Review article: issues in oral administration of locally acting glucocorticosteroids for treatment of inflammatory bowel disease

Cortisone in Ulcerative Colitis

Truelove, S. C., & Witts, L. J. (1955) · BMJ · doi:10.1136/bmj.2.4947.1041 · Cited by 2,793 · see citing works

Measurement of gastrointestinal pH profiles in normal ambulant human subjects

Evans, D. F., Pye, G., Bramley, R., Clark, A. G., Dyson, T. J., & Hardcastle, J. D. (1988) · Gut · doi:10.1136/gut.29.8.1035 · Cited by 1,240 · see citing works

Glucocorticosteroid Therapy: Mechanisms of Action and Clinical Considerations

FAUCI, A. S., DALE, D. C., & BALOW, J. E. (1976) · Annals of Internal Medicine · doi:10.7326/0003-4819-84-3-304 · Cited by 1,044 · see citing works

Transit of pharmaceutical dosage forms through the small intestine.

Davis, S. S., Hardy, J. G., & Fara, J. W. (1986) · Gut · doi:10.1136/gut.27.8.886 · Cited by 855 · see citing works

Fractal growth viscous fingers: quantitative characterization of a fluid instability phenomenon

Nittmann, J., Daccord, G., & Stanley, H. E. (1985) · Nature · doi:10.1038/314141a0 · Cited by 620 · see citing works

Cortisone in Ulcerative Colitis

Truelove, S. C., & Witts, L. J. (1954) · BMJ · doi:10.1136/bmj.2.4884.375 · Cited by 538 · see citing works

Segmental colonic transit time

Arhan, P., Devroede, G. J., Jehannin, B., Lanza, M., Faverdin, C., Dornic, C., Persoz, B., Tétreault, L., Perey, B. J., & Pellerin, D. (1981) · Diseases of the Colon & Rectum · doi:10.1007/bf02605761 · Cited by 465 · see citing works

Biochemistry, Molecular Biology, and Physiology of the Glucocorticoid Receptor*

Gustafsson, J.-Α., Carlstedt‐Duke, J., Poellinger, L., Okret, S., Wikström, A., Brönnegård, M., Gillner, M., Dong, Y., Fuxé, K., Cintra, A., et al. (1987) · Endocrine Reviews · doi:10.1210/edrv-8-2-185 · Cited by 402 · see citing works

The human pharmacology of fluticasone propionate

Harding, S. M. (1990) · Respiratory Medicine · doi:10.1016/s0954-6111(08)80004-2 · Cited by 315 · see citing works

Pharmacokinetics and metabolism of budesonide, a selective glucocorticoid.

Ryrfeldt, Å., Andersson, P., Edsbäcker, S., Tönnesson, M., Davies, D., & Pauwels, R. (1982) · PubMed · Cited by 301 · see citing works

Growth and activities of sulphate-reducing bacteria in gut contents of healthy subjects and patients with ulcerative colitis

Gibson, G. R., Cummings, J. H., & Macfarlane, G. T. (1991) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1991.tb04799.x · Cited by 301 · see citing works

Oral budesonide as maintenance treatment for Crohn's disease: A placebo-controlled, dose-ranging study. Canadian Inflammatory Bowel Disease Study Group

Greenberg, G. R., Feagan, B., Martin, F., Sutherland, L. R., Thomson, A., Williams, C. N., Nilsson, L., & Persson, T. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8536887 · Cited by 287 · see citing works

pH‐Profile and regional transit times of the normal gut measured by a radiotelemetry device

Fallingborg, J., Christensen, L. A., Ingeman‐Nielsen, M., Jacobsen, B. A., ABILDGAARD, K., & Rasmussen, H. H. (1989) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.1989.tb00254.x · Cited by 243 · see citing works

Studies of Intestinal Microflora

Gorbach, S. L., Nahas, L., Plaut, A. G., Weinstein, L., Patterson, J. F., & Levitan, R. (1968) · Gastroenterology · doi:10.1016/s0016-5085(68)80072-1 · Cited by 243 · see citing works

An in vitro investigation into the suitability of pH-dependent polymers for colonic targeting

Ashford, M. B., Fell, J. T., Attwood, D., & Woodhead, P. J. (1993) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(93)90344-f · Cited by 239 · see citing works

Colonic transit scintigraphy. A physiologic approach to the quantitative measurement of colonic transit in humans.

Krevsky, B., Malmud, L., D'Ercole, F., Maurer, A., & Fisher, R. S. (1986) · Gastroenterology · doi:10.1016/s0016-5085(86)80004-x · Cited by 230 · see citing works

Very low intraluminal colonic pH in patients with active ulcerative colitis

Fallingborg, J., Christensen, L. A., Jacobsen, B. A., & Rasmussen, S. N. (1993) · Digestive Diseases and Sciences · doi:10.1007/bf01297074 · Cited by 227 · see citing works

Human gastric emptying and colonic filling of solids characterized by a new method

Camilleri, M., Colemont, L. J., Phillips, S. F., Brown, M. L., Thomforde, G. M., Chapman, N., & Zinsmeister, A. R. (1989) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1989.257.2.g284 · Cited by 227 · see citing works

An Assessment of Prednisone, Salazopyrin, and Topical Hydrocortisone Hemisuccinate Used as Out-patient Treatment for Ulcerative Colitis

Lennard‐Jones, J. E., Longmore, A. J., Newell, A. C., Wilson, C. W. E., & Jones, F. A. (1960) · Gut · doi:10.1136/gut.1.3.217 · Cited by 226 · see citing works

Studies on the mechanism of bowel disturbance in ulcerative colitis

Rao, S. S. C., Read, N. W., Brown, C., Bruce, C., & Holdsworth, C. D. (1987) · Gastroenterology · doi:10.1016/0016-5085(87)90554-3 · Cited by 215 · see citing works

Transit of solids through the human colon: regional quantification in the unprepared bowel

Proano, M., Camilleri, M., Phillips, S. F., Brown, M. L., & Thomforde, G. M. (1990) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1990.258.6.g856 · Cited by 215 · see citing works

The effect of density on the gastric emptying of single- and multiple-unit dosage forms

Davis, S. S., Stockwell, A. F., Taylor, M. J., Hardy, J. G., WHALLEY, D. R., WILSON, C. G., Bechgaard, H., & Christensen, F. N. (1986) · Pharmaceutical Research · doi:10.1023/a:1016334629169 · Cited by 210 · see citing works

Colonic Drug Delivery

Watts, P. J., & Lllum, L. (1997) · Drug Development and Industrial Pharmacy · doi:10.3109/03639049709148695 · Cited by 209 · see citing works

A comparative study of the gastrointestinal transit of a pellet and tablet formulation

Davis, S. S., Hardy, J. G., Taylor, M. J., WHALLEY, D. R., & WILSON, C. G. (1984) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(84)90091-7 · Cited by 206 · see citing works

Some parameters of large bowel motility in normal man.

