CoChat
Sign Up
Cited by 58Treatment of Major DepressionBlood Pressure and Hypertension StudiesNeurotransmitter Receptor Influence on Behavior

Comparison of the effects of venlafaxine, desipramine, and paroxetine on noradrenaline‐ and methoxamine‐evoked constriction of the dorsal hand vein

Open access
Abdelmawla, Langley, Szabadi, Bradshaw·1999·British Journal of Clinical Pharmacology
DOI 10.1046/j.1365-2125.1999.00031.xPMC PMC2014332
Open this paper in CoChat — free accountOpen PDF

Abstract

Aims To examine whether the antidepressant venlafaxine, a novel serotonin‐noradrenaline re‐uptake inhibitor (SNRI), can modify α‐adrenoceptor‐mediated venoconstriction in man. The effects of venlafaxine were compared with those of desipramine, a tricyclic antidepressant with noradrenaline uptake inhibiting properties, and paroxetine, a selective serotonin re‐uptake inhibitor (SSRI), on noradrenaline‐and methoxamine‐evoked venoconstriction using the dorsal hand vein compliance technique. Methods Fifteen healthy male volunteers participated in five weekly experimental sessions. Each session was associated with a clinically effective dose of an antidepressant or placebo. The following oral dosages were used: venlafaxine 75 mg, venlafaxine 150 mg, desipramine 100 mg, paroxetine 20 mg, or placebo. A double‐blind, cross‐over, balanced design was used. In each session, dose–response curves to both locally infused noradrenaline acid tartrate (0.1–33.33 ng min−1 ) and methoxamine hydrochloride (0.5–121.5 μg min−1 ) were constructed. Systolic and diastolic blood pressure and pulse rate were measured in the supine and erect positions. Salivation was measured by the dental roll technique. Results Venlafaxine 150 mg and desipramine 100 mg potentiated the venoconstrictor response to noradrenaline (anova of log ED 50 s: P<0.01; individual comparisons: venlafaxine 150 mg vs placebo: P<0.005; mean difference, 95% CI: −0.49 (−0.81, −0.17); desipramine 100 mg vs placebo: P<0.005; mean difference, 95% CI: −0.34 (−0.60, −0.09) without affecting the response to methoxamine. Neither paroxetine nor placebo had any effects on the venoconstrictor responses. Both doses of venlafaxine increased systolic blood pressure (supine and erect) and venlafaxine 150 mg increased diastolic blood pressure (supine) (anova, P<0.05). Desipramine increased heart rate (P<0.05). Desipramine and both doses of venlafaxine reduced salivation (P<0.025). Conclusions These results show that, similarly to desipramine 100 mg, venlafaxine 150 mg can potentiate venoconstrictor responses to noradrenaline, consistent with venlafaxine’s ability to block noradrenaline uptake in man. The importance of noradrenaline uptake blockade in these observations is confirmed by the lack of effect of the antidepressants on methoxamine‐evoked venoconstriction and the failure of paroxetine to modify noradrenaline‐evoked venoconstriction.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1046/j.1365-2125.1999.00031.x

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The central accumulation of norepinephrine from SNRIs might have activated alpha-2 receptors and concurrent inhibition of parasympathetic salivary neurons in the brainstem, which lead to decreased salivary flow and dry mouth.

    “The central accumulation of norepinephrine from SNRIs might have activated alpha-2 receptors and concurrent inhibition of parasympathetic salivary neurons in the brainstem, which lead to decreased salivary flow and dry mouth.3435”

    From Addressing the Side Effects of Contemporary Antidepressant Drugs: A Comprehensive Review (2018) · cites this paper as [35]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 3

  1. References effects of locally infused angiotensin I and noradrenaline in human dorsal hand veins. Br J Clin Pharmacol 1989; 28: 1
  2. Szabadi E, Bradshaw CM, Boston PF, Langley RW. The J Pharmacol Exp Ther 1984; 230: 94-102.
  3. Hassan SM, Wainscott G, Turner P. A comparison of the 1979; 186: 505-528.

Cited by

Sorted by citations

Related

Authors
Abdelmawla, Langley, Szabadi, & Bradshaw
Affiliations
Queen's Medical Centre (GB)
Corresponding author
Szabadi
Venue
British Journal of Clinical Pharmacology
Publisher
Wiley
Published
1999-09
Volume
48
Issue
3
Pages
345-354
ISSN
  • 0306-5251 (ISSN-L)
  • 1365-2125
DOI
10.1046/j.1365-2125.1999.00031.x
PMC
PMC2014332
OpenAlex
W1542427252
Cited by
58
References
30
Citations by year
2024: 3 · 2022: 2 · 2021: 2 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 1 · 2014: 2 · 2013: 4 · 2012: 2
FWCI
2.18
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 845 d)
Locations
  • British Journal of Clinical Pharmacology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
venlafaxine, desipramine, paroxetine, antidepressants, venoconstriction, dorsal hand vein, norepinephrine, methoxamine, alpha-adrenergic receptors, serotonin-norepinephrine reuptake inhibitors, tricyclic antidepressants, selective serotonin reuptake inhibitors, blood pressure, salivary secretion, dose-response relationship, venous compliance
MeSH terms
Venlafaxine Hydrochloride, Adrenergic alpha-Agonists, Adult, Blood Pressure, Cyclohexanols, Desipramine, Double-Blind Method, Drug Interactions, Hand, Heart Rate, Humans, Male, Methoxamine, Norepinephrine, Salivation, Vasoconstriction, Veins, Selective Serotonin Reuptake Inhibitors, Paroxetine, Cross-Over Studies

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review