Cited by 54Treatment of Major DepressionCardiac Health and Mental HealthBlood Pressure and Hypertension Studies

Cardiovascular adverse effects of newer antidepressants

Mago, Rajnish, Tripathi, Neeta, Andrade, Chittaranjan·2014·Expert Review of Neurotherapeutics

Abstract

Newer antidepressants that are more selective in their neurotransmitter effects include the selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and others (agomelatine, bupropion, mirtazapine, reboxetine, vilazodone, vortioxetine). This article systematically reviews data from a variety of sources regarding the potential adverse effects of these medications on various cardiovascular parameters. Potential biochemical mechanisms by which these antidepressants may adversely affect the cardiovascular system are also discussed. Antidepressants that are associated with higher cardiovascular risk (SNRIs, reboxetine), lower risk (SSRIs), and without current evidence of cardiovascular risk (agomelatine, mirtazapine, vilazodone, vortioxetine) are identified. The FDA's recommendations regarding citalopram are organized and summarized, and situations with higher risk of cardiovascular adverse effects are identified.

Integrity signals

Registry

Crossref · 10.1586/14737175.2014.908709

Cites

93 of 93 references verified0 citation errors · 0 not checkable

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Authors
Mago, R., Tripathi, N., & Andrade, C.
Affiliations
  • Thomas Jefferson University (US)
  • National Institute of Mental Health and Neurosciences (IN)
Corresponding author
Andrade, Chittaranjan
Venue
Expert Review of Neurotherapeutics
Published
2014-04-17
Volume
14
Issue
5
Pages
539-551
ISSN
  • 1473-7175 (ISSN-L)
  • 1744-8360
OpenAlex
W2106353554
Cited by
54
References
94
Citations by year
2026: 4 · 2025: 7 · 2024: 3 · 2023: 6 · 2022: 7 · 2021: 5 · 2020: 2 · 2019: 1 · 2018: 9 · 2017: 6 · 2016: 1 · 2015: 3
FWCI
0.43
Type
journal article
Language
en
Open access
closed
Locations
  • Expert Review of Neurotherapeutics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords
antidepressants, cardiovascular adverse events, selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, reboxetine, agomelatine, mirtazapine, vilazodone, vortioxetine, bupropion, citalopram, cardiovascular risk, drug mechanisms of action
MeSH terms
Antidepressive Agents, Cardiovascular Diseases, Depression, Humans, MEDLINE

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