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Bifidobacterium animalis strain DN‐173 010 shortens the colonic transit time in healthy women: a double‐blind, randomized, controlled study
Open accessAbstract
Background: A previous study has suggested that Bifidobacterium animalis DN‐173 010 shortens the colonic transit time in women. Aim: To confirm this effect and to determine whether modifications of the faecal bacterial mass and/or faecal secondary bile salts may be the explanation. Methods: A double‐blind, cross‐over study was performed. Thirty‐six healthy women were studied in four consecutive 10‐day periods. During periods 2 and 4, they ingested three 125 g cups per day of a fermented milk which was either a product containing B. animalis DN‐173 010 or a control without bifidobacteria. Periods 1 and 3 were run‐in and washout periods, respectively. The total and segmental colonic transit times were assessed using a pellet method. In 12 subjects, all stools were collected and analysed for pH, faecal weight, bacterial mass and bile acids. Results: The total and sigmoid transit times were significantly shorter during dosing with B. animalis compared to the control period. The other transit times, faecal weight, pH, bacterial mass and bile acids were not significantly affected. Conclusions: B. animalis DN‐173 010 shortens the colonic transit time in healthy women. This effect is not explained by modifications of the faecal bacterial mass or secondary bile acids.
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“In healthy adults as well as elderly subjects, a fermented milk containing Bifidobacterium animalis DN-173 010 alone or in association with the yoghurt starters Lactobacillus bulgaricus and Streptococcus thermophilus has been shown to decrease orofecal and ⁄ or colonic, especially sigmoid, transit time; [22][23][24][25]”
From Effect of a fermented milk containing Bifidobacterium animalis DN‐173 010 on the health‐related quality of life and symptoms in irritable bowel syndrome in adults in primary care: a multicentre, randomized, double‐blind, controlled trial (2007) · cites this paper as [24]
Experimental — accuracy not yet measuredIn the citing paper
“Clinical evidence of the efficacy of some probiotics in the improvement of symptoms in irritable bowel syndrome (IBS) has recently emerged (1 -3) .”
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“The variability of the effects reported has highlighted the product and strain specificity, which is supported by the high variability in their properties (anti-inflammatory activity, effect on motility or visceral sensation) (1,2) .”
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“Given the fact that alterations of gut microbiota have been identified in IBS (1,39) ,”
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“intervention with probiotics could be accompanied by modification of intestinal transit time as observed by Marteau et al. [26].”
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Metadata
- Authors
- Marteau, P., Cuillerier, E., Meance, S., Gerhardt, M. F., Myara, A., Bouvier, M., Bouley, C., Tondu, F., Bommelaer, G., & Grimaud, J. C.
- Affiliations
- Hôpital Européen Georges-Pompidou (FR)
- Hôpital Paris Saint-Joseph (FR)
- Hôpital Nord (FR)
- Danone (France) (FR)
- Centre Hospitalier Universitaire de Clermont-Ferrand (FR)
- Corresponding author
- Marteau, P.
- Venue
- Alimentary Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2002-03
- Volume
- 16
- Issue
- 3
- Pages
- 587-593
- ISSN
- 0269-2813 (ISSN-L)
- 1365-2036
- OpenAlex
- W2095211103
- Semantic Scholar
- 5b7ed18525ff7f83410a6fa94631c733746de855
- Cited by
- 254
- References
- 28
- Citations by year
- 2026: 3 · 2024: 6 · 2023: 8 · 2022: 8 · 2021: 7 · 2020: 6 · 2019: 9 · 2018: 6 · 2017: 15 · 2016: 9 · 2015: 8 · 2014: 20 · 2013: 19 · 2012: 12
- FWCI
- 4.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Alimentary Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- colonic transit time, fermented milk, probiotics, women, secondary bile acids, fecal weight, intestinal motility
- MeSH terms
- Adult, Bifidobacterium, Diet, Double-Blind Method, Feces, Female, Fermentation, Gastrointestinal Transit, Humans, Yogurt, Biomass, Cross-Over Studies
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