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Cited by 27Muscle Physiology and DisordersHormonal and reproductive studiesEstrogen and related hormone effects

Differential effects of diminished oestrogen and androgen levels on development of skeletal muscle fibres in hypogonadal mice

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Sciote, J. J., Horton, M. J., Zyman, Y., Pascoe, G.·2001·Acta Physiologica Scandinavica
DOI 10.1046/j.1365-201x.2001.00854.x
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Abstract

Androgen and oestrogen hormones influence skeletal muscle size and the characteristics of skeletal muscle fibre types. These effects have typically been assessed by producing acute shortages (castration/ovariectomy) or by hormone supplementation. Little evidence exists, however, on how sex hormone shortages affect muscle development from early stages through to adulthood. Using the hypogonadal mouse model (hpg) we examined the effects of diminished androgen and oestrogen upon muscle size and fibre type composition in murine gastrocnemius and soleus muscles. Hypogonadal male soleus muscle was significantly smaller than normal males, and approximated the normal and hypogonadal females weight and fibre type characteristics. The hypogonadal male gastrocnemius muscle, however, was significantly small in comparison with normal and hypogonadal female gastrocnemius muscles, with the type IIB fibre diameters decreased most markedly. The hypogonadal female soleus muscle approximated the normal female phenotype, but the gastrocnemius muscle was larger than the normal female, approximating the size of the normal male gastrocnemius muscle. Here too, the type IIB fibres showed the most alteration, with greatly increased fibre diameters. Appropriate amounts of androgens were necessary for gender‐specific patterns of growth in male muscles, whilst similar amounts of oestrogen were necessary for female gastrocnemius muscle growth, but not for female soleus muscle. Hypogonadism in this murine model generally retards muscle development in males, but has no apparent influence or enhances muscle development in females. Type IIB fibres are most dependent upon sex hormones for appropriate development, but this relationship is muscle‐specific.

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  • Analysis of fiber-type distribution in hypogonadal male vs. female mice reveals no significant changes in type-I, -IIA, -IIX, or -IIB fibers in gastrocnemius muscle or in type-I or -IIA fibers in the soleus.

    “Analysis of fiber-type distribution in hypogonadal males vs. females reveals no significant changes in type-I, -IIA, -IIX, or -IIB fibers in gastrocnemius muscle or in type-I or -IIA fibers in the soleus (79).”

    From Sex-Based Differences in Skeletal Muscle Kinetics and Fiber-Type Composition (2015) · cites this paper as [79]

  • In female hypogonadal mice, the hypogonadal phenotype leads to an increase in IIB fiber diameter compared with wild-type females.

    “Surprisingly, in females, the hypogonadal phenotype leads to an increase in IIB fiber diameter compared with wild-type females (79).”

    From Sex-Based Differences in Skeletal Muscle Kinetics and Fiber-Type Composition (2015) · cites this paper as [79]

  • In male hypogonadal mice, IIB fiber-type diameter significantly declines compared with wild-type males.

    “However, in other instances, IIB fiber-type diameter in male hypogonadal mice significantly declines compared with wild-type males.”

    From Sex-Based Differences in Skeletal Muscle Kinetics and Fiber-Type Composition (2015) · cites this paper as [79]

  • In hypogonadal mice, gastrocnemius fiber-type distribution is relatively unchanged from wild-type mice, with relative contribution I < IIX < IIA < IIB in both males and females.

    “Additionally fiber-type distribution of the gastrocnemius is relatively unchanged from wild-type mice, with I < IIX < IIA < IIB being the relative contribution of each fiber-type in males and females (79).”

    From Sex-Based Differences in Skeletal Muscle Kinetics and Fiber-Type Composition (2015) · cites this paper as [79]

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Research works printed but not linked: 2

  1. Gondos, B. 1980. Development and differentiation of the testis and male reproductive tract. In: A. Steinberger & E. Steinberger (eds) Testicular Development Structure and Function, pp. 3±20. Raven Press, New York.
  2. Siiteri, P.K. & MacDonald, P.C. 1973. Role of extraglandular oestrogen in human endocrinology. In: R.O. Greep & E.B. Astwood (eds) Sect 7: Endocrinology, Vol. II. Female Reproductive System, Part I, pp. 615±629. American Physiological Society, Washington DC.

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Authors
Sciote, J. J., Horton, M. J., Zyman, Y., & Pascoe, G.
Affiliations
University of Pittsburgh (US)
Corresponding author
Sciote, J. J.
ORCID
Venue
Acta Physiologica Scandinavica
Publisher
Wiley
Published
2001-07-24
Volume
172
Issue
3
Pages
179-187
ISSN
  • 0001-6772 (ISSN-L)
  • 1365-201X
DOI
10.1046/j.1365-201x.2001.00854.x
OpenAlex
W2069975915
Cited by
27
References
49
Citations by year
2026: 1 · 2024: 1 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 4 · 2015: 2 · 2013: 1 · 2012: 1
FWCI
0.23
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 149 d)
Locations
  • Acta Physiologica Scandinavica (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords
hypogonadism, estrogen, androgens, skeletal muscle development, muscle fiber type distribution, type IIb muscle fibers, muscle fiber diameter, sex differences, gastrocnemius, soleus muscle, muscle growth
MeSH terms
Adenosine Triphosphatases, Aging, Androgens, Animals, Estrogens, Female, Hypogonadism, Immunohistochemistry, Male, Muscle, Skeletal, Muscle Fibers, Skeletal, Muscle Development, Mice

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