Martelli, H., Devroede, G. J., Arhan, P., Duguay, C., Dornic, C., & Faverdin, C. (1978) · PubMed · Cited by 204 · see citing works

Corticosteroids

Swartz, S. L., & Dluhy, R. G. (1978) · Drugs · doi:10.2165/00003495-197816030-00006 · Cited by 200 · see citing works

Effects of glucocorticosteroids on inflammatory cells relevant to their therapeutic applications in asthma.

Schleimer, R. P. (1990) · PubMed · Cited by 194 · see citing works

Oral budesonide versus prednisolone in patients with active extensive and left-sided ulcerative colitis

Löfberg, R., Danielsson, Å., Suhr, O. B., Nilsson, A., Schiöler, R., Nyberg, A. H., Hultcrantz, R., Kollberg, B., Gillberg, R., Wïllén, R., et al. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8964395 · Cited by 188 · see citing works

Clinical Pharmacokinetics of Prednisone and Prednisolone

Pickup, M. E. (1979) · Clinical Pharmacokinetics · doi:10.2165/00003088-197904020-00004 · Cited by 187 · see citing works

Budesonide

Brogden, R. N., & McTavish, D. (1992) · Drugs · doi:10.2165/00003495-199244030-00007 · Cited by 178 · see citing works

Colon-specific drug delivery

Friend, D. R. (1991) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(91)90051-d · Cited by 171 · see citing works

Drug delivery to the proximal colon

Hardy, J. G., WILSON, C. G., & Wood, E. (1985) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1985.tb04992.x · Cited by 169 · see citing works

Approaches and Opportunities in Colon-Specific Drug Delivery

Rubinstein, A. (1995) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.v12.i2-3.10 · Cited by 167 · see citing works

Pharmacodynamics and pharmacokinetics of inhaled glucocorticoids

Johnson, M. (1996) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(96)80217-x · Cited by 162 · see citing works

Microbially controlled drug delivery to the colon

Rubinstein, A. (1990) · Biopharmaceutics & Drug Disposition · doi:10.1002/bdd.2510110602 · Cited by 158 · see citing works

Overview of Newer Glucocorticosteroid Preparations for Inflammatory Bowel Disease

Brattsand, R. (1990) · Canadian Journal of Gastroenterology · doi:10.1155/1990/708916 · Cited by 157 · see citing works

The assessment of faecal flora in patients with inflammatory bowel disease by a simplified bacteriological technique

GIAFFER, M. H., HOLDSWORTH, C. D., & DUERDEN, B. I. (1991) · Journal of Medical Microbiology · doi:10.1099/00222615-35-4-238 · Cited by 151 · see citing works

Influence of inflammatory bowel disease on intestinal microflora.

Keighley, M. R. B., Arabi, Y., Dimock, F., Burdon, D. W., Allan, R. N., & Alexander-Williams, J. (1978) · Gut · doi:10.1136/gut.19.12.1099 · Cited by 147 · see citing works

Gastrointestinal transit of non-disintegrating tablets in fed subjects

Khosla, R., Feely, L. C., & Davis, S. S. (1989) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(89)90234-2 · Cited by 137 · see citing works

An in vivo investigation into the suitability of pH dependent polymers for colonic targeting

Ashford, M. B., Fell, J. T., Attwood, D., Sharma, H. L., & Woodhead, P. J. (1993) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(93)90406-6 · Cited by 134 · see citing works

Budesonide A Preliminary Review of its Pharmacodynamic Properties and Therapeutic Efficacy in Asthma and Rhinitis

Clissold, S. P., & Heel, R. C. (1984) · Drugs · doi:10.2165/00003495-198428060-00001 · Cited by 133 · see citing works

Symptoms and stool patterns in patients with ulcerative colitis.

Rao, S. S. C., Holdsworth, C. D., & Read, N. W. (1988) · Gut · doi:10.1136/gut.29.3.342 · Cited by 131 · see citing works

Treatment of Ulcerative Colitis with Local Hydrocortisone

Truelove, S. C. (1956) · BMJ · doi:10.1136/bmj.2.5004.1267 · Cited by 107 · see citing works

Improved localizing method of radiopill in measurement of entire gastrointestinal pH profiles: colonic luminal pH in normal subjects and patients with Crohn's disease.

Sasaki, Y., Hada, R., Nakajima, H., Fukuda, S., & Munakata, A. (1997) · PubMed · Cited by 107 · see citing works

Budesonide

Spencer, C. M., & McTavish, D. (1995) · Drugs · doi:10.2165/00003495-199550050-00006 · Cited by 106 · see citing works

Effect of glucocorticoids on rectal transport in normal subjects and patients with ulcerative colitis.

Sandle, G. I., Hayslett, J. P., & Binder, H. J. (1986) · Gut · doi:10.1136/gut.27.3.309 · Cited by 100 · see citing works

Emptying of the terminal ileum in intact humans

Spiller, R. C., Brown, M. L., & Phillips, S. F. (1987) · Gastroenterology · doi:10.1016/0016-5085(87)90024-2 · Cited by 98 · see citing works

THE FAECAL FLORA IN ULCERATIVE COLITIS

van der Wiel-Korstanje, J. A. A., & Winkler, K. (1975) · Journal of Medical Microbiology · doi:10.1099/00222615-8-4-491 · Cited by 98 · see citing works

Estimation of Agitation Intensity in the GI Tract in Humans and Dogs Based on in Vitro/in Vivo Correlation

Katori, N., Aoyagi, N., & Terao, T. (1995) · Pharmaceutical Research · doi:10.1023/a:1016231010301 · Cited by 96 · see citing works

