Stanford, I. M., & Hall, S. D. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00132 · Cited by 29
Gender Differences in the Efficacy and Safety of Chronic Nightly Zolpidem
Roehrs, T., & Roth, T. G. (2016) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.5574 · Cited by 27
Zolpidem pharmacokinetics and pharmacodynamics in metabolic interactions involving CYP3A: sex as a differentiating factor
Cubała, W. J., Wiglusz, M. S., Burkiewicz, A., & Gałuszko‐Węgielnik, M. (2010) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-010-0854-x · Cited by 27
Insomnia in the Elderly
Lichstein, K. L., Stone, K. C., Nau, S. D., McCrae, C. S., & Payne, K. L. (2006) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2006.04.009 · Cited by 26
Effect of voriconazole on the pharmacokinetics and pharmacodynamics of zolpidem in healthy subjects
Saari, T. I., Laine, K., Leino, K. A., Valtonen, M., Neuvonen, P. J., & Olkkola, K. T. (2006) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2006.02707.x · Cited by 23
Population analyses of amlodipine in patients living in the community and patients living in nursing homes
KANG, D., Verotta, D., & Schwartz, J. B. (2006) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2005.09.007 · Cited by 23
Zolpidem use and motor vehicle collisions in older drivers
Booth, J. N., Behring, M. P., Cantor, R. S., Colantonio, L. D., Davidson, S. L., Donnelly, J. P., Johnson, E., Jordan, K. H., Singleton, C. R., Xie, F., et al. (2015) · Sleep Medicine · doi:10.1016/j.sleep.2015.12.004 · Cited by 21
Pharmacokinetic dosage guidelines for elderly subjects
Turnheim, K. (2005) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.1.1.33 · Cited by 21
Regulation of drug-metabolizing enzymes by sex-related hormones: clinical implications for transgender medicine
Le, A., Huang, K. J., & Cirrincione, L. R. (2022) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2022.03.006 · Cited by 20
Effects of steady-state clarithromycin on the pharmacokinetics of zolpidem in healthy subjects
Lee, C., Jung, E. H., Byeon, J.-Y., Kim, S., Jang, C., Lee, Y. J., & Lee, S. (2019) · Archives of Pharmacal Research · doi:10.1007/s12272-019-01201-5 · Cited by 19
Lost in translational biology: Understanding sex differences to inform studies of diseases of the nervous system
Pearse, R. V., & Young‐Pearse, T. L. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146352 · Cited by 22
Sex-Biased Expression of Pharmacogenes across Human Tissues
Idda, M. L., Campesi, I., Fiorito, G., Vecchietti, A., Urru, S. A. M., Solinas, G., Franconi, F., & Floris, M. (2021) · Biomolecules · doi:10.3390/biom11081206 · Cited by 17
Population Analyses of Atorvastatin Clearance in Patients Living in the Community and in Nursing Homes
Schwartz, J. B., & Verotta, D. (2009) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2009.100 · Cited by 16
A therapeutic dose of zolpidem has limited abuse-like effects in drug-naïve females: A pilot study
Licata, S. C., Penetar, D. M., Dunlap, S., & Lukas, S. E. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.09.011 · Cited by 16
Pharmacotherapy of Insomnia: Focus on Zolpidem Extended Release
Monti, J. M., Spence, D. W., Pandi-Perumal, S. R., Langer, S. Z., & Hardeland, R. (2009) · Clinical Medicine Therapeutics · doi:10.4137/cmt.s2040 · Cited by 16
Risk of Type 2 Diabetes in Patients With Nonapnea Sleep Disorders in Using Different Types of Hypnotics
Lin, C., Yeh, M. C., Harnod, T., Lin, C., & Kao, C. (2015) · Medicine · doi:10.1097/md.0000000000001621 · Cited by 16
A new sublingual formulation of zolpidem for the treatment of sleep-onset insomnia
Staner, L., Danjou, P., & Luthringer, R. (2012) · Expert Review of Neurotherapeutics · doi:10.1586/ern.11.197 · Cited by 15
Pharmacologic Treatment of Disturbed Sleep in the Elderly
Salzman, C. (2008) · Harvard Review of Psychiatry · doi:10.1080/10673220802432442 · Cited by 15
Chapter 87 – Pharmacologic Treatment of Insomnia: Benzodiazepine Receptor Agonists
Walsh, J., & Roth, T. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-24288-2.00087-8 · Cited by 7
