Gender‐related differences in the regulatory influence of thyroid hormone on the expression of myosin isoforms in young and old rats
Abstract
The effects of 4 weeks of thyroid hormone (3,5,3′‐triiodothyronine, T3) treatment on the expression of myosin heavy chain (MyHC) isoforms were examined in young (3–6 months) and old (20–24 months) female rats, and compared with those in age‐matched male rats (Larsson et al. 1995). In control rats, ageing was associated with a type IIA to I MyHC isoform switching in the slow‐twitch soleus and a type IIB to IIX MyHC isoform switching in the fast‐twitch extensor digitorum longus muscle (EDL). Gender‐ and muscle‐specific differences were observed in the regulation of MyHC isoforms by T3. In the soleus, dramatic downregulation of the type I and upregulation of the type IIA MyHC isoform were observed in both females and males, but upregulation of the IIX MyHC isoform was observed only in male rats. In EDL, T3 treatment had no significant influence on the MyHC isoform composition in the males irrespective of the age of the animal. In the females, on the other hand, T3 treatment resulted in a significant MyHC transformation from IIA to IIB, probably via IIX myosin, in spite of the fact that type IIA mRNA has been reported to be downregulated in both females and males. It is concluded that the regulation of MyHC isoforms by thyroid hormone differs between females and males, presumably as a result of a gender‐related difference in the translational or post‐translational regulation of MyHC synthesis.
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In another study of euthyroid animals, treatment with T3 induces expression of IIX in the soleus of aged male rats (4-15%), whereas there is no detectable IIX in females at any age.
“In another study of euthyroid animals, treatment with T3 induces expression of IIX in the soleus of aged male rats (4–15%), whereas there is no detectable IIX in females at any age (52).”
From Sex-Based Differences in Skeletal Muscle Kinetics and Fiber-Type Composition (2015) · cites this paper as [52]
T3 treatment in euthyroid animals leads to a conversion from IIA to IIB fibers in the EDL of young and old female rats vs. no transition in males.
“T3 treatment in euthyroid animals leads to a conversion from IIA to IIB fibers in the EDL of young and old female rats vs. no transition in males (52).”
From Sex-Based Differences in Skeletal Muscle Kinetics and Fiber-Type Composition (2015) · cites this paper as [52]
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- Authors
- LARSSON, L., & YU, F.
- Affiliations
- Karolinska University Hospital (SE)
- Corresponding author
- LARSSON, L.
- ORCID
- LARSSON, L.
- Venue
- Acta Physiologica Scandinavica
- Publisher
- Wiley
- Published
- 1997-01
- Volume
- 159
- Issue
- 1
- Pages
- 81-89
- ISSN
- 0001-6772 (ISSN-L)
- 1365-201X
- OpenAlex
- W2062345367
- Cited by
- 24
- References
- 0
- Citations by year
- 2021: 2 · 2018: 1 · 2017: 1 · 2015: 1
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Physiologica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- thyroid hormones, triiodothyronine, myosin heavy chain isoforms, sex differences, aging, soleus muscle, extensor digitorum longus, post-translational regulation, translational regulation
- MeSH terms
- Age Factors, Aging, Animals, Female, Male, Sex Characteristics, Thyroid Hormones, Rats, Wistar, Myosin Heavy Chains, Rats
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