Spread and distribution of 5-ASA colonic foam and 5-ASA enema in patients with ulcerative colitis

Campieri, M., Corbelli, C., Gionchetti, P., Brignola, C., Belluzzi, A., Febo, G. D., Zagni, P., Brunetti, G., Miglioli, M., & Barbara, L. (1992) · Digestive Diseases and Sciences · doi:10.1007/bf01308084 · Cited by 88 · see citing works

Correlation of the Gastric Emptying of Nondisintegrating Tablets with Gastrointestinal Motility

Coupe, A. J., Davis, S. S., Evans, D. F., & Wilding, I. R. (1991) · Pharmaceutical Research · doi:10.1023/a:1015855829864 · Cited by 85 · see citing works

Clinical Appearance at Diagnosis of Ulcerative Colitis and Crohn's Disease in a Regional Patient Group

BOTH, H., Torp-Pedersen, K., Kreiner, S., Hendriksen, C., & Binder, V. (1983) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365528309182127 · Cited by 83 · see citing works

Colonic transit of different sized tablets in healthy subjects

Adkin, D., Davis, S., Sparrow, R. A., & Wilding, I. (1993) · Journal of Controlled Release · doi:10.1016/0168-3659(93)90040-c · Cited by 82 · see citing works

Anaerobic gram-negative faecal flora in patients with Crohn's Disease and healthy subjects

Embden, J. G. H. R.-V., & Both-Patoir, H. C. (1983) · Antonie van Leeuwenhoek · doi:10.1007/bf00393670 · Cited by 82 · see citing works

The faecal flora of patients with Crohn's disease

Wensinck, F., Lieshout, L. M. C. V., Poppelaars-Kustermans, P. A. J., & Schröder, A. (1981) · Journal of Hygiene · doi:10.1017/s0022172400069187 · Cited by 80 · see citing works

The rectal mucosa-associated microflora in patients with ulcerative colitis

Hartley, M. G., HUDSON, M. J., Swarbrick, E. T., Hill, M. J., Gent, A. E., Hellier, M. D., & Grace, R. H. (1992) · Journal of Medical Microbiology · doi:10.1099/00222615-36-2-96 · Cited by 80 · see citing works

Oral Solid Controlled Release Dosage Forms: Role of GI-Mechanical Destructive Forces and Colonic Release in Drug Absorption Under Fasted and Fed Conditions in Humans

Shameem, M., Katori, N., Aoyagi, N., & Kojima, S. (1995) · Pharmaceutical Research · doi:10.1023/a:1016270701021 · Cited by 79 · see citing works

Treatment of distal ulcerative colitis (proctosigmoiditis) in relapse: comparison of hydrocortisone enemas and rectal hydrocortisone foam.

Ruddell, W. S., Dickinson, R., Dixon, M. F., & Axon, A. T. R. (1980) · Gut · doi:10.1136/gut.21.10.885 · Cited by 75 · see citing works

Gastrointestinal Drug Absorption: Is It Time to Consider Heterogeneity as Well as Homogeneity?

Macheras, P. E., & Argyrakis, P. (1997) · Pharmaceutical Research · doi:10.1023/a:1012183313218 · Cited by 73 · see citing works

BECLOMETHASONE DIPROPIONATE ENEMAS FOR TREATING INFLAMMATORY BOWEL DISEASE WITHOUT PRODUCING CUSHING'S SYNDROME OR HYPOTHALAMIC PITUITARY ADRENAL SUPRESSION

Kumana, C., Meghji, M. A., Seaton, T., Castelli, M., Benson, R., & Sivakumaran, T. (1982) · The Lancet · doi:10.1016/s0140-6736(82)91747-0 · Cited by 72 · see citing works

Liver metabolism of budesonide in rat, mouse, and man. Comparative aspects.

Edsbäcker, S., Andersson, P., Lindberg, C., Paulson, J., Ryrfeldt, Å., & Thalén, A. (1987) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(25)06716-9 · Cited by 70 · see citing works

The in-vivo evaluation of an osmotic device (Osmet) using gamma scintigraphy

Davis, S. S., Hardy, J. G., Taylor, M. J., Stockwell, A. F., WHALLEY, D. R., & WILSON, C. G. (1984) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1984.tb04862.x · Cited by 66 · see citing works

Targeting of drugs and vaccines to the gut

Wilding, I. R., Davis, S. S., & O’Hagan, D. T. (1994) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(94)90006-x · Cited by 64 · see citing works

Plasma prednisolone levels after administration of prednisolone-21-phosphate as a retention enema in colitis.

Powell-Tuck, J., Lennard‐Jones, J. E., May, C., Wilson, C. G., & Paterson, J. W. (1976) · BMJ · doi:10.1136/bmj.1.6003.193 · Cited by 64 · see citing works

Serum Electrolytes and Colonic Transfer of Water and Electrolytes in Chronic Ulcerative Colitis

Duthie, H. L., Watts, J. M., deDombal, F. T., & Goligher, J. C. (1964) · Gastroenterology · doi:10.1016/s0016-5085(19)34701-8 · Cited by 62 · see citing works

Therapeutic benefits from a poorly absorbed prednisolone enema in distal colitis.

McIntyre, P. B., Macrae, F., Berghouse, L., English, J., & Lennard‐Jones, J. E. (1985) · Gut · doi:10.1136/gut.26.8.822 · Cited by 58 · see citing works

A budesonide prodrug accelerates treatment of colitis in rats.

Cui, N., Friend, D. R., & Fedorak, R. N. (1994) · Gut · doi:10.1136/gut.35.10.1439 · Cited by 58 · see citing works

Dynamic Modeling of Cortisol Reduction after Inhaled Administration of Fluticasone Propionate

Rohatagi, S., Bye, A., Falcoz, C., Mackie, A. E., Meibohm, B., Möllmann, H., & Derendorf, H. (1996) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1996.tb04761.x · Cited by 56 · see citing works

Faecal mucus degrading glycosidases in ulcerative colitis and Crohn's disease.

Rhodes, J. M., Gallimore, R., Elias, E., Allan, R. N., & Kennedy, J. F. (1985) · Gut · doi:10.1136/gut.26.8.761 · Cited by 55 · see citing works

Metabolic pathways of the topical glucocorticoid budesonide in man.