Zolpidem for the Treatment of Dystonia
Badillo, S. P. J., & Jamora, R. D. G. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00779 · Cited by 14
Pharmacokinetics of Zolpidem from Sublingual Zolpidem Tartrate Tablets In Healthy Elderly Versus Non-Elderly Subjects
Greenblatt, D. J., Harmatz, J. S., Singh, N., Steinberg, F. J., Roth, T. G., Harris, S., & Kapil, R. P. (2014) · Drugs & Aging · doi:10.1007/s40266-014-0211-3 · Cited by 13
Self-citation
In-vitro–in-silico investigation of the negative food effect of zolpidem when administered as immediate-release tablets
Paraiso, R. L. M., Watanabe, A., Andreas, C. J., Turner, D. B., Zane, P. A., & Dressman, J. (2019) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.13161 · Cited by 14
Safety analysis of zolpidem in elderly subjects 80 years of age or older: adverse event monitoring in Japanese subjects
Kajiwara, A., Yamamura, M., Murase, M., Koda, H., Hirota, S., Ishizuka, T., Morita, K., Oniki, K., Saruwatari, J., & Nakagawa, K. (2015) · Aging & Mental Health · doi:10.1080/13607863.2015.1031640 · Cited by 12
Sedative and anticonvulsant effects of zolpidem in adult and aged mice
Peričić, D., Vlainić, J., & Štrac, D. Š. (2008) · Journal of Neural Transmission · doi:10.1007/s00702-008-0020-0 · Cited by 12
Pharmacokinetic Determinants of the Clinical Effects of Benzodiazepine Agonist Hypnotics
Greenblatt, D. J. (2010) · Springer eBooks · doi:10.1007/978-3-0346-0226-6_4 · Cited by 10
Self-citation
Alcohol and Aldehyde Dehydrogenases Contribute to Sex-Related Differences in Clearance of Zolpidem in Rats
Peer, C. J., Strope, J. D., Beedie, S., Ley, A. M., Holly, A. J., Calis, K. A., Farkas, R. H., Parepally, J. M. R., Men, A. Y., Fadiran, E. O., et al. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00260 · Cited by 10
Treatment of depression: Are psychotropic drugs appropriately dosed in women and in the elderly? Dosages of psychotropic drugs by sex and age in routine clinical practice
Greil, W., de Bardeci, M., Seifert, J., Bernegger, X., Cattapan, K., Stassen, H. H., Wagner, A. L., Sieberer, M. G., Grohmann, R., & Toto, S. (2021) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2809 · Cited by 10
Zolpidem: Forensic Aspects for the Toxicologist and Pathologist
Rohrig, T. P., & Moore, C. M. (2005) · Forensic Science Medicine and Pathology · doi:10.1385/fsmp:1:2:081 · Cited by 10
Comparative pharmacokinetics of zolpidem tartrate in five ethnic populations of China
Guo, T., Mao, G., Zhao, L., Xia, D., & Yang, L. (2014) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2014.02.001 · Cited by 9
Pharmacokinetics and pharmacodynamics of zolpidem after oral administration of a single dose in dogs
Gıorgı, M., Portela, D. A., Breghi, G., & Briganti, A. (2012) · American Journal of Veterinary Research · doi:10.2460/ajvr.73.10.1650 · Cited by 8
Sleep Medications and Women: a Review of Issues to Consider for Optimizing the Care of Women with Sleep Disorders
Krystal, A. D., & Attarian, H. P. (2016) · Current Sleep Medicine Reports · doi:10.1007/s40675-016-0060-1 · Cited by 7
Reintroduction of quazepam
Moniri, N. H. (2019) · International Clinical Psychopharmacology · doi:10.1097/yic.0000000000000277 · Cited by 7
Validated Stability Indicating HPLC Method for Determination of Zolpidem in the Presence of Its Degradation Products
Souri, E. (2012) · The Open Conference Proceedings Journal · doi:10.2174/2210289201203010013 · Cited by 6
Gender influences on efficacy and safety of sublingual zolpidem tartrate for middle‐of‐the‐night awakening in insomnia
Roth, T. G., Steinberg, F. J., Singh, N., & Moline, M. L. (2013) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2364 · Cited by 6
Fast-Acting Sublingual Zolpidem for Middle-of-the-Night Wakefulness
Pergolizzi, J. V., Taylor, R., Raffa, R. B., Nalamachu, S. R., & Chopra, M. (2014) · Sleep Disorders · doi:10.1155/2014/527109 · Cited by 6
2017, Sexual Dimorphism, Sexual Pluralism, and More
Shader, R. I. (2016) · Clinical Therapeutics · doi:10.1016/j.clinthera.2016.12.004 · Cited by 6
Self-citation
Sleep Pharmacogenetics: The Promise of Precision Medicine.
