Cardiovascular adverse effects of newer antidepressants
Abstract
Newer antidepressants that are more selective in their neurotransmitter effects include the selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and others (agomelatine, bupropion, mirtazapine, reboxetine, vilazodone, vortioxetine). This article systematically reviews data from a variety of sources regarding the potential adverse effects of these medications on various cardiovascular parameters. Potential biochemical mechanisms by which these antidepressants may adversely affect the cardiovascular system are also discussed. Antidepressants that are associated with higher cardiovascular risk (SNRIs, reboxetine), lower risk (SSRIs), and without current evidence of cardiovascular risk (agomelatine, mirtazapine, vilazodone, vortioxetine) are identified. The FDA's recommendations regarding citalopram are organized and summarized, and situations with higher risk of cardiovascular adverse effects are identified.
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Newer classes of antidepressants were suggested to have a high risk of cardiovascular adverse effects.
“In recent years, newer classes of antidepressants were also suggested to have a high risk of cardiovascular adverse effects.”
From Addressing the Side Effects of Contemporary Antidepressant Drugs: A Comprehensive Review (2018) · cites this paper as [23]
Among newer antidepressants, SNRIs are associated with an increased incidence of cardiovascular AEs, especially hypertension.
“Among newer antidepressants, SNRIs are associated with an increased incidence of cardiovascular AEs, especially hypertension.23”
From Addressing the Side Effects of Contemporary Antidepressant Drugs: A Comprehensive Review (2018) · cites this paper as [23]
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Diretriz Brasileira de Cardiogeriatria – 2026
Helber, I., Zanon, J. C. D. C., Peixoto, J. M., Caixeta, A. M., Nussbacher, A., de Oliveira, D. C., de Freitas, E. V., Cintra, F. D., Garcia, J. S., Miranda, R. D., et al. (2026) · Arquivos Brasileiros de Cardiologia · doi:10.36660/abc.20260795
- Authors
- Mago, R., Tripathi, N., & Andrade, C.
- Affiliations
- Thomas Jefferson University (US)
- National Institute of Mental Health and Neurosciences (IN)
- Corresponding author
- Andrade, Chittaranjan
- Venue
- Expert Review of Neurotherapeutics
- Publisher
- Informa UK Limited
- Published
- 2014-04-17
- Volume
- 14
- Issue
- 5
- Pages
- 539-551
- ISSN
- 1473-7175 (ISSN-L)
- 1744-8360
- OpenAlex
- W2106353554
- Cited by
- 54
- References
- 94
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 3 · 2023: 6 · 2022: 7 · 2021: 5 · 2020: 2 · 2019: 1 · 2018: 9 · 2017: 6 · 2016: 1 · 2015: 3
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Expert Review of Neurotherapeutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- antidepressants, cardiovascular adverse events, selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, reboxetine, agomelatine, mirtazapine, vilazodone, vortioxetine, bupropion, citalopram, cardiovascular risk, drug mechanisms of action
- MeSH terms
- Antidepressive Agents, Cardiovascular Diseases, Depression, Humans, MEDLINE
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