Edsbäcker, S., Jönsson, S., Lindberg, C., Ryrfeldt, Å., & Thalén, A. (1983) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(25)08073-0 · Cited by 51 · see citing works

Bacterial enzymes used for colon-specific drug delivery are decreased in active Crohn's disease

Carrette, O., Favier, C., Mizon, C., Neut, C., Cortot, A., Colombel, J., & Mizon, J. (1995) · Digestive Diseases and Sciences · doi:10.1007/bf02220454 · Cited by 51 · see citing works

Treatment of distal ulcerative colitis with beclomethasone enemas

Bansky, G., Bühler, H., Stamm, B., Häcki, W. H., Buchmann, P., & Müller, J. (1987) · Diseases of the Colon & Rectum · doi:10.1007/bf02556177 · Cited by 50 · see citing works

Rectally administered prednisolone--evidence for a predominantly local action.

Lee, D. A., Taylor, M., James, V. H. T., & Walker, G. (1980) · Gut · doi:10.1136/gut.21.3.215 · Cited by 50 · see citing works

Double blind trial of oral fluticasone propionate v prednisolone in the treatment of active ulcerative colitis.

Hawthorne, A. B., Record, C. O., Holdsworth, C. D., Giaffer, M. H., Burke, D., Keech, M. L., & Hawkey, C. J. (1993) · Gut · doi:10.1136/gut.34.1.125 · Cited by 49 · see citing works

Colonic mucosal pH in humans

McDougall, C. J., Wong, R., Scudera, P., Lesser, M., & DeCosse, J. J. (1993) · Digestive Diseases and Sciences · doi:10.1007/bf01316512 · Cited by 48 · see citing works

Intrarectal Treatment of 100 Cases of Ulcerative Colitis with Prednisolone-21-phosphate Enemata

Matts, S. G. F. (1961) · BMJ · doi:10.1136/bmj.1.5220.165 · Cited by 47 · see citing works

Steroid complications in patients with ulcerative colitis

Kusunoki, M., Möeslein, G., Shoji, Y., Fujita, S., Yanagi, H., Sakanoue, Y., Saito, N., & Utsunomiya, J. (1992) · Diseases of the Colon & Rectum · doi:10.1007/bf02253508 · Cited by 46 · see citing works

Oral fluticasone propionate in active distal ulcerative colitis.

Angus, P. W., Snook, J. A., Reid, M., & Jewell, D. P. (1992) · Gut · doi:10.1136/gut.33.5.711 · Cited by 46 · see citing works

A quantitative comparison of the faecal flora of patients with ulcerative colitis and that of normal persons

Cooke, E. M. (1967) · The Journal of Pathology and Bacteriology · doi:10.1002/path.1700940225 · Cited by 45 · see citing works

A Controlled Trial of Beclomethasone Versus Betamethasone Enemas in Distal Ulcerative Colitis

Halpern, Z., Sold, O., Baratz, M., Konikoff, F. M., Halak, A., & Gilat, T. (1991) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-199102000-00009 · Cited by 44 · see citing works

A glucocorticoid prodrug facilitates normal mucosal function in rat colitis without adrenal suppression

McLeod, A. D., Fedorak, R. N., Friend, D. R., Tozer, T. N., & Cui, N. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90599-1 · Cited by 43 · see citing works

Faecal stasis in proctocolitis

Lennard‐Jones, J. E., Langman, M. J. S., & Jones, F. A. (1962) · Gut · doi:10.1136/gut.3.4.301 · Cited by 42 · see citing works

Oral or rectal administration of drugs in IBD?

Moody, G. A., Eaden, J., Helves, Z., & Mayberry, J. F. (1997) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.1997.tb00001.x · Cited by 41 · see citing works

Functional Alterations of the Microflora in Patients with Ulcerative Colitis

Benno, P., Leijonmarck, C.-E., Monsén, U., Uribe, A., & Midtvedt, T. (1993) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529309104019 · Cited by 40 · see citing works

Pharmacokinetics and retrograde colonic spread of budesonide enemas in patients with distal ulcerative colitis

NYMAN‐PANTELIDIS, M., Nilsson, Å., G‐WAGNER, Z., & BORGA, O. (1994) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.1994.tb00339.x · Cited by 39 · see citing works

Treatment of ulcerative colitis with hydrocortisone enemas

Farmer, R. G., & Schumacher, P. O. (1970) · Diseases of the Colon & Rectum · doi:10.1007/bf02616754 · Cited by 39 · see citing works

Tixocortol pivalate, a corticosteroid with no systemic glucocorticoid effect after oral, intrarectal, and intranasal application

Larochelle, P. M., du Souich, P., Bolté, E., LeLorier, J., & Goyer, R. (1983) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1983.43 · Cited by 38 · see citing works

Colonic delivery of dexamethasone from a prodrug accelerates healing of colitis in rats without adrenal suppression

Fedorak, R. N., Haeberlin, B., Empey, L. R., Cui, N., Nolen, H. W., Jewell, L. D., & Friend, D. R. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90130-2 · Cited by 37 · see citing works

Fluticasone propionate in Crohn's disease.

de Kaski, M. C., Peters, A. M., Lavender, J. P., & Hodgson, H. J. F. (1991) · Gut · doi:10.1136/gut.32.6.657 · Cited by 35 · see citing works

The in vivo behaviour of a colonic delivery system: a pilot study in man

Steed, K. P., Hooper, G., Ventura, P., Musa, R., & Wilding, I. R. (1994) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(94)90355-7 · Cited by 34 · see citing works

Pharmacokinetics of budesonide enema in patients with distal ulcerative colitis or proctitis

Danielsson, Å., Edsbäcker, S., Löfberg, R., Nilsson, Å., NYMAN‐PANTELIDIS, M., Olsson, O., Suhr, O. B., & Wïllén, R. (1993) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.1993.tb00113.x · Cited by 33 · see citing works

Gastrointestinal transit of a multiparticulate tablet formulation in patients with active ulcerative colitis

Davis, S. S., Robertson, C. S., & Wilding, I. R. (1991) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(91)90142-b · Cited by 31 · see citing works

Increased Faecal Glycosidases in Patients with Crohn’s Disease

Embden, J. G. H. R.-V., & Lieshout, L. M. C. V. (2009) · Digestion · doi:10.1159/000199486 · Cited by 29 · see citing works

Scintigraphic and pharmacokinetic assessment of a multiparticulate sustained release formulation of diltiazem

Wilding, I. R., Hardy, J. G., Maccari, M., Ravelli, V., & Davis, S. S. (1991) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(91)90351-n · Cited by 29 · see citing works

Cell-mediated immunity in gastrointestinal disease

MacDermott, R. P. (1986) · Human Pathology · doi:10.1016/s0046-8177(83)80215-9 · Cited by 25 · see citing works

Experience with Short and Long Term Courses of Local Adrenal Steroid Therapy For Ulcerative Colitis

Spencer, J. A., & Kirsner, J. B. (1962) · Gastroenterology · doi:10.1016/s0016-5085(62)80117-6 · Cited by 25 · see citing works

Medical and Dietary Management

Eastwood, M. A. (1975) · Clinics in Gastroenterology · doi:10.1016/s0300-5089(21)00099-7 · Cited by 25 · see citing works

Recent insight into the structure and function of the glucocorticoid receptor.

Distelhorst, C. (1989) · PubMed · Cited by 24 · see citing works

Betamethasone enemata in ulcerative colitis

Matts, S. G. F. (1962) · Gut · doi:10.1136/gut.3.4.312 · Cited by 18 · see citing works

Decreased faecal exoglycosidase activities identify a subset of patients with active Crohn's disease

Yamani, J. E., Mizon, C., Capon, C., Colombel, J., Fournet, B., Cortot, A., & Mizon, J. (1992) · Clinical Science · doi:10.1042/cs0830409 · Cited by 17 · see citing works

Oral budesonide competes favourably with prednisolone in active Crohn's disease

Campieri, M., Ferguson, A., & Doe, W. F. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)27471-5 · Cited by 14 · see citing works

Role of the Intestinal Microflora in Ulcerative Colitis

Onderdonk, A. B. (1983) · Elsevier eBooks · doi:10.1016/b978-0-12-341280-5.50024-0 · Cited by 14 · see citing works

Dose-proportional kinetics of budesonide controlled ileal release capsules

Nilsson, M., Edsbäcker, S., Larsson, P., & Wirén, J. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)27845-1 · Cited by 13 · see citing works

Immunopathology of ulcerative colitis: a review.

Herbay, A. V., Gebbers, J., & Otto, H. F. (1990) · PubMed · Cited by 11 · see citing works

[Decrease of fecal beta-galactosidase activity in Crohn disease].

Canva-Delcambre, V., Soenen, V., Mizon, C., Cortot, A., Mizon, J., & Colombel, J. (1993) · PubMed · Cited by 8 · see citing works

The oral systemic availability of fluticasone propionate in man– preliminary data [letter]

Bye, A. (1993) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1993.tb04212.x · Cited by 7 · see citing works

Overdosage of tetracosactrin in rheumatoid arthritis.

Hart, F. D., Taylor, R. T., HUSKISSON, E. C., & Shenfield, G. M. (1971) · BMJ · doi:10.1136/bmj.2.5754.165-a · Cited by 4 · see citing works

Smallpox in Central Province, Nyasaland

Sword, J. M. (1961) · BMJ · doi:10.1136/bmj.2.5245.165 · Cited by 4 · see citing works

Oral budesonide as maintenance treatment for Crohn's disease

(1995) · Gastroenterology · doi:10.1016/0016-5085(95)27615-7 · Cited by 3 · see citing works

Update on glucocorticoid action and resistance

Ito, K., Chung, K. F., & Adcock, I. M. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.01.032 · Cited by 401 · see citing works

New oral delivery systems for treatment of inflammatory bowel disease

Friend, D. R. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.08.011 · Cited by 306 · see citing works

Perspectives of biodegradable natural polysaccharides for site-specific drug delivery to the colon.

Jain, A., Gupta, Y., & Jain, S. (2007) · PubMed · Cited by 227 · see citing works

Using Corticosteroids to Reshape the Gut Microbiome: Implications for Inflammatory Bowel Diseases

Huang, E. Y., Inoue, T., Leone, V. A., Dalal, S., Touw, K., Wang, Y., Musch, M. W., Theriault, B., Higuchi, K., Donovan, S., et al. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000332 · Cited by 204 · see citing works

Medical therapy for ulcerative colitis 2004

Hanauer, S. B. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.02.071 · Cited by 156 · see citing works

Topical delivery of therapeutic agents in the treatment of inflammatory bowel disease

Klotz, U. E., & Schwab, M. G. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.08.007 · Cited by 142 · see citing works

Eosinophilic Gastroenteritis and Related Eosinophilic Disorders

Prussin, C. (2014) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2014.02.013 · Cited by 129 · see citing works

A pH-sensitive microsphere system for the colon delivery of tacrolimus containing nanoparticles

Lamprecht, A., Yamamoto, H., Takeuchi, H., & Kawashimà, Y. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.02.011 · Cited by 118 · see citing works

Local delivery of macromolecules to treat diseases associated with the colon

Bak, A., Ashford, M. B., & Brayden, D. J. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.10.009 · Cited by 107 · see citing works

Development of an Oral Drug Delivery System Targeting Immune-Regulating Cells in Experimental Inflammatory Bowel Disease: A New Therapeutic Strategy

Nakase, H., Okazaki, K., Tabata, Y., Uose, S., Ohana, M., Uchida, K., Matsushima, Y., Kawanami, C., Oshima, C., Ikada, Y., et al. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35256-5 · Cited by 101 · see citing works

Expression and function of β-glucuronidase in pancreatic cancer: potential role in drug targeting

Sperker, B., Werner, U., Mürdter, T. E., Tekkaya, C., Fritz, P., Wacke, R., Adam, U., Gerken, M., Drewelow, B., & Kroemer, H. K. (2000) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s002100000260 · Cited by 90 · see citing works

Clinical trial: Preliminary efficacy and safety study of a new Budesonide-MMX® 9mg extended-release tablets in patients with active left-sided ulcerative colitis

D’Haens, G., Kovács, Á., Vergauwe, P. L., Nagy, F. T., Molnár, T., Bouhnik, Y., Weiss, W., Brünner, H., Lavergne‐Slove, A., Binelli, D., et al. (2009) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2009.09.007 · Cited by 81 · see citing works

Production of enteric capsules by means of hot-melt extrusion

Mehuys, E., Remon, J., & Vervaet, C. (2004) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2004.10.011 · Cited by 66 · see citing works

What should be considered on design of a colon-specific prodrug?

Jung, Y., & Kim, Y. M. (2010) · Expert Opinion on Drug Delivery · doi:10.1517/17425240903490401 · Cited by 64 · see citing works

AC biosusceptometry in the study of drug delivery

Corá, L. A., Romeiro, F. G., Stelzer, M., Américo, M. F., de Oliveira, R. B., Baffa, O., & Miranda, J. R. D. A. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2005.01.026 · Cited by 62 · see citing works

Target-specific drug release to the colon

Jain, S., & Jain, A. (2008) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.5.5.483 · Cited by 61 · see citing works

Colonic drug delivery

Rubinstein, A. (2005) · Drug Discovery Today Technologies · doi:10.1016/j.ddtec.2005.05.021 · Cited by 56 · see citing works

Inflammation-triggered local drug release ameliorates colitis by inhibiting dendritic cell migration and Th1/Th17 differentiation

Regmi, S., Pathak, S., Nepal, M. R., Shrestha, P. S., Park, J., Kim, J. O., Yong, C. S., Choi, D.-Y., Chang, J., Jeong, T. C., et al. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.11.001 · Cited by 56 · see citing works

Effectiveness of budesonide-succinate-dextran conjugate as a novel prodrug of budesonide against acetic acid-induced colitis in rats

Varshosaz, J., Emami, J., Fassihi, A., Tavakoli, N., Minaiyan, M., Ahmadi, F., Mahzouni, P., & Dorkoosh, F. A. (2010) · International Journal of Colorectal Disease · doi:10.1007/s00384-010-1026-2 · Cited by 53 · see citing works

In vitro evaluation of coating polymers for enteric coating and human ileal targeting

Huyghebaert, N., Vermeire, A., & Remon, J. P. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.03.032 · Cited by 51 · see citing works

Novel drug delivery strategies for the treatment of inflammatory bowel disease

Kesisoglou, F., & Zimmermann, E. M. (2005) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2.3.451 · Cited by 43 · see citing works

Gastrointestinal transit and disintegration of enteric coated magnetic tablets assessed by ac biosusceptometry

Corá, L. A., Romeiro, F. G., Américo, M. F., de Oliveira, R. B., Baffa, O., Stelzer, M., & Miranda, J. R. D. A. (2005) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2005.08.009 · Cited by 40 · see citing works

Preparation of budesonide–dextran conjugates using glutarate spacer as a colon-targeted drug delivery system:in vitro/in vivoevaluation in induced ulcerative colitis

Varshosaz, J., Emami, J., Ahmadi, F., Tavakoli, N., Minaiyan, M., Fassihi, A., Mahzouni, P., & Dorkoosh, F. A. (2010) · Journal of drug targeting · doi:10.3109/10611861003801826 · Cited by 39 · see citing works

Immunosuppression-induced alterations in fish gut microbiota may increase the susceptibility to pathogens

Qi, X., Tu, X., Zha, J.-W., Huang, A., Wang, G., & Ling, F. (2019) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2019.03.035 · Cited by 37 · see citing works

Nonabsorbable Corticosteroids Use in the Treatment of Gastrointestinal Graft-versus-Host Disease

Ibrahim, R. B., Abidi, M. H., Cronin, S. M., Lum, L. G., Al-Kadhimi, Z. S., Ratanatharathorn, V., & Uberti, J. P. (2009) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2008.12.487 · Cited by 34 · see citing works

FK506 Microparticles Mitigate Experimental Colitis with Minor Renal Calcineurin Suppression

Lamprecht, A., Yamamoto, H., Ubrich, N., Takeuchi, H., Maincent, P., & Kawashimà, Y. (2005) · Pharmaceutical Research · doi:10.1007/s11095-004-1186-2 · Cited by 33 · see citing works

Effect of food on the pharmacokinetics of budesonide controlled ileal release capsules in patients with active Crohn’s disease

Lundin, P., Naber, A. H. J., Nilsson, M., & Edsbäcker, S. (2001) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2001.00910.x · Cited by 33 · see citing works

Differential glucocorticoid effects on repair mechanisms and NF-κB activity in the intestinal epithelium

Göke, M. N., Schneider, M., Beil, W., & Manns, M. P. (2002) · Regulatory Peptides · doi:10.1016/s0167-0115(02)00023-x · Cited by 33 · see citing works

Microencapsulation of budesonide with dextran by spray drying technique for colon-targeted delivery: anin vitro/in vivoevaluation in induced colitis in rat

Varshosaz, J., Ahmadi, F., Emami, J., Tavakoli, N., Minaiyan, M., Mahzouni, P., & Dorkoosh, F. A. (2010) · Journal of Microencapsulation · doi:10.3109/02652048.2010.529947 · Cited by 32 · see citing works

Magnetic hyperthermia controlled drug release in the GI tract: solving the problem of detection

Bear, J. C., Patrick, P. S., Casson, A., Southern, P., Lin, F.-Y., Powell, M. J., Pankhurst, Q. A., Kalber, T. L., Lythgoe, M. F., Parkin, I. P., et al. (2016) · Scientific Reports · doi:10.1038/srep34271 · Cited by 32 · see citing works

Effect of steroids on energy expenditure and substrate oxidation in women with crohn's disease

Al-Jaouni, R., Schneider, S. M., Piche, T., Rampal, P., & Hébuterne, X. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.07032.x · Cited by 30 · see citing works

Oral Budesonide in the Management of Crohn's Disease

Hofer, K. N. (2003) · Annals of Pharmacotherapy · doi:10.1345/aph.1d059 · Cited by 29 · see citing works

Pharmacological Management of Acute Endodontic Pain

khan, A. W. A., & Diogenes, A. R. (2021) · Drugs · doi:10.1007/s40265-021-01564-4 · Cited by 25 · see citing works

Pectin Film Coated Pellets for Colon-targeted Delivery of Budesonide: In-vitro/In-vivo Evaluation in Induced Ulcerative Colitis in Rat.