Krystal, A., & Prather, A. (2019) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2019.05.003 · Cited by 6
Evaluation of Physiologically Based Pharmacokinetic Models to Predict the Absorption of BCS Class I Drugs in Different Pediatric Age Groups
Liu, X. I., van den Anker, J. N., Burckart, G. J., & Dallmann, A. (2021) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.1845 · Cited by 6
Qualitative analysis of 7- and 8-hydroxyzolpidem and discovery of novel zolpidem metabolites in postmortem urine using liquid chromatography–tandem mass spectrometry
Yamaguchi, K., Miyaguchi, H., Ohno, Y., & Kanawaku, Y. (2022) · Forensic Toxicology · doi:10.1007/s11419-021-00611-9 · Cited by 6
Novos sedativos hipnóticos
Sukys-Claudino, L., Moraes, W. A. D. S., Tufik, S., & Poyares, D. (2010) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462010000300014 · Cited by 6
Incidence of and Risk Ractors for Zolpidem-Induced Delirium
Kim, Y. M., Lee, S., Jung, J. Y., Shin, K. H., Kim, D. H., Kim, J. H., & Jee, Y. (2013) · Korean Journal of Medicine · doi:10.3904/kjm.2013.84.6.804 · Cited by 5
POLYPHARMACY AND USE OF POTENTIALLY INAPPROPRIATE MEDICATIONS IN PATIENTS WITH DEMENTIA AND MILD COGNITIVE IMPAIRMENT
Dhikav, V., Sethi, M., Singhal, A. K., & Anand, K. S. (2014) · Asian Journal of Pharmaceutical and Clinical Research · Cited by 5
Hipnóticos-z no tratamento da insônia
da Silva, L. A. T., Soliani, F. C. D. B. G., & Sanches, A. C. S. (2022) · Revista Neurociências · doi:10.34024/rnc.2022.v30.12663 · Cited by 4
Zolpidem related persistent genital arousal disorder: An interesting case
Ferenidou, F., Mourikis, I., Sotiropoulou, P., & Vaidakis, N. (2020) · Psychiatriki · doi:10.22365/jpsych.2019.304.339 · Cited by 4
Impact of Pre–ICU benzodiazepine and Z–Drug exposure on mortality in critically ill Adults: A nationwide retrospective cohort study
Oh, T. K., & In-Ae, S. (2025) · Intensive and Critical Care Nursing · doi:10.1016/j.iccn.2025.104322 · Cited by 3
Variables influencing patient satisfaction for hypnotics: difference between zolpidem and brotizolam
Hosono, T., Homma, M., Satoh, M., & Kohda, Y. (2014) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/jcpt.12174 · Cited by 3
Zolpidem in the Treatment of Adult and Elderly Primary Insomnia Patients
Staner, L., Cornette, F., Otmani, S., Nedelec, J. F., & Danjou, P. (2010) · Springer eBooks · doi:10.1007/978-3-0346-0226-6_17 · Cited by 3
Synthesis and Evaluation of Molecularly Imprinted Nanoparticles for Detection and Quantification of Zolpidem In Human Plasma
Landi, B., Kobarfard, F., Banan, K., Keçili, R., & Ghorbani‐Bidkorbeh, F. (2023) · ChemistrySelect · doi:10.1002/slct.202303575 · Cited by 2
Sex and Gender Differences in Medical Education: The Impact on Scientific Reports
Mattioli, A. V., Coppi, F., Bucciarelli, V., Nasi, M., Pinti, M., Palumbo, C., & Gallina, S. (2023) · Current pharmacogenomics and personalized medicine (Online)/Current pharmacogenomics and personalized medicine · doi:10.2174/1875692120666230811092856 · Cited by 2
Response to “Zolpidem pharmacokinetics and pharmacodynamics in metabolic interactions involving CYP3A: sex as differentiating factor”
Polasek, T. M., & Miners, J. O. (2010) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-010-0855-9 · Cited by 2
PHARMACOLOGY ACROSS THE AGING CONTINUUM
Gronich, N., & Abernethy, D. R. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-3291-5.50023-8 · Cited by 2
ASSESSMENT OF THE EFFECTS OF STEADY-STATE BUPROPION ON THE PHARMACOKINETIC PROFILE OF ZOLPIDEM IN HEALTHY VOLUNTEERS
Gheldiu, A.-M. (2019) · FARMACIA · doi:10.31925/farmacia.2019.3.8 · Cited by 2
Analysis of the variability of the pharmacokinetics of multiple drugs in young adult and elderly subjects and its implications for acceptable daily exposures and cleaning validation limits
Streeter, A. J., & Faria, E. C. (2017) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2017.03.007 · Cited by 2
Psychopharmacology and the Consequences of Alcohol and Drug Interactions
Ramchandani, V. A., Slattum, P. W., Patkar, A. A., Wu, L.-T. T., Lee, J. C., Mohanty, M., Coe, M. A., & Li, T. (2014) · Wiley eBooks · doi:10.1002/9781118430965.ch12 · Cited by 2