Varshosaz, J., Emami, J., Tavakoli, N., Minaiyan, M., Rahmani, N., Dorkoosh, F. A., & Mahzouni, P. (2012) · Europe PMC (PubMed Central) · Cited by 23 · see citing works

Glucocorticoid sensitivity in inflammatory bowel disease

Sidoroff, M., & Kolho, K. (2011) · Annals of Medicine · doi:10.3109/07853890.2011.590521 · Cited by 22 · see citing works

Colonic delivery of carboxyfluorescein by pH-sensitive microspheres in experimental colitis

Kietzmann, D., Moulari, B., Béduneau, A., Pellequer, Y., & Lamprecht, A. (2010) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2010.06.013 · Cited by 21 · see citing works

Colon delivery of budesonide using solid dispersion in dextran for the treatment and secondary prevention of ulcerative colitis in rat.

Varshosaz, J., Ahmadi, F., Emami, J., Tavakoli, N., Minaiyan, M., Mahzouni, P., & Dorkoosh, F. A. (2010) · Europe PMC (PubMed Central) · Cited by 21 · see citing works

Preparation and Characterization of Colon-Specific Microspheres of Diclofenac for Colorectal Cancer

Dang, T., Cui, Y., Chen, Y., Meng, X., Tang, B., & Wu, J. (2015) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v14i9.1 · Cited by 17 · see citing works

Budesonide for ulcerative colitis

Marín‐Jiménez, I., & Peña, A. S. (2006) · Revista Española de Enfermedades Digestivas · doi:10.4321/s1130-01082006000500007 · Cited by 17 · see citing works

Low bioavailability and traditional systemic steroids in IBD: can the former take over the latter?

Spurio, F. F., Aratari, A., Margagnoni, G., Clemente, V., Moretti, A., & Papi, C. (2013) · PubMed · Cited by 17 · see citing works

Development of novel budesonide pellets based on CODES(TM) technology: In vitro/in vivo evaluation in induced colitis in rats.

Varshosaz, J., Emami, J., Tavakoli, N., Minaiyan, M., Rahmani, N., Dorkoosh, F. A., & Mahzouni, P. (2011) · Europe PMC (PubMed Central) · Cited by 17 · see citing works

On-demand, magnetic hyperthermia-triggered drug delivery: optimisation for the GI tract

Rose, L. C., Bear, J. C., Southern, P., McNaughter, P. D., Piggott, R. B., Parkin, I. P., Qi, S., Hills, B. P., & Mayes, A. G. (2016) · Journal of Materials Chemistry B · doi:10.1039/c5tb02068a · Cited by 17 · see citing works

Soy Protein-Based Systems for Different Tissue Regeneration Applications

Vaz, C. M., Graaf, L. A., Reis, R. L., & Cunha, A. M. (2002) · Springer eBooks · doi:10.1007/978-94-010-0305-6_7 · Cited by 15 · see citing works

Dexamethasone 21-Sulfate Improves the Therapeutic Properties of Dexamethasone Against Experimental Rat Colitis by Specifically Delivering the Steroid to the Large Intestine

Kim, I., Kong, H., Lee, Y., Hong, S., Han, J., Jung, S., Jung, Y., & Kim, Y. M. (2008) · Pharmaceutical Research · doi:10.1007/s11095-008-9758-1 · Cited by 13 · see citing works

Preparation and in vitro/in vivo evaluation of dextran matrix tablets of budesonide in experimental ulcerative colitis in rats

Ahmadi, F., Varshosaz, J., Emami, J., Tavakoli, N., Minaiyan, M., Mahzouni, P., & Dorkoosh, F. A. (2010) · Drug Delivery · doi:10.3109/10717544.2010.520352 · Cited by 13 · see citing works

pH-sensitive microparticles for oral drug delivery

Lamprecht, A., & Kawashimà, Y. (2006) · Journal of Drug Delivery Science and Technology · doi:10.1016/s1773-2247(06)50004-8 · Cited by 12 · see citing works

Local level of TGF-β1 determines the effectiveness of dexamethasone through regulating the balance of Treg/Th17 cells in TNBS-induced mouse colitis

You, P., Chen, N., Su, L., Peng, T., Chen, G., & Liu, Y. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.5852 · Cited by 12 · see citing works

Celecoxib coupled to dextran via a glutamic acid linker yields a polymeric prodrug suitable for colonic delivery

Jung, Y., Lee, Y., Kim, J., Kim, W., Nam, J., Jeong, S., Lee, S., Yoo, J., & Kim, M. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s89077 · Cited by 11 · see citing works

Recurrent Spontaneous Gastrointestinal Graft-Versus-Host Disease in Autologous Hematopoietic Stem Cell Transplantation

Krishna, S. G., Barlogie, B., Lamps, L. W., Krishna, K., Aduli, F., & Anaissie, E. J. (2010) · Clinical Lymphoma Myeloma & Leukemia · doi:10.3816/clml.2010.n.012 · Cited by 11 · see citing works

Low bioavailability steroids in inflammatory bowel disease: an old chestnut or a whole new ballgame?

Saibeni, S., Meucci, G., Papi, C., Manes, G., & Fascì-Spurio, F. (2014) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2014.924396 · Cited by 10 · see citing works

Treatment of steroid-naive ulcerative colitis

Bossa, F., Colombo, E. M., Andriulli, A., & Annese, V. (2009) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656560902973728 · Cited by 8 · see citing works

How Important is Onset of Action in Ulcerative Colitis Therapy?

Masson, S., Nylander, D. L., & Mansfield, J. C. (2005) · Drugs · doi:10.2165/00003495-200565150-00001 · Cited by 6 · see citing works

Cystic fibrosis and inflammatory bowel disease: parallels in gut physiology and microbiota

Barrack, K. E., & O’Toole, G. A. (2025) · Journal of Bacteriology · doi:10.1128/jb.00167-25 · Cited by 6 · see citing works

Structural effects of N‐aromatic acyl‐amino acid conjugates on their deconjugation in the cecal contents of rats: implication in design of a colon‐specific prodrug with controlled conversion rate at the target site

Kong, H., Kim, H.-J., Do, H., Lee, Y., Hong, S., Yoon, J.-H., Jung, Y., & Kim, Y. M. (2011) · Biopharmaceutics & Drug Disposition · doi:10.1002/bdd.763 · Cited by 4 · see citing works

Iatrogenic Cushing's syndrome related to the interaction between oral budesonide with fluvoxamine: a case report

Martin, S. C., Blaga, C.-M., Lambrescu, I. M., Fierbinteanu-Braticevici, C. G., & Fica, S. V. (2015) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/jcpt.12312 · Cited by 4 · see citing works

IBD – Impact of Colonic pH, Onset of Action and other Factors in Modern Therapeutic Approach

Newton, A. M. J., & Kumar, N. (2014) · Global Journal of Gastroenterology & Hepatology · doi:10.12970/2308-6483.2014.02.03.1 · Cited by 4 · see citing works

Degradability of the linear azo polymer conjugated 5,5′‐azodisalicylic acid segment in the main chain for colon‐specific drug delivery

Lai, J., Tu, K., Wang, H., Chen, Z., & Wang, L. (2008) · Journal of Applied Polymer Science · doi:10.1002/app.27741 · Cited by 4 · see citing works

Topical and Oral Anti-inflammatory Activity of Budesonide Compared with Oral Prednisolone in an Animal Model Using Allergen-induced Gut Mucosal Exudation of Plasma as a Marker

Gustafsson, B. (2001) · Scandinavian Journal of Gastroenterology · doi:10.1080/003655201750422666 · Cited by 4 · see citing works

Treatment of Crohn's disease with budesonide: this rose still has thorns!

Valentine, J. F. (2002) · The American Journal of Gastroenterology · doi:10.1016/s0002-9270(02)03949-7 · Cited by 3 · see citing works

Intestinal microbiota in nephrotic children treated with immunosuppressive agents

Szlachciński, R., Szlachcińska, A., Szlachciński, Ł., Borycz-Stevens, I., Almeer, F., & Tkaczyk, M. (2020) · Pediatria Polska · doi:10.5114/polp.2020.94910 · Cited by 2 · see citing works

Corticosteroids

Adcock, I. M., & Ito, K. (2005) · Birkhäuser Basel eBooks · doi:10.1007/3-7643-7408-x_26 · Cited by 2 · see citing works

Budesonide for ulcerative colitis

Peña, A. S., & Marín‐Jiménez, I. (2007) · Springer eBooks · doi:10.1007/1-4020-4316-3_12 · Cited by 2 · see citing works

Targeted Delivery of Drugs to the Colon

Philip, A. K., & Zingales, S. K. (2016) · Drug Delivery · doi:10.1002/9781118833322.ch18 · Cited by 1 · see citing works

Targeted Cyclodextrins

Salmaso, S., & Sonvico, F. (2011) · doi:10.1002/9780470926819.ch13 · Cited by 1 · see citing works

Chapter 15. Emerging opportunities for the treatment of inflammatory bowel disease

Gale, J. D., McClure, K. F., & Pullen, N. (2003) · Annual reports in medicinal chemistry · doi:10.1016/s0065-7743(03)38016-9

Treatment of experimental colitis by modulating microbiota and eicosanoids : Effects of probiotics, prebiotics and leukotriene antagonist

Holma, R. (2002) · Työväentutkimus Vuosikirja

Current perspectives Update on glucocorticoid action and resistance

Ito, K., Chung, K. F., Adcock, I. M., & Kingdom, U. (2006)

UNIVERSIDADE FEDERAL DE SANTA CATARINA CENTRO DE CIÊNCIAS DA SAÚDE PROGRAMA DE PÓS-GRADUAÇÃO EM FARMÁCIA DESENVOLVIMENTO DE SISTEMAS DE LIBERAÇÃO NANO- E MICROESTRUTURADOS CONSTITUÍDOS DE COMPLEXOS DE LECITINA E QUITOSANA PARA A LIBERAÇÃO COLÔNICA DA NARINGENINA

Dalagnol, M. (2011)

DESENVOLVIMENTO DE DISPERSÕES SÓLIDAS PARA LIBERAÇÃO COLÔNICA DE METRONIDAZOL

Filho, M. (2008)

Allergic Inflammatory Diseases of the Gastrointestinal Tract

Prussin, C. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-415847-4.00083-5

C13 Corticosteroids

Adcock, I. M., Ito, K., & Kirkham, P. (2011) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0346-0136-8_28

Multi-site therapeutic modalities for inflammatory bowel diseases — mechanisms of action

Rogler, G. (2003) · Springer eBooks · doi:10.1007/978-1-4020-3477-0_26

Multi-site therapeutic modalities for inflammatory bowel diseases — mechanisms of action

Rogler, G. (2007) · Springer eBooks · doi:10.1007/0-387-25808-6_26

Rectal Glucocorticoid Use in Ulcerative Colitis

Katz, S. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1677-1_10

Caracterização físico-química de galactomananas de Adenanthera pavonina (Carolina) e Delonix regia (Flamboyant) reticuladas com trimetafosfato de sódio

de Matos, F. C. (2008) · Aleph UCLA Undergraduate Research Journal for the Humanities and Social Sciences

Steady-state pharmacokinetics of corticosteroid delivery from glucuronide prodrugs in normal and colitic rats

Nolen, H. W., Fedorak, R. N., & Friend, D. R. (1997) · Biopharmaceutics & Drug Disposition · doi:10.1002/(sici)1099-081x(199711)18:8 · Cited by 10 · see citing works

Topical Delivery of Steroids in Inflammatory Bowel Disease

Girlich, C., & Schölmerich, J. (2012) · Current Drug Delivery · doi:10.2174/156720112801323071 · Cited by 10 · see citing works

A REVIEW ON EXTENDED RELEASE DOSAGE FORM OF NSAIDS USED IN COLON TARGETED DRUG DELIVERY

Mukesh, G., & Mishra, A. (2013) · International Journal of Pharma Professional’s Research (IJPPR) · doi:10.69580/6yd35f61

Development and In Vitro Evaluation of a pH-Responsive Hydrogel for Colon-Targeted Delivery of a Glucocorticoid

(2026) · International Journal of Drug Delivery Technology · doi:10.25258/ijddt.16.65s.116

Carrier systems for the treatment of inflammatory bowel disease

Lamprecht, A., Stallmach, A., Kawashimà, Y., & Lehr, C. (2002) · Drugs of the Future · doi:10.1358/dof.2002.027.10.740182 · Cited by 17 · see citing works