Pharmacotherapeutic options for treatment of insomnia
Singh, J., & Singh, J. (2014) · International Journal of Basic & Clinical Pharmacology · doi:10.5455/2319-2003.ijbcp20141035 · Cited by 1
Repeated Zolpidem Treatment Effects on Sedative Tolerance, Withdrawal, mRNA Levels, and Protein Expression
Wright, B. T. (2016) · doi:10.21007/etd.cghs.2016.0408 · Cited by 1
Z-drug abuse and dependence: Clinical guideline of the Brazilian Academy of Neurology for diagnosis and management
Stelzer, F. G., Bacelar, A., Éckeli, A. L., Negrão, A. B., Almeida, C. M. O., Franco, C. M. R., Pires, G. N., Gitaí, L. L. G., Sobreira-Neto, M. A., Assis, M., et al. (2025) · Arquivos de Neuro-Psiquiatria · doi:10.1055/s-0045-1812323 · Cited by 1
Molecular Modelling Analysis of the Metabolism of Zolpidem
Huq, F. (2008) · Journal of Pharmacology and Toxicology · doi:10.3923/jpt.2008.93.101
The Effects of Body Weight, Food Intake, Activity, and Anxiety in Female Rats
Mangan, R. (2016) · Carroll Collected (John Carroll University)
A Tribute to Dr. Hermann R. Ochs, 1943–2013
Greenblatt, D. J. (2014) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000241
Self-citation
Psychopharmaka und das Risiko von Stürzen in der stationären geriatrischen Versorgung
Wedmann, F. (2019) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-7608
Hypersomnia due to a medication or substance
Schweitzer, P. K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822963-7.00103-1
A physiologically based biopharmaceutical analysis of zolpidem
Paraiso, R. L. M. (2021) · Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) · doi:10.21248/gups.61326
In Silico Dose Adjustment of Zolpidem in Females Using Physiologically Based Pharmacokinetic Modeling and Simulations
Malayandi, R., Karmakar, A., Dhake, P. R., Malgave, A., Natesan, S., & Ravichandiran, V. (2024) · Sleep and Vigilance · doi:10.1007/s41782-024-00283-6
Seizure Following Zolpidem Withdrawal in a Patient Presenting as a Stroke Lysis Call: A Case Report
Chishti, H., Melby, E., & Mansoor, Z. (2025) · Cureus · doi:10.7759/cureus.94684

Authors: Olubodun, J. O., Ochs, H. R., Von Moltke, L. L., Roubenoff, R., Hesse, L. M., Harmatz, J. S., Shader, R. I., & Greenblatt, D. J.
Affiliations: Tufts University (US)
Corresponding author: Greenblatt, David J.
ORCID: Roubenoff, Ronenn
Hesse, Leah M.
Shader, Richard I.
Greenblatt, David J.
Venue: British Journal of Clinical Pharmacology
Publisher: Wiley
Published: 2003-07-22
Volume: 56
Issue: 3
Pages: 297-304
ISSN: 0306-5251 (ISSN-L)
1365-2125
DOI: 10.1046/j.0306-5251.2003.01852.x
PMC: PMC1884349
OpenAlex: W2169843481
Cited by: 104
References: 60
Citations by year: 2026: 3 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 8 · 2020: 2 · 2019: 9 · 2018: 1 · 2017: 3 · 2016: 8 · 2015: 4 · 2014: 12 · 2013: 6 · 2012: 4
FWCI: 3.36
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: British Journal of Clinical Pharmacology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG-17880, R01AG017880)
National Institute of Mental Health (MH 02137, MH 58435, R01MH058435)
National Institute on Drug Abuse (R21DA013209, R01DA005258, DA 13209, DA05258)
National Institute of Diabetes and Digestive and Kidney Diseases (DK/AI 58496, R01DK058496)
National Center for Research Resources (RR00054, M01RR000054)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
Keywords: zolpidem, pharmacokinetics, aging, older adults, testosterone, CYP3A4, drug metabolism, oral clearance, Cmax, half-life, hypnotics, liver microsomes, CYP3A4 induction, sex differences, drug interactions, drug safety in older adults
MeSH terms: Zolpidem, Administration, Oral, Adult, Aged, Aged, 80 and over, Aging, Chromatography, High Pressure Liquid, Drug Interactions, Female, Half-Life, Humans, Hypnotics and Sedatives, Male, Microsomes, Liver, Middle Aged, Pyridines, Testosterone, GABA Agonists, Hepatocytes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Pharmacokinetic properties of zolpidem in elderly and young adults: possible modulation by testosterone in